Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders / Nadine PARKER ; Laurie J. HANNIGAN ; Espen HAGEN ; Pravesh PAREKH ; Alexey SHADRIN ; Piotr JAHOLKOWSKI ; Evgeniia FREI ; Viktoria BIRKENÆS ; Guy HINDLEY ; Laura HEGEMANN ; Elizabeth C. CORFIELD ; Martin TESLI ; Alexandra HAVDAHL ; Ole A. ANDREASSEN in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Titre : Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders Type de document : texte imprimé Auteurs : Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.350-365 Langues : Anglais (eng) Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n 54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5 5 years) and latent profile analyses (1.5 8 years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5 5 years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders [texte imprimé] / Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur . - p.350-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n 54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5 5 years) and latent profile analyses (1.5 8 years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5 5 years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Youth psychotic experiences: psychometric evaluation and diagnostic associations of the CAPE-16 in adolescents from the Norwegian Mother, Father and Child Cohort / Viktoria BIRKENÆS in Journal of Child Psychology and Psychiatry, 67-1 (January 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.27-40 Titre : Youth psychotic experiences: psychometric evaluation and diagnostic associations of the CAPE-16 in adolescents from the Norwegian Mother, Father and Child Cohort Type de document : texte imprimé Auteurs : Viktoria BIRKENÆS, Auteur ; Pravesh PAREKH, Auteur ; Laura HEGEMANN, Auteur ; Nora R. BAKKEN, Auteur ; Evgeniia FREI, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Olav B. SMELAND, Auteur ; Ezra SUSSER, Auteur ; Katrina M. RODRIGUEZ, Auteur ; Markos TESFAYE, Auteur ; Ole A. ANDREASSEN, Auteur ; Alexandra HAVDAHL, Auteur ; Ida E. SØNDERBY, Auteur Article en page(s) : p.27-40 Langues : Anglais (eng) Mots-clés : Youth psychotic experiences  subgroup differences  subsequent mental illness  digitalization  COVID-19  MoBa Index. décimale : PER Périodiques Résumé : Background Adolescent self-reported psychotic experiences are associated with mental illness and could help guide prevention strategies. Youth report substantially more experiences than adults. However, with large societal changes like the digital revolution and COVID-19 pandemic, existing questionnaires may no longer accurately capture youth experiences. We aimed to determine the ability of the CAPE-16 questionnaire in capturing psychotic experiences across contexts (biological sex and COVID-19 response) and generations, thereby validating important psychometric aspects of the tool in modern adolescents. Methods We used data from the Norwegian Mother, Father and Child Study (MoBa), a population-based pregnancy cohort. Adolescents responded to the CAPE-16 questionnaire (n?=?18,835). For a comparison between age groups, we included adult men from the parent generation who responded to the CAPE-9 (n?=?28,793). We investigated the psychometric properties of CAPE-16 through confirmatory factor analyses, measurement invariance testing across biological sex, response before/during the COVID-19 pandemic, and generations (adolescents and fathers), and examined subscale and item-level associations with subsequent registry-based psychiatric diagnoses (average time between CAPE and last registry update: 3.68?±?1.34?years). Results Out of 18,835 adolescents, 33.2% reported lifetime psychotic experiences. We confirmed a three-factor structure (paranoia, bizarre thoughts, and hallucinations) and good subscale reliability (??=?.86 and .90). CAPE-16 scores were stable across biological sex and pandemic status. CAPE-9 response patterns were non-invariant across adolescents and adult men, with an item related to digital technology particularly prone to bias. CAPE-16 subscales were associated with subsequent psychiatric diagnoses, especially psychotic disorders. Conclusions CAPE-16 is a reliable measure of psychotic experiences across sex and a major societal stressor in adolescents. More frequent and distressing experiences increase the risk of subsequent psychiatric diagnoses. Different response patterns between adults and adolescents for items related to digital technology suggest differences in interpretation. Hence, certain items may benefit from revisions. En ligne : https://doi.org/10.1111/jcpp.70007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577 [article] Youth psychotic experiences: psychometric evaluation and diagnostic associations of the CAPE-16 in adolescents from the Norwegian Mother, Father and Child Cohort [texte imprimé] / Viktoria BIRKENÆS, Auteur ; Pravesh PAREKH, Auteur ; Laura HEGEMANN, Auteur ; Nora R. BAKKEN, Auteur ; Evgeniia FREI, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Olav B. SMELAND, Auteur ; Ezra SUSSER, Auteur ; Katrina M. RODRIGUEZ, Auteur ; Markos TESFAYE, Auteur ; Ole A. ANDREASSEN, Auteur ; Alexandra HAVDAHL, Auteur ; Ida E. SØNDERBY, Auteur . - p.27-40. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.27-40 Mots-clés : Youth psychotic experiences  subgroup differences  subsequent mental illness  digitalization  COVID-19  MoBa Index. décimale : PER Périodiques Résumé : Background Adolescent self-reported psychotic experiences are associated with mental illness and could help guide prevention strategies. Youth report substantially more experiences than adults. However, with large societal changes like the digital revolution and COVID-19 pandemic, existing questionnaires may no longer accurately capture youth experiences. We aimed to determine the ability of the CAPE-16 questionnaire in capturing psychotic experiences across contexts (biological sex and COVID-19 response) and generations, thereby validating important psychometric aspects of the tool in modern adolescents. Methods We used data from the Norwegian Mother, Father and Child Study (MoBa), a population-based pregnancy cohort. Adolescents responded to the CAPE-16 questionnaire (n?=?18,835). For a comparison between age groups, we included adult men from the parent generation who responded to the CAPE-9 (n?=?28,793). We investigated the psychometric properties of CAPE-16 through confirmatory factor analyses, measurement invariance testing across biological sex, response before/during the COVID-19 pandemic, and generations (adolescents and fathers), and examined subscale and item-level associations with subsequent registry-based psychiatric diagnoses (average time between CAPE and last registry update: 3.68?±?1.34?years). Results Out of 18,835 adolescents, 33.2% reported lifetime psychotic experiences. We confirmed a three-factor structure (paranoia, bizarre thoughts, and hallucinations) and good subscale reliability (??=?.86 and .90). CAPE-16 scores were stable across biological sex and pandemic status. CAPE-9 response patterns were non-invariant across adolescents and adult men, with an item related to digital technology particularly prone to bias. CAPE-16 subscales were associated with subsequent psychiatric diagnoses, especially psychotic disorders. Conclusions CAPE-16 is a reliable measure of psychotic experiences across sex and a major societal stressor in adolescents. More frequent and distressing experiences increase the risk of subsequent psychiatric diagnoses. Different response patterns between adults and adolescents for items related to digital technology suggest differences in interpretation. Hence, certain items may benefit from revisions. En ligne : https://doi.org/10.1111/jcpp.70007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577

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