Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders / Nadine PARKER ; Laurie J. HANNIGAN ; Espen HAGEN ; Pravesh PAREKH ; Alexey SHADRIN ; Piotr JAHOLKOWSKI ; Evgeniia FREI ; Viktoria BIRKENÆS ; Guy HINDLEY ; Laura HEGEMANN ; Elizabeth C. CORFIELD ; Martin TESLI ; Alexandra HAVDAHL ; Ole A. ANDREASSEN in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Titre : Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders Type de document : Texte imprimé et/ou numérique Auteurs : Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.350-365 Langues : Anglais (eng) Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n?=?54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5?5?years) and latent profile analyses (1.5?8?years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5?5?years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders [Texte imprimé et/ou numérique] / Nadine PARKER, Auteur ; Laurie J. HANNIGAN, Auteur ; Espen HAGEN, Auteur ; Pravesh PAREKH, Auteur ; Alexey SHADRIN, Auteur ; Piotr JAHOLKOWSKI, Auteur ; Evgeniia FREI, Auteur ; Viktoria BIRKENÆS, Auteur ; Guy HINDLEY, Auteur ; Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Martin TESLI, Auteur ; Alexandra HAVDAHL, Auteur ; Ole A. ANDREASSEN, Auteur . - p.350-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.350-365 Mots-clés : Emotional problems  behavioral problems  polygenic risk (PRS)  mood disorder  anxiety disorder  development  MoBa  MBRN Index. décimale : PER Périodiques Résumé : Background Symptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders. Methods This study uses data from a genotyped sample of children (n?=?54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5?5?years) and latent profile analyses (1.5?8?years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGSBD), anxiety (PGSANX), depression (PGSDEP), and neuroticism (PGSNEUR). Results Associations between PGSDEP, PGSANX, and PGSNEUR, and emotional and behavioral difficulties in childhood were more persistent than age-specific across early childhood (1.5?5?years). Higher PGSANX and PGSDEP were associated with steeper increases in behavioral difficulties across early childhood. Latent profile analyses identified five profiles with different associations with emotional disorder diagnosis. All PGS were associated with the probability of classification into profiles characterized by some form of difficulties (vs. a normative reference profile), but only PGSBD was uniquely associated with a single developmental profile. Conclusions Genetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention. En ligne : https://doi.org/10.1111/jcpp.14063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Early manifestations of genetic risk for neurodevelopmental disorders / Ragna Bugge ASKELAND in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819 Titre : Early manifestations of genetic risk for neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.810-819 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with  Hyperactivity/complications/epidemiology/genetics  Autism Spectrum Disorder/complications/epidemiology/genetics  Child  Child, Preschool  Cohort Studies  Female  Humans  Male  Mothers  Neurodevelopmental Disorders/complications/epidemiology/genetics  Risk Factors  Adhd  MoBa  Polygenic risk score  autism  hyperactivity  inattention  language and motor difficulties  neurodevelopmental disorders  repetitive behavior  schizophrenia  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Early manifestations of genetic risk for neurodevelopmental disorders [Texte imprimé et/ou numérique] / Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur . - p.810-819. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819 Mots-clés : Attention Deficit Disorder with  Hyperactivity/complications/epidemiology/genetics  Autism Spectrum Disorder/complications/epidemiology/genetics  Child  Child, Preschool  Cohort Studies  Female  Humans  Male  Mothers  Neurodevelopmental Disorders/complications/epidemiology/genetics  Risk Factors  Adhd  MoBa  Polygenic risk score  autism  hyperactivity  inattention  language and motor difficulties  neurodevelopmental disorders  repetitive behavior  schizophrenia  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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