
- <Centre d'Information et de documentation du CRA Rhône-Alpes
- CRA
- Informations pratiques
-
Adresse
Centre d'information et de documentation
Horaires
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexLundi au Vendredi
Contact
9h00-12h00 13h30-16h00Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Adresse
Détail de l'auteur
Auteur Laurie J. HANNIGAN |
Documents disponibles écrits par cet auteur (5)



Developmental change in the association between adolescent depressive symptoms and the home environment: results from a longitudinal, genetically informative investigation / Laurie J. HANNIGAN in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)
![]()
[article]
Titre : Developmental change in the association between adolescent depressive symptoms and the home environment: results from a longitudinal, genetically informative investigation Type de document : Texte imprimé et/ou numérique Auteurs : Laurie J. HANNIGAN, Auteur ; Tom A. MCADAMS, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.787-797 Langues : Anglais (eng) Mots-clés : Depression adolescence home environment parenting gene–environment correlation Index. décimale : PER Périodiques Résumé : Background Depression is already highly prevalent by late adolescence, indicating that research into its developmental emergence should consider earlier risk factors and environmental contexts. The home environment is a key context for children and adolescents throughout development. However, the nature of relationships that exist between aspects of the home environment and the development of depressive symptoms cannot be assumed. Genetically informative studies have been used to provide insights about the aetiology of such relationships, often finding them to be partly confounded by the influence of children's genes. Here, we investigate developmental change in the aetiology of the association between aspects of the home environment and depressive symptoms at the onset of adolescence. Methods We used longitudinal child- and parent-report data from >5,000 twin pairs enrolled in the UK-representative Twins Early Development Study. Multivariate, genetically sensitive structural equation models were used to decompose latent variance and covariance in depressive symptoms (measured at 12 and 16 years) and aspects of the home environment (at 9 and 14 years) into genetic and environmental influences. Results Going from childhood to adolescence, genetic influences accounted for an increasing proportion of the association [30% (16–42) of r = .44 in childhood; 40% (25–61) of r = .43 in adolescence], at the expense of shared environmental influences, which decreased from 70% (58–83) to 48% (29–62). Unique environmental influences accounted for a significant proportion of the association in adolescence only [12% (06–18)]. Developmental changes could largely be attributed to subtle shifts in the relative importance of stable aetiological factors, rather than the emergence of influences unique to adolescence. Conclusions These findings emphasise the importance of developmental and aetiological context in interpreting associations between aspects of the home environment and child emotional outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316
in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.787-797[article] Developmental change in the association between adolescent depressive symptoms and the home environment: results from a longitudinal, genetically informative investigation [Texte imprimé et/ou numérique] / Laurie J. HANNIGAN, Auteur ; Tom A. MCADAMS, Auteur ; Thalia C. ELEY, Auteur . - p.787-797.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.787-797
Mots-clés : Depression adolescence home environment parenting gene–environment correlation Index. décimale : PER Périodiques Résumé : Background Depression is already highly prevalent by late adolescence, indicating that research into its developmental emergence should consider earlier risk factors and environmental contexts. The home environment is a key context for children and adolescents throughout development. However, the nature of relationships that exist between aspects of the home environment and the development of depressive symptoms cannot be assumed. Genetically informative studies have been used to provide insights about the aetiology of such relationships, often finding them to be partly confounded by the influence of children's genes. Here, we investigate developmental change in the aetiology of the association between aspects of the home environment and depressive symptoms at the onset of adolescence. Methods We used longitudinal child- and parent-report data from >5,000 twin pairs enrolled in the UK-representative Twins Early Development Study. Multivariate, genetically sensitive structural equation models were used to decompose latent variance and covariance in depressive symptoms (measured at 12 and 16 years) and aspects of the home environment (at 9 and 14 years) into genetic and environmental influences. Results Going from childhood to adolescence, genetic influences accounted for an increasing proportion of the association [30% (16–42) of r = .44 in childhood; 40% (25–61) of r = .43 in adolescence], at the expense of shared environmental influences, which decreased from 70% (58–83) to 48% (29–62). Unique environmental influences accounted for a significant proportion of the association in adolescence only [12% (06–18)]. Developmental changes could largely be attributed to subtle shifts in the relative importance of stable aetiological factors, rather than the emergence of influences unique to adolescence. Conclusions These findings emphasise the importance of developmental and aetiological context in interpreting associations between aspects of the home environment and child emotional outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12689 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors / Tong CHEN in Journal of Child Psychology and Psychiatry, 66-1 (January 2025)
![]()
[article]
Titre : Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Tong CHEN, Auteur ; Olakunle A. OGINNI, Auteur ; Laurie J. HANNIGAN, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. MAGGS, Auteur ; Ashley N. LINDEN-CARMICHAEL, Auteur ; Jenae M. NEIDERHISER, Auteur Article en page(s) : p.85-97 Langues : Anglais (eng) Mots-clés : Behavior problems alcohol abuse longitudinal studies development genetics Index. décimale : PER Périodiques Résumé : Background Whether emotional problems during childhood and adolescence are longitudinally associated with adult alcohol use behaviors is unclear. This study examined associations between developmental trajectories of emotional problems and early adult alcohol use behaviors, while considering co-occurring conduct problems, developmental change/timing, sex differences, and potential confounds. Methods Participants were from the Twins Early Development Study (analytic N?=?19,908 individuals). Emotional and conduct problems were measured by parent reports at child ages 4, 7, and 9?years and via self-reports at ages 9, 11, and 16?years on the Strengths and Difficulties Questionnaire. Alcohol use behaviors (alcohol consumption and alcohol-related problems) were self-reported by the twins on the Alcohol Use Disorders Identification Test at age 22?years. Piecewise latent growth curve models described nonlinear developmental trajectories of emotional and conduct problems from ages 4 to 16. At age 22, alcohol use was regressed on emotional and conduct problems' intercepts and slopes from piecewise latent growth curve model and sex differences in regression coefficients were tested. Using twin modeling, Cholesky decompositions and direct path models were compared to test whether significant phenotypic associations were best explained by direct phenotypic influences or correlated genetic and environmental influences. Results Emotional problems had different associations with alcohol-related problems versus alcohol consumption. After accounting for direct influences from conduct problems, emotional problems were not associated with alcohol-related problems, while emotional problems at age 9 were negatively associated with alcohol consumption in males. Conclusions Overall, findings did not support emotional problems as prospective risk factors for severe alcohol use above and beyond risks associated with conduct problems. Sex- and age-specific links between emotional problems and alcohol consumption in early adulthood may be worthy of further exploration, particularly as twin analyses improved our confidence that such links may be underpinned by causal mechanisms. En ligne : https://dx.doi.org/10.1111/jcpp.14034 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545
in Journal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.85-97[article] Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors [Texte imprimé et/ou numérique] / Tong CHEN, Auteur ; Olakunle A. OGINNI, Auteur ; Laurie J. HANNIGAN, Auteur ; Thalia C. ELEY, Auteur ; Jennifer L. MAGGS, Auteur ; Ashley N. LINDEN-CARMICHAEL, Auteur ; Jenae M. NEIDERHISER, Auteur . - p.85-97.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 66-1 (January 2025) . - p.85-97
Mots-clés : Behavior problems alcohol abuse longitudinal studies development genetics Index. décimale : PER Périodiques Résumé : Background Whether emotional problems during childhood and adolescence are longitudinally associated with adult alcohol use behaviors is unclear. This study examined associations between developmental trajectories of emotional problems and early adult alcohol use behaviors, while considering co-occurring conduct problems, developmental change/timing, sex differences, and potential confounds. Methods Participants were from the Twins Early Development Study (analytic N?=?19,908 individuals). Emotional and conduct problems were measured by parent reports at child ages 4, 7, and 9?years and via self-reports at ages 9, 11, and 16?years on the Strengths and Difficulties Questionnaire. Alcohol use behaviors (alcohol consumption and alcohol-related problems) were self-reported by the twins on the Alcohol Use Disorders Identification Test at age 22?years. Piecewise latent growth curve models described nonlinear developmental trajectories of emotional and conduct problems from ages 4 to 16. At age 22, alcohol use was regressed on emotional and conduct problems' intercepts and slopes from piecewise latent growth curve model and sex differences in regression coefficients were tested. Using twin modeling, Cholesky decompositions and direct path models were compared to test whether significant phenotypic associations were best explained by direct phenotypic influences or correlated genetic and environmental influences. Results Emotional problems had different associations with alcohol-related problems versus alcohol consumption. After accounting for direct influences from conduct problems, emotional problems were not associated with alcohol-related problems, while emotional problems at age 9 were negatively associated with alcohol consumption in males. Conclusions Overall, findings did not support emotional problems as prospective risk factors for severe alcohol use above and beyond risks associated with conduct problems. Sex- and age-specific links between emotional problems and alcohol consumption in early adulthood may be worthy of further exploration, particularly as twin analyses improved our confidence that such links may be underpinned by causal mechanisms. En ligne : https://dx.doi.org/10.1111/jcpp.14034 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 Early manifestations of genetic risk for neurodevelopmental disorders / Ragna Bugge ASKELAND in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
![]()
[article]
Titre : Early manifestations of genetic risk for neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.810-819 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/complications/epidemiology/genetics Autism Spectrum Disorder/complications/epidemiology/genetics Child Child, Preschool Cohort Studies Female Humans Male Mothers Neurodevelopmental Disorders/complications/epidemiology/genetics Risk Factors Adhd MoBa Polygenic risk score autism hyperactivity inattention language and motor difficulties neurodevelopmental disorders repetitive behavior schizophrenia social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819[article] Early manifestations of genetic risk for neurodevelopmental disorders [Texte imprimé et/ou numérique] / Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål Rasmus NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur . - p.810-819.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819
Mots-clés : Attention Deficit Disorder with Hyperactivity/complications/epidemiology/genetics Autism Spectrum Disorder/complications/epidemiology/genetics Child Child, Preschool Cohort Studies Female Humans Male Mothers Neurodevelopmental Disorders/complications/epidemiology/genetics Risk Factors Adhd MoBa Polygenic risk score autism hyperactivity inattention language and motor difficulties neurodevelopmental disorders repetitive behavior schizophrenia social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15?205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18?months, 3, 5 and 8?years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8?years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18?months, motor difficulties at 36?months, and hyperactivity and inattention at 8?years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18?months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study / Laura HEGEMANN in Molecular Autism, 15 (2024)
![]()
[article]
Titre : Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study Type de document : Texte imprimé et/ou numérique Auteurs : Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Adrian Dahl ASKELUND, Auteur ; Andrea G. ALLEGRINI, Auteur ; Ragna Bugge ASKELAND, Auteur ; Angelica RONALD, Auteur ; Helga ASK, Auteur ; Beate ST POURCAIN, Auteur ; Ole A. ANDREASSEN, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra. HAVDAHL, Auteur Article en page(s) : 25p. Langues : Anglais (eng) Mots-clés : Humans Norway Female Male Phenotype Child, Preschool Cohort Studies Neurodevelopmental Disorders/genetics/diagnosis Mothers Autistic Disorder/genetics Genetic Predisposition to Disease Adult Fathers Genome-Wide Association Study Attention Deficit Disorder with Hyperactivity/genetics/diagnosis Schizophrenia/genetics Genetic Heterogeneity Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism and different neurodevelopmental conditions frequently co-occur, as do their symptoms at sub-diagnostic threshold levels. Overlapping traits and shared genetic liability are potential explanations. METHODS: In the population-based Norwegian Mother, Father, and Child Cohort study (MoBa), we leverage item-level data to explore the phenotypic factor structure and genetic architecture underlying neurodevelopmental traits at age 3 years (N = 41,708-58,630) using maternal reports on 76 items assessing children's motor and language development, social functioning, communication, attention, activity regulation, and flexibility of behaviors and interests. RESULTS: We identified 11 latent factors at the phenotypic level. These factors showed associations with diagnoses of autism and other neurodevelopmental conditions. Most shared genetic liabilities with autism, ADHD, and/or schizophrenia. Item-level GWAS revealed trait-specific genetic correlations with autism (items r(g) range = -?0.27-0.78), ADHD (items r(g) range = -?0.40-1), and schizophrenia (items r(g) range = -?0.24-0.34). We find little evidence of common genetic liability across all neurodevelopmental traits but more so for several genetic factors across more specific areas of neurodevelopment, particularly social and communication traits. Some of these factors, such as one capturing prosocial behavior, overlap with factors found in the phenotypic analyses. Other areas, such as motor development, seemed to have more heterogenous etiology, with specific traits showing a less consistent pattern of genetic correlations with each other. CONCLUSIONS: These exploratory findings emphasize the etiological complexity of neurodevelopmental traits at this early age. In particular, diverse associations with neurodevelopmental conditions and genetic heterogeneity could inform follow-up work to identify shared and differentiating factors in the early manifestations of neurodevelopmental traits and their relation to autism and other neurodevelopmental conditions. This in turn could have implications for clinical screening tools and programs. En ligne : https://dx.doi.org/10.1186/s13229-024-00599-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538
in Molecular Autism > 15 (2024) . - 25p.[article] Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study [Texte imprimé et/ou numérique] / Laura HEGEMANN, Auteur ; Elizabeth C. CORFIELD, Auteur ; Adrian Dahl ASKELUND, Auteur ; Andrea G. ALLEGRINI, Auteur ; Ragna Bugge ASKELAND, Auteur ; Angelica RONALD, Auteur ; Helga ASK, Auteur ; Beate ST POURCAIN, Auteur ; Ole A. ANDREASSEN, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra. HAVDAHL, Auteur . - 25p.
Langues : Anglais (eng)
in Molecular Autism > 15 (2024) . - 25p.
Mots-clés : Humans Norway Female Male Phenotype Child, Preschool Cohort Studies Neurodevelopmental Disorders/genetics/diagnosis Mothers Autistic Disorder/genetics Genetic Predisposition to Disease Adult Fathers Genome-Wide Association Study Attention Deficit Disorder with Hyperactivity/genetics/diagnosis Schizophrenia/genetics Genetic Heterogeneity Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism and different neurodevelopmental conditions frequently co-occur, as do their symptoms at sub-diagnostic threshold levels. Overlapping traits and shared genetic liability are potential explanations. METHODS: In the population-based Norwegian Mother, Father, and Child Cohort study (MoBa), we leverage item-level data to explore the phenotypic factor structure and genetic architecture underlying neurodevelopmental traits at age 3 years (N = 41,708-58,630) using maternal reports on 76 items assessing children's motor and language development, social functioning, communication, attention, activity regulation, and flexibility of behaviors and interests. RESULTS: We identified 11 latent factors at the phenotypic level. These factors showed associations with diagnoses of autism and other neurodevelopmental conditions. Most shared genetic liabilities with autism, ADHD, and/or schizophrenia. Item-level GWAS revealed trait-specific genetic correlations with autism (items r(g) range = -?0.27-0.78), ADHD (items r(g) range = -?0.40-1), and schizophrenia (items r(g) range = -?0.24-0.34). We find little evidence of common genetic liability across all neurodevelopmental traits but more so for several genetic factors across more specific areas of neurodevelopment, particularly social and communication traits. Some of these factors, such as one capturing prosocial behavior, overlap with factors found in the phenotypic analyses. Other areas, such as motor development, seemed to have more heterogenous etiology, with specific traits showing a less consistent pattern of genetic correlations with each other. CONCLUSIONS: These exploratory findings emphasize the etiological complexity of neurodevelopmental traits at this early age. In particular, diverse associations with neurodevelopmental conditions and genetic heterogeneity could inform follow-up work to identify shared and differentiating factors in the early manifestations of neurodevelopmental traits and their relation to autism and other neurodevelopmental conditions. This in turn could have implications for clinical screening tools and programs. En ligne : https://dx.doi.org/10.1186/s13229-024-00599-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire / Ragna BUGGE ASKELAND ; Stian BARBO VALAND ; Anne-Siri ØYEN ; Synnve SCHJØLBERG ; Vanessa H. BAL ; Somer L. BISHOP ; Camilla STOLTENBERG ; Tilmann VON SOEST ; Laurie J. HANNIGAN ; Alexandra HAVDAHL in Autism, 28-8 (August 2024)
![]()
[article]
Titre : Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire Type de document : Texte imprimé et/ou numérique Auteurs : Ragna BUGGE ASKELAND, Auteur ; Stian BARBO VALAND, Auteur ; Anne-Siri ØYEN, Auteur ; Synnve SCHJØLBERG, Auteur ; Vanessa H. BAL, Auteur ; Somer L. BISHOP, Auteur ; Camilla STOLTENBERG, Auteur ; Tilmann VON SOEST, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.2105-2119 Langues : Anglais (eng) Mots-clés : cohort studies factor analysis MBRN measurement invariance MoBa psychometrics statistical surveys and questionnaires Index. décimale : PER Périodiques Résumé : Autism screening questionnaires are sometimes used as a measure of "autism-associated traits" in samples drawn from the general population, even though such tools are primarily developed and designed for use in samples of children diagnosed with or being assessed for autism. Here, we explore the psychometric properties of the Social Communication Questionnaire (SCQ) current version reported at age 8 in a large population-based sample. Using data from the Norwegian Mother, Father and Child Cohort study (MoBa), we perform exploratory (N = 21,775) and confirmatory (N = 21,674) factor analyses on items and compare our results with previously suggested factor structure models of the SCQ. Furthermore, we test for measurement invariance across sex and registry-ascertained autism diagnostic status (Ndiagnosed = 636). A 5-factor model provided best fit to the data in both children with and without autism diagnoses, though with some qualitative differences in what the factors represent across these groups. This model performed largely consistently across boys and girls in the general population. Taken together, the SCQ?s measurement properties must be carefully considered when it is used in population-based samples and measurement invariance testing of other autism screening tools used in similar contexts is warranted. Lay abstract Using questionnaires in research relies on the expectation that they measure the same things across different groups of individuals. If this is not true, then interpretations of results can be misleading when researchers compare responses across different groups of individuals or use in it a group that differs from that in which the questionnaire was developed. For the questionnaire we investigated, the Social Communication Questionnaire (SCQ), we found that parents of boys and girls responded to questionnaire items in largely the same way but that the SCQ measured traits and behaviors slightly differently depending on whether the children had autism. Based on these results, we concluded that researchers using this questionnaire should carefully consider these differences when deciding how to interpret findings. SCQ scores as a reflection of "autism-associated traits" in samples that are mostly or entirely made up of individuals without an autism diagnosis may be misleading and we encourage a more precise interpretation of scores as a broader indication of social-communicative and behavioral traits. En ligne : https://dx.doi.org/10.1177/13623613231219306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533
in Autism > 28-8 (August 2024) . - p.2105-2119[article] Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire [Texte imprimé et/ou numérique] / Ragna BUGGE ASKELAND, Auteur ; Stian BARBO VALAND, Auteur ; Anne-Siri ØYEN, Auteur ; Synnve SCHJØLBERG, Auteur ; Vanessa H. BAL, Auteur ; Somer L. BISHOP, Auteur ; Camilla STOLTENBERG, Auteur ; Tilmann VON SOEST, Auteur ; Laurie J. HANNIGAN, Auteur ; Alexandra HAVDAHL, Auteur . - p.2105-2119.
Langues : Anglais (eng)
in Autism > 28-8 (August 2024) . - p.2105-2119
Mots-clés : cohort studies factor analysis MBRN measurement invariance MoBa psychometrics statistical surveys and questionnaires Index. décimale : PER Périodiques Résumé : Autism screening questionnaires are sometimes used as a measure of "autism-associated traits" in samples drawn from the general population, even though such tools are primarily developed and designed for use in samples of children diagnosed with or being assessed for autism. Here, we explore the psychometric properties of the Social Communication Questionnaire (SCQ) current version reported at age 8 in a large population-based sample. Using data from the Norwegian Mother, Father and Child Cohort study (MoBa), we perform exploratory (N = 21,775) and confirmatory (N = 21,674) factor analyses on items and compare our results with previously suggested factor structure models of the SCQ. Furthermore, we test for measurement invariance across sex and registry-ascertained autism diagnostic status (Ndiagnosed = 636). A 5-factor model provided best fit to the data in both children with and without autism diagnoses, though with some qualitative differences in what the factors represent across these groups. This model performed largely consistently across boys and girls in the general population. Taken together, the SCQ?s measurement properties must be carefully considered when it is used in population-based samples and measurement invariance testing of other autism screening tools used in similar contexts is warranted. Lay abstract Using questionnaires in research relies on the expectation that they measure the same things across different groups of individuals. If this is not true, then interpretations of results can be misleading when researchers compare responses across different groups of individuals or use in it a group that differs from that in which the questionnaire was developed. For the questionnaire we investigated, the Social Communication Questionnaire (SCQ), we found that parents of boys and girls responded to questionnaire items in largely the same way but that the SCQ measured traits and behaviors slightly differently depending on whether the children had autism. Based on these results, we concluded that researchers using this questionnaire should carefully consider these differences when deciding how to interpret findings. SCQ scores as a reflection of "autism-associated traits" in samples that are mostly or entirely made up of individuals without an autism diagnosis may be misleading and we encourage a more precise interpretation of scores as a broader indication of social-communicative and behavioral traits. En ligne : https://dx.doi.org/10.1177/13623613231219306 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533