Early life adversity is associated with greater similarity in neural representations of ambiguous and threatening stimuli / Natalie M. SARAGOSA-HARRIS in Development and Psychopathology, 37-2 (May 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-2 (May 2025) . - p.802-814 Titre : Early life adversity is associated with greater similarity in neural representations of ambiguous and threatening stimuli Type de document : Texte imprimé et/ou numérique Auteurs : Natalie M. SARAGOSA-HARRIS, Auteur ; João F. GUASSI MOREIRA, Auteur ; Yael WAIZMAN, Auteur ; Anna SEDYKIN, Auteur ; Tara S. PERIS, Auteur ; Jennifer A. SILVERS, Auteur Article en page(s) : p.802-814 Langues : Anglais (eng) Mots-clés : ambiguity tolerance  early life adversity  representational similarity analysis  threat hypervigilance  valence bias Index. décimale : PER Périodiques Résumé : Exposure to early life adversity (ELA) is hypothesized to sensitize threat-responsive neural circuitry. This may lead individuals to overestimate threat in the face of ambiguity, a cognitive-behavioral phenotype linked to poor mental health. The tendency to process ambiguity as threatening may stem from difficulty distinguishing between ambiguous and threatening stimuli. However, it is unknown how exposure to ELA relates to neural representations of ambiguous and threatening stimuli, or how processing of ambiguity following ELA relates to psychosocial functioning. The current fMRI study examined multivariate representations of threatening and ambiguous social cues in 41 emerging adults (aged 18 to 19 years). Using representational similarity analysis, we assessed neural representations of ambiguous and threatening images within affective neural circuitry and tested whether similarity in these representations varied by ELA exposure. Greater exposure to ELA was associated with greater similarity in neural representations of ambiguous and threatening images. Moreover, individual differences in processing ambiguity related to global functioning, an association that varied as a function of ELA. By evidencing reduced neural differentiation between ambiguous and threatening cues in ELA-exposed emerging adults and linking behavioral responses to ambiguity to psychosocial wellbeing, these findings have important implications for future intervention work in at-risk, ELA-exposed populations. En ligne : https://dx.doi.org/10.1017/S0954579424000683 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Early life adversity is associated with greater similarity in neural representations of ambiguous and threatening stimuli [Texte imprimé et/ou numérique] / Natalie M. SARAGOSA-HARRIS, Auteur ; João F. GUASSI MOREIRA, Auteur ; Yael WAIZMAN, Auteur ; Anna SEDYKIN, Auteur ; Tara S. PERIS, Auteur ; Jennifer A. SILVERS, Auteur . - p.802-814. Langues : Anglais (eng) in Development and Psychopathology > 37-2 (May 2025) . - p.802-814 Mots-clés : ambiguity tolerance  early life adversity  representational similarity analysis  threat hypervigilance  valence bias Index. décimale : PER Périodiques Résumé : Exposure to early life adversity (ELA) is hypothesized to sensitize threat-responsive neural circuitry. This may lead individuals to overestimate threat in the face of ambiguity, a cognitive-behavioral phenotype linked to poor mental health. The tendency to process ambiguity as threatening may stem from difficulty distinguishing between ambiguous and threatening stimuli. However, it is unknown how exposure to ELA relates to neural representations of ambiguous and threatening stimuli, or how processing of ambiguity following ELA relates to psychosocial functioning. The current fMRI study examined multivariate representations of threatening and ambiguous social cues in 41 emerging adults (aged 18 to 19 years). Using representational similarity analysis, we assessed neural representations of ambiguous and threatening images within affective neural circuitry and tested whether similarity in these representations varied by ELA exposure. Greater exposure to ELA was associated with greater similarity in neural representations of ambiguous and threatening images. Moreover, individual differences in processing ambiguity related to global functioning, an association that varied as a function of ELA. By evidencing reduced neural differentiation between ambiguous and threatening cues in ELA-exposed emerging adults and linking behavioral responses to ambiguity to psychosocial wellbeing, these findings have important implications for future intervention work in at-risk, ELA-exposed populations. En ligne : https://dx.doi.org/10.1017/S0954579424000683 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology / João F. Guassi MOREIRA ; Adriana S. Méndez LEAL ; Natalie M. SARAGOSA-HARRIS ; Elizabeth GAINES ; Wesley J. MEREDITH ; Yael WAIZMAN ; Emilia NINOVA ; Jennifer A. SILVERS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Titre : Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : João F. Guassi MOREIRA, Auteur ; Adriana S. Méndez LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur Article en page(s) : p.1833-1845 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology [Texte imprimé et/ou numérique] / João F. Guassi MOREIRA, Auteur ; Adriana S. Méndez LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur . - p.1833-1845. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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