Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? / Meredith X. HAN in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1875-1888 Titre : Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? Type de document : texte imprimé Auteurs : Meredith X. HAN, Auteur ; Ivan VORONIN, Auteur ; Margherita MALANCHINI, Auteur ; Tom A. MCADAMS, Auteur Article en page(s) : p.1875-1888 Langues : Anglais (eng) Mots-clés : Cognition  internalising disorder  behavioural genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Emotional problems co-occur with difficulties in verbal and nonverbal cognitive ability, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what extent they may run from cognition to emotion, or vice versa. Methods Our preregistered analyses included 5,124 twin pairs from the Twins Early Development Study (TEDS). At ages 7, 9 and 12, emotional problems were assessed through the strengths and difficulties questionnaire, and cognition was assessed using task-based measures. Cross-lagged models examined the influence of cognition and subdomains of verbal and nonverbal abilities on emotional problems and vice versa, across development. Genetic cross-lagged models examined the effect of cognition on emotional problems and vice versa, after controlling for shared genetic and environmental influence. Results Cross-lagged paths in both directions were observed between cognitive ability and emotional problems (from ?0.11 to ?0.05). Cross-lagged associations that persisted after accounting for common genetic and environmental influences were between nonverbal ability and emotional problems. Higher emotional problems at age 7 predicted lower nonverbal ability at age 9, with 22% of the phenotypic association remaining. This, in turn, predicted greater emotional problems at age 12, with 13% of the association remaining. Conclusions Genetic and environmental factors accounted for a large proportion of the cross-lagged associations. Emotional problems in early childhood could result in a cascade effect, leading to lower nonverbal cognition in middle childhood, which increases the risk of emotional problems in late childhood. These findings highlight the importance of age- and domain-specific interventions. En ligne : https://doi.org/10.1111/jcpp.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? [texte imprimé] / Meredith X. HAN, Auteur ; Ivan VORONIN, Auteur ; Margherita MALANCHINI, Auteur ; Tom A. MCADAMS, Auteur . - p.1875-1888. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1875-1888 Mots-clés : Cognition  internalising disorder  behavioural genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Emotional problems co-occur with difficulties in verbal and nonverbal cognitive ability, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what extent they may run from cognition to emotion, or vice versa. Methods Our preregistered analyses included 5,124 twin pairs from the Twins Early Development Study (TEDS). At ages 7, 9 and 12, emotional problems were assessed through the strengths and difficulties questionnaire, and cognition was assessed using task-based measures. Cross-lagged models examined the influence of cognition and subdomains of verbal and nonverbal abilities on emotional problems and vice versa, across development. Genetic cross-lagged models examined the effect of cognition on emotional problems and vice versa, after controlling for shared genetic and environmental influence. Results Cross-lagged paths in both directions were observed between cognitive ability and emotional problems (from ?0.11 to ?0.05). Cross-lagged associations that persisted after accounting for common genetic and environmental influences were between nonverbal ability and emotional problems. Higher emotional problems at age 7 predicted lower nonverbal ability at age 9, with 22% of the phenotypic association remaining. This, in turn, predicted greater emotional problems at age 12, with 13% of the association remaining. Conclusions Genetic and environmental factors accounted for a large proportion of the cross-lagged associations. Emotional problems in early childhood could result in a cascade effect, leading to lower nonverbal cognition in middle childhood, which increases the risk of emotional problems in late childhood. These findings highlight the importance of age- and domain-specific interventions. En ligne : https://doi.org/10.1111/jcpp.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort / Marie-Claude GEOFFROY ; Rachel LANGEVIN ; Léa C. PERRET ; Delphine COLLIN-VÉZINA ; Ivan VORONIN ; Jean-Philippe GOUIN ; Xiangfei MENG ; Michel BOIVIN ; Isabelle OUELLET-MORIN in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Titre : Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort Type de document : texte imprimé Auteurs : Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur Article en page(s) : p.2099-2110 Langues : Anglais (eng) Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort [texte imprimé] / Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur . - p.2099-2110. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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