Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression / Isabelle OUELLET-MORIN in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.852-865 Titre : Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression Type de document : texte imprimé Auteurs : Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur ; Pascal LOUIS, Auteur ; Ivan VORONIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Rachel LANGEVIN, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Charles-Édouard GIGUERE, Auteur ; Mélanie BOULIANE, Auteur ; Amélie PETITCLERC, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Richard Ernest TREMBLAY, Auteur ; Michel BOIVIN, Auteur Article en page(s) : p.852-865 Langues : Anglais (eng) Mots-clés : Childhood maltreatment  genetics  gene–environmental correlation (rGE)  longitudinal studies: proactive and reactive aggression Index. décimale : PER Périodiques Résumé : Background:Childhood maltreatment is a robust predictor of aggression. Research indicates that both maltreatment experiences and aggression are moderately heritable. It has been hypothesized that gene–environment correlation may be at play, whereby genetic predispositions to aggression in parents and children may be confounded with family environments conducive to its expression. Building on this framework, we tested whether maltreatment mediates the association between a polygenic score for aggression (PGSAGG) and school-age aggression, and whether this varied for reactive and proactive aggression.Methods:The sample comprised 721 participants (44.9% males; 99.0% White) with prospective assessments of maltreatment from 5 months to 12 years (10 assessments;1998–2010), and teachers-reported aggression from ages 6 to 13 (6 assessments; 2004–2011). The PGSAGG was derived using a Bayesian estimation method (PRS-CS).Results:PGSAGG was associated with most aggression measures across specific ages and trajectories. Maltreatment experiences partially mediated the association between PGSAGG and the Childhood-Limited trajectory of reactive – but not proactive – aggression.Conclusion:Children with higher genetic propensities for aggression were more likely to experience maltreatment, which partly explained the association between PGSAGG and a Childhood-Limited trajectory of reactive aggression during elementary school. This finding reinforces the possibility of confounding influences between genetic liability for aggression and maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579425100801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression [texte imprimé] / Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur ; Pascal LOUIS, Auteur ; Ivan VORONIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Rachel LANGEVIN, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Charles-Édouard GIGUERE, Auteur ; Mélanie BOULIANE, Auteur ; Amélie PETITCLERC, Auteur ; Mara BRENDGEN, Auteur ; Frank VITARO, Auteur ; Richard Ernest TREMBLAY, Auteur ; Michel BOIVIN, Auteur . - p.852-865. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.852-865 Mots-clés : Childhood maltreatment  genetics  gene–environmental correlation (rGE)  longitudinal studies: proactive and reactive aggression Index. décimale : PER Périodiques Résumé : Background:Childhood maltreatment is a robust predictor of aggression. Research indicates that both maltreatment experiences and aggression are moderately heritable. It has been hypothesized that gene–environment correlation may be at play, whereby genetic predispositions to aggression in parents and children may be confounded with family environments conducive to its expression. Building on this framework, we tested whether maltreatment mediates the association between a polygenic score for aggression (PGSAGG) and school-age aggression, and whether this varied for reactive and proactive aggression.Methods:The sample comprised 721 participants (44.9% males; 99.0% White) with prospective assessments of maltreatment from 5 months to 12 years (10 assessments;1998–2010), and teachers-reported aggression from ages 6 to 13 (6 assessments; 2004–2011). The PGSAGG was derived using a Bayesian estimation method (PRS-CS).Results:PGSAGG was associated with most aggression measures across specific ages and trajectories. Maltreatment experiences partially mediated the association between PGSAGG and the Childhood-Limited trajectory of reactive – but not proactive – aggression.Conclusion:Children with higher genetic propensities for aggression were more likely to experience maltreatment, which partly explained the association between PGSAGG and a Childhood-Limited trajectory of reactive aggression during elementary school. This finding reinforces the possibility of confounding influences between genetic liability for aggression and maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579425100801 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? / Meredith X. HAN in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1875-1888 Titre : Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? Type de document : texte imprimé Auteurs : Meredith X. HAN, Auteur ; Ivan VORONIN, Auteur ; Margherita MALANCHINI, Auteur ; Tom A. MCADAMS, Auteur Article en page(s) : p.1875-1888 Langues : Anglais (eng) Mots-clés : Cognition  internalising disorder  behavioural genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Emotional problems co-occur with difficulties in verbal and nonverbal cognitive ability, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what extent they may run from cognition to emotion, or vice versa. Methods Our preregistered analyses included 5,124 twin pairs from the Twins Early Development Study (TEDS). At ages 7, 9 and 12, emotional problems were assessed through the strengths and difficulties questionnaire, and cognition was assessed using task-based measures. Cross-lagged models examined the influence of cognition and subdomains of verbal and nonverbal abilities on emotional problems and vice versa, across development. Genetic cross-lagged models examined the effect of cognition on emotional problems and vice versa, after controlling for shared genetic and environmental influence. Results Cross-lagged paths in both directions were observed between cognitive ability and emotional problems (from ?0.11 to ?0.05). Cross-lagged associations that persisted after accounting for common genetic and environmental influences were between nonverbal ability and emotional problems. Higher emotional problems at age 7 predicted lower nonverbal ability at age 9, with 22% of the phenotypic association remaining. This, in turn, predicted greater emotional problems at age 12, with 13% of the association remaining. Conclusions Genetic and environmental factors accounted for a large proportion of the cross-lagged associations. Emotional problems in early childhood could result in a cascade effect, leading to lower nonverbal cognition in middle childhood, which increases the risk of emotional problems in late childhood. These findings highlight the importance of age- and domain-specific interventions. En ligne : https://doi.org/10.1111/jcpp.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? [texte imprimé] / Meredith X. HAN, Auteur ; Ivan VORONIN, Auteur ; Margherita MALANCHINI, Auteur ; Tom A. MCADAMS, Auteur . - p.1875-1888. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1875-1888 Mots-clés : Cognition  internalising disorder  behavioural genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Emotional problems co-occur with difficulties in verbal and nonverbal cognitive ability, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what extent they may run from cognition to emotion, or vice versa. Methods Our preregistered analyses included 5,124 twin pairs from the Twins Early Development Study (TEDS). At ages 7, 9 and 12, emotional problems were assessed through the strengths and difficulties questionnaire, and cognition was assessed using task-based measures. Cross-lagged models examined the influence of cognition and subdomains of verbal and nonverbal abilities on emotional problems and vice versa, across development. Genetic cross-lagged models examined the effect of cognition on emotional problems and vice versa, after controlling for shared genetic and environmental influence. Results Cross-lagged paths in both directions were observed between cognitive ability and emotional problems (from ?0.11 to ?0.05). Cross-lagged associations that persisted after accounting for common genetic and environmental influences were between nonverbal ability and emotional problems. Higher emotional problems at age 7 predicted lower nonverbal ability at age 9, with 22% of the phenotypic association remaining. This, in turn, predicted greater emotional problems at age 12, with 13% of the association remaining. Conclusions Genetic and environmental factors accounted for a large proportion of the cross-lagged associations. Emotional problems in early childhood could result in a cascade effect, leading to lower nonverbal cognition in middle childhood, which increases the risk of emotional problems in late childhood. These findings highlight the importance of age- and domain-specific interventions. En ligne : https://doi.org/10.1111/jcpp.70008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? / Jack K. NEJAND in Journal of Child Psychology and Psychiatry, 67-2 (February 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-2 (February 2026) . - p.266-281 Titre : How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? Type de document : texte imprimé Auteurs : Jack K. NEJAND, Auteur ; Margherita MALANCHINI, Auteur ; Ivan VORONIN, Auteur ; Thalia C. ELEY, Auteur ; Kaili RIMFELD, Auteur Article en page(s) : p.266-281 Langues : Anglais (eng) Mots-clés : General factor of psychopathology  p-factor  childhood psychopathology  twin analysis  home environment  cross-lag model Index. décimale : PER Périodiques Résumé : Background Comorbidity and heterogeneity in psychiatric disorders may stem from a general psychopathology (p) factor influenced by both genetic and environmental factors. Although the relative contributions of these influences on psychopathology are established, the longitudinal associations between the p-factor and specific environmental exposures and the aetiology of these associations across development are not well understood. Here, we examine whether twin-rated home environment contributes to changes in the p-factor over time or, conversely, whether the p-factor influences twin-rated home environment, reflecting potential evocative gene?environment processes. Methods Data were obtained from the Twins Early Development Study (TEDS). Cross-lagged panel analyses were conducted separately to ascertain the direction of associations between parent-rated p, twin-rated p, and twin-rated home environment (chaos at home and parental discipline) at ages 9, 12, and 16 (N?=?6,213). Biometric autoregressive cross-lagged twin models were used to assess the aetiology of these associations, and MZ differences analyses were used to control for familial effects. Results Both parent-rated and twin-rated p-factor and twin-rated home environment were stable over time, although the twin-rated p-factor (r?=?.44 [0.42, 0.46]?.40 [0.37, 0.41]) was more variable than the parent-rated p-factor (r?=?.72 [0.71, 0.74]?.63 [0.61, 0.64]). Twin-rated home environment was more variable than p-factor in all cross-lagged models (phenotypic and MZ differences). Small, significant bidirectional associations were found between the p-factor and twin-rated home environment, with stronger cross-lagged paths from the p-factor to the twin-rated home environment than vice versa. These longitudinal associations persisted over time, though attenuated for parent-rated p-factor. Genetic analyses revealed that bidirectional cross-lagged paths were largely explained by shared environmental factors, with a smaller proportion explained by genetic factors. This pattern of results was confirmed in MZ difference analyses. Conclusions Our findings suggest a dynamic and bidirectional relationship between p-factor and twin-rated home environment across development, predominantly influenced by shared environmental factors. Changes in one can affect the other, highlighting the complexity of psychopathology's environmental influences. This underscores the need for further investigation into gene?environment interplay to inform prevention and intervention strategies for psychopathology. En ligne : https://doi.org/10.1111/jcpp.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? [texte imprimé] / Jack K. NEJAND, Auteur ; Margherita MALANCHINI, Auteur ; Ivan VORONIN, Auteur ; Thalia C. ELEY, Auteur ; Kaili RIMFELD, Auteur . - p.266-281. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-2 (February 2026) . - p.266-281 Mots-clés : General factor of psychopathology  p-factor  childhood psychopathology  twin analysis  home environment  cross-lag model Index. décimale : PER Périodiques Résumé : Background Comorbidity and heterogeneity in psychiatric disorders may stem from a general psychopathology (p) factor influenced by both genetic and environmental factors. Although the relative contributions of these influences on psychopathology are established, the longitudinal associations between the p-factor and specific environmental exposures and the aetiology of these associations across development are not well understood. Here, we examine whether twin-rated home environment contributes to changes in the p-factor over time or, conversely, whether the p-factor influences twin-rated home environment, reflecting potential evocative gene?environment processes. Methods Data were obtained from the Twins Early Development Study (TEDS). Cross-lagged panel analyses were conducted separately to ascertain the direction of associations between parent-rated p, twin-rated p, and twin-rated home environment (chaos at home and parental discipline) at ages 9, 12, and 16 (N?=?6,213). Biometric autoregressive cross-lagged twin models were used to assess the aetiology of these associations, and MZ differences analyses were used to control for familial effects. Results Both parent-rated and twin-rated p-factor and twin-rated home environment were stable over time, although the twin-rated p-factor (r?=?.44 [0.42, 0.46]?.40 [0.37, 0.41]) was more variable than the parent-rated p-factor (r?=?.72 [0.71, 0.74]?.63 [0.61, 0.64]). Twin-rated home environment was more variable than p-factor in all cross-lagged models (phenotypic and MZ differences). Small, significant bidirectional associations were found between the p-factor and twin-rated home environment, with stronger cross-lagged paths from the p-factor to the twin-rated home environment than vice versa. These longitudinal associations persisted over time, though attenuated for parent-rated p-factor. Genetic analyses revealed that bidirectional cross-lagged paths were largely explained by shared environmental factors, with a smaller proportion explained by genetic factors. This pattern of results was confirmed in MZ difference analyses. Conclusions Our findings suggest a dynamic and bidirectional relationship between p-factor and twin-rated home environment across development, predominantly influenced by shared environmental factors. Changes in one can affect the other, highlighting the complexity of psychopathology's environmental influences. This underscores the need for further investigation into gene?environment interplay to inform prevention and intervention strategies for psychopathology. En ligne : https://doi.org/10.1111/jcpp.70046 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort / Marie-Claude GEOFFROY ; Rachel LANGEVIN ; Léa C. PERRET ; Delphine COLLIN-VÉZINA ; Ivan VORONIN ; Jean-Philippe GOUIN ; Xiangfei MENG ; Michel BOIVIN ; Isabelle OUELLET-MORIN in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Titre : Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort Type de document : texte imprimé Auteurs : Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur Article en page(s) : p.2099-2110 Langues : Anglais (eng) Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort [texte imprimé] / Marie-Claude GEOFFROY, Auteur ; Rachel LANGEVIN, Auteur ; Léa C. PERRET, Auteur ; Delphine COLLIN-VÉZINA, Auteur ; Ivan VORONIN, Auteur ; Jean-Philippe GOUIN, Auteur ; Xiangfei MENG, Auteur ; Michel BOIVIN, Auteur ; Isabelle OUELLET-MORIN, Auteur . - p.2099-2110. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2099-2110 Mots-clés : Childhood maltreatment  depression  polygenic risk score  prospective  retrospective Index. décimale : PER Périodiques Résumé : Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatment and depressive symptoms, while accounting for different types of maltreatment and whether it was evaluated through prospective and retrospective reports. The sample included 541-617 participants from the Quebec Longitudinal Study of Child Development with information on maltreatment, including threat, deprivation, assessed prospectively (5 months-17 years) and retrospectively (reported at 23 years), PGSDEP and self-reported depressive symptoms (20-23 years). Using hierarchical linear regressions, we found that retrospective, but not prospective indicators of maltreatment (threat/deprivation/cumulative) were associated with later depressive symptoms, above and beyond the PGSDEP. Our findings also show the presence of gene-environment interactions, whereby the association between maltreatment (retrospective cumulative maltreatment/threat, prospective deprivation) and depression was strengthened among youth with higher PGSDEP scores. Consistent with the Diathesis-Stress hypothesis, our findings suggest that a genetic predisposition for depression may exacerbate the putative impact of maltreatment on later depressive symptoms, especially when maltreatment is retrospective. Understanding the gene-environment interplay emerging in the context of maltreatment has the potential to guide prevention efforts. En ligne : https://dx.doi.org/10.1017/S0954579424001688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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