Autistic symptomatology and language ability in autism spectrum disorder and specific language impairment / Tom LOUCAS in Journal of Child Psychology and Psychiatry, 49-11 (November 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1184-1192 Titre : Autistic symptomatology and language ability in autism spectrum disorder and specific language impairment Type de document : Texte imprimé et/ou numérique Auteurs : Tom LOUCAS, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur ; Gillian BAIRD, Auteur ; Susie CHANDLER, Auteur ; David MELDRUM, Auteur Année de publication : 2008 Article en page(s) : p.1184-1192 Langues : Anglais (eng) Mots-clés : Autistic-disorder specific-language-impairment SNAP-cohort Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) and specific language impairment (SLI) are common developmental disorders characterised by deficits in language and communication. The nature of the relationship between them continues to be a matter of debate. This study investigates whether the co-occurrence of ASD and language impairment is associated with differences in severity or pattern of autistic symptomatology or language profile. Methods: Participants (N = 97) were drawn from a total population cohort of 56,946 screened as part of study to ascertain the prevalence of ASD, aged 9 to 14 years. All children received an ICD-10 clinical diagnosis of ASD or No ASD. Children with nonverbal IQ ≥80 were divided into those with a language impairment (language score of 77 or less) and those without, creating three groups: children with ASD and a language impairment (ALI; N = 41), those with ASD and but no language impairment (ANL; N = 31) and those with language impairment but no ASD (SLI; N = 25). Results: Children with ALI did not show more current autistic symptoms than those with ANL. Children with SLI were well below the threshold for ASD. Their social adaptation was higher than the ASD groups, but still nearly 2 SD below average. In ALI the combination of ASD and language impairment was associated with weaker functional communication and more severe receptive language difficulties than those found in SLI. Receptive and expressive language were equally impaired in ALI, whereas in SLI receptive language was stronger than expressive. Conclusions: Co-occurrence of ASD and language impairment is not associated with increased current autistic symptomatology but appears to be associated with greater impairment in receptive language and functional communication. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01951.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633 [article] Autistic symptomatology and language ability in autism spectrum disorder and specific language impairment [Texte imprimé et/ou numérique] / Tom LOUCAS, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur ; Gillian BAIRD, Auteur ; Susie CHANDLER, Auteur ; David MELDRUM, Auteur . - 2008 . - p.1184-1192. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1184-1192 Mots-clés : Autistic-disorder specific-language-impairment SNAP-cohort Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) and specific language impairment (SLI) are common developmental disorders characterised by deficits in language and communication. The nature of the relationship between them continues to be a matter of debate. This study investigates whether the co-occurrence of ASD and language impairment is associated with differences in severity or pattern of autistic symptomatology or language profile. Methods: Participants (N = 97) were drawn from a total population cohort of 56,946 screened as part of study to ascertain the prevalence of ASD, aged 9 to 14 years. All children received an ICD-10 clinical diagnosis of ASD or No ASD. Children with nonverbal IQ ≥80 were divided into those with a language impairment (language score of 77 or less) and those without, creating three groups: children with ASD and a language impairment (ALI; N = 41), those with ASD and but no language impairment (ANL; N = 31) and those with language impairment but no ASD (SLI; N = 25). Results: Children with ALI did not show more current autistic symptoms than those with ANL. Children with SLI were well below the threshold for ASD. Their social adaptation was higher than the ASD groups, but still nearly 2 SD below average. In ALI the combination of ASD and language impairment was associated with weaker functional communication and more severe receptive language difficulties than those found in SLI. Receptive and expressive language were equally impaired in ALI, whereas in SLI receptive language was stronger than expressive. Conclusions: Co-occurrence of ASD and language impairment is not associated with increased current autistic symptomatology but appears to be associated with greater impairment in receptive language and functional communication. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01951.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633

Book review: Assessment of Autism Spectrum Disorders by S. Goldstein, J.A. Naglieri and S. Ozonoff (Eds). London: Guildford Press, 2009. ISBN 978—1—59385 —983—1. £27.45 hdk. 384 pp / Tom LOUCAS in Autism, 13-5 (September 2009)  

Public ISBD [article]  inAutism > 13-5 (September 2009) . - p.539-541 Titre : Book review: Assessment of Autism Spectrum Disorders by S. Goldstein, J.A. Naglieri and S. Ozonoff (Eds). London: Guildford Press, 2009. ISBN 978—1—59385 —983—1. £27.45 hdk. 384 pp Type de document : Texte imprimé et/ou numérique Auteurs : Tom LOUCAS, Auteur Année de publication : 2009 Article en page(s) : p.539-541 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361309346113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=834 [article] Book review: Assessment of Autism Spectrum Disorders by S. Goldstein, J.A. Naglieri and S. Ozonoff (Eds). London: Guildford Press, 2009. ISBN 978—1—59385 —983—1. £27.45 hdk. 384 pp [Texte imprimé et/ou numérique] / Tom LOUCAS, Auteur . - 2009 . - p.539-541. Langues : Anglais (eng) in Autism > 13-5 (September 2009) . - p.539-541 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361309346113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=834

Gut Permeability in Autism Spectrum Disorders / Neil R. DALTON in Autism Research, 7-3 (June 2014)  

Public ISBD [article]  inAutism Research > 7-3 (June 2014) . - p.305-313 Titre : Gut Permeability in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Neil R. DALTON, Auteur ; Susie CHANDLER, Auteur ; Charles TURNER, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; Emily SIMONOFF, Auteur ; Peter SULLIVAN, Auteur ; Gillian BAIRD, Auteur Article en page(s) : p.305-313 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorders  gut permeability  lactulose/mannitol ratio Index. décimale : PER Périodiques Résumé : Objective To test whether gut permeability is increased in autism spectrum disorders (ASD) by evaluating gut permeability in a population-derived cohort of children with ASD compared with age- and intelligence quotient-matched controls without ASD but with special educational needs (SEN). Patients and Methods One hundred thirty-three children aged 10–14 years, 103 with ASD and 30 with SEN, were given an oral test dose of mannitol and lactulose and urine collected for 6?hr. Gut permeability was assessed by measuring the urine lactulose/mannitol (L/M) recovery ratio by electrospray mass spectrometry-mass spectrometry. The ASD group was subcategorized for comparison into those without (n?=?83) and with (n?=?20) regression. Results There was no significant difference in L/M recovery ratio (mean (95% confidence interval)) between the groups with ASD: 0.015 (0.013–0.018), and SEN: 0.014 (0.009–0.019), nor in lactulose, mannitol, or creatinine recovery. No significant differences were observed in any parameter for the regressed versus non-regressed ASD groups. Results were consistent with previously published normal ranges. Eleven children (9/103?=?8.7% ASD and 2/30?=?6.7% SEN) had L/M recovery ratio ?0.03 (the accepted normal range cut-off), of whom two (one ASD and one SEN) had more definitely pathological L/M recovery ratios ?0.04. Conclusion There is no statistically significant group difference in small intestine permeability in a population cohort-derived group of children with ASD compared with a control group with SEN. Of the two children (one ASD and one SEN) with an L/M recovery ratio of ?0.04, one had undiagnosed asymptomatic celiac disease (ASD) and the other (SEN) past extensive surgery for gastroschisis. Autism Res 2014, 7: 305–313. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Gut Permeability in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Neil R. DALTON, Auteur ; Susie CHANDLER, Auteur ; Charles TURNER, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; Emily SIMONOFF, Auteur ; Peter SULLIVAN, Auteur ; Gillian BAIRD, Auteur . - p.305-313. Langues : Anglais (eng) in Autism Research > 7-3 (June 2014) . - p.305-313 Mots-clés : autism  autism spectrum disorders  gut permeability  lactulose/mannitol ratio Index. décimale : PER Périodiques Résumé : Objective To test whether gut permeability is increased in autism spectrum disorders (ASD) by evaluating gut permeability in a population-derived cohort of children with ASD compared with age- and intelligence quotient-matched controls without ASD but with special educational needs (SEN). Patients and Methods One hundred thirty-three children aged 10–14 years, 103 with ASD and 30 with SEN, were given an oral test dose of mannitol and lactulose and urine collected for 6?hr. Gut permeability was assessed by measuring the urine lactulose/mannitol (L/M) recovery ratio by electrospray mass spectrometry-mass spectrometry. The ASD group was subcategorized for comparison into those without (n?=?83) and with (n?=?20) regression. Results There was no significant difference in L/M recovery ratio (mean (95% confidence interval)) between the groups with ASD: 0.015 (0.013–0.018), and SEN: 0.014 (0.009–0.019), nor in lactulose, mannitol, or creatinine recovery. No significant differences were observed in any parameter for the regressed versus non-regressed ASD groups. Results were consistent with previously published normal ranges. Eleven children (9/103?=?8.7% ASD and 2/30?=?6.7% SEN) had L/M recovery ratio ?0.03 (the accepted normal range cut-off), of whom two (one ASD and one SEN) had more definitely pathological L/M recovery ratios ?0.04. Conclusion There is no statistically significant group difference in small intestine permeability in a population cohort-derived group of children with ASD compared with a control group with SEN. Of the two children (one ASD and one SEN) with an L/M recovery ratio of ?0.04, one had undiagnosed asymptomatic celiac disease (ASD) and the other (SEN) past extensive surgery for gastroschisis. Autism Res 2014, 7: 305–313. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

Loss of language in early development of autism and specific language impairment / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 50-7 (July 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-7 (July 2009) . - p.843-852 Titre : Loss of language in early development of autism and specific language impairment Type de document : Texte imprimé et/ou numérique Auteurs : Andrew PICKLES, Auteur ; Tony CHARMAN, Auteur ; Gina CONTI-RAMSDEN, Auteur ; Zoë SIMKIN, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Tom LOUCAS, Auteur ; Susie CHANDLER, Auteur ; Milena FALCARO, Auteur Année de publication : 2009 Article en page(s) : p.843-852 Langues : Anglais (eng) Mots-clés : Language-loss autism specific-language-impairment-(SLI) early-language-development SNAP Index. décimale : PER Périodiques Résumé : Background: Several authors have highlighted areas of overlap in symptoms and impairment among children with autism spectrum disorder (ASD) and children with specific language impairment (SLI). By contrast, loss of language and broadly defined regression have been reported as relatively specific to autism. We compare the incidence of language loss and language progression of children with autism and SLI. Methods: We used two complementary studies: the Special Needs and Autism Project (SNAP) and the Manchester Language Study (MLS) involving children with SLI. This yielded a combined sample of 368 children (305 males and 63 females) assessed in late childhood for autism, history of language loss, epilepsy, language abilities and nonverbal IQ. Results: language loss occurred in just 1% of children with SLI but in 15% of children classified as having autism or autism spectrum disorder. Loss was more common among children with autism rather than milder ASD and is much less frequently reported when language development is delayed. For children who lost language skills before their first phrases, the phrased speech milestone was postponed but long-term language skills were not significantly lower than children with autism but without loss. For the few who experienced language loss after acquiring phrased speech, subsequent cognitive performance is more uncertain. Conclusions: Language loss is highly specific to ASD. The underlying developmental abnormality may be more prevalent than raw data might suggest, its possible presence being hidden for children whose language development is delayed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02032.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=771 [article] Loss of language in early development of autism and specific language impairment [Texte imprimé et/ou numérique] / Andrew PICKLES, Auteur ; Tony CHARMAN, Auteur ; Gina CONTI-RAMSDEN, Auteur ; Zoë SIMKIN, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Tom LOUCAS, Auteur ; Susie CHANDLER, Auteur ; Milena FALCARO, Auteur . - 2009 . - p.843-852. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-7 (July 2009) . - p.843-852 Mots-clés : Language-loss autism specific-language-impairment-(SLI) early-language-development SNAP Index. décimale : PER Périodiques Résumé : Background: Several authors have highlighted areas of overlap in symptoms and impairment among children with autism spectrum disorder (ASD) and children with specific language impairment (SLI). By contrast, loss of language and broadly defined regression have been reported as relatively specific to autism. We compare the incidence of language loss and language progression of children with autism and SLI. Methods: We used two complementary studies: the Special Needs and Autism Project (SNAP) and the Manchester Language Study (MLS) involving children with SLI. This yielded a combined sample of 368 children (305 males and 63 females) assessed in late childhood for autism, history of language loss, epilepsy, language abilities and nonverbal IQ. Results: language loss occurred in just 1% of children with SLI but in 15% of children classified as having autism or autism spectrum disorder. Loss was more common among children with autism rather than milder ASD and is much less frequently reported when language development is delayed. For children who lost language skills before their first phrases, the phrased speech milestone was postponed but long-term language skills were not significantly lower than children with autism but without loss. For the few who experienced language loss after acquiring phrased speech, subsequent cognitive performance is more uncertain. Conclusions: Language loss is highly specific to ASD. The underlying developmental abnormality may be more prevalent than raw data might suggest, its possible presence being hidden for children whose language development is delayed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02032.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=771

Parent-Reported Gastro-intestinal Symptoms in Children with Autism Spectrum Disorders / Susie CHANDLER in Journal of Autism and Developmental Disorders, 43-12 (December 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2737-2747 Titre : Parent-Reported Gastro-intestinal Symptoms in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Susie CHANDLER, Auteur ; Iris CARCANI-RATHWELL, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; David MELDRUM, Auteur ; Emily SIMONOFF, Auteur ; Peter SULLIVAN, Auteur ; Gillian BAIRD, Auteur Article en page(s) : p.2737-2747 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorders  Gastro-intestinal symptoms  Dietary intake  Regression Index. décimale : PER Périodiques Résumé : The objective of this study is to investigate whether parentally-reported gastro-intestinal (GI) symptoms are increased in a population-derived sample of children with autism spectrum disorders (ASD) compared to controls. Participants included 132 children with ASD and 81 with special educational needs (SEN) but no ASD, aged 10–14 years plus 82 typically developing (TD) children. Data were collected on GI symptoms, diet, cognitive abilities, and developmental histories. Nearly half (weighted rate 46.5 %) of children with ASD had at least one individual lifetime GI symptom compared with 21.8 % of TD children and 29.2 % of those with SEN. Children with ASD had more past and current GI symptoms than TD or SEN groups although fewer current symptoms were reported in all groups compared with the past. The ASD group had significantly increased past vomiting and diarrhoea compared with the TD group and more abdominal pain than the SEN group. The ASD group had more current constipation (when defined as bowel movement less than three times per week) and soiling than either the TD or SEN groups. No association was found between GI symptoms and intellectual ability, ASD severity, ASD regression or limited or faddy diet. Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups. En ligne : http://dx.doi.org/10.1007/s10803-013-1768-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] Parent-Reported Gastro-intestinal Symptoms in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Susie CHANDLER, Auteur ; Iris CARCANI-RATHWELL, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Tom LOUCAS, Auteur ; David MELDRUM, Auteur ; Emily SIMONOFF, Auteur ; Peter SULLIVAN, Auteur ; Gillian BAIRD, Auteur . - p.2737-2747. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2737-2747 Mots-clés : Autism  Autism spectrum disorders  Gastro-intestinal symptoms  Dietary intake  Regression Index. décimale : PER Périodiques Résumé : The objective of this study is to investigate whether parentally-reported gastro-intestinal (GI) symptoms are increased in a population-derived sample of children with autism spectrum disorders (ASD) compared to controls. Participants included 132 children with ASD and 81 with special educational needs (SEN) but no ASD, aged 10–14 years plus 82 typically developing (TD) children. Data were collected on GI symptoms, diet, cognitive abilities, and developmental histories. Nearly half (weighted rate 46.5 %) of children with ASD had at least one individual lifetime GI symptom compared with 21.8 % of TD children and 29.2 % of those with SEN. Children with ASD had more past and current GI symptoms than TD or SEN groups although fewer current symptoms were reported in all groups compared with the past. The ASD group had significantly increased past vomiting and diarrhoea compared with the TD group and more abdominal pain than the SEN group. The ASD group had more current constipation (when defined as bowel movement less than three times per week) and soiling than either the TD or SEN groups. No association was found between GI symptoms and intellectual ability, ASD severity, ASD regression or limited or faddy diet. Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups. En ligne : http://dx.doi.org/10.1007/s10803-013-1768-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study / Gillian BAIRD in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

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The experience of friendship, victimization and bullying in children with an autism spectrum disorder: Associations with child characteristics and school placement / Emma ROWLEY in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)  

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Using music to assist language learning in autistic children with minimal verbal language: The MAP feasibility RCT / Tim I. WILLIAMS in Autism, 28-10 (October 2024)  

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