Trajectories of Autism Symptoms and Overlapping Patterns in a Chinese Cohort From 18 to 36 Months / Feixia ZHANG in Autism Research, 19-5 (May 2026)  

Public ISBD [article]  inAutism Research > 19-5 (May 2026) . - p.e70219 Titre : Trajectories of Autism Symptoms and Overlapping Patterns in a Chinese Cohort From 18 to 36 Months Type de document : texte imprimé Auteurs : Feixia ZHANG, Auteur ; YanTing XU, Auteur ; Linru LIU, Auteur ; Yu XING, Auteur ; Cong YOU, Auteur ; ShaoLi LV, Auteur ; Huishi HUANG, Auteur ; YuanYuan ZOU, Auteur ; Fengjing LIANG, Auteur ; QianYing YE, Auteur ; Yijie LI, Auteur ; ShiHuan WANG, Auteur ; Kaiyun CHEN, Auteur ; Hongzhu DENG, Auteur Article en page(s) : p.e70219 Langues : Anglais (eng) Mots-clés : autism  autism symptoms  broader autism phenotype  early life  overlap Index. décimale : PER Périodiques Résumé : ABSTRACT Several studies have examined trajectories of autism symptoms in autistic children and their siblings. However, less is known about developmental patterns across different neurodevelopmental conditions, as well as the clinical characteristics and early predictors among children with distinct diagnoses but overlapping trajectories. This study investigated trajectories of autism symptoms [ADOS-2 Calibrated Severity Score; Total CSS, social affect (SA) CSS, and restricted and repetitive behaviors (RRB) CSS] and their overlap across symptom domains in a Chinese cohort of 163 children aged 18?36?months, including autism, broader autism phenotype (BAP), developmental delay (DD), and typical development (TD). Latent class growth modeling identified three trajectories for Total CSS and SA CSS, and two for RRB CSS. Cross-domain analyses revealed overlapping CSS trajectories between 51 autistic children (Overlap-Autism) and 36 children with BAP (Overlap-BAP). Clinical comparisons between these two groups revealed distinct temporal profiles in CSS and ADI-R scores. Hierarchical logistic regression analyses indicated that female sex was a protective factor for Overlap-Autism (OR?=?0.20, p?=?0.009) relative to the Overlap-BAP group, whereas higher SA CSS at 18?months independently predicted Overlap-Autism (OR?=?1.61, p?=?0.003). These findings highlight the challenges of early diagnostic differentiation among children with autism-related traits and underscore the importance of comprehensive and longitudinal assessment. En ligne : https://doi.org/10.1002/aur.70219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] Trajectories of Autism Symptoms and Overlapping Patterns in a Chinese Cohort From 18 to 36 Months [texte imprimé] / Feixia ZHANG, Auteur ; YanTing XU, Auteur ; Linru LIU, Auteur ; Yu XING, Auteur ; Cong YOU, Auteur ; ShaoLi LV, Auteur ; Huishi HUANG, Auteur ; YuanYuan ZOU, Auteur ; Fengjing LIANG, Auteur ; QianYing YE, Auteur ; Yijie LI, Auteur ; ShiHuan WANG, Auteur ; Kaiyun CHEN, Auteur ; Hongzhu DENG, Auteur . - p.e70219. Langues : Anglais (eng) in Autism Research > 19-5 (May 2026) . - p.e70219 Mots-clés : autism  autism symptoms  broader autism phenotype  early life  overlap Index. décimale : PER Périodiques Résumé : ABSTRACT Several studies have examined trajectories of autism symptoms in autistic children and their siblings. However, less is known about developmental patterns across different neurodevelopmental conditions, as well as the clinical characteristics and early predictors among children with distinct diagnoses but overlapping trajectories. This study investigated trajectories of autism symptoms [ADOS-2 Calibrated Severity Score; Total CSS, social affect (SA) CSS, and restricted and repetitive behaviors (RRB) CSS] and their overlap across symptom domains in a Chinese cohort of 163 children aged 18?36?months, including autism, broader autism phenotype (BAP), developmental delay (DD), and typical development (TD). Latent class growth modeling identified three trajectories for Total CSS and SA CSS, and two for RRB CSS. Cross-domain analyses revealed overlapping CSS trajectories between 51 autistic children (Overlap-Autism) and 36 children with BAP (Overlap-BAP). Clinical comparisons between these two groups revealed distinct temporal profiles in CSS and ADI-R scores. Hierarchical logistic regression analyses indicated that female sex was a protective factor for Overlap-Autism (OR?=?0.20, p?=?0.009) relative to the Overlap-BAP group, whereas higher SA CSS at 18?months independently predicted Overlap-Autism (OR?=?1.61, p?=?0.003). These findings highlight the challenges of early diagnostic differentiation among children with autism-related traits and underscore the importance of comprehensive and longitudinal assessment. En ligne : https://doi.org/10.1002/aur.70219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

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