Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families / Raphael BERNIER in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.13-20 Titre : Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families Type de document : Texte imprimé et/ou numérique Auteurs : Raphael BERNIER, Auteur ; Jennifer GERDTS, Auteur ; Jeffrey MUNSON, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur Année de publication : 2012 Article en page(s) : p.13-20 Langues : Anglais (eng) Mots-clés : broader autism phenotype  autism spectrum disorders  genetics  autism assessment Index. décimale : PER Périodiques Résumé : The broader autism phenotype (BAP) was assessed in parents who have two or more children with autism spectrum disorder (ASD) (multiplex (MPX) autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated BAP characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post hoc comparisons. Further, ratings of videotapes by observers naïve to family status were compared with live, non-naive ratings by observers who were aware of family status (non-naïve). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from MPX autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the BAP, specifically in the social and communication domains, are present in MPX autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism. En ligne : http://dx.doi.org/10.1002/aur.226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families [Texte imprimé et/ou numérique] / Raphael BERNIER, Auteur ; Jennifer GERDTS, Auteur ; Jeffrey MUNSON, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur . - 2012 . - p.13-20. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.13-20 Mots-clés : broader autism phenotype  autism spectrum disorders  genetics  autism assessment Index. décimale : PER Périodiques Résumé : The broader autism phenotype (BAP) was assessed in parents who have two or more children with autism spectrum disorder (ASD) (multiplex (MPX) autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated BAP characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post hoc comparisons. Further, ratings of videotapes by observers naïve to family status were compared with live, non-naive ratings by observers who were aware of family status (non-naïve). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from MPX autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the BAP, specifically in the social and communication domains, are present in MPX autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism. En ligne : http://dx.doi.org/10.1002/aur.226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Fear-Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders / Lindsey STERLING in Autism Research, 6-5 (October 2013)  

Public ISBD [article]  inAutism Research > 6-5 (October 2013) . - p.320-331 Titre : Fear-Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lindsey STERLING, Auteur ; Jeffrey MUNSON, Auteur ; Annette ESTES, Auteur ; Michael MURIAS, Auteur ; Sara Jane WEBB, Auteur ; Bryan KING, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.320-331 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  anxiety  startle response  amygdala Index. décimale : PER Périodiques Résumé : It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (ASDs). Previous research has demonstrated that adolescents and adults with ASD generate normal response during a fear-potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with ASD. The present study partially replicates prior work by examining the fear-potentiated startle response in adolescents with ASD, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; EMG) were collected from 20 adolescents with ASD and 19 typically developing (TD) age-matched adolescents during a fear-potentiated startle paradigm. Parent-report and self-report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with ASD compared with TD adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in EMG were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear-potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in ASD. En ligne : http://dx.doi.org/10.1002/aur.1289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] Fear-Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lindsey STERLING, Auteur ; Jeffrey MUNSON, Auteur ; Annette ESTES, Auteur ; Michael MURIAS, Auteur ; Sara Jane WEBB, Auteur ; Bryan KING, Auteur ; Geraldine DAWSON, Auteur . - p.320-331. Langues : Anglais (eng) in Autism Research > 6-5 (October 2013) . - p.320-331 Mots-clés : autism spectrum disorders  anxiety  startle response  amygdala Index. décimale : PER Périodiques Résumé : It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (ASDs). Previous research has demonstrated that adolescents and adults with ASD generate normal response during a fear-potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with ASD. The present study partially replicates prior work by examining the fear-potentiated startle response in adolescents with ASD, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; EMG) were collected from 20 adolescents with ASD and 19 typically developing (TD) age-matched adolescents during a fear-potentiated startle paradigm. Parent-report and self-report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with ASD compared with TD adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in EMG were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear-potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in ASD. En ligne : http://dx.doi.org/10.1002/aur.1289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Head Circumference as an Early Predictor of Autism Symptoms in Younger Siblings of Children with Autism Spectrum Disorder / Lauren ELDER in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1104-1111 Titre : Head Circumference as an Early Predictor of Autism Symptoms in Younger Siblings of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren ELDER, Auteur ; Karen TOTH, Auteur ; Geraldine DAWSON, Auteur ; Jeffrey MUNSON, Auteur ; Deborah A. FEIN, Auteur Année de publication : 2008 Article en page(s) : p.1104-1111 Langues : Anglais (eng) Mots-clés : Autism Head-circumference Infant-siblings Index. décimale : PER Périodiques Résumé : Siblings of children with autism have an increased risk for autism spectrum disorders (ASD). As children with autism often exhibit an atypical trajectory of head circumference (HC) growth, HC may be an indicator of vulnerability to autism. This study investigated whether infant siblings of children with ASD (n = 77) with an atypical trajectory of HC growth were more likely than those without an atypical HC trajectory to develop autism symptoms. Results showed that infants who had larger HC at 12 months, and whose HC growth rate decelerated more rapidly between 12 and 24 months were more likely to exhibit autism symptoms than infants with more typical HC trajectories. Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation. En ligne : http://dx.doi.org/10.1007/s10803-007-0495-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Head Circumference as an Early Predictor of Autism Symptoms in Younger Siblings of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lauren ELDER, Auteur ; Karen TOTH, Auteur ; Geraldine DAWSON, Auteur ; Jeffrey MUNSON, Auteur ; Deborah A. FEIN, Auteur . - 2008 . - p.1104-1111. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1104-1111 Mots-clés : Autism Head-circumference Infant-siblings Index. décimale : PER Périodiques Résumé : Siblings of children with autism have an increased risk for autism spectrum disorders (ASD). As children with autism often exhibit an atypical trajectory of head circumference (HC) growth, HC may be an indicator of vulnerability to autism. This study investigated whether infant siblings of children with ASD (n = 77) with an atypical trajectory of HC growth were more likely than those without an atypical HC trajectory to develop autism symptoms. Results showed that infants who had larger HC at 12 months, and whose HC growth rate decelerated more rapidly between 12 and 24 months were more likely to exhibit autism symptoms than infants with more typical HC trajectories. Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation. En ligne : http://dx.doi.org/10.1007/s10803-007-0495-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay / Annette ESTES in Autism, 13-4 (July 2009)  

Public ISBD [article]  inAutism > 13-4 (July 2009) . - p.375-387 Titre : Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay Type de document : Texte imprimé et/ou numérique Auteurs : Annette ESTES, Auteur ; Geraldine DAWSON, Auteur ; Jeffrey MUNSON, Auteur ; Robert ABBOTT, Auteur ; Elizabeth KOEHLER, Auteur ; Xiao-Hua ZHOU, Auteur Année de publication : 2009 Article en page(s) : p.375-387 Langues : Anglais (eng) Mots-clés : autism distress mothers parenting Index. décimale : PER Périodiques Résumé : Parents of children with developmental disabilities, particularly autism spectrum disorders (ASDs), are at risk for high levels of distress. The factors contributing to this are unclear. This study investigated how child characteristics influence maternal parenting stress and psychological distress. Participants consisted of mothers and developmental-age matched preschool-aged children with ASD (N = 51) and developmental delay without autism (DD) ( N = 22). Evidence for higher levels of parenting stress and psychological distress was found in mothers in the ASD group compared to the DD group. Children's problem behavior was associated with increased parenting stress and psychological distress in mothers in the ASD and DD groups. This relationship was stronger in the DD group. Daily living skills were not related to parenting stress or psychological distress. Results suggest clinical services aiming to support parents should include a focus on reducing problem behaviors in children with developmental disabilities. En ligne : http://dx.doi.org/10.1177/1362361309105658 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=768 [article] Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay [Texte imprimé et/ou numérique] / Annette ESTES, Auteur ; Geraldine DAWSON, Auteur ; Jeffrey MUNSON, Auteur ; Robert ABBOTT, Auteur ; Elizabeth KOEHLER, Auteur ; Xiao-Hua ZHOU, Auteur . - 2009 . - p.375-387. Langues : Anglais (eng) in Autism > 13-4 (July 2009) . - p.375-387 Mots-clés : autism distress mothers parenting Index. décimale : PER Périodiques Résumé : Parents of children with developmental disabilities, particularly autism spectrum disorders (ASDs), are at risk for high levels of distress. The factors contributing to this are unclear. This study investigated how child characteristics influence maternal parenting stress and psychological distress. Participants consisted of mothers and developmental-age matched preschool-aged children with ASD (N = 51) and developmental delay without autism (DD) ( N = 22). Evidence for higher levels of parenting stress and psychological distress was found in mothers in the ASD group compared to the DD group. Children's problem behavior was associated with increased parenting stress and psychological distress in mothers in the ASD and DD groups. This relationship was stronger in the DD group. Daily living skills were not related to parenting stress or psychological distress. Results suggest clinical services aiming to support parents should include a focus on reducing problem behaviors in children with developmental disabilities. En ligne : http://dx.doi.org/10.1177/1362361309105658 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=768

Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale / Geraldine DAWSON in Journal of Autism and Developmental Disorders, 37-3 (March 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-3 (March 2007) . - p.523-536 Titre : Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale Type de document : Texte imprimé et/ou numérique Auteurs : Geraldine DAWSON, Auteur ; Annette ESTES, Auteur ; Jeffrey MUNSON, Auteur ; Gerard SCHELLENBERG, Auteur ; Raphael BERNIER, Auteur ; Robert ABBOTT, Auteur Année de publication : 2007 Article en page(s) : p.523-536 Langues : Anglais (eng) Mots-clés : Broader-phenotype Genetics Quantitative-traits Index. décimale : PER Périodiques Résumé : Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0182-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=656 [article] Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale [Texte imprimé et/ou numérique] / Geraldine DAWSON, Auteur ; Annette ESTES, Auteur ; Jeffrey MUNSON, Auteur ; Gerard SCHELLENBERG, Auteur ; Raphael BERNIER, Auteur ; Robert ABBOTT, Auteur . - 2007 . - p.523-536. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-3 (March 2007) . - p.523-536 Mots-clés : Broader-phenotype Genetics Quantitative-traits Index. décimale : PER Périodiques Résumé : Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies. En ligne : http://dx.doi.org/10.1007/s10803-006-0182-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=656

Sleep Problems and Trajectories of Restricted and Repetitive Behaviors in Children with Neurodevelopmental Disabilities / Katherine E. MACDUFFIE in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

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Sleep problems in autism: Sex differences in the school-age population / Jeffrey MUNSON ; Tanya ST. JOHN ; Robin FINLAYSON ; Juhi PANDEY ; Bridget GOTTLIEB ; John HERRINGTON ; Robert T. SCHULTZ in Autism Research, 16-1 (January 2023)  

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The effect of early autism intervention on parental sense of efficacy in a randomized trial depends on the initial level of parent stress / Annette ESTES in Autism, 26-7 (October 2022)  

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The Impact of Parent-Delivered Intervention on Parents of Very Young Children with Autism / Annette ESTES in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

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The Role of Face Familiarity in Eye Tracking of Faces by Individuals with Autism Spectrum Disorders / Lindsey STERLING in Journal of Autism and Developmental Disorders, 38-9 (October 2008)  

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