The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Titre : The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur Année de publication : 2009 Article en page(s) : p.317-325 Langues : Anglais (eng) Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719 [article] The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur . - 2009 . - p.317-325. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325 Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective. Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years. Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size. Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719

The role played by the interaction between genetic factors and attachment in the stress response in infancy / Alessandra FRIGERIO in Journal of Child Psychology and Psychiatry, 50-12 (December 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1513-1522 Titre : The role played by the interaction between genetic factors and attachment in the stress response in infancy Type de document : Texte imprimé et/ou numérique Auteurs : Alessandra FRIGERIO, Auteur ; Roberto GIORDA, Auteur ; Richard M. PASCO FEARON, Auteur ; Marianna RUSCONI, Auteur ; Elisa CEPPI, Auteur ; Maria Elisabetta RAGGI, Auteur Année de publication : 2009 Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Gene–environment-interaction attachment alpha-amylase cortisol infancy Index. décimale : PER Périodiques Résumé : Background: The importance of understanding which environmental and biological factors are involved in determining individual differences in physiological response to stress is widely recognized, given the impact that stress has on physical and mental health. Methods: The child–mother attachment relationship and some genetic polymorphisms (5-HTTLPR, COMT and GABRA6) were tested as predictors of salivary cortisol and alpha amylase concentrations, two biomarkers of hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic adrenomedullary (SAM) system activity, during the Strange Situation (SS) procedure in a sample of more than 100 healthy infants, aged 12 to 18 months. Results: Individual differences in alpha amylase response to separation were predicted by security of attachment in interaction with 5-HTTLPR and GABRA6 genetic polymorphisms, whereas alpha amylase basal levels were predicted by COMT × attachment interaction. No significant effect of attachment, genetics and their interaction on cortisol activity emerged. Conclusions: These results help to disentangle the role played by both genetic and environmental factors in determining individual differences in stress response in infancy. The results also shed light on the suggestion that HPA and SAM systems are likely to have different characteristic responses to stress. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02126.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883 [article] The role played by the interaction between genetic factors and attachment in the stress response in infancy [Texte imprimé et/ou numérique] / Alessandra FRIGERIO, Auteur ; Roberto GIORDA, Auteur ; Richard M. PASCO FEARON, Auteur ; Marianna RUSCONI, Auteur ; Elisa CEPPI, Auteur ; Maria Elisabetta RAGGI, Auteur . - 2009 . - p.1513-1522. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1513-1522 Mots-clés : Gene–environment-interaction attachment alpha-amylase cortisol infancy Index. décimale : PER Périodiques Résumé : Background: The importance of understanding which environmental and biological factors are involved in determining individual differences in physiological response to stress is widely recognized, given the impact that stress has on physical and mental health. Methods: The child–mother attachment relationship and some genetic polymorphisms (5-HTTLPR, COMT and GABRA6) were tested as predictors of salivary cortisol and alpha amylase concentrations, two biomarkers of hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic adrenomedullary (SAM) system activity, during the Strange Situation (SS) procedure in a sample of more than 100 healthy infants, aged 12 to 18 months. Results: Individual differences in alpha amylase response to separation were predicted by security of attachment in interaction with 5-HTTLPR and GABRA6 genetic polymorphisms, whereas alpha amylase basal levels were predicted by COMT × attachment interaction. No significant effect of attachment, genetics and their interaction on cortisol activity emerged. Conclusions: These results help to disentangle the role played by both genetic and environmental factors in determining individual differences in stress response in infancy. The results also shed light on the suggestion that HPA and SAM systems are likely to have different characteristic responses to stress. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02126.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883

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