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Auteur Laura VANZIN |
Documents disponibles écrits par cet auteur (2)
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Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence / Maria NOBILE in Development and Psychopathology, 19-4 (Fall 2007)
[article]
Titre : Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur Année de publication : 2007 Article en page(s) : p.1147-1160 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160[article] Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Valentina PASTORE, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur . - 2007 . - p.1147-1160.
Langues : Anglais (eng)
in Development and Psychopathology > 19-4 (Fall 2007) . - p.1147-1160
Index. décimale : PER Périodiques Résumé : The impact of socioeconomic status (SES) and genetic polymorphisms on individual differences for externalized behaviors have often been investigated separately in studies of children and adults. In a general population sample of 607 Italian preadolescents, we examined the independent and joint effects of SES and the dopamine receptor D4 (DRD4) and serotonin transporter linked promoter region (5-HTTLPR) polymorphisms upon rule-breaking and aggressive behaviors measured with the Child Behavior CheckList/6–18. We found evidence, which was based on both one locus and two-loci genotype analyses, that low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores. The effects were similar but more modest and limited to one locus genotype analyses for rule-breaking behavior. Consistent with studies that showed the effects of societal moderators on the heritability of externalized behaviors across different segments of the population, we suggest that diminished social constraints associated with low parental SES may act as enhancers of the genetic influence of specific DRD4 and 5-HTTLPR alleles over aggressive behaviors in preadolescence. En ligne : http://dx.doi.org/10.1017/s0954579407000594 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)
[article]
Titre : The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur Année de publication : 2009 Article en page(s) : p.317-325 Langues : Anglais (eng) Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective.
Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years.
Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size.
Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719
in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325[article] The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Roberto GIORDA, Auteur ; Cecilia MARINO, Auteur ; Ombretta CARLET, Auteur ; Laura VANZIN, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur ; Marco BATTAGLIA, Auteur ; Marianna RUSCONI, Auteur . - 2009 . - p.317-325.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-3 (March 2009) . - p.317-325
Mots-clés : Children depression gene–environment-interaction serotonin divorce family affective-disorders Index. décimale : PER Périodiques Résumé : Background: Both genetic and psychosocial risk factors influence the risk for depression in development. While the impacts of family structure and of serotonergic polymorphisms upon individual differences for affective problems have been investigated separately, they have never been considered together in a gene–environment interplay perspective.
Methods: We examined the effects of family structure and two serotonergic polymorphisms (the TPH2 G-703T and the 5-HTTLPR) upon depressive symptoms assessed by the new CBCL/6-18 DSM-oriented Affective Problems scale in a general population sample of 607 Italian children aged 10–14 years.
Results: Belonging to 'one-parent' families, the TPH2 G-703T 'G variant', and the 5-HTTLPR 'short' alleles were associated – both alone and in apparent gene-by-environment interaction – with higher Affective Problems scores. As predicted by quantitative genetics theory, both polymorphisms contributed with a small effect size, while 'family structure' had a moderate effect size.
Conclusions: A putative hazard factor impinging on individual risk at the family-wide level, namely family structure, appears to act interactively with two pivotal serotonergic genes in heightening risk for Affective Problems. Although it remains to be demonstrated that belonging to a one- rather than a two-parent family has true environmental causal effects on Affective Problems, these data may contribute to identify/prevent risk for depression in childhood.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01958.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=719