Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills / Denis PERUZZO ; Filippo ARRIGONI ; Silvia BUSTI CECCARELLI ; Laura VILLA ; Elisa MANI ; Eleonora MAGGIONI ; Paolo BRAMBILLA ; Maria NOBILE ; Massimo MOLTENI ; Alessandro CRIPPA in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202626 Titre : Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills Type de document : Texte imprimé et/ou numérique Auteurs : Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur Article en page(s) : p.202626 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills [Texte imprimé et/ou numérique] / Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur . - p.202626. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202626 Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

Enhanced motor noise in an autism subtype with poor motor skills / Veronica MANDELLI in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 36p. Titre : Enhanced motor noise in an autism subtype with poor motor skills Type de document : Texte imprimé et/ou numérique Auteurs : Veronica MANDELLI, Auteur ; Isotta LANDI, Auteur ; Silvia Busti CECCARELLI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur ; Alessandro D'AUSILIO, Auteur ; Luciano FADIGA, Auteur ; Alessandro CRIPPA, Auteur ; Michael V. LOMBARDO, Auteur Article en page(s) : 36p. Langues : Anglais (eng) Mots-clés : Humans  Child  Male  Female  Adolescent  Motor Skills  Autistic Disorder/physiopathology  Child, Preschool  Biomechanical Phenomena  Clustering  Kinematics  Motor  Stratification  Subtypes  competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor difficulties are common in many, but not all, autistic individuals. These difficulties can co-occur with other problems, such as delays in language, intellectual, and adaptive functioning. Biological mechanisms underpinning such difficulties are less well understood. Poor motor skills tend to be more common in individuals carrying highly penetrant rare genetic mutations. Such mechanisms may have downstream consequences of altering neurophysiological excitation-inhibition balance and lead to enhanced behavioral motor noise. METHODS: This study combined publicly available and in-house datasets of autistic (n = 156), typically-developing (TD, n = 149), and developmental coordination disorder (DCD, n = 23) children (age 3-16 years). Autism motor subtypes were identified based on patterns of motor abilities measured from the Movement Assessment Battery for Children 2nd edition. Stability-based relative clustering validation was used to identify autism motor subtypes and evaluate generalization accuracy in held-out data. Autism motor subtypes were tested for differences in motor noise, operationalized as the degree of dissimilarity between repeated motor kinematic trajectories recorded during a simple reach-to-drop task. RESULTS: Relatively 'high' (n = 87) versus 'low' (n = 69) autism motor subtypes could be detected and which generalize with 89% accuracy in held-out data. The relatively 'low' subtype was lower in general intellectual ability and older at age of independent walking, but did not differ in age at first words or autistic traits or symptomatology. Motor noise was considerably higher in the 'low' subtype compared to 'high' (Cohen's d = 0.77) or TD children (Cohen's d = 0.85), but similar between autism 'high' and TD children (Cohen's d = 0.08). Enhanced motor noise in the 'low' subtype was also most pronounced during the feedforward phase of reaching actions. LIMITATIONS: The sample size of this work is limited. Future work in larger samples along with independent replication is important. Motor noise was measured only on one specific motor task. Thus, a more comprehensive assessment of motor noise on many other motor tasks is needed. CONCLUSIONS: Autism can be split into at least two discrete motor subtypes that are characterized by differing levels of motor noise. This suggests that autism motor subtypes may be underpinned by different biological mechanisms. En ligne : https://dx.doi.org/10.1186/s13229-024-00618-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Enhanced motor noise in an autism subtype with poor motor skills [Texte imprimé et/ou numérique] / Veronica MANDELLI, Auteur ; Isotta LANDI, Auteur ; Silvia Busti CECCARELLI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur ; Alessandro D'AUSILIO, Auteur ; Luciano FADIGA, Auteur ; Alessandro CRIPPA, Auteur ; Michael V. LOMBARDO, Auteur . - 36p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 36p. Mots-clés : Humans  Child  Male  Female  Adolescent  Motor Skills  Autistic Disorder/physiopathology  Child, Preschool  Biomechanical Phenomena  Clustering  Kinematics  Motor  Stratification  Subtypes  competing interests to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Motor difficulties are common in many, but not all, autistic individuals. These difficulties can co-occur with other problems, such as delays in language, intellectual, and adaptive functioning. Biological mechanisms underpinning such difficulties are less well understood. Poor motor skills tend to be more common in individuals carrying highly penetrant rare genetic mutations. Such mechanisms may have downstream consequences of altering neurophysiological excitation-inhibition balance and lead to enhanced behavioral motor noise. METHODS: This study combined publicly available and in-house datasets of autistic (n = 156), typically-developing (TD, n = 149), and developmental coordination disorder (DCD, n = 23) children (age 3-16 years). Autism motor subtypes were identified based on patterns of motor abilities measured from the Movement Assessment Battery for Children 2nd edition. Stability-based relative clustering validation was used to identify autism motor subtypes and evaluate generalization accuracy in held-out data. Autism motor subtypes were tested for differences in motor noise, operationalized as the degree of dissimilarity between repeated motor kinematic trajectories recorded during a simple reach-to-drop task. RESULTS: Relatively 'high' (n = 87) versus 'low' (n = 69) autism motor subtypes could be detected and which generalize with 89% accuracy in held-out data. The relatively 'low' subtype was lower in general intellectual ability and older at age of independent walking, but did not differ in age at first words or autistic traits or symptomatology. Motor noise was considerably higher in the 'low' subtype compared to 'high' (Cohen's d = 0.77) or TD children (Cohen's d = 0.85), but similar between autism 'high' and TD children (Cohen's d = 0.08). Enhanced motor noise in the 'low' subtype was also most pronounced during the feedforward phase of reaching actions. LIMITATIONS: The sample size of this work is limited. Future work in larger samples along with independent replication is important. Motor noise was measured only on one specific motor task. Thus, a more comprehensive assessment of motor noise on many other motor tasks is needed. CONCLUSIONS: Autism can be split into at least two discrete motor subtypes that are characterized by differing levels of motor noise. This suggests that autism motor subtypes may be underpinned by different biological mechanisms. En ligne : https://dx.doi.org/10.1186/s13229-024-00618-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait / Maria NOBILE in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.263-283 Titre : Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait Type de document : Texte imprimé et/ou numérique Auteurs : Maria NOBILE, Auteur ; Paolo PEREGO, Auteur ; Luigi PICCININI, Auteur ; Elisa MANI, Auteur ; Agnese ROSSI, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur Année de publication : 2011 Article en page(s) : p.263-283 Langues : Anglais (eng) Mots-clés : autism  gait analysis  jerk  locomotion system  motor dysfunction Index. décimale : PER Périodiques Résumé : In order to increase the knowledge of locomotor disturbances in children with autism, and of the mechanism underlying them, the objective of this exploratory study was to reliably and quantitatively evaluate linear gait parameters (spatio-temporal and kinematic parameters), upper body kinematic parameters, walk orientation and smoothness using an automatic motion analyser (ELITE systems) in drug naïve children with Autistic Disorder (AD) and healthy controls. The children with AD showed a stiffer gait in which the usual fluidity of walking was lost, trunk postural abnormalities, highly significant difficulties to maintain a straight line and a marked loss of smoothness (increase of jerk index), compared to the healthy controls. As a whole, these data suggest a complex motor dysfunction involving both the cortical and the subcortical area or, maybe, a possible deficit in the integration of sensory-motor information within motor networks (i.e., anomalous connections within the fronto-cerebello-thalamo-frontal network). Although the underlying neural structures involved remain to be better defined, these data may contribute to highlighting the central role of motor impairment in autism and suggest the usefulness of taking into account motor difficulties when developing new diagnostic and rehabilitation programs. En ligne : http://dx.doi.org/10.1177/1362361309356929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait [Texte imprimé et/ou numérique] / Maria NOBILE, Auteur ; Paolo PEREGO, Auteur ; Luigi PICCININI, Auteur ; Elisa MANI, Auteur ; Agnese ROSSI, Auteur ; Monica BELLINA, Auteur ; Massimo MOLTENI, Auteur . - 2011 . - p.263-283. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.263-283 Mots-clés : autism  gait analysis  jerk  locomotion system  motor dysfunction Index. décimale : PER Périodiques Résumé : In order to increase the knowledge of locomotor disturbances in children with autism, and of the mechanism underlying them, the objective of this exploratory study was to reliably and quantitatively evaluate linear gait parameters (spatio-temporal and kinematic parameters), upper body kinematic parameters, walk orientation and smoothness using an automatic motion analyser (ELITE systems) in drug naïve children with Autistic Disorder (AD) and healthy controls. The children with AD showed a stiffer gait in which the usual fluidity of walking was lost, trunk postural abnormalities, highly significant difficulties to maintain a straight line and a marked loss of smoothness (increase of jerk index), compared to the healthy controls. As a whole, these data suggest a complex motor dysfunction involving both the cortical and the subcortical area or, maybe, a possible deficit in the integration of sensory-motor information within motor networks (i.e., anomalous connections within the fronto-cerebello-thalamo-frontal network). Although the underlying neural structures involved remain to be better defined, these data may contribute to highlighting the central role of motor impairment in autism and suggest the usefulness of taking into account motor difficulties when developing new diagnostic and rehabilitation programs. En ligne : http://dx.doi.org/10.1177/1362361309356929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1481-1491 Titre : A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur Article en page(s) : p.1481-1491 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11?years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder [Texte imprimé et/ou numérique] / Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur . - p.1481-1491. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1481-1491 Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11?years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1481-1491 Titre : A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur Article en page(s) : p.1481-1491 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  autism spectrum disorder  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder [Texte imprimé et/ou numérique] / Alessandro CRIPPA, Auteur ; Francesco CRAIG, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Maddalena MAURI, Auteur ; Silvia GRAZIOLI, Auteur ; Nicoletta SCIONTI, Auteur ; Alice CREMASCOLI, Auteur ; Camilla FERRANTE, Auteur ; Chiara VISIOLI, Auteur ; Gian Marco MARZOCCHI, Auteur ; Massimo MOLTENI, Auteur ; Maria NOBILE, Auteur . - p.1481-1491. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1481-1491 Mots-clés : Autism Spectrum Disorder  Child  Female  Humans  Male  Motor Skills  Quality of Life  Sex Factors  autism spectrum disorder  kinematics  motion capture  sex differences Index. décimale : PER Périodiques Résumé : Motor peculiarities are often reported in children with autism spectrum disorder and may predict subsequent adaptive functioning and quality of life. Although the sex bias in the prevalence of the disorder is well documented, little is known about differences in motor profile in males and females with autism spectrum disorder. Our goal was to study differences in motor functioning of boys and girls with autism spectrum disorder aged 3-11years compared with typically developing children. Their motor performances were evaluated using a multimethod approach, including standardized motor tests, caregiver reports, and a detailed motion capture analysis of a simple reach-to-drop movement. We found that, irrespective of sex, children with autism spectrum disorder had worse scores than typically developing children on standardized tests and on caregiver reports. Interestingly, girls with autism spectrum disorder, but not boys, presented altered motor anticipation in reach-to-drop. Our findings emphasize the need for more sex-specific assessment of motor function in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361321995634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

A multimodal approach can identify specific motor profiles in autism and attention-deficit/hyperactivity disorder / Stefano DE FRANCESCO in Autism Research, 16-8 (August 2023)  

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Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence / Maria NOBILE in Development and Psychopathology, 19-4 (Fall 2007)  

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The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10–14 years / Maria NOBILE in Journal of Child Psychology and Psychiatry, 50-3 (March 2009)  

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Use of Machine Learning to Identify Children with Autism and Their Motor Abnormalities / Alessandro CRIPPA in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

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