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Auteur Robin MORRIS |
Documents disponibles écrits par cet auteur (2)
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Common and unique multimodal covarying patterns in autism spectrum disorder subtypes / Shile QI in Molecular Autism, 11 (2020)
[article]
Titre : Common and unique multimodal covarying patterns in autism spectrum disorder subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur Année de publication : 2020 Langues : Anglais (eng) Mots-clés : Asperger’s disorder Autism spectrum disorder Autistic disorder Heterogeneity Multimodal fusion Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Common and unique multimodal covarying patterns in autism spectrum disorder subtypes [Texte imprimé et/ou numérique] / Shile QI, Auteur ; Robin MORRIS, Auteur ; Jessica A TURNER, Auteur ; Zening FU, Auteur ; Rongtao JIANG, Auteur ; Thomas P. DERAMUS, Auteur ; Dongmei ZHI, Auteur ; Vince D. CALHOUN, Auteur ; Jing SUI, Auteur . - 2020.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Asperger’s disorder Autism spectrum disorder Autistic disorder Heterogeneity Multimodal fusion Pervasive developmental disorder-not otherwise specified (PDD-NOS) Index. décimale : PER Périodiques Résumé : BACKGROUND: The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. METHODS: In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n?=?79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n?=?58) and Autistic disorder (n?=?92) from ABIDE II were used as discovery cohort, and ABIDE I (n?=?400) was used for replication. RESULTS: Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. CONCLUSIONS: Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population. En ligne : http://dx.doi.org/10.1186/s13229-020-00397-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation / Jessica BRAMHAM in Autism, 13-3 (May 2009)
[article]
Titre : Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur Année de publication : 2009 Article en page(s) : p.245-264 Langues : Anglais (eng) Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728
in Autism > 13-3 (May 2009) . - p.245-264[article] Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation [Texte imprimé et/ou numérique] / Jessica BRAMHAM, Auteur ; Philip ASHERSON, Auteur ; Declan G. MURPHY, Auteur ; Ailsa RUSSELL, Auteur ; Fiona AMBERY, Auteur ; Robin MORRIS, Auteur ; Kiriakos XENITIDIS, Auteur ; Susan E. YOUNG, Auteur . - 2009 . - p.245-264.
Langues : Anglais (eng)
in Autism > 13-3 (May 2009) . - p.245-264
Mots-clés : ADHD adults ASD executive-functioning Index. décimale : PER Périodiques Résumé : Executive functioning deficits characterize the neuropsychological profiles of the childhood neurodevelopmental disorders of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). This study sought to determine whether similar impairments exist in adults with ADHD (N = 53) and ASD (N = 45) in comparison with a healthy control group (N = 31), whether the two disorders can be distinguished on the basis of their executive functioning features, and whether these impairments are related to symptom severity. Both clinical groups were found to exhibit executive functioning deficits. The ADHD group had difficulty withholding a response, with relative preservation of initiation and planning abilities. In contrast, the ASD group exhibited significant impairments in initiation, planning and strategy formation. The specific executive functioning deficits were related to severity of response inhibition impairments in ADHD and stereotyped, repetitive behaviours in ASD. These findings suggest the pattern of executive functioning deficits follows a consistent trajectory into adulthood. En ligne : http://dx.doi.org/10.1177/1362361309103790 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=728