Atypical Inter-Network Deactivation Associated With the Posterior Default-Mode Network in Autism Spectrum Disorder / Aija KOTILA in Autism Research, 14-2 (February 2021)  

Public ISBD [article]  inAutism Research > 14-2 (February 2021) . - p.248-264 Titre : Atypical Inter-Network Deactivation Associated With the Posterior Default-Mode Network in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Aija KOTILA, Auteur ; Matti JÄRVELÄ, Auteur ; Vesa KORHONEN, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Vesa KIVINIEMI, Auteur ; Ville RAATIKAINEN, Auteur Article en page(s) : p.248-264 Langues : Anglais (eng) Mots-clés : Asd  Mreg  brain network  default-mode network  dynamic lag analysis  resting-state fMRI Index. décimale : PER Périodiques Résumé : Previous studies have suggested that atypical deactivation of functional brain networks contributes to the complex cognitive and behavioral profile associated with autism spectrum disorder (ASD). However, these studies have not considered the temporal dynamics of deactivation mechanisms between the networks. In this study, we examined (a) mutual deactivation and (b) mutual activation-deactivation (i.e., anticorrelated) time-lag patterns between resting-state networks (RSNs) in young adults with ASD (n = 20) and controls (n = 20) by applying the recently defined dynamic lag analysis (DLA) method, which measures time-lag variations peak-by-peak between the networks. In order to achieve temporally accurate lag patterns, the brain imaging data was acquired with a fast functional magnetic resonance imaging (fMRI) sequence (TR = 100?ms). Group-level independent component analysis was used to identify 16 RSNs for the DLA. We found altered mutual deactivation timings in ASD in (a) three of the deactivated and (b) two of the transiently anticorrelated (activated-deactivated) RSN pairs, which survived the strict threshold for significance of surrogate data. Of the significant RSN pairs, 80% included the posterior default-mode network (DMN). We propose that temporally altered deactivation mechanisms, including timings and directionality, between the posterior DMN and RSNs mediating processing of socially relevant information may contribute to the ASD phenotype. LAY SUMMARY: To understand autistic traits on a neural level, we examined temporal fluctuations in information flow between brain regions in young adults with autism spectrum disorder (ASD) and controls. We used a fast neuroimaging procedure to investigate deactivation mechanisms between brain regions. We found that timings and directionality of communication between certain brain regions were temporally altered in ASD, suggesting atypical deactivation mechanisms associated with the posterior default-mode network. En ligne : http://dx.doi.org/10.1002/aur.2433 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 [article] Atypical Inter-Network Deactivation Associated With the Posterior Default-Mode Network in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Aija KOTILA, Auteur ; Matti JÄRVELÄ, Auteur ; Vesa KORHONEN, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Vesa KIVINIEMI, Auteur ; Ville RAATIKAINEN, Auteur . - p.248-264. Langues : Anglais (eng) in Autism Research > 14-2 (February 2021) . - p.248-264 Mots-clés : Asd  Mreg  brain network  default-mode network  dynamic lag analysis  resting-state fMRI Index. décimale : PER Périodiques Résumé : Previous studies have suggested that atypical deactivation of functional brain networks contributes to the complex cognitive and behavioral profile associated with autism spectrum disorder (ASD). However, these studies have not considered the temporal dynamics of deactivation mechanisms between the networks. In this study, we examined (a) mutual deactivation and (b) mutual activation-deactivation (i.e., anticorrelated) time-lag patterns between resting-state networks (RSNs) in young adults with ASD (n = 20) and controls (n = 20) by applying the recently defined dynamic lag analysis (DLA) method, which measures time-lag variations peak-by-peak between the networks. In order to achieve temporally accurate lag patterns, the brain imaging data was acquired with a fast functional magnetic resonance imaging (fMRI) sequence (TR = 100?ms). Group-level independent component analysis was used to identify 16 RSNs for the DLA. We found altered mutual deactivation timings in ASD in (a) three of the deactivated and (b) two of the transiently anticorrelated (activated-deactivated) RSN pairs, which survived the strict threshold for significance of surrogate data. Of the significant RSN pairs, 80% included the posterior default-mode network (DMN). We propose that temporally altered deactivation mechanisms, including timings and directionality, between the posterior DMN and RSNs mediating processing of socially relevant information may contribute to the ASD phenotype. LAY SUMMARY: To understand autistic traits on a neural level, we examined temporal fluctuations in information flow between brain regions in young adults with autism spectrum disorder (ASD) and controls. We used a fast neuroimaging procedure to investigate deactivation mechanisms between brain regions. We found that timings and directionality of communication between certain brain regions were temporally altered in ASD, suggesting atypical deactivation mechanisms associated with the posterior default-mode network. En ligne : http://dx.doi.org/10.1002/aur.2433 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441

Autistic adults and adults with sub-clinical autistic traits differ from non-autistic adults in social-pragmatic inferencing and narrative discourse / Katja DINDAR in Autism, 27-5 (July 2023)  

Public ISBD [article]  inAutism > 27-5 (July 2023) . - p.1320-1335 Titre : Autistic adults and adults with sub-clinical autistic traits differ from non-autistic adults in social-pragmatic inferencing and narrative discourse Type de document : Texte imprimé et/ou numérique Auteurs : Katja DINDAR, Auteur ; Soile LOUKUSA, Auteur ; Eeva LEINONEN, Auteur ; Leena MAKINEN, Auteur ; Laura MÄMMELÄ, Auteur ; Marja-Leena MATTILA, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur Article en page(s) : p.1320-1335 Langues : Anglais (eng) Mots-clés : autism spectrum;narrative discourse;narrative skills;pragmatics;social-pragmatic ability Index. décimale : PER Périodiques Résumé : Since prior research has mostly focused on children, less is known about how autistic adults and adults with sub-clinical autistic traits interpret pragmatically complex social situations and the kind of narrative discourse they produce. 32 autistic young adults, 18 young adults with sub-clinical autistic traits and 34 non-autistic young adults participated this study. They were shown videos of social interactions which required complex pragmatic processing and were asked to freely narrate what they thought was occurring in each video. Their narratives were coded for aspects of social-pragmatic and narrative discourse. The results indicate that the autistic and sub-clinical groups differed from the comparison group in what they inferred as relevant video content. The narratives of the autistic group also differed from the comparison group in meaning, focus and emphasis on details. In addition, the comparison group produced more holistic narratives whereas the autistic and sub-clinical groups produced more atomistic narratives. Correlational findings indicated that perceptual reasoning has stronger associations with pragmatic inferencing in the autistic and sub-clinical groups than in the comparison group. This study suggests that autistic adults and adults with sub-clinical autistic traits differ from non-autistic adults in what they perceive to be relevant in their social world. Lay Abstract Previous social-pragmatic and narrative research involving autistic individuals has mostly focused on children. Little is known about how autistic adults and adults who have autistic traits but do not have a diagnosis of an autism spectrum disorder (ASD) interpret complex social situations and tell narratives about these situations. We asked 32 autistic young adults, 18 adults with autistic traits but no ASD diagnosis, and 34 non-autistic young adults to watch socially complex situations and freely tell narratives about what they thought was occurring in each situation. These narratives were analysed for how the participants had interpreted the situations and for the type of narratives they produced. We found that the groups had both similarities and differences. Regarding the differences, we found that the autistic adults and adults with autistic traits interpreted the situations differently from the non-autistic adults. The autistic adults found different aspects of the situations relevant, had different foci and placed greater importance on details than the non-autistic adults. The autistic adults and adults with autistic traits also differed from the non-autistic adults by having more detail- and event-focused narratives whereas the non-autistic adults were more likely to base their narratives on their own broad interpretations of the situations. Perceptual processing styles appeared to play a bigger role in interpreting the situations for the autistic adults and adults with autistic traits than the non-autistic adults. Our findings suggest that autistic adults and adults with autistic traits focus on different aspects in their social world than non-autistic adults. En ligne : http://dx.doi.org/10.1177/13623613221136003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] Autistic adults and adults with sub-clinical autistic traits differ from non-autistic adults in social-pragmatic inferencing and narrative discourse [Texte imprimé et/ou numérique] / Katja DINDAR, Auteur ; Soile LOUKUSA, Auteur ; Eeva LEINONEN, Auteur ; Leena MAKINEN, Auteur ; Laura MÄMMELÄ, Auteur ; Marja-Leena MATTILA, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur . - p.1320-1335. Langues : Anglais (eng) in Autism > 27-5 (July 2023) . - p.1320-1335 Mots-clés : autism spectrum;narrative discourse;narrative skills;pragmatics;social-pragmatic ability Index. décimale : PER Périodiques Résumé : Since prior research has mostly focused on children, less is known about how autistic adults and adults with sub-clinical autistic traits interpret pragmatically complex social situations and the kind of narrative discourse they produce. 32 autistic young adults, 18 young adults with sub-clinical autistic traits and 34 non-autistic young adults participated this study. They were shown videos of social interactions which required complex pragmatic processing and were asked to freely narrate what they thought was occurring in each video. Their narratives were coded for aspects of social-pragmatic and narrative discourse. The results indicate that the autistic and sub-clinical groups differed from the comparison group in what they inferred as relevant video content. The narratives of the autistic group also differed from the comparison group in meaning, focus and emphasis on details. In addition, the comparison group produced more holistic narratives whereas the autistic and sub-clinical groups produced more atomistic narratives. Correlational findings indicated that perceptual reasoning has stronger associations with pragmatic inferencing in the autistic and sub-clinical groups than in the comparison group. This study suggests that autistic adults and adults with sub-clinical autistic traits differ from non-autistic adults in what they perceive to be relevant in their social world. Lay Abstract Previous social-pragmatic and narrative research involving autistic individuals has mostly focused on children. Little is known about how autistic adults and adults who have autistic traits but do not have a diagnosis of an autism spectrum disorder (ASD) interpret complex social situations and tell narratives about these situations. We asked 32 autistic young adults, 18 adults with autistic traits but no ASD diagnosis, and 34 non-autistic young adults to watch socially complex situations and freely tell narratives about what they thought was occurring in each situation. These narratives were analysed for how the participants had interpreted the situations and for the type of narratives they produced. We found that the groups had both similarities and differences. Regarding the differences, we found that the autistic adults and adults with autistic traits interpreted the situations differently from the non-autistic adults. The autistic adults found different aspects of the situations relevant, had different foci and placed greater importance on details than the non-autistic adults. The autistic adults and adults with autistic traits also differed from the non-autistic adults by having more detail- and event-focused narratives whereas the non-autistic adults were more likely to base their narratives on their own broad interpretations of the situations. Perceptual processing styles appeared to play a bigger role in interpreting the situations for the autistic adults and adults with autistic traits than the non-autistic adults. Our findings suggest that autistic adults and adults with autistic traits focus on different aspects in their social world than non-autistic adults. En ligne : http://dx.doi.org/10.1177/13623613221136003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 40-9 (September 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Titre : Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study Type de document : Texte imprimé et/ou numérique Auteurs : Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur Année de publication : 2010 Article en page(s) : p.1080-1093 Langues : Anglais (eng) Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study [Texte imprimé et/ou numérique] / Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur . - 2010 . - p.1080-1093. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder / Katja JUSSILA in Research in Autism Spectrum Disorders, 9 (January 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 9 (January 2015) . - p.38-44 Titre : Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katja JUSSILA, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Marja-Leena MATTILA, Auteur ; Soile LOUKUSA, Auteur ; Rachel POLLOCK-WURMAN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Tuula HURTIG, Auteur Année de publication : 2015 Article en page(s) : p.38-44 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Social reciprocity  Social Responsiveness Scale  Cross-cultural differences  Screening Index. décimale : PER Périodiques Résumé : Abstract When importing screening questionnaires of ASD, it has been found that parental interpretation/reporting of autistic traits may be culturally influenced. In the current study, our aim was preliminary evaluation of the Finnish parent rated SRS in order to determine whether the measure would show promise as an aid in screening. The study sample consisted of high-functioning school aged male ASD outpatients of Oulu University Hospital (n = 44, age 11.4 ± 2.3) and age-matched controls (n = 44, age 11.8 ± 2.4 years). Internal consistency as well as convergent and discriminative validity was in line with previous research. However, the results indicated that the cut-off published in the SRS manual might be too high to be used in Finland. Our results emphasize the importance of determining the normative range and clinical cut-offs in various cultures when importing diagnostic screening questionnaires in order to avoid getting high percentages of false negatives in the screening phase, and thus risk leaving many children without adequate diagnostic evaluation and rehabilitation. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Katja JUSSILA, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Marja-Leena MATTILA, Auteur ; Soile LOUKUSA, Auteur ; Rachel POLLOCK-WURMAN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Tuula HURTIG, Auteur . - 2015 . - p.38-44. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.38-44 Mots-clés : Autism spectrum disorder  Social reciprocity  Social Responsiveness Scale  Cross-cultural differences  Screening Index. décimale : PER Périodiques Résumé : Abstract When importing screening questionnaires of ASD, it has been found that parental interpretation/reporting of autistic traits may be culturally influenced. In the current study, our aim was preliminary evaluation of the Finnish parent rated SRS in order to determine whether the measure would show promise as an aid in screening. The study sample consisted of high-functioning school aged male ASD outpatients of Oulu University Hospital (n = 44, age 11.4 ± 2.3) and age-matched controls (n = 44, age 11.8 ± 2.4 years). Internal consistency as well as convergent and discriminative validity was in line with previous research. However, the results indicated that the cut-off published in the SRS manual might be too high to be used in Finland. Our results emphasize the importance of determining the normative range and clinical cut-offs in various cultures when importing diagnostic screening questionnaires in order to avoid getting high percentages of false negatives in the screening phase, and thus risk leaving many children without adequate diagnostic evaluation and rehabilitation. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder / Ville RAATIKAINEN in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.244-258 Titre : Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur Article en page(s) : p.244-258 Langues : Anglais (eng) Mots-clés : Asd  Mreg  dynamic lag analysis  human brain  lag pattern  resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder [Texte imprimé et/ou numérique] / Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur . - p.244-258. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.244-258 Mots-clés : Asd  Mreg  dynamic lag analysis  human brain  lag pattern  resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Emotion Recognition in Children and Adolescents with Autism Spectrum Disorders / Sanna KUUSIKKO in Journal of Autism and Developmental Disorders, 39-6 (June 2009)  

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Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism / Tuula HURTIG in Autism, 13-6 (November 2009)  

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Valence Scaling of Dynamic Facial Expressions is Altered in High-Functioning Subjects with Autism Spectrum Disorders: an fMRI Study / Jukka S. RAHKO in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

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Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

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