Affective neural response to restricted interests in autism spectrum disorders / Carissa J. CASCIO in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171 Titre : Affective neural response to restricted interests in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur Article en page(s) : p.162-171 Langues : Anglais (eng) Mots-clés : Autism  restricted interests  reward  repetitive behavior  fMRI  insula  salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Affective neural response to restricted interests in autism spectrum disorders [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Jessica L. HEACOCK, Auteur ; Kimberly B. SCHAUDER, Auteur ; Whitney A. LORING, Auteur ; Baxter P. ROGERS, Auteur ; Jennifer R. PRYWELLER, Auteur ; Cassandra R. NEWSOM, Auteur ; Jurnell COCKHREN, Auteur ; Aize CAO, Auteur ; Scott BOLTON, Auteur . - p.162-171. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.162-171 Mots-clés : Autism  restricted interests  reward  repetitive behavior  fMRI  insula  salience Index. décimale : PER Périodiques Résumé : Background Restricted interests are a class of repetitive behavior in autism spectrum disorders (ASD) whose intensity and narrow focus often contribute to significant interference with daily functioning. While numerous neuroimaging studies have investigated executive circuits as putative neural substrates of repetitive behavior, recent work implicates affective neural circuits in restricted interests. We sought to explore the role of affective neural circuits and determine how restricted interests are distinguished from hobbies or interests in typical development. Methods We compared a group of children with ASD to a typically developing (TD) group of children with strong interests or hobbies, employing parent report, an operant behavioral task, and functional imaging with personalized stimuli based on individual interests. Results While performance on the operant task was similar between the two groups, parent report of intensity and interference of interests was significantly higher in the ASD group. Both the ASD and TD groups showed increased BOLD response in widespread affective neural regions to the pictures of their own interest. When viewing pictures of other children's interests, the TD group showed a similar pattern, whereas BOLD response in the ASD group was much more limited. Increased BOLD response in the insula and anterior cingulate cortex distinguished the ASD from the TD group, and parent report of the intensity and interference with daily life of the child's restricted interest predicted insula response. Conclusions While affective neural network response and operant behavior are comparable in typical and restricted interests, the narrowness of focus that clinically distinguishes restricted interests in ASD is reflected in more interference in daily life and aberrantly enhanced insula and anterior cingulate response to individuals’ own interests in the ASD group. These results further support the involvement of affective neural networks in repetitive behaviors in ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Early Predictors of Growth in Diversity of Key Consonants Used in Communication in Initially Preverbal Children with Autism Spectrum Disorder / Tiffany G. WOYNAROSKI in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1013-1024 Titre : Early Predictors of Growth in Diversity of Key Consonants Used in Communication in Initially Preverbal Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany G. WOYNAROSKI, Auteur ; Linda R. WATSON, Auteur ; Elizabeth GARDNER, Auteur ; Cassandra R. NEWSOM, Auteur ; Bahar KECELI-KAYSILI, Auteur ; Paul J. YODER, Auteur Article en page(s) : p.1013-1024 Langues : Anglais (eng) Mots-clés : Vocal communication  Consonant inventory  Predictors  Autism  Intentional communication  Parent linguistic responses  Receptive vocabulary Index. décimale : PER Périodiques Résumé : Diversity of key consonants used in communication (DKCC) is a value-added predictor of expressive language growth in initially preverbal children with autism spectrum disorder (ASD). Studying the predictors of DKCC growth in young children with ASD might inform treatment of this under-studied aspect of prelinguistic development. Eighty-seven initially preverbal preschoolers with ASD and their parents were observed at five measurement periods. In this longitudinal correlational investigation, we found that child intentional communication acts and parent linguistic responses to child leads predicted DKCC growth, after controlling for two other predictors and two background variables. As predicted, receptive vocabulary mediated the association between the value-added predictors and endpoint DKCC. En ligne : http://dx.doi.org/10.1007/s10803-015-2647-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Early Predictors of Growth in Diversity of Key Consonants Used in Communication in Initially Preverbal Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tiffany G. WOYNAROSKI, Auteur ; Linda R. WATSON, Auteur ; Elizabeth GARDNER, Auteur ; Cassandra R. NEWSOM, Auteur ; Bahar KECELI-KAYSILI, Auteur ; Paul J. YODER, Auteur . - p.1013-1024. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1013-1024 Mots-clés : Vocal communication  Consonant inventory  Predictors  Autism  Intentional communication  Parent linguistic responses  Receptive vocabulary Index. décimale : PER Périodiques Résumé : Diversity of key consonants used in communication (DKCC) is a value-added predictor of expressive language growth in initially preverbal children with autism spectrum disorder (ASD). Studying the predictors of DKCC growth in young children with ASD might inform treatment of this under-studied aspect of prelinguistic development. Eighty-seven initially preverbal preschoolers with ASD and their parents were observed at five measurement periods. In this longitudinal correlational investigation, we found that child intentional communication acts and parent linguistic responses to child leads predicted DKCC growth, after controlling for two other predictors and two background variables. As predicted, receptive vocabulary mediated the association between the value-added predictors and endpoint DKCC. En ligne : http://dx.doi.org/10.1007/s10803-015-2647-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

Neurocognitive and Behavioral Outcomes of Younger Siblings of Children with Autism Spectrum Disorder at Age Five / Zachary WARREN in Journal of Autism and Developmental Disorders, 42-3 (March 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.409-418 Titre : Neurocognitive and Behavioral Outcomes of Younger Siblings of Children with Autism Spectrum Disorder at Age Five Type de document : Texte imprimé et/ou numérique Auteurs : Zachary WARREN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Elizabeth MALESA, Auteur ; Evon B. LEE, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Cassandra R. NEWSOM, Auteur ; Julie CRITTENDON, Auteur ; Wendy L. STONE, Auteur Année de publication : 2012 Article en page(s) : p.409-418 Langues : Anglais (eng) Mots-clés : Autism  Siblings  Cognition  Language  Behavior  Broad autism phenotype Index. décimale : PER Périodiques Résumé : Later-born siblings of children with Autism Spectrum Disorders (ASD) are at increased risk for ASD as well as qualitatively similar traits not meeting clinical cutoffs for the disorder. This study examined age five neurocognitive and behavioral outcomes of 39 younger siblings of children with ASD (Sibs-ASD) and 22 younger siblings of typically developing children (Sibs-TD) previously assessed in a longitudinal investigation starting in the second year of life. There were few group differences between Sibs-TD and Sibs-ASD on global measures of IQ, language, or behavior problems. Sibs-ASD did show vulnerabilities on measures of executive functioning, social cognition, and repetitive behaviors. These results highlight the importance of following sibling risk groups over an extended time period and employing measures targeting broader aspects of development. En ligne : http://dx.doi.org/10.1007/s10803-011-1263-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Neurocognitive and Behavioral Outcomes of Younger Siblings of Children with Autism Spectrum Disorder at Age Five [Texte imprimé et/ou numérique] / Zachary WARREN, Auteur ; Jennifer H. FOSS-FEIG, Auteur ; Elizabeth MALESA, Auteur ; Evon B. LEE, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Cassandra R. NEWSOM, Auteur ; Julie CRITTENDON, Auteur ; Wendy L. STONE, Auteur . - 2012 . - p.409-418. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.409-418 Mots-clés : Autism  Siblings  Cognition  Language  Behavior  Broad autism phenotype Index. décimale : PER Périodiques Résumé : Later-born siblings of children with Autism Spectrum Disorders (ASD) are at increased risk for ASD as well as qualitatively similar traits not meeting clinical cutoffs for the disorder. This study examined age five neurocognitive and behavioral outcomes of 39 younger siblings of children with ASD (Sibs-ASD) and 22 younger siblings of typically developing children (Sibs-TD) previously assessed in a longitudinal investigation starting in the second year of life. There were few group differences between Sibs-TD and Sibs-ASD on global measures of IQ, language, or behavior problems. Sibs-ASD did show vulnerabilities on measures of executive functioning, social cognition, and repetitive behaviors. These results highlight the importance of following sibling risk groups over an extended time period and employing measures targeting broader aspects of development. En ligne : http://dx.doi.org/10.1007/s10803-011-1263-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

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