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Détail de l'auteur
Auteur Mostafa I. WALY |
Documents disponibles écrits par cet auteur (2)
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Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity / Chai K. LIM in Autism Research, 9-6 (June 2016)
[article]
Titre : Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity Type de document : Texte imprimé et/ou numérique Auteurs : Chai K. LIM, Auteur ; Musthafa M. ESSA, Auteur ; Roberta DE PAULA MARTINS, Auteur ; David B. LOVEJOY, Auteur ; Ayse A. BILGIN, Auteur ; Mostafa I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mohammed A. AL-SHAFFAE, Auteur ; Gilles J. GUILLEMIN, Auteur Article en page(s) : p.621-631 Langues : Anglais (eng) Mots-clés : kynurenine pathway quinolinic acid excitotoxicity autism neuroinflammation glutamatergic activity Index. décimale : PER Périodiques Résumé : Dysfunction of the serotoninergic and glutamatergic systems is implicated in the pathogenesis of autism spectrum disorder (ASD) together with various neuroinflammatory mediators. As the kynurenine pathway (KP) of tryptophan degradation is activated in neuroinflammatory states, we hypothesized that there may be a link between inflammation in ASD and enhanced KP activation resulting in reduced serotonin synthesis from tryptophan and production of KP metabolites capable of modulating glutamatergic activity. A cross-sectional study of 15 different Omani families with newly diagnosed children with ASD (n?=?15) and their age-matched healthy siblings (n?=?12) was designed. Immunological profile and the KP metabolic signature were characterized in the study participants. Our data indicated that there were alterations to the KP in ASD. Specifically, increased production of the downstream metabolite, quinolinic acid, which is capable of enhancing glutamatergic neurotransmission was noted. Correlation studies also demonstrated that the presence of inflammation induced KP activation in ASD. Until now, previous studies have failed to establish a link between inflammation, glutamatergic activity, and the KP. Our findings also suggest that increased quinolinic acid may be linked to 16p11.2 mutations leading to abnormal glutamatergic activity associated with ASD pathogenesis and may help rationalize the efficacy of sulforaphane treatment in ASD. Autism Res 2016, 9: 621–631. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290
in Autism Research > 9-6 (June 2016) . - p.621-631[article] Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity [Texte imprimé et/ou numérique] / Chai K. LIM, Auteur ; Musthafa M. ESSA, Auteur ; Roberta DE PAULA MARTINS, Auteur ; David B. LOVEJOY, Auteur ; Ayse A. BILGIN, Auteur ; Mostafa I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; Mohammed A. AL-SHAFFAE, Auteur ; Gilles J. GUILLEMIN, Auteur . - p.621-631.
Langues : Anglais (eng)
in Autism Research > 9-6 (June 2016) . - p.621-631
Mots-clés : kynurenine pathway quinolinic acid excitotoxicity autism neuroinflammation glutamatergic activity Index. décimale : PER Périodiques Résumé : Dysfunction of the serotoninergic and glutamatergic systems is implicated in the pathogenesis of autism spectrum disorder (ASD) together with various neuroinflammatory mediators. As the kynurenine pathway (KP) of tryptophan degradation is activated in neuroinflammatory states, we hypothesized that there may be a link between inflammation in ASD and enhanced KP activation resulting in reduced serotonin synthesis from tryptophan and production of KP metabolites capable of modulating glutamatergic activity. A cross-sectional study of 15 different Omani families with newly diagnosed children with ASD (n?=?15) and their age-matched healthy siblings (n?=?12) was designed. Immunological profile and the KP metabolic signature were characterized in the study participants. Our data indicated that there were alterations to the KP in ASD. Specifically, increased production of the downstream metabolite, quinolinic acid, which is capable of enhancing glutamatergic neurotransmission was noted. Correlation studies also demonstrated that the presence of inflammation induced KP activation in ASD. Until now, previous studies have failed to establish a link between inflammation, glutamatergic activity, and the KP. Our findings also suggest that increased quinolinic acid may be linked to 16p11.2 mutations leading to abnormal glutamatergic activity associated with ASD pathogenesis and may help rationalize the efficacy of sulforaphane treatment in ASD. Autism Res 2016, 9: 621–631. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1565 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 Awareness about autism among school teachers in Oman: A cross-sectional study / Marwan M. AL-SHARBATI in Autism, 19-1 (January 2015)
[article]
Titre : Awareness about autism among school teachers in Oman: A cross-sectional study Type de document : Texte imprimé et/ou numérique Auteurs : Marwan M. AL-SHARBATI, Auteur ; Yahya M. AL-FARSI, Auteur ; Allal OUHTIT, Auteur ; Mostafa I. WALY, Auteur ; Mohamed AL-SHAFAEE, Auteur ; Omar A. AL-FARSI, Auteur ; Maha AL-KHADURI, Auteur ; Mona F. AL-SAID, Auteur ; Samir AL-ADAWI, Auteur Année de publication : 2015 Article en page(s) : p.6-13 Langues : Anglais (eng) Mots-clés : autism autism spectrum disorder awareness misconceptions Oman teachers Index. décimale : PER Périodiques Résumé : Children with special needs such as those with autism spectrum disorder have been recorded as ostracized and stigmatized in many parts of the world. Little is known about whether such negative views are present among mainstream teachers in Oman. A cross-sectional study was conducted to evaluate school teachers’ awareness about autism spectrum disorder in an urban region in Oman. A total of 164 teachers were randomly enrolled from five schools. Misconceptions about autism spectrum disorder were found to be common among mainstream teachers in the country. We posit that such lack of awareness was likely to be rooted with sociocultural patterning as well as conflicting views often “spun” by the scientific community and mass media. Enlightened views toward children with autism spectrum disorder should be presented to Omani teachers to overcome misconceptions and negative attitudes toward children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313508025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245
in Autism > 19-1 (January 2015) . - p.6-13[article] Awareness about autism among school teachers in Oman: A cross-sectional study [Texte imprimé et/ou numérique] / Marwan M. AL-SHARBATI, Auteur ; Yahya M. AL-FARSI, Auteur ; Allal OUHTIT, Auteur ; Mostafa I. WALY, Auteur ; Mohamed AL-SHAFAEE, Auteur ; Omar A. AL-FARSI, Auteur ; Maha AL-KHADURI, Auteur ; Mona F. AL-SAID, Auteur ; Samir AL-ADAWI, Auteur . - 2015 . - p.6-13.
Langues : Anglais (eng)
in Autism > 19-1 (January 2015) . - p.6-13
Mots-clés : autism autism spectrum disorder awareness misconceptions Oman teachers Index. décimale : PER Périodiques Résumé : Children with special needs such as those with autism spectrum disorder have been recorded as ostracized and stigmatized in many parts of the world. Little is known about whether such negative views are present among mainstream teachers in Oman. A cross-sectional study was conducted to evaluate school teachers’ awareness about autism spectrum disorder in an urban region in Oman. A total of 164 teachers were randomly enrolled from five schools. Misconceptions about autism spectrum disorder were found to be common among mainstream teachers in the country. We posit that such lack of awareness was likely to be rooted with sociocultural patterning as well as conflicting views often “spun” by the scientific community and mass media. Enlightened views toward children with autism spectrum disorder should be presented to Omani teachers to overcome misconceptions and negative attitudes toward children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313508025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245