Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur L. TEBARTZ VAN ELST |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study / D. ENDRES in Molecular Autism, 8 (2017)
[article]
Titre : Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study Type de document : Texte imprimé et/ou numérique Auteurs : D. ENDRES, Auteur ; L. TEBARTZ VAN ELST, Auteur ; S. A. MEYER, Auteur ; B. FEIGE, Auteur ; K. NICKEL, Auteur ; A. BUBL, Auteur ; A. RIEDEL, Auteur ; D. EBERT, Auteur ; T. LANGE, Auteur ; V. GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; A. PHILIPSEN, Auteur ; S. J. MAIER, Auteur ; E. PERLOV, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/metabolism/*psychology Female Glutathione/*metabolism Humans Male Middle Aged Prefrontal Cortex/*metabolism Proton Magnetic Resonance Spectroscopy/*methods *Anterior cingulate cortex *Asperger syndrome *Autism spectrum disorder *Dlpfc *Glutathione *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330
in Molecular Autism > 8 (2017) . - 10p.[article] Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study [Texte imprimé et/ou numérique] / D. ENDRES, Auteur ; L. TEBARTZ VAN ELST, Auteur ; S. A. MEYER, Auteur ; B. FEIGE, Auteur ; K. NICKEL, Auteur ; A. BUBL, Auteur ; A. RIEDEL, Auteur ; D. EBERT, Auteur ; T. LANGE, Auteur ; V. GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; A. PHILIPSEN, Auteur ; S. J. MAIER, Auteur ; E. PERLOV, Auteur . - 10p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 10p.
Mots-clés : Adult Autism Spectrum Disorder/metabolism/*psychology Female Glutathione/*metabolism Humans Male Middle Aged Prefrontal Cortex/*metabolism Proton Magnetic Resonance Spectroscopy/*methods *Anterior cingulate cortex *Asperger syndrome *Autism spectrum disorder *Dlpfc *Glutathione *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 Intuitive Moral Reasoning in High-Functioning Autism Spectrum Disorder: A Matter of Social Schemas? / U. M. SCHALLER in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
[article]
Titre : Intuitive Moral Reasoning in High-Functioning Autism Spectrum Disorder: A Matter of Social Schemas? Type de document : Texte imprimé et/ou numérique Auteurs : U. M. SCHALLER, Auteur ; Monica BISCALDI, Auteur ; T. FANGMEIER, Auteur ; L. TEBARTZ VAN ELST, Auteur ; R. RAUH, Auteur Article en page(s) : p.1807-1824 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Dual-process theory Empathy Moral Moral cognition Moral dilemma Moral reasoning Schema theory Social schema Theory of mind Index. décimale : PER Périodiques Résumé : Using a schema-theoretical perspective in the field of moral cognition, we assessed response behavior of adolescent (n = 15) and adult (n = 22) individuals with Autism Spectrum Disorder (ASD) in comparison with adolescent (n = 22) and adult (n = 22) neurotypically developed controls. We conceptualized the Intuitive Moral Reasoning Test-in five moral dilemmas, participants had to choose between two alternative actions and assess their decision with respect to emotional valence, arousal, moral acceptability and permissibility from both the perspective of the acting person and then of the victim. Patients with ASD displayed a different decision and response behavior, particularly when the dilemmas were based on extreme life situations in combination with a social schema involving close social relationships. En ligne : http://dx.doi.org/10.1007/s10803-018-03869-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1807-1824[article] Intuitive Moral Reasoning in High-Functioning Autism Spectrum Disorder: A Matter of Social Schemas? [Texte imprimé et/ou numérique] / U. M. SCHALLER, Auteur ; Monica BISCALDI, Auteur ; T. FANGMEIER, Auteur ; L. TEBARTZ VAN ELST, Auteur ; R. RAUH, Auteur . - p.1807-1824.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.1807-1824
Mots-clés : Autism Spectrum Disorder Dual-process theory Empathy Moral Moral cognition Moral dilemma Moral reasoning Schema theory Social schema Theory of mind Index. décimale : PER Périodiques Résumé : Using a schema-theoretical perspective in the field of moral cognition, we assessed response behavior of adolescent (n = 15) and adult (n = 22) individuals with Autism Spectrum Disorder (ASD) in comparison with adolescent (n = 22) and adult (n = 22) neurotypically developed controls. We conceptualized the Intuitive Moral Reasoning Test-in five moral dilemmas, participants had to choose between two alternative actions and assess their decision with respect to emotional valence, arousal, moral acceptability and permissibility from both the perspective of the acting person and then of the victim. Patients with ASD displayed a different decision and response behavior, particularly when the dilemmas were based on extreme life situations in combination with a social schema involving close social relationships. En ligne : http://dx.doi.org/10.1007/s10803-018-03869-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393