Dopamine receptor D2 (DRD2), dopamine transporter solute carrier family C6, member 4 (SLC6A3), and catechol-O-methyltransferase (COMT) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation / Vanessa VILLANI in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.581-592 Titre : Dopamine receptor D2 (DRD2), dopamine transporter solute carrier family C6, member 4 (SLC6A3), and catechol-O-methyltransferase (COMT) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation Type de document : Texte imprimé et/ou numérique Auteurs : Vanessa VILLANI, Auteur ; Jaclyn LUDMER, Auteur ; Andrea GONZALEZ, Auteur ; Robert LEVITAN, Auteur ; James KENNEDY, Auteur ; Mario MASELLIS, Auteur ; Vincenzo S. BASILE, Auteur ; Christine WEKERLE, Auteur ; Leslie ATKINSON, Auteur Article en page(s) : p.581-592 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior. A community sample (N = 193) of mother–infant dyads participated in a toy frustration challenge at infant age 15 months, and infant emotion regulation behavior was coded. Buccal cells were collected for genotyping. Maternal maltreatment history significantly interacted with infant SLC6A3 and COMT genotypes, such that infants with more 10-repeat and valine alleles of SLC6A3 and COMT, respectively, relative to infants with fewer or no 10-repeat and valine alleles, utilized more independent (i.e., maladaptive) regulatory behavior if mother reported a more extensive maltreatment history, as opposed to less. The findings indicate that child genetic factors moderate the intergenerational impact of maternal maltreatment history. The results are discussed in terms of potential mechanism of Gene × Environment interaction. En ligne : http://dx.doi.org/10.1017/S0954579417001122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Dopamine receptor D2 (DRD2), dopamine transporter solute carrier family C6, member 4 (SLC6A3), and catechol-O-methyltransferase (COMT) genes as moderators of the relation between maternal history of maltreatment and infant emotion regulation [Texte imprimé et/ou numérique] / Vanessa VILLANI, Auteur ; Jaclyn LUDMER, Auteur ; Andrea GONZALEZ, Auteur ; Robert LEVITAN, Auteur ; James KENNEDY, Auteur ; Mario MASELLIS, Auteur ; Vincenzo S. BASILE, Auteur ; Christine WEKERLE, Auteur ; Leslie ATKINSON, Auteur . - p.581-592. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.581-592 Index. décimale : PER Périodiques Résumé : Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior. A community sample (N = 193) of mother–infant dyads participated in a toy frustration challenge at infant age 15 months, and infant emotion regulation behavior was coded. Buccal cells were collected for genotyping. Maternal maltreatment history significantly interacted with infant SLC6A3 and COMT genotypes, such that infants with more 10-repeat and valine alleles of SLC6A3 and COMT, respectively, relative to infants with fewer or no 10-repeat and valine alleles, utilized more independent (i.e., maladaptive) regulatory behavior if mother reported a more extensive maltreatment history, as opposed to less. The findings indicate that child genetic factors moderate the intergenerational impact of maternal maltreatment history. The results are discussed in terms of potential mechanism of Gene × Environment interaction. En ligne : http://dx.doi.org/10.1017/S0954579417001122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Effectiveness of nurse-home visiting in improving child and maternal outcomes prenatally to age two years: a randomised controlled trial (British Columbia Healthy Connections Project) / Nicole L. A. CATHERINE in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.644-655 Titre : Effectiveness of nurse-home visiting in improving child and maternal outcomes prenatally to age two years: a randomised controlled trial (British Columbia Healthy Connections Project) Type de document : Texte imprimé et/ou numérique Auteurs : Nicole L. A. CATHERINE, Auteur ; Harriet MACMILLAN, Auteur ; Ange CULLEN, Auteur ; Yufei ZHENG, Auteur ; Hui XIE, Auteur ; Michael BOYLE, Auteur ; Debbie SHEEHAN, Auteur ; Rosemary LEVER, Auteur ; Susan M. JACK, Auteur ; Andrea GONZALEZ, Auteur ; Amiram GAFNI, Auteur ; Lil TONMYR, Auteur ; Ronald BARR, Auteur ; Lenora MARCELLUS, Auteur ; Colleen VARCOE, Auteur ; Charlotte WADDELL, Auteur Article en page(s) : p.644-655 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background We investigated the effectiveness of Nurse-Family Partnership (NFP), a prenatal-to-age-two-years home-visiting programme, in British Columbia (BC), Canada. Methods For this randomised controlled trial, we recruited participants from 26 public health settings who were: <25?years, nulliparous, <28?weeks gestation and experiencing socioeconomic disadvantage. We randomly allocated participants (one-to-one; computer-generated) to intervention (NFP plus existing services) or comparison (existing services) groups. Prespecified outcomes were prenatal substance exposure (reported previously); child injuries (primary), language, cognition and mental health (problem behaviour) by age two years; and subsequent pregnancies by 24?months postpartum. Research interviewers were masked. We used intention-to-treat analyses. (ClinicalTrials.gov, NCT01672060.) Results From 2013 to 2016 we enrolled 739 participants (368 NFP, 371 comparison) who had 737 children. Counts for child injury healthcare encounters [rate per 1,000 person-years or RPY] were similar for NFP (223 [RPY 316.17]) and comparison (223 [RPY 305.43]; rate difference 10.74, 95% CI -46.96, 68.44; rate ratio 1.03, 95% CI 0.78, 1.38). Maternal-reported language scores (mean, M [SD]) were statistically significantly higher for NFP (313.46 [195.96]) than comparison (282.77 [188.15]; mean difference [MD] 31.33, 95% CI 0.96, 61.71). Maternal-reported problem-behaviour scores (M [SD]) were statistically significantly lower for NFP (52.18 [9.19]) than comparison (54.42 [9.02]; MD -2.19, 95% CI ?3.62, ?0.75). Subsequent pregnancy counts were similar (NFP 115 [RPY 230.69] and comparison 117 [RPY 227.29]; rate difference 3.40, 95% CI -55.54, 62.34; hazard ratio 1.01, 95% CI 0.79, 1.29). We observed no unanticipated adverse events. Conclusions NFP did not reduce child injuries or subsequent maternal pregnancies but did improve maternal-reported child language and mental health (problem behaviour) at age two years. Follow-up of long-term outcomes is warranted given that further benefits may emerge across childhood and adolescence. En ligne : https://doi.org/10.1111/jcpp.13846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Effectiveness of nurse-home visiting in improving child and maternal outcomes prenatally to age two years: a randomised controlled trial (British Columbia Healthy Connections Project) [Texte imprimé et/ou numérique] / Nicole L. A. CATHERINE, Auteur ; Harriet MACMILLAN, Auteur ; Ange CULLEN, Auteur ; Yufei ZHENG, Auteur ; Hui XIE, Auteur ; Michael BOYLE, Auteur ; Debbie SHEEHAN, Auteur ; Rosemary LEVER, Auteur ; Susan M. JACK, Auteur ; Andrea GONZALEZ, Auteur ; Amiram GAFNI, Auteur ; Lil TONMYR, Auteur ; Ronald BARR, Auteur ; Lenora MARCELLUS, Auteur ; Colleen VARCOE, Auteur ; Charlotte WADDELL, Auteur . - p.644-655. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.644-655 Index. décimale : PER Périodiques Résumé : Background We investigated the effectiveness of Nurse-Family Partnership (NFP), a prenatal-to-age-two-years home-visiting programme, in British Columbia (BC), Canada. Methods For this randomised controlled trial, we recruited participants from 26 public health settings who were: <25?years, nulliparous, <28?weeks gestation and experiencing socioeconomic disadvantage. We randomly allocated participants (one-to-one; computer-generated) to intervention (NFP plus existing services) or comparison (existing services) groups. Prespecified outcomes were prenatal substance exposure (reported previously); child injuries (primary), language, cognition and mental health (problem behaviour) by age two years; and subsequent pregnancies by 24?months postpartum. Research interviewers were masked. We used intention-to-treat analyses. (ClinicalTrials.gov, NCT01672060.) Results From 2013 to 2016 we enrolled 739 participants (368 NFP, 371 comparison) who had 737 children. Counts for child injury healthcare encounters [rate per 1,000 person-years or RPY] were similar for NFP (223 [RPY 316.17]) and comparison (223 [RPY 305.43]; rate difference 10.74, 95% CI -46.96, 68.44; rate ratio 1.03, 95% CI 0.78, 1.38). Maternal-reported language scores (mean, M [SD]) were statistically significantly higher for NFP (313.46 [195.96]) than comparison (282.77 [188.15]; mean difference [MD] 31.33, 95% CI 0.96, 61.71). Maternal-reported problem-behaviour scores (M [SD]) were statistically significantly lower for NFP (52.18 [9.19]) than comparison (54.42 [9.02]; MD -2.19, 95% CI ?3.62, ?0.75). Subsequent pregnancy counts were similar (NFP 115 [RPY 230.69] and comparison 117 [RPY 227.29]; rate difference 3.40, 95% CI -55.54, 62.34; hazard ratio 1.01, 95% CI 0.79, 1.29). We observed no unanticipated adverse events. Conclusions NFP did not reduce child injuries or subsequent maternal pregnancies but did improve maternal-reported child language and mental health (problem behaviour) at age two years. Follow-up of long-term outcomes is warranted given that further benefits may emerge across childhood and adolescence. En ligne : https://doi.org/10.1111/jcpp.13846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance / Andrée-Anne BOUVETTE-TURCOT in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.605-613 Titre : Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance Type de document : Texte imprimé et/ou numérique Auteurs : Andrée-Anne BOUVETTE-TURCOT, Auteur ; Alison S. FLEMING, Auteur ; Eva UNTERNAEHRER, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.605-613 Langues : Anglais (eng) Mots-clés : intergenerational risk transmission  maternal adversity  maternal depression  maternal sensitivity  negative emotionality/behavioral dysregulation Index. décimale : PER Périodiques Résumé : We examined maternal depression and maternal sensitivity as mediators of the association between maternal childhood adversity and her child's temperament in 239 mother-child dyads from a longitudinal, birth cohort study. We used an integrated measure of maternal childhood adversity that included the Childhood Trauma Questionnaire and the Parental Bonding Index. Maternal depression was assessed with the Edinburgh Postnatal Depression Scale at 6 months postpartum. Maternal sensitivity was assessed with the Ainsworth maternal sensitivity scales at 6 months. A measure of "negative emotionality/behavioral dysregulation" was derived from the Early Childhood Behaviour Questionnaire administered at 36 months. Bootstrapping-based mediation analyses revealed that maternal depression mediated the effect of maternal childhood adversity on offspring negative emotionality/behavioral dysregulation (95% confidence interval [0.026, 0.144]). We also found a serial, indirect effect of maternal childhood adversity on child negative emotionality/behavioral mediated first by maternal depression and then by maternal sensitivity (95% confidence interval [0.031, 0.156]). Results suggest the intergenerational transmission of the effects of maternal childhood adversity to the offspring occurs through a two-step, serial pathway, involving maternal depression and maternal sensitivity. En ligne : http://dx.doi.org/10.1017/s0954579419000488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance [Texte imprimé et/ou numérique] / Andrée-Anne BOUVETTE-TURCOT, Auteur ; Alison S. FLEMING, Auteur ; Eva UNTERNAEHRER, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Michael J. MEANEY, Auteur . - p.605-613. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.605-613 Mots-clés : intergenerational risk transmission  maternal adversity  maternal depression  maternal sensitivity  negative emotionality/behavioral dysregulation Index. décimale : PER Périodiques Résumé : We examined maternal depression and maternal sensitivity as mediators of the association between maternal childhood adversity and her child's temperament in 239 mother-child dyads from a longitudinal, birth cohort study. We used an integrated measure of maternal childhood adversity that included the Childhood Trauma Questionnaire and the Parental Bonding Index. Maternal depression was assessed with the Edinburgh Postnatal Depression Scale at 6 months postpartum. Maternal sensitivity was assessed with the Ainsworth maternal sensitivity scales at 6 months. A measure of "negative emotionality/behavioral dysregulation" was derived from the Early Childhood Behaviour Questionnaire administered at 36 months. Bootstrapping-based mediation analyses revealed that maternal depression mediated the effect of maternal childhood adversity on offspring negative emotionality/behavioral dysregulation (95% confidence interval [0.026, 0.144]). We also found a serial, indirect effect of maternal childhood adversity on child negative emotionality/behavioral mediated first by maternal depression and then by maternal sensitivity (95% confidence interval [0.031, 0.156]). Results suggest the intergenerational transmission of the effects of maternal childhood adversity to the offspring occurs through a two-step, serial pathway, involving maternal depression and maternal sensitivity. En ligne : http://dx.doi.org/10.1017/s0954579419000488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Mother-infant cortisol attunement: Associations with mother-infant attachment disorganization / Jaclyn A. LUDMER NOFECH-MOZES in Development and Psychopathology, 32-1 (February 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-1 (February 2020) . - p.43-55 Titre : Mother-infant cortisol attunement: Associations with mother-infant attachment disorganization Type de document : Texte imprimé et/ou numérique Auteurs : Jaclyn A. LUDMER NOFECH-MOZES, Auteur ; Brittany JAMIESON, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur Article en page(s) : p.43-55 Langues : Anglais (eng) Mots-clés : attachment  attunement  cortisol  disorganized  strange situation Index. décimale : PER Périodiques Résumé : This study explores the conceptualization of mother-infant cortisol attunement both theoretically and empirically, and its association with mother-infant attachment disorganization. In a community sample (N = 256), disorganization and cortisol were assessed during the Strange Situation Procedure (SSP) at infant age 17 months. Salivary cortisol was collected at baseline, and 20 and 40 min after the SSP. We utilized three statistical approaches: correlated growth modeling (probing a simultaneous conceptualization of attunement), cross-lagged modeling (probing a lagged, reciprocal conceptualization of attunement), and a multilevel model difference score analysis (to examine the pattern of discrepancies in mother-infant cortisol values). Correlated growth modeling revealed that disorganized, relative to organized, dyads had significant magnitude of change over time, such that, among disorganized dyads, as mothers had greater declines in cortisol, infants had greater increases. The difference score analysis revealed that disorganized, relative to organized, dyads had a greater divergence between maternal and infant cortisol values, such that maternal values were lower than infant values. Disorganized attachment status was not significantly associated with attunement when conceptualized as reciprocal and lagged in the cross-lagged model. Findings suggest that mother-infant dyads in disorganized attachment relationships, who are by definition behaviorally misattuned, are also misattuned in their adrenocortical responses. En ligne : http://dx.doi.org/10.1017/s0954579418001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Mother-infant cortisol attunement: Associations with mother-infant attachment disorganization [Texte imprimé et/ou numérique] / Jaclyn A. LUDMER NOFECH-MOZES, Auteur ; Brittany JAMIESON, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur . - p.43-55. Langues : Anglais (eng) in Development and Psychopathology > 32-1 (February 2020) . - p.43-55 Mots-clés : attachment  attunement  cortisol  disorganized  strange situation Index. décimale : PER Périodiques Résumé : This study explores the conceptualization of mother-infant cortisol attunement both theoretically and empirically, and its association with mother-infant attachment disorganization. In a community sample (N = 256), disorganization and cortisol were assessed during the Strange Situation Procedure (SSP) at infant age 17 months. Salivary cortisol was collected at baseline, and 20 and 40 min after the SSP. We utilized three statistical approaches: correlated growth modeling (probing a simultaneous conceptualization of attunement), cross-lagged modeling (probing a lagged, reciprocal conceptualization of attunement), and a multilevel model difference score analysis (to examine the pattern of discrepancies in mother-infant cortisol values). Correlated growth modeling revealed that disorganized, relative to organized, dyads had significant magnitude of change over time, such that, among disorganized dyads, as mothers had greater declines in cortisol, infants had greater increases. The difference score analysis revealed that disorganized, relative to organized, dyads had a greater divergence between maternal and infant cortisol values, such that maternal values were lower than infant values. Disorganized attachment status was not significantly associated with attunement when conceptualized as reciprocal and lagged in the cross-lagged model. Findings suggest that mother-infant dyads in disorganized attachment relationships, who are by definition behaviorally misattuned, are also misattuned in their adrenocortical responses. En ligne : http://dx.doi.org/10.1017/s0954579418001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

---

1 (1 - 4 / 4)