Neurotransmitter precursors and metabolites in CSF of human neonates / George M. ANDERSON in Developmental Medicine & Child Neurology, 27-2 (April 1985)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 27-2 (April 1985) . - p.207-217 Titre : Neurotransmitter precursors and metabolites in CSF of human neonates Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Donald COHEN, Auteur ; Bennett A. SHAYWITZ, Auteur ; E. Lawrence HODER, Auteur Année de publication : 1985 Article en page(s) : p.207-217 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The amino-acid precursors tryptophan and tyrosine, and the major metabolites 5-hydroxyindoleacetic acid, indoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxyphenethyleneglycol, related to the central neurotransmitters serotonin, dopamine and norepinephrine, were measured in 62 samples of cerebrospinal fluid from human neonates. Means are reported for the samples from 17 medically uncomplicated infants and for the larger group (42 to 45) of infants with medical complications. The latter group was divided according to diagnosis and medication. All groups had significantly higher levels of all compounds in comparison with older children and adults. There were few significant subgroup differences in the group with complications. In both the normal and complicated groups a number of significant correlations were observed between the compounds themselves and with other physiological measures. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Neurotransmitter precursors and metabolites in CSF of human neonates [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Donald COHEN, Auteur ; Bennett A. SHAYWITZ, Auteur ; E. Lawrence HODER, Auteur . - 1985 . - p.207-217. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 27-2 (April 1985) . - p.207-217 Index. décimale : PER Périodiques Résumé : The amino-acid precursors tryptophan and tyrosine, and the major metabolites 5-hydroxyindoleacetic acid, indoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxyphenethyleneglycol, related to the central neurotransmitters serotonin, dopamine and norepinephrine, were measured in 62 samples of cerebrospinal fluid from human neonates. Means are reported for the samples from 17 medically uncomplicated infants and for the larger group (42 to 45) of infants with medical complications. The latter group was divided according to diagnosis and medication. All groups had significantly higher levels of all compounds in comparison with older children and adults. There were few significant subgroup differences in the group with complications. In both the normal and complicated groups a number of significant correlations were observed between the compounds themselves and with other physiological measures. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

Obstetric and Parental Psychiatric Variables as Potential Predictors of Autism Severity / Anna E. WALLACE in Journal of Autism and Developmental Disorders, 38-8 (September 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-8 (September 2008) . - p.1542-1554 Titre : Obstetric and Parental Psychiatric Variables as Potential Predictors of Autism Severity Type de document : Texte imprimé et/ou numérique Auteurs : Anna E. WALLACE, Auteur ; George M. ANDERSON, Auteur ; Robert DUBROW, Auteur Année de publication : 2008 Article en page(s) : p.1542-1554 Langues : Anglais (eng) Mots-clés : Autism Preeclampsia Psychiatric Obstetric Hypertension Depression Index. décimale : PER Périodiques Résumé : Associations between obstetric and parental psychiatric variables and subjects’ Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) domain scores were examined using linear mixed effects models. Data for the 228 families studied were provided by the Autism Genetic Resource Exchange. Hypertension (P = 0.002), preeclampsia (P = 0.021) and generalized edema (P = 0.011) were associated with higher ADI-R communication scores. Hypertension (P = 0.011), albuminuria (P = 0.039) and generalized edema (P = 0.009) were associated with higher ADI-R repetitive behaviors scores. Parent depression was associated with higher ADI-R repetitive behaviors scores (P = 0.005), and parent anxiety with lower ADOS social/communication composite scores (P = 0.025). The associations between hypertension-related obstetric conditions and autistic severity warrant further investigation and raise intriguing questions regarding potential causal and modifying factors in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0536-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Obstetric and Parental Psychiatric Variables as Potential Predictors of Autism Severity [Texte imprimé et/ou numérique] / Anna E. WALLACE, Auteur ; George M. ANDERSON, Auteur ; Robert DUBROW, Auteur . - 2008 . - p.1542-1554. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-8 (September 2008) . - p.1542-1554 Mots-clés : Autism Preeclampsia Psychiatric Obstetric Hypertension Depression Index. décimale : PER Périodiques Résumé : Associations between obstetric and parental psychiatric variables and subjects’ Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) domain scores were examined using linear mixed effects models. Data for the 228 families studied were provided by the Autism Genetic Resource Exchange. Hypertension (P = 0.002), preeclampsia (P = 0.021) and generalized edema (P = 0.011) were associated with higher ADI-R communication scores. Hypertension (P = 0.011), albuminuria (P = 0.039) and generalized edema (P = 0.009) were associated with higher ADI-R repetitive behaviors scores. Parent depression was associated with higher ADI-R repetitive behaviors scores (P = 0.005), and parent anxiety with lower ADOS social/communication composite scores (P = 0.025). The associations between hypertension-related obstetric conditions and autistic severity warrant further investigation and raise intriguing questions regarding potential causal and modifying factors in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0536-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin / Tal LEVIN-DECANINI in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.621-630 Titre : Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin Type de document : Texte imprimé et/ou numérique Auteurs : Tal LEVIN-DECANINI, Auteur ; Nell MALTMAN, Auteur ; Sunday M. FRANCIS, Auteur ; Steve GUTER, Auteur ; George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur ; Suma JACOB, Auteur Année de publication : 2013 Article en page(s) : p.621-630 Langues : Anglais (eng) Mots-clés : broader autism phenotype  serotonin  autism  SSRI Index. décimale : PER Périodiques Résumé : Relationships between parental broader autism phenotype (BAP) scores, gender, selective serotonin reuptake inhibitor (SSRI) treatment, serotonin (5HT) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (ASD). The Broader Autism Phenotype Questionnaire (BAPQ) was used to measure the BAP of 275 parents. Fathers not taking SSRIs (F-SSRI; n?=?115) scored significantly higher on BAP Total and Aloof subscales compared to mothers not receiving treatment (M-SSRI; n?=?136.) However, mothers taking SSRIs (M?+?SSRI; n?=?19) scored higher than those not taking medication on BAP Total and Rigid subscales, and they were more likely to be BAPQ Total, Aloof, and Rigid positive. Significant correlations were noted between proband autism symptoms and parental BAPQ scores such that Total, Aloof, and Rigid subscale scores of F-SSRI correlated with proband restricted repetitive behavior (RRB) measures on the ADOS, CRI, and RBS-R. However, only the Aloof subscale score of M?+?SSRI correlated with proband RRB on the ADOS. The correlation between the BAPQ scores of mothers taking SSRIs and child scores, as well as the increase in BAPQ scores of this group of mothers, requires careful interpretation and further study because correlations would not withstand multiple corrections. As expected by previous research, significant parent–child correlations were observed for 5HT levels. However, 5HT levels were not correlated with behavioral measures. Study results suggest that the expression of the BAP varies not only across parental gender, but also across individuals using psychotropic medication and those who do not. En ligne : http://dx.doi.org/10.1002/aur.1322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin [Texte imprimé et/ou numérique] / Tal LEVIN-DECANINI, Auteur ; Nell MALTMAN, Auteur ; Sunday M. FRANCIS, Auteur ; Steve GUTER, Auteur ; George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur ; Suma JACOB, Auteur . - 2013 . - p.621-630. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.621-630 Mots-clés : broader autism phenotype  serotonin  autism  SSRI Index. décimale : PER Périodiques Résumé : Relationships between parental broader autism phenotype (BAP) scores, gender, selective serotonin reuptake inhibitor (SSRI) treatment, serotonin (5HT) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (ASD). The Broader Autism Phenotype Questionnaire (BAPQ) was used to measure the BAP of 275 parents. Fathers not taking SSRIs (F-SSRI; n?=?115) scored significantly higher on BAP Total and Aloof subscales compared to mothers not receiving treatment (M-SSRI; n?=?136.) However, mothers taking SSRIs (M?+?SSRI; n?=?19) scored higher than those not taking medication on BAP Total and Rigid subscales, and they were more likely to be BAPQ Total, Aloof, and Rigid positive. Significant correlations were noted between proband autism symptoms and parental BAPQ scores such that Total, Aloof, and Rigid subscale scores of F-SSRI correlated with proband restricted repetitive behavior (RRB) measures on the ADOS, CRI, and RBS-R. However, only the Aloof subscale score of M?+?SSRI correlated with proband RRB on the ADOS. The correlation between the BAPQ scores of mothers taking SSRIs and child scores, as well as the increase in BAPQ scores of this group of mothers, requires careful interpretation and further study because correlations would not withstand multiple corrections. As expected by previous research, significant parent–child correlations were observed for 5HT levels. However, 5HT levels were not correlated with behavioral measures. Study results suggest that the expression of the BAP varies not only across parental gender, but also across individuals using psychotropic medication and those who do not. En ligne : http://dx.doi.org/10.1002/aur.1322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Presence of autism, hyperserotonemia, and severe expressive language impairment in Williams-Beuren syndrome / Sylvie TORDJMAN in Molecular Autism, (August 2013)  

Public ISBD [article]  inMolecular Autism > (August 2013) Titre : Presence of autism, hyperserotonemia, and severe expressive language impairment in Williams-Beuren syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Sylvie TORDJMAN, Auteur ; George M. ANDERSON, Auteur ; David COHEN, Auteur ; Solenn KERMARREC, Auteur ; Michèle CARLIER, Auteur ; Yvan TOUITOU, Auteur ; Pascale SAUGIER-VEBER, Auteur ; Celine LAGNEAUX, Auteur ; Claire CHEVREUIL, Auteur ; Alain VERLOES, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND:Deletion of the Williams-Beuren syndrome (WBS) critical region (WBSCR), at 7q11.23, causes a developmental disorder commonly characterized by hypersociability and excessive talkativeness and often considered the opposite behavioral phenotype to autism. Duplication of the WBSCR leads to severe delay in expressive language. Gene-dosage effects on language development at 7q11.23 have been hypothesized.METHODS:Molecular characterization of the WBSCR was performed by fluorescence in situ hybridization and high-resolution single-nucleotide polymorphism array in two individuals with severe autism enrolled in a genetic study of autism who showed typical WBS facial dysmorphism on systematic clinical genetic examination. The serotonin transporter promoter polymorphism (5-HTTLPR, locus SLC6A4) was genotyped. Platelet serotonin levels and urinary 6-sulfatoxymelatonin excretion were measured. Behavioral and cognitive phenotypes were examined.RESULTS:The two patients had common WBSCR deletions between proximal and medial low copy repeat clusters, met diagnostic criteria for autism and displayed severe impairment in communication, including a total absence of expressive speech. Both patients carried the 5-HTTLPR ss genotype and exhibited platelet hyperserotonemia and low melatonin production.CONCLUSIONS:Our observations indicate that behaviors and neurochemical phenotypes typically associated with autism can occur in patients with common WBSCR deletions. The results raise intriguing questions about phenotypic heterogeneity in WBS and regarding genetic and/or environmental factors interacting with specific genes at 7q11.23 sensitive to dosage alterations that can influence the development of social communication skills. Thus, the influence of WBSCR genes on social communication expression might be dramatically modified by other genes, such as 5-HTTLPR, known to influence the severity of social communication impairments in autism, or by environmental factors, such as hyperserotonemia, given that hyperserotonemia is found in WBS associated with autism but not in WBS without autism. In this regard, WBS provides a potentially fruitful model with which to develop integrated genetic, cognitive, behavioral and neurochemical approaches to study genotype-phenotype correlations, possible gene-environment interactions and genetic background effects. The results underscore the importance of considering careful clinical and molecular genetic examination of individuals diagnosed with autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-29 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Presence of autism, hyperserotonemia, and severe expressive language impairment in Williams-Beuren syndrome [Texte imprimé et/ou numérique] / Sylvie TORDJMAN, Auteur ; George M. ANDERSON, Auteur ; David COHEN, Auteur ; Solenn KERMARREC, Auteur ; Michèle CARLIER, Auteur ; Yvan TOUITOU, Auteur ; Pascale SAUGIER-VEBER, Auteur ; Celine LAGNEAUX, Auteur ; Claire CHEVREUIL, Auteur ; Alain VERLOES, Auteur. Langues : Anglais (eng) in Molecular Autism > (August 2013) Index. décimale : PER Périodiques Résumé : BACKGROUND:Deletion of the Williams-Beuren syndrome (WBS) critical region (WBSCR), at 7q11.23, causes a developmental disorder commonly characterized by hypersociability and excessive talkativeness and often considered the opposite behavioral phenotype to autism. Duplication of the WBSCR leads to severe delay in expressive language. Gene-dosage effects on language development at 7q11.23 have been hypothesized.METHODS:Molecular characterization of the WBSCR was performed by fluorescence in situ hybridization and high-resolution single-nucleotide polymorphism array in two individuals with severe autism enrolled in a genetic study of autism who showed typical WBS facial dysmorphism on systematic clinical genetic examination. The serotonin transporter promoter polymorphism (5-HTTLPR, locus SLC6A4) was genotyped. Platelet serotonin levels and urinary 6-sulfatoxymelatonin excretion were measured. Behavioral and cognitive phenotypes were examined.RESULTS:The two patients had common WBSCR deletions between proximal and medial low copy repeat clusters, met diagnostic criteria for autism and displayed severe impairment in communication, including a total absence of expressive speech. Both patients carried the 5-HTTLPR ss genotype and exhibited platelet hyperserotonemia and low melatonin production.CONCLUSIONS:Our observations indicate that behaviors and neurochemical phenotypes typically associated with autism can occur in patients with common WBSCR deletions. The results raise intriguing questions about phenotypic heterogeneity in WBS and regarding genetic and/or environmental factors interacting with specific genes at 7q11.23 sensitive to dosage alterations that can influence the development of social communication skills. Thus, the influence of WBSCR genes on social communication expression might be dramatically modified by other genes, such as 5-HTTLPR, known to influence the severity of social communication impairments in autism, or by environmental factors, such as hyperserotonemia, given that hyperserotonemia is found in WBS associated with autism but not in WBS without autism. In this regard, WBS provides a potentially fruitful model with which to develop integrated genetic, cognitive, behavioral and neurochemical approaches to study genotype-phenotype correlations, possible gene-environment interactions and genetic background effects. The results underscore the importance of considering careful clinical and molecular genetic examination of individuals diagnosed with autism. En ligne : http://dx.doi.org/10.1186/2040-2392-4-29 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Serotonin in autism / George M. ANDERSON

Public ISBD contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Titre : Serotonin in autism Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur Année de publication : 2006 Importance : p.303-318 Langues : Anglais (eng) Mots-clés : Sérotonine Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793 contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Serotonin in autism [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur . - 2006 . - p.303-318. Langues : Anglais (eng) Mots-clés : Sérotonine Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793

Exemplaires

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The potential role for emergence in autism / George M. ANDERSON in Autism Research, 1-1 (February 2008)  

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The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability / Annelies A. DE BILDT in Autism Research, 5-1 (February 2012)  

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Twin Studies in Autism: What Might They Say About Genetic and Environmental Influences / George M. ANDERSON in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

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Two Proposed Early Biomarker Tests of ASD: More Harm Than Good / George M. ANDERSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

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Visual preference for social stimuli in individuals with autism or neurodevelopmental disorders: an eye-tracking study / Hayley CRAWFORD in Molecular Autism, 7 (2016)  

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Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder / E. AARON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

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