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Auteur Declan MURPHY |
Documents disponibles écrits par cet auteur (12)
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Age-related differences in white matter diffusion measures in autism spectrum condition / Abigail THOMPSON in Molecular Autism, 11 (2020)
[article]
Titre : Age-related differences in white matter diffusion measures in autism spectrum condition Type de document : Texte imprimé et/ou numérique Auteurs : Abigail THOMPSON, Auteur ; Asal SHAHIDIANI, Auteur ; Anne FRITZ, Auteur ; Jonathan O'MUIRCHEARTAIGH, Auteur ; Lindsay WALKER, Auteur ; Vera D'ALMEIDA, Auteur ; Clodagh M. MURPHY, Auteur ; Eileen DALY, Auteur ; Declan MURPHY, Auteur ; Steve WILLIAMS, Auteur ; Sean DEONI, Auteur ; Christine ECKER, Auteur Article en page(s) : 36 p. Langues : Anglais (eng) Mots-clés : Autism Connectivity Diffusion weighted imaging Tract-based spatial statistics Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are heterogeneous and vary across the age range of study participants and varying methodological approaches. To characterize the neurodevelopmental trajectory of white matter maturation, it is necessary to examine a broad age range of individuals on the autism spectrum and typically developing controls, and investigate age × group interactions. METHODS: Here, we employed a spatially unbiased tract-based spatial statistics (TBSS) approach to examine age-related differences in white matter connectivity in a sample of 41 individuals with ASC, and 41 matched controls between 7-17 years of age. RESULTS: We found significant age-related differences between the ASC and control group in widespread brain regions. This included age-related differences in the uncinate fasciculus, corticospinal tract, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, superior longitudinal fasciculus and forceps major. Measures of fractional anisotropy (FA) were significantly positively associated with age in both groups. However, this relationship was significantly stronger in the ASC group relative to controls. Measures of radial diffusivity (RD) were significantly negatively associated with age in both groups, but this relationship was significantly stronger in the ASC group relative to controls. LIMITATIONS: The generalisability of our findings is limited by the restriction of the sample to right-handed males with an IQ > 70. Furthermore, a longitudinal design would be required to fully investigate maturational processes across this age group. CONCLUSIONS: Taken together, our findings suggest that autistic males have an altered trajectory of white matter maturation relative to controls. Future longitudinal analyses are required to further characterize the extent and time course of these differences. En ligne : http://dx.doi.org/10.1186/s13229-020-00325-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 36 p.[article] Age-related differences in white matter diffusion measures in autism spectrum condition [Texte imprimé et/ou numérique] / Abigail THOMPSON, Auteur ; Asal SHAHIDIANI, Auteur ; Anne FRITZ, Auteur ; Jonathan O'MUIRCHEARTAIGH, Auteur ; Lindsay WALKER, Auteur ; Vera D'ALMEIDA, Auteur ; Clodagh M. MURPHY, Auteur ; Eileen DALY, Auteur ; Declan MURPHY, Auteur ; Steve WILLIAMS, Auteur ; Sean DEONI, Auteur ; Christine ECKER, Auteur . - 36 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 36 p.
Mots-clés : Autism Connectivity Diffusion weighted imaging Tract-based spatial statistics Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are heterogeneous and vary across the age range of study participants and varying methodological approaches. To characterize the neurodevelopmental trajectory of white matter maturation, it is necessary to examine a broad age range of individuals on the autism spectrum and typically developing controls, and investigate age × group interactions. METHODS: Here, we employed a spatially unbiased tract-based spatial statistics (TBSS) approach to examine age-related differences in white matter connectivity in a sample of 41 individuals with ASC, and 41 matched controls between 7-17 years of age. RESULTS: We found significant age-related differences between the ASC and control group in widespread brain regions. This included age-related differences in the uncinate fasciculus, corticospinal tract, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, superior longitudinal fasciculus and forceps major. Measures of fractional anisotropy (FA) were significantly positively associated with age in both groups. However, this relationship was significantly stronger in the ASC group relative to controls. Measures of radial diffusivity (RD) were significantly negatively associated with age in both groups, but this relationship was significantly stronger in the ASC group relative to controls. LIMITATIONS: The generalisability of our findings is limited by the restriction of the sample to right-handed males with an IQ > 70. Furthermore, a longitudinal design would be required to fully investigate maturational processes across this age group. CONCLUSIONS: Taken together, our findings suggest that autistic males have an altered trajectory of white matter maturation relative to controls. Future longitudinal analyses are required to further characterize the extent and time course of these differences. En ligne : http://dx.doi.org/10.1186/s13229-020-00325-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Cognitive behaviour therapy for adults with autism spectrum disorders and psychiatric co-morbidity: A review / Debbie SPAIN in Research in Autism Spectrum Disorders, 9 (January 2015)
[article]
Titre : Cognitive behaviour therapy for adults with autism spectrum disorders and psychiatric co-morbidity: A review Type de document : Texte imprimé et/ou numérique Auteurs : Debbie SPAIN, Auteur ; Jacqueline SIN, Auteur ; Trudie CHALDER, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur Année de publication : 2015 Article en page(s) : p.151-162 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Psychiatric co-morbidity Mental health Cognitive behaviour therapy CBT Mindfulness Index. décimale : PER Périodiques Résumé : Abstract Co-morbid mental health conditions are highly prevalent in autism spectrum disorders (ASD). Cognitive behaviour therapy (CBT) is frequently used to treat these symptoms. Hence, a systematic review was undertaken to synthesise published data about the effectiveness of CBT interventions for adults with ASD and psychiatric co-morbidity. Only six studies met pre-determined review inclusion criteria: two RCTs; one quasi-experimental study; one case series; and two case studies. Meta-analysis was not possible due to study heterogeneity. A narrative analysis of the data suggested that CBT interventions – including behavioural, cognitive, and mindfulness-based techniques – were moderately effective treatments for co-morbid anxiety and depression symptoms, albeit that sample sizes were small, participant characteristics varied widely, and psychometric properties of self-report outcome measurements utilised in the ASD population remain subject to some debate. Several studies described adaptations to standard CBT including an increase in the number of sessions, or accommodation of core ASD characteristics and associated neuropsychological impairments within the therapy process. We suggest further empirical research is needed to (1) investigate the acceptability and effectiveness of a range of CBT interventions for adults who have ASD and co-morbidity, and (2) to identify which adaptations are requisite for optimising CBT techniques and outcomes in this population. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.151-162[article] Cognitive behaviour therapy for adults with autism spectrum disorders and psychiatric co-morbidity: A review [Texte imprimé et/ou numérique] / Debbie SPAIN, Auteur ; Jacqueline SIN, Auteur ; Trudie CHALDER, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur . - 2015 . - p.151-162.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.151-162
Mots-clés : Autism spectrum disorder Psychiatric co-morbidity Mental health Cognitive behaviour therapy CBT Mindfulness Index. décimale : PER Périodiques Résumé : Abstract Co-morbid mental health conditions are highly prevalent in autism spectrum disorders (ASD). Cognitive behaviour therapy (CBT) is frequently used to treat these symptoms. Hence, a systematic review was undertaken to synthesise published data about the effectiveness of CBT interventions for adults with ASD and psychiatric co-morbidity. Only six studies met pre-determined review inclusion criteria: two RCTs; one quasi-experimental study; one case series; and two case studies. Meta-analysis was not possible due to study heterogeneity. A narrative analysis of the data suggested that CBT interventions – including behavioural, cognitive, and mindfulness-based techniques – were moderately effective treatments for co-morbid anxiety and depression symptoms, albeit that sample sizes were small, participant characteristics varied widely, and psychometric properties of self-report outcome measurements utilised in the ASD population remain subject to some debate. Several studies described adaptations to standard CBT including an increase in the number of sessions, or accommodation of core ASD characteristics and associated neuropsychological impairments within the therapy process. We suggest further empirical research is needed to (1) investigate the acceptability and effectiveness of a range of CBT interventions for adults who have ASD and co-morbidity, and (2) to identify which adaptations are requisite for optimising CBT techniques and outcomes in this population. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample / Fiona S. MCEWEN in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)
[article]
Titre : Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample Type de document : Texte imprimé et/ou numérique Auteurs : Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.161-170 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder adolescence assessment diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ? 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (? = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170[article] Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample [Texte imprimé et/ou numérique] / Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur . - p.161-170.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170
Mots-clés : Autism spectrum disorder adolescence assessment diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ? 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (? = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy / Aine RODDY ; Martin KNAPP ; Celso ARANGO ; Maria Andreina MENDEZ ; James CUSACK ; Declan MURPHY ; Roberto CANITANO ; Bethany OAKLEY ; Vinciane QUOIDBACH in Journal of Autism and Developmental Disorders, 54-7 (July 2024)
[article]
Titre : Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy Type de document : Texte imprimé et/ou numérique Auteurs : Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; Maria Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur Article en page(s) : p.2733-2741 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children?s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533
in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741[article] Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy [Texte imprimé et/ou numérique] / Aine RODDY, Auteur ; Martin KNAPP, Auteur ; Celso ARANGO, Auteur ; Maria Andreina MENDEZ, Auteur ; James CUSACK, Auteur ; Declan MURPHY, Auteur ; Roberto CANITANO, Auteur ; Bethany OAKLEY, Auteur ; Vinciane QUOIDBACH, Auteur . - p.2733-2741.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2733-2741
Index. décimale : PER Périodiques Résumé : We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children?s families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. En ligne : https://doi.org/10.1007/s10803-023-05941-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project / Bethany OAKLEY in Autism, 25-2 (February 2021)
[article]
Titre : How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Eva LOTH, Auteur Article en page(s) : p.389-404 Langues : Anglais (eng) Mots-clés : anxiety autism depression quality of life well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Autism > 25-2 (February 2021) . - p.389-404[article] How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project [Texte imprimé et/ou numérique] / Bethany OAKLEY, Auteur ; Julian TILLMANN, Auteur ; Jumana AHMAD, Auteur ; Daisy CRAWLEY, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Rosemary HOLT, Auteur ; Tony CHARMAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Jan K. BUITELAAR, Auteur ; Emily SIMONOFF, Auteur ; Declan MURPHY, Auteur ; Eva LOTH, Auteur . - p.389-404.
Langues : Anglais (eng)
in Autism > 25-2 (February 2021) . - p.389-404
Mots-clés : anxiety autism depression quality of life well-being Index. décimale : PER Périodiques Résumé : Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people. En ligne : http://dx.doi.org/10.1177/1362361320959959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Large multicenter randomized trials in autism: key insights gained from the balovaptan clinical development program / Suma JACOB in Molecular Autism, 13 (2022)
PermalinkMapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)
PermalinkA new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders / Kim MURRAY in Autism Research, 10-6 (June 2017)
PermalinkObsessive-Compulsive Disorder in Adults with High-Functioning Autism Spectrum Disorder: What Does Self-Report with the OCI-R Tell Us? / Tim CADMAN in Autism Research, 8-5 (October 2015)
PermalinkPatterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project / Tristan LOODEN in Molecular Autism, 13 (2022)
PermalinkRelationship Between Surface-Based Brain Morphometric Measures and Intelligence in Autism Spectrum Disorders: Influence of History of Language Delay / Joana Bisol BALARDIN in Autism Research, 8-5 (October 2015)
PermalinkScreening for co-occurring conditions in adults with autism spectrum disorder using the strengths and difficulties questionnaire: A pilot study / James FINDON in Autism Research, 9-12 (December 2016)
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