5 recherche sur le mot-clé 'subcortical volume'

Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study / In-Seong HWANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2238-2249 Titre : Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study Type de document : Texte imprimé et/ou numérique Auteurs : In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur Article en page(s) : p.2238-2249 Langues : Anglais (eng) Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study [Texte imprimé et/ou numérique] / In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur . - p.2238-2249. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2238-2249 Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (Î2 = -0.384, p = 0.010; Î2 = -0.336, p = 0.030; Î2 = -0.317, p = 0.040; Î2 = 0.322, p = 0.010; Î2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (Î2 = 0.434, p = 0.014; Î2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Dissecting the heterogeneous subcortical brain volume of autism spectrum disorder using community detection / T. LI in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.42-55 Titre : Dissecting the heterogeneous subcortical brain volume of autism spectrum disorder using community detection Type de document : Texte imprimé et/ou numérique Auteurs : T. LI, Auteur ; M. HOOGMAN, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; A. A. VASQUEZ, Auteur ; B. FRANKE, Auteur ; D. VAN ROOIJ, Auteur Article en page(s) : p.42-55 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Case-Control Studies  Humans  Magnetic Resonance Imaging  Male  Neuroimaging  Asd  community detection  neuroanatomical heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : Structural brain alterations in autism spectrum disorder (ASD) are heterogeneous, with limited effect sizes overall. In this study, we aimed to identify subgroups in ASD, based on neuroanatomical profiles; we hypothesized that the effect sizes for case/control differences would be increased in the newly defined subgroups. Analyzing a large data set from the ENIGMA-ASD working group (n =?2661), we applied exploratory factor analysis (EFA) to seven subcortical volumes of individuals with and without ASD to uncover the underlying organization of subcortical structures. Based on earlier findings and data availability, we focused on three age groups: boys (<=14?years), male adolescents (15-22?years), and adult men (> = 22?years). The resulting factor scores were used in a community detection (CD) analysis to cluster participants into subgroups. Three factors were found in each subsample; the factor structure in adult men differed from that in boys and male adolescents. From these factors, CD uncovered four distinct communities in boys and three communities in adolescents and adult men, irrespective of ASD diagnosis. The effect sizes for case/control comparisons were more pronounced than in the combined sample, for some communities. A significant group difference in ADOS scores between communities was observed in boys and male adolescents with ASD. We succeeded in stratifying participants into more homogeneous subgroups based on subcortical brain volumes. This stratification enhanced our ability to observe case/control differences in subcortical brain volumes in ASD, and may help to explain the heterogeneity of previous findings in ASD. LAY SUMMARY: Structural brain alterations in ASD are heterogeneous, with overall limited effect sizes. Here we aimed to identify subgroups in ASD based on neuroimaging measures. We tested whether the effect sizes for case/control differences would be increased in the newly defined subgroups. Based on neuroanatomical profiles, we succeeded in stratifying our participants into more homogeneous subgroups. The effect sizes of case/control differences were more pronounced in some subgroups than those in the whole sample. En ligne : http://dx.doi.org/10.1002/aur.2627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Dissecting the heterogeneous subcortical brain volume of autism spectrum disorder using community detection [Texte imprimé et/ou numérique] / T. LI, Auteur ; M. HOOGMAN, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; A. A. VASQUEZ, Auteur ; B. FRANKE, Auteur ; D. VAN ROOIJ, Auteur . - p.42-55. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.42-55 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Case-Control Studies  Humans  Magnetic Resonance Imaging  Male  Neuroimaging  Asd  community detection  neuroanatomical heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : Structural brain alterations in autism spectrum disorder (ASD) are heterogeneous, with limited effect sizes overall. In this study, we aimed to identify subgroups in ASD, based on neuroanatomical profiles; we hypothesized that the effect sizes for case/control differences would be increased in the newly defined subgroups. Analyzing a large data set from the ENIGMA-ASD working group (n =?2661), we applied exploratory factor analysis (EFA) to seven subcortical volumes of individuals with and without ASD to uncover the underlying organization of subcortical structures. Based on earlier findings and data availability, we focused on three age groups: boys (<=14?years), male adolescents (15-22?years), and adult men (> = 22?years). The resulting factor scores were used in a community detection (CD) analysis to cluster participants into subgroups. Three factors were found in each subsample; the factor structure in adult men differed from that in boys and male adolescents. From these factors, CD uncovered four distinct communities in boys and three communities in adolescents and adult men, irrespective of ASD diagnosis. The effect sizes for case/control comparisons were more pronounced than in the combined sample, for some communities. A significant group difference in ADOS scores between communities was observed in boys and male adolescents with ASD. We succeeded in stratifying participants into more homogeneous subgroups based on subcortical brain volumes. This stratification enhanced our ability to observe case/control differences in subcortical brain volumes in ASD, and may help to explain the heterogeneity of previous findings in ASD. LAY SUMMARY: Structural brain alterations in ASD are heterogeneous, with overall limited effect sizes. Here we aimed to identify subgroups in ASD based on neuroimaging measures. We tested whether the effect sizes for case/control differences would be increased in the newly defined subgroups. Based on neuroanatomical profiles, we succeeded in stratifying our participants into more homogeneous subgroups. The effect sizes of case/control differences were more pronounced in some subgroups than those in the whole sample. En ligne : http://dx.doi.org/10.1002/aur.2627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes / T. LI in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1140-1149 Titre : Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes Type de document : Texte imprimé et/ou numérique Auteurs : T. LI, Auteur ; D. VAN ROOIJ, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; M. HOOGMAN, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; B. FRANKE, Auteur Article en page(s) : p.1140-1149 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnostic imaging/epidemiology  Brain/diagnostic imaging  Case-Control Studies  Female  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Adhd  community detection  effect sizes  neuroanatomic heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. METHODS: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. RESULTS: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. CONCLUSIONS: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups. En ligne : http://dx.doi.org/10.1111/jcpp.13384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes [Texte imprimé et/ou numérique] / T. LI, Auteur ; D. VAN ROOIJ, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; M. HOOGMAN, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; B. FRANKE, Auteur . - p.1140-1149. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1140-1149 Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnostic imaging/epidemiology  Brain/diagnostic imaging  Case-Control Studies  Female  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Adhd  community detection  effect sizes  neuroanatomic heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. METHODS: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. RESULTS: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. CONCLUSIONS: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups. En ligne : http://dx.doi.org/10.1111/jcpp.13384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms / S. C. HUIJBREGTS in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.32 Titre : Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms Type de document : Texte imprimé et/ou numérique Auteurs : S. C. HUIJBREGTS, Auteur ; M. LOITFELDER, Auteur ; S. A. ROMBOUTS, Auteur ; H. SWAAB, Auteur ; B. M. VERBIST, Auteur ; E. B. ARKINK, Auteur ; M. A. VAN BUCHEM, Auteur ; I. M. VEER, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Executive and social functioning  Gray matter  Magnetic resonance imaging  Neurofibromatosis type 1  Subcortical volume  Voxel-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofibromatosis type 1 (NF1) is a single-gene neurodevelopmental disorder, in which social and cognitive problems are highly prevalent. Several commonly observed central nervous system (CNS) abnormalities in NF1 might underlie these social and cognitive problems. Cerebral volumetric abnormalities are among the most consistently observed CNS abnormalities in NF1. This study investigated whether differences were present between NF1 patients and healthy controls (HC) in volumetric measures of cortical and subcortical brain regions and whether differential associations existed for NF1 patients and HC between the volumetric measures and parent ratings of social skills, attention problems, social problems, autistic mannerisms, and executive dysfunction. METHODS: Fifteen NF1 patients (mean age 12.9 years, SD 2.6) and 18 healthy controls (HC, mean age 13.8 years, SD 3.6) underwent 3 T MRI scanning. Segmentation of cortical gray and white matter, as well as volumetry of subcortical nuclei, was carried out. Voxel-based morphometry was performed to assess cortical gray matter density. Correlations were calculated, for NF1-patients and HC separately, between MRI parameters and scores on selected dimensions of the following behavior rating scales: the Social Skills Rating System, the Child Behavior Checklist, the Social Responsiveness Scale, the Behavior Rating Inventory of Executive Functioning, and the Dysexecutive Questionnaire. RESULTS: After correction for age, sex, and intracranial volume, larger volumes of all subcortical regions were found in NF1 patients compared to controls. Patients further showed decreased gray matter density in midline regions of the frontal and parietal lobes and larger total white matter volume. Significantly more social and attention problems, more autistic mannerisms, and poorer executive functioning were reported for NF1 patients compared to HC. In NF1 patients, larger left putamen volume and larger total white matter volume were associated with more social problems and poorer executive functioning, larger right amygdala volume with poorer executive functioning and autistic mannerisms, and smaller precentral gyrus gray matter density was associated with more social problems. In controls, only significant negative correlations were observed: larger volumes (and greater gray matter density) were associated with better outcomes. CONCLUSIONS: Widespread volumetric differences between patients and controls were found in cortical and subcortical brain regions. In NF1 patients but not HC, larger volumes were associated with poorer behavior ratings. En ligne : http://dx.doi.org/10.1186/s11689-015-9128-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 [article] Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms [Texte imprimé et/ou numérique] / S. C. HUIJBREGTS, Auteur ; M. LOITFELDER, Auteur ; S. A. ROMBOUTS, Auteur ; H. SWAAB, Auteur ; B. M. VERBIST, Auteur ; E. B. ARKINK, Auteur ; M. A. VAN BUCHEM, Auteur ; I. M. VEER, Auteur . - p.32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.32 Mots-clés : Executive and social functioning  Gray matter  Magnetic resonance imaging  Neurofibromatosis type 1  Subcortical volume  Voxel-based morphometry Index. décimale : PER Périodiques Résumé : BACKGROUND: Neurofibromatosis type 1 (NF1) is a single-gene neurodevelopmental disorder, in which social and cognitive problems are highly prevalent. Several commonly observed central nervous system (CNS) abnormalities in NF1 might underlie these social and cognitive problems. Cerebral volumetric abnormalities are among the most consistently observed CNS abnormalities in NF1. This study investigated whether differences were present between NF1 patients and healthy controls (HC) in volumetric measures of cortical and subcortical brain regions and whether differential associations existed for NF1 patients and HC between the volumetric measures and parent ratings of social skills, attention problems, social problems, autistic mannerisms, and executive dysfunction. METHODS: Fifteen NF1 patients (mean age 12.9 years, SD 2.6) and 18 healthy controls (HC, mean age 13.8 years, SD 3.6) underwent 3 T MRI scanning. Segmentation of cortical gray and white matter, as well as volumetry of subcortical nuclei, was carried out. Voxel-based morphometry was performed to assess cortical gray matter density. Correlations were calculated, for NF1-patients and HC separately, between MRI parameters and scores on selected dimensions of the following behavior rating scales: the Social Skills Rating System, the Child Behavior Checklist, the Social Responsiveness Scale, the Behavior Rating Inventory of Executive Functioning, and the Dysexecutive Questionnaire. RESULTS: After correction for age, sex, and intracranial volume, larger volumes of all subcortical regions were found in NF1 patients compared to controls. Patients further showed decreased gray matter density in midline regions of the frontal and parietal lobes and larger total white matter volume. Significantly more social and attention problems, more autistic mannerisms, and poorer executive functioning were reported for NF1 patients compared to HC. In NF1 patients, larger left putamen volume and larger total white matter volume were associated with more social problems and poorer executive functioning, larger right amygdala volume with poorer executive functioning and autistic mannerisms, and smaller precentral gyrus gray matter density was associated with more social problems. In controls, only significant negative correlations were observed: larger volumes (and greater gray matter density) were associated with better outcomes. CONCLUSIONS: Widespread volumetric differences between patients and controls were found in cortical and subcortical brain regions. In NF1 patients but not HC, larger volumes were associated with poorer behavior ratings. En ligne : http://dx.doi.org/10.1186/s11689-015-9128-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348

Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.917-929 Titre : Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Article en page(s) : p.917-929 Langues : Anglais (eng) Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - p.917-929. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.917-929 Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403