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Détail de l'auteur
Auteur D. T. BUTCHER |
Documents disponibles écrits par cet auteur (1)
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DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders / M. T. SIU in Journal of Autism and Developmental Disorders, 51-10 (October 2021)
[article]
Titre : DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur Article en page(s) : p.3610-3623 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics Autism Spectrum Disorder/genetics DNA Methylation Female Humans Male Obsessive-Compulsive Disorder Oxytocin/metabolism Receptors, Oxytocin/genetics Adhd Asd Ocd Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623[article] DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders [Texte imprimé et/ou numérique] / M. T. SIU, Auteur ; S. J. GOODMAN, Auteur ; I. YELLAN, Auteur ; D. T. BUTCHER, Auteur ; M. JANGJOO, Auteur ; D. GRAFODATSKAYA, Auteur ; R. RAJENDRAM, Auteur ; Y. LOU, Auteur ; R. ZHANG, Auteur ; C. ZHAO, Auteur ; R. NICOLSON, Auteur ; S. GEORGIADES, Auteur ; P. SZATMARI, Auteur ; Stephen SCHERER, Auteur ; W. ROBERTS, Auteur ; Evdokia ANAGNOSTOU, Auteur ; R. WEKSBERG, Auteur . - p.3610-3623.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3610-3623
Mots-clés : Attention Deficit Disorder with Hyperactivity/genetics Autism Spectrum Disorder/genetics DNA Methylation Female Humans Male Obsessive-Compulsive Disorder Oxytocin/metabolism Receptors, Oxytocin/genetics Adhd Asd Ocd Oxtr Index. décimale : PER Périodiques Résumé : Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. En ligne : http://dx.doi.org/10.1007/s10803-020-04792-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453