Social motivation in infancy is associated with familial recurrence of ASD / Natasha MARRUS in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.101-111 Titre : Social motivation in infancy is associated with familial recurrence of ASD Type de document : Texte imprimé et/ou numérique Auteurs : Natasha MARRUS, Auteur ; Kelly N. BOTTERON, Auteur ; Zoe HAWKS, Auteur ; John R. PRUETT, Auteur ; Jed T. ELISON, Auteur ; Joshua J. JACKSON, Auteur ; Lori MARKSON, Auteur ; Adam T. EGGEBRECHT, Auteur ; Catherine A. BURROWS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather Cody HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Joseph PIVEN, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.101-111 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  infancy  measurement  social motivation Index. décimale : PER Périodiques Résumé : Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation?s course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation?s importance to risk assessment and clarification of the ontogeny of ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Social motivation in infancy is associated with familial recurrence of ASD [Texte imprimé et/ou numérique] / Natasha MARRUS, Auteur ; Kelly N. BOTTERON, Auteur ; Zoe HAWKS, Auteur ; John R. PRUETT, Auteur ; Jed T. ELISON, Auteur ; Joshua J. JACKSON, Auteur ; Lori MARKSON, Auteur ; Adam T. EGGEBRECHT, Auteur ; Catherine A. BURROWS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; Annette M. ESTES, Auteur ; Heather Cody HAZLETT, Auteur ; Robert T. SCHULTZ, Auteur ; Joseph PIVEN, Auteur ; John N. CONSTANTINO, Auteur . - p.101-111. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.101-111 Mots-clés : autism spectrum disorder  infancy  measurement  social motivation Index. décimale : PER Périodiques Résumé : Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation?s course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation?s importance to risk assessment and clarification of the ontogeny of ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

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