Brainstem as a developmental gateway to social attention / Ronny GEVA in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1351-1359 Titre : Brainstem as a developmental gateway to social attention Type de document : Texte imprimé et/ou numérique Auteurs : Ronny GEVA, Auteur ; Ayelet DITAL, Auteur ; Dan RAMON, Auteur ; Jessica YARMOLOVSKY, Auteur ; Maor GIDRON, Auteur ; Jacob KUINT, Auteur Article en page(s) : p.1351-1359 Langues : Anglais (eng) Mots-clés : Brainstem  development  social attention  attention Index. décimale : PER Périodiques Résumé : Background Evolution preserves social attention due to its key role in supporting survival. Humans are attracted to social cues from infancy, but the neurobiological mechanisms for the development of social attention are unknown. An evolutionary-based, vertical-hierarchical theoretical model of self-regulation suggests that neonatal brainstem inputs are key for the development of well-regulated social attention. Methods Neonates born preterm (N = 44, GA 34 w.) were recruited and diagnosed at birth as a function of their auditory brainstem evoked responses (ABR). Participants enrolled in a prospective 8-year-long, double-blind, follow-up study comparing participants with brainstem dysfunctions and well-matched controls. Groups had comparable fetal, neonatal, and familial characteristics. Methods incorporated EEG power analysis and gaze tracking during the Attention Network Test (ANT, four cue types, and two targets) and a Triadic Gaze Engagement task (TGE, three social cue levels). Results Results showed that neonatal brainstem compromise is related to long-term changes in Alpha- and Theta-band power asymmetries (p < .034, p < .016, respectively), suggesting suppressed bottom-up input needed to alert social attention. Gaze tracking indicated dysregulated arousal-modulated attention (p < .004) and difficulty in gaze engagement to socially neutral compared to nonsocial cues (p < .012). Conclusions Integrating models of Autism and cross-species data with current long-term follow-up of infants with discrete neonatal brainstem dysfunction suggests neonatal brainstem input as a gateway for bottom-up regulation of social attention. En ligne : http://dx.doi.org/10.1111/jcpp.12746 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Brainstem as a developmental gateway to social attention [Texte imprimé et/ou numérique] / Ronny GEVA, Auteur ; Ayelet DITAL, Auteur ; Dan RAMON, Auteur ; Jessica YARMOLOVSKY, Auteur ; Maor GIDRON, Auteur ; Jacob KUINT, Auteur . - p.1351-1359. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1351-1359 Mots-clés : Brainstem  development  social attention  attention Index. décimale : PER Périodiques Résumé : Background Evolution preserves social attention due to its key role in supporting survival. Humans are attracted to social cues from infancy, but the neurobiological mechanisms for the development of social attention are unknown. An evolutionary-based, vertical-hierarchical theoretical model of self-regulation suggests that neonatal brainstem inputs are key for the development of well-regulated social attention. Methods Neonates born preterm (N = 44, GA 34 w.) were recruited and diagnosed at birth as a function of their auditory brainstem evoked responses (ABR). Participants enrolled in a prospective 8-year-long, double-blind, follow-up study comparing participants with brainstem dysfunctions and well-matched controls. Groups had comparable fetal, neonatal, and familial characteristics. Methods incorporated EEG power analysis and gaze tracking during the Attention Network Test (ANT, four cue types, and two targets) and a Triadic Gaze Engagement task (TGE, three social cue levels). Results Results showed that neonatal brainstem compromise is related to long-term changes in Alpha- and Theta-band power asymmetries (p < .034, p < .016, respectively), suggesting suppressed bottom-up input needed to alert social attention. Gaze tracking indicated dysregulated arousal-modulated attention (p < .004) and difficulty in gaze engagement to socially neutral compared to nonsocial cues (p < .012). Conclusions Integrating models of Autism and cross-species data with current long-term follow-up of infants with discrete neonatal brainstem dysfunction suggests neonatal brainstem input as a gateway for bottom-up regulation of social attention. En ligne : http://dx.doi.org/10.1111/jcpp.12746 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Intrauterine Growth Restriction / Ronny GEVA

Public ISBD in Cognitive and Behavioral Abnormalities of Pediatric Diseases / Ruth D. NASS Titre : Intrauterine Growth Restriction Type de document : Texte imprimé et/ou numérique Auteurs : Ronny GEVA, Auteur Année de publication : 2010 Importance : p.426-435 Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239 in Cognitive and Behavioral Abnormalities of Pediatric Diseases / Ruth D. NASS Intrauterine Growth Restriction [Texte imprimé et/ou numérique] / Ronny GEVA, Auteur . - 2010 . - p.426-435. Langues : Anglais (eng) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239

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Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome / Omri WEISMAN in Journal of Autism and Developmental Disorders, 45-8 (August 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2567-2577 Titre : Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Omri WEISMAN, Auteur ; Ruth FELDMAN, Auteur ; Merav BURG-MALKI, Auteur ; Miri KEREN, Auteur ; Ronny GEVA, Auteur ; Gil DIESENDRUCK, Auteur ; Doron GOTHELF, Auteur Année de publication : 2015 Article en page(s) : p.2567-2577 Langues : Anglais (eng) Mots-clés : 22q11.2DS  Williams syndrome  Mother–child interaction  Behavior  COMT gene Index. décimale : PER Périodiques Résumé : Mother-child interactions in 22q11.2 Deletion syndrome (22q11.2DS) and Williams syndrome (WS) were coded for maternal sensitivity/intrusiveness, child’s expression of affect, levels of engagement, and dyadic reciprocity. WS children were found to express more positive emotions towards their mothers compared to 22q11.2DS children and those with developmental delay in a conflict interaction. During the same interaction, dyads of 22q11.2DS children were characterized by higher levels of maternal intrusiveness, lower levels of child’s engagement and reduced reciprocity compared to dyads of typically developing children. Finally, 22q11.2DS children with the COMT Met allele showed less adaptive behaviors than children with the Val allele. Dyadic behaviors partially coincided with the distinct social phenotypes in these syndromes and are potential behavioral markers of psychopathological trajectory. En ligne : http://dx.doi.org/10.1007/s10803-015-2425-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome [Texte imprimé et/ou numérique] / Omri WEISMAN, Auteur ; Ruth FELDMAN, Auteur ; Merav BURG-MALKI, Auteur ; Miri KEREN, Auteur ; Ronny GEVA, Auteur ; Gil DIESENDRUCK, Auteur ; Doron GOTHELF, Auteur . - 2015 . - p.2567-2577. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2567-2577 Mots-clés : 22q11.2DS  Williams syndrome  Mother–child interaction  Behavior  COMT gene Index. décimale : PER Périodiques Résumé : Mother-child interactions in 22q11.2 Deletion syndrome (22q11.2DS) and Williams syndrome (WS) were coded for maternal sensitivity/intrusiveness, child’s expression of affect, levels of engagement, and dyadic reciprocity. WS children were found to express more positive emotions towards their mothers compared to 22q11.2DS children and those with developmental delay in a conflict interaction. During the same interaction, dyads of 22q11.2DS children were characterized by higher levels of maternal intrusiveness, lower levels of child’s engagement and reduced reciprocity compared to dyads of typically developing children. Finally, 22q11.2DS children with the COMT Met allele showed less adaptive behaviors than children with the Val allele. Dyadic behaviors partially coincided with the distinct social phenotypes in these syndromes and are potential behavioral markers of psychopathological trajectory. En ligne : http://dx.doi.org/10.1007/s10803-015-2425-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Neonatal brainstem dysfunction after preterm birth predicts behavioral inhibition / Ronny GEVA in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.802-810 Titre : Neonatal brainstem dysfunction after preterm birth predicts behavioral inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Ronny GEVA, Auteur ; Jessica SCHREIBER, Auteur ; Lihi SEGAL-CASPI, Auteur ; Michal MARKUS-SHIFFMAN, Auteur Article en page(s) : p.802-810 Langues : Anglais (eng) Mots-clés : Prematurity  temperament  infancy  neural development  motor inhibition Index. décimale : PER Périodiques Résumé : Background Behavioral inhibition (BI), the tendency to withdraw or exhibit negative affect when experiencing stressful situations, is a major risk factor for the development of social anxiety. However, neonatal biologic origins of this progression are still unknown. Click here to enter text.This study aimed to extend frameworks of behavioral inhibition by exploring empirically the central role of neonatal brainstem electrophysiologic functions in the development of social disengagement and BI. Methods Sixty-six preterm neonates (means ±SD: gestation age = 33.1 ± 1.22 weeks, birth weight = 1775 + 346.7 g; 51% female) participated in a prospective longitudinal study. The infants were tested within the first 2 weeks of postnatal life using an auditory brainstem-evoked response test. Based on the typicality of the major ABR wave latencies, waves I, III and V, neonates were divided into two groups (compromised, CBSF- with at least one component ?1.5 SDs from the mean for the respective gestation age; normal, NBSF, with all components within 1.5 SD around the mean), and were enrolled in a prospective longitudinal follow-up study. This report extends previous work from 4 m by testing responses to socioemotional challenges during the Separation–Reunion paradigm at 12 m. Results Results show that infants with neonatal CBSF were more susceptible to be classified as BI at 12 m (age corrected for prematurity) than infants with NBSF (66% vs. 40%, respectively). The most striking symptom in the CBSF group was a disability to initiate self-regulatory activities in response to a socioemotional challenge, resulting in frequent passivity/dependency (p .001). Statistical regression analysis revealed that face-to-face gaze engagement at 4 m moderates the risk related to neonatal CBSF for the emergence of BI at 12 m, but did not overturn the emergence of BI. Conclusion Results support the hypothesis that neonatal brainstem dysfunction canalizes behavioral inhibition. These findings highlight, for the first time, the role of the early developing brainstem in later development of BI and in abilities to initiate self-regulatory behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Neonatal brainstem dysfunction after preterm birth predicts behavioral inhibition [Texte imprimé et/ou numérique] / Ronny GEVA, Auteur ; Jessica SCHREIBER, Auteur ; Lihi SEGAL-CASPI, Auteur ; Michal MARKUS-SHIFFMAN, Auteur . - p.802-810. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.802-810 Mots-clés : Prematurity  temperament  infancy  neural development  motor inhibition Index. décimale : PER Périodiques Résumé : Background Behavioral inhibition (BI), the tendency to withdraw or exhibit negative affect when experiencing stressful situations, is a major risk factor for the development of social anxiety. However, neonatal biologic origins of this progression are still unknown. Click here to enter text.This study aimed to extend frameworks of behavioral inhibition by exploring empirically the central role of neonatal brainstem electrophysiologic functions in the development of social disengagement and BI. Methods Sixty-six preterm neonates (means ±SD: gestation age = 33.1 ± 1.22 weeks, birth weight = 1775 + 346.7 g; 51% female) participated in a prospective longitudinal study. The infants were tested within the first 2 weeks of postnatal life using an auditory brainstem-evoked response test. Based on the typicality of the major ABR wave latencies, waves I, III and V, neonates were divided into two groups (compromised, CBSF- with at least one component ?1.5 SDs from the mean for the respective gestation age; normal, NBSF, with all components within 1.5 SD around the mean), and were enrolled in a prospective longitudinal follow-up study. This report extends previous work from 4 m by testing responses to socioemotional challenges during the Separation–Reunion paradigm at 12 m. Results Results show that infants with neonatal CBSF were more susceptible to be classified as BI at 12 m (age corrected for prematurity) than infants with NBSF (66% vs. 40%, respectively). The most striking symptom in the CBSF group was a disability to initiate self-regulatory activities in response to a socioemotional challenge, resulting in frequent passivity/dependency (p .001). Statistical regression analysis revealed that face-to-face gaze engagement at 4 m moderates the risk related to neonatal CBSF for the emergence of BI at 12 m, but did not overturn the emergence of BI. Conclusion Results support the hypothesis that neonatal brainstem dysfunction canalizes behavioral inhibition. These findings highlight, for the first time, the role of the early developing brainstem in later development of BI and in abilities to initiate self-regulatory behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

A neurobiological model for the effects of early brainstem functioning on the development of behavior and emotion regulation in infants: implications for prenatal and perinatal risk / Ronny GEVA in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1031-1041 Titre : A neurobiological model for the effects of early brainstem functioning on the development of behavior and emotion regulation in infants: implications for prenatal and perinatal risk Type de document : Texte imprimé et/ou numérique Auteurs : Ronny GEVA, Auteur ; Ruth FELDMAN, Auteur Année de publication : 2008 Article en page(s) : p.1031-1041 Langues : Anglais (eng) Mots-clés : Audiology brain-development emotion-regulation executive-function perinatal prematurity Index. décimale : PER Périodiques Résumé : Neurobiological models propose an evolutionary, vertical-integrative perspective on emotion and behavior regulation, which postulates that regulatory functions are processed along three core brain systems: the brainstem, limbic, and cortical systems. To date, few developmental studies applied these models to research on prenatal and perinatal risk. We propose a conceptual model that incorporates three integrated levels of observations for the study of early risk: (a) brainstem-related physiological regulation of cyclic processes and sensory integration, e.g., vagal regulation, circadian rhythms; (b) emotion and attention regulation capacities that draw on the integration of brainstem and limbic systems; and (c) higher-level outcomes that draw on the intactness of brainstem and limbic networks, including socio-emotional self-regulation, inhibitory control, and cognitive processing. We discuss implications of the model for the development of regulatory capacities during the prenatal and early postnatal stages in infants born with specific perinatal risk. We underscore the importance of assessing sub-cortical and brainstem systems and the longitudinal effects of transitory brainstem dysfunction on physiological homeostasis, motivation, arousal-modulated attention, stress reactivity, and mother-infant co-regulation. The assessment of brainstem dysfunction can be conducted during hospitalization and may help detect infants at risk for the development of self-regulatory deficits at the first weeks of life. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01918.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606 [article] A neurobiological model for the effects of early brainstem functioning on the development of behavior and emotion regulation in infants: implications for prenatal and perinatal risk [Texte imprimé et/ou numérique] / Ronny GEVA, Auteur ; Ruth FELDMAN, Auteur . - 2008 . - p.1031-1041. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1031-1041 Mots-clés : Audiology brain-development emotion-regulation executive-function perinatal prematurity Index. décimale : PER Périodiques Résumé : Neurobiological models propose an evolutionary, vertical-integrative perspective on emotion and behavior regulation, which postulates that regulatory functions are processed along three core brain systems: the brainstem, limbic, and cortical systems. To date, few developmental studies applied these models to research on prenatal and perinatal risk. We propose a conceptual model that incorporates three integrated levels of observations for the study of early risk: (a) brainstem-related physiological regulation of cyclic processes and sensory integration, e.g., vagal regulation, circadian rhythms; (b) emotion and attention regulation capacities that draw on the integration of brainstem and limbic systems; and (c) higher-level outcomes that draw on the intactness of brainstem and limbic networks, including socio-emotional self-regulation, inhibitory control, and cognitive processing. We discuss implications of the model for the development of regulatory capacities during the prenatal and early postnatal stages in infants born with specific perinatal risk. We underscore the importance of assessing sub-cortical and brainstem systems and the longitudinal effects of transitory brainstem dysfunction on physiological homeostasis, motivation, arousal-modulated attention, stress reactivity, and mother-infant co-regulation. The assessment of brainstem dysfunction can be conducted during hospitalization and may help detect infants at risk for the development of self-regulatory deficits at the first weeks of life. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01918.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606

Prolonged auditory brainstem responses in infants with autism / Oren MIRON in Autism Research, 9-6 (June 2016)  

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Verbal short-term memory span in children: long-term modality dependent effects of intrauterine growth restriction / Ronny GEVA in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)  

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