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Research Review: The role of cytokines in depression in adolescents: a systematic review / Natalie T. MILLS in Journal of Child Psychology and Psychiatry, 54-8 (August 2013)
[article]
Titre : Research Review: The role of cytokines in depression in adolescents: a systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Natalie T. MILLS, Auteur ; James G. SCOTT, Auteur ; Naomi R. WRAY, Auteur ; Sarah COHEN-WOODS, Auteur ; BERNHARD T. BAUNE, Auteur Article en page(s) : p.816-835 Langues : Anglais (eng) Mots-clés : Cytokines inflammation immune system MDD cognition stress Index. décimale : PER Périodiques Résumé : Background While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression. Method A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases. Results Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1? and TNF-?). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma. Conclusions There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.12080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210
in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.816-835[article] Research Review: The role of cytokines in depression in adolescents: a systematic review [Texte imprimé et/ou numérique] / Natalie T. MILLS, Auteur ; James G. SCOTT, Auteur ; Naomi R. WRAY, Auteur ; Sarah COHEN-WOODS, Auteur ; BERNHARD T. BAUNE, Auteur . - p.816-835.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-8 (August 2013) . - p.816-835
Mots-clés : Cytokines inflammation immune system MDD cognition stress Index. décimale : PER Périodiques Résumé : Background While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear. This article therefore reviews the literature (a) to explore the relationship between cytokines and depression in adolescents, and (b) to examine how cytokines may be related to adolescent depression in the context of other neurobiological theories of depression. Method A systematic review of the scientific literature on the subject was conducted in February 2013, searching the Web of Knowledge, PubMed (Medline), PsycInfo and Cochrane electronic databases. Results Eighteen studies were identified measuring both depression or depressive symptoms and cytokines or immune markers in adolescents. Adolescents with depression show age-specific characteristics of the immune and inflammatory system, specifically in NK cell activity and in pro-inflammatory cytokines (such as IL-1? and TNF-?). In addition, the role of cytokines in adolescent depression is influenced by neurodevelopment, hormonal changes, stress and trauma. Conclusions There may be differences in the neurobiology of adolescent major depressive disorder (MDD) compared with adult MDD. Increased understanding of the role of cytokines in adolescent MDD may lead to improved outcomes in the treatment of adolescent depression. En ligne : http://dx.doi.org/10.1111/jcpp.12080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study / Monika TRINKL in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)
[article]
Titre : Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study Type de document : Texte imprimé et/ou numérique Auteurs : Monika TRINKL, Auteur ; Ellen GREIMEL, Auteur ; Jürgen BARTLING, Auteur ; Barbara GRÜNEWALD, Auteur ; Gerd SCHULTE-KÖRNE, Auteur ; Nicola GROSSHEINRICH, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : ERP MDD major depression emotion regulation asymmetry left frontal hypoactivation endophenotype sensation seeking experience seeking appetitive stimuli impulsivity adolescence go nogo Index. décimale : PER Périodiques Résumé : Background Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go/no-go paradigms. To date, no study has examined if the left-frontal hypoactivation associated with depression generalizes to active tasks. The aim of this study was therefore to investigate the hemispheric asymmetry of the N2 component in depressed adolescents in an emotion regulation paradigm. Methods Twenty-four adolescents diagnosed with major depression (age 11–18) and 30 healthy controls (age 11–18) performed two emotional go/no-go tasks exhibiting negative faces as go trials and positive faces as no-go trials and vice versa. Results On the behavioral level, no significant group differences emerged. On the neural level, we found a more right-lateralized N2-amplitude in depressed subjects, while it was more left-lateralized in controls. Furthermore, both groups showed a less negative N2-amplitude to positive no-go stimuli. Conclusion This study provides strong support for a general left-frontal hypoactivity in adolescent depression, which also applies to active emotional go/no-go paradigms. Furthermore, the less negative N2 to positive stimuli is consistent with a generally enhanced impulsivity of adolescents toward appetitive stimuli, which is possibly the base of the differential clinical pattern of adolescent in contrast to adult depression. En ligne : http://dx.doi.org/10.1111/jcpp.12282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.76-86[article] Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study [Texte imprimé et/ou numérique] / Monika TRINKL, Auteur ; Ellen GREIMEL, Auteur ; Jürgen BARTLING, Auteur ; Barbara GRÜNEWALD, Auteur ; Gerd SCHULTE-KÖRNE, Auteur ; Nicola GROSSHEINRICH, Auteur . - p.76-86.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.76-86
Mots-clés : ERP MDD major depression emotion regulation asymmetry left frontal hypoactivation endophenotype sensation seeking experience seeking appetitive stimuli impulsivity adolescence go nogo Index. décimale : PER Périodiques Résumé : Background Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go/no-go paradigms. To date, no study has examined if the left-frontal hypoactivation associated with depression generalizes to active tasks. The aim of this study was therefore to investigate the hemispheric asymmetry of the N2 component in depressed adolescents in an emotion regulation paradigm. Methods Twenty-four adolescents diagnosed with major depression (age 11–18) and 30 healthy controls (age 11–18) performed two emotional go/no-go tasks exhibiting negative faces as go trials and positive faces as no-go trials and vice versa. Results On the behavioral level, no significant group differences emerged. On the neural level, we found a more right-lateralized N2-amplitude in depressed subjects, while it was more left-lateralized in controls. Furthermore, both groups showed a less negative N2-amplitude to positive no-go stimuli. Conclusion This study provides strong support for a general left-frontal hypoactivity in adolescent depression, which also applies to active emotional go/no-go paradigms. Furthermore, the less negative N2 to positive stimuli is consistent with a generally enhanced impulsivity of adolescents toward appetitive stimuli, which is possibly the base of the differential clinical pattern of adolescent in contrast to adult depression. En ligne : http://dx.doi.org/10.1111/jcpp.12282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259