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Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children / T. HORINOUCHI in Journal of Autism and Developmental Disorders, 52-2 (February 2022)
[article]
Titre : Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children Type de document : Texte imprimé et/ou numérique Auteurs : T. HORINOUCHI, Auteur ; K. MAEYAMA, Auteur ; M. NAGAI, Auteur ; M. MIZOBUCHI, Auteur ; Y. TAKAGI, Auteur ; Y. OKADA, Auteur ; T. KATO, Auteur ; M. NISHIMURA, Auteur ; Y. KAWASAKI, Auteur ; M. YOSHIOKA, Auteur ; S. TAKADA, Auteur ; H. MATSUMOTO, Auteur ; Y. NAKAMACHI, Auteur ; J. SAEGUSA, Auteur ; S. FUKUSHIMA, Auteur ; K. FUJIOKA, Auteur ; K. TOMIOKA, Auteur ; H. NAGASE, Auteur ; K. NOZU, Auteur ; K. IIJIMA, Auteur ; N. NISHIMURA, Auteur Article en page(s) : p.483-489 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics Child Female Glucuronosyltransferase/genetics Humans Infant, Newborn Jaundice, Neonatal/complications Polymorphism, Genetic Pregnancy Risk Factors Umbilical Cord Autism spectrum disorder Dried umbilical cord Neonatal jaundice Polymorphism Ugt1a1 Index. décimale : PER Périodiques Résumé : Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G?>?A), and UGT1A1*27 (c.686 C?>?A). The allele frequency of UGT1A1*6 (OR?=?1.34, p?=?0.26) and UGT1A1*28 (OR?=?0.80, p?=?0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04941-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.483-489[article] Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children [Texte imprimé et/ou numérique] / T. HORINOUCHI, Auteur ; K. MAEYAMA, Auteur ; M. NAGAI, Auteur ; M. MIZOBUCHI, Auteur ; Y. TAKAGI, Auteur ; Y. OKADA, Auteur ; T. KATO, Auteur ; M. NISHIMURA, Auteur ; Y. KAWASAKI, Auteur ; M. YOSHIOKA, Auteur ; S. TAKADA, Auteur ; H. MATSUMOTO, Auteur ; Y. NAKAMACHI, Auteur ; J. SAEGUSA, Auteur ; S. FUKUSHIMA, Auteur ; K. FUJIOKA, Auteur ; K. TOMIOKA, Auteur ; H. NAGASE, Auteur ; K. NOZU, Auteur ; K. IIJIMA, Auteur ; N. NISHIMURA, Auteur . - p.483-489.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.483-489
Mots-clés : Autism Spectrum Disorder/diagnosis/genetics Child Female Glucuronosyltransferase/genetics Humans Infant, Newborn Jaundice, Neonatal/complications Polymorphism, Genetic Pregnancy Risk Factors Umbilical Cord Autism spectrum disorder Dried umbilical cord Neonatal jaundice Polymorphism Ugt1a1 Index. décimale : PER Périodiques Résumé : Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G?>?A), and UGT1A1*27 (c.686 C?>?A). The allele frequency of UGT1A1*6 (OR?=?1.34, p?=?0.26) and UGT1A1*28 (OR?=?0.80, p?=?0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-04941-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455