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2 recherche sur le mot-clé 'Autism Spectrum Disorder/genetics/therapy'
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Autism spectrum disorder: prospects for treatment using gene therapy / M. BENGER in Molecular Autism, 9 (2018)
[article]
Titre : Autism spectrum disorder: prospects for treatment using gene therapy Type de document : Texte imprimé et/ou numérique Auteurs : M. BENGER, Auteur ; M. KINALI, Auteur ; N. D. MAZARAKIS, Auteur Article en page(s) : 39p. Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder/genetics/therapy Genetic Therapy/methods ASD models Autistic spectrum disorder Gene therapy Synaptic dysfunction Viral vector Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterised by the concomitant occurrence of impaired social interaction; restricted, perseverative and stereotypical behaviour; and abnormal communication skills. Recent epidemiological studies have reported a dramatic increase in the prevalence of ASD with as many as 1 in every 59 children being diagnosed with ASD. The fact that ASD appears to be principally genetically driven, and may be reversible postnatally, has raised the exciting possibility of using gene therapy as a disease-modifying treatment. Such therapies have already started to seriously impact on human disease and particularly monogenic disorders (e.g. metachromatic leukodystrophy, SMA type 1). In regard to ASD, technical advances in both our capacity to model the disorder in animals and also our ability to deliver genes to the central nervous system (CNS) have led to the first preclinical studies in monogenic ASD, involving both gene replacement and silencing. Furthermore, our increasing awareness and understanding of common dysregulated pathways in ASD have broadened gene therapy's potential scope to include various polygenic ASDs. As this review highlights, despite a number of outstanding challenges, gene therapy has excellent potential to address cognitive dysfunction in ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0222-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 39p.[article] Autism spectrum disorder: prospects for treatment using gene therapy [Texte imprimé et/ou numérique] / M. BENGER, Auteur ; M. KINALI, Auteur ; N. D. MAZARAKIS, Auteur . - 39p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 39p.
Mots-clés : Animals Autism Spectrum Disorder/genetics/therapy Genetic Therapy/methods ASD models Autistic spectrum disorder Gene therapy Synaptic dysfunction Viral vector Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterised by the concomitant occurrence of impaired social interaction; restricted, perseverative and stereotypical behaviour; and abnormal communication skills. Recent epidemiological studies have reported a dramatic increase in the prevalence of ASD with as many as 1 in every 59 children being diagnosed with ASD. The fact that ASD appears to be principally genetically driven, and may be reversible postnatally, has raised the exciting possibility of using gene therapy as a disease-modifying treatment. Such therapies have already started to seriously impact on human disease and particularly monogenic disorders (e.g. metachromatic leukodystrophy, SMA type 1). In regard to ASD, technical advances in both our capacity to model the disorder in animals and also our ability to deliver genes to the central nervous system (CNS) have led to the first preclinical studies in monogenic ASD, involving both gene replacement and silencing. Furthermore, our increasing awareness and understanding of common dysregulated pathways in ASD have broadened gene therapy's potential scope to include various polygenic ASDs. As this review highlights, despite a number of outstanding challenges, gene therapy has excellent potential to address cognitive dysfunction in ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0222-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 Brief Report: Neuroimaging Endophenotypes of Social Robotic Applications in Autism Spectrum Disorder / A. CERASA in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
[article]
Titre : Brief Report: Neuroimaging Endophenotypes of Social Robotic Applications in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. CERASA, Auteur ; L. RUTA, Auteur ; F. MARINO, Auteur ; G. BIAMONTI, Auteur ; G. PIOGGIA, Auteur Article en page(s) : p.2538-2542 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics/therapy Autistic Disorder Child Creativity Endophenotypes Humans Male Neuroimaging Research Report Robotics/methods Autism spectrum disorder Neuroendophenotype Social robot Index. décimale : PER Périodiques Résumé : A plethora of neuroimaging studies have focused on the discovery of potential neuroendophenotypes useful to understand the etiopathogenesis of autism and predict treatment response. Social robotics has recently been proposed as an effective tool to strengthen the current treatments in children with autism. However, the high clinical heterogeneity characterizing this disorder might interfere with behavioral effects. Neuroimaging is set to overcome these limitations by capturing the level of heterogeneity. Here, we provide a preliminary evaluation of the neural basis of social robotics and how extracting neural hallmarks useful to design more effective behavioral applications. Despite the endophenotype-oriented neuroimaging research approach is in its relative infancy, this preliminary evidence encourages innovation to address its current limitations. En ligne : http://dx.doi.org/10.1007/s10803-020-04708-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2538-2542[article] Brief Report: Neuroimaging Endophenotypes of Social Robotic Applications in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. CERASA, Auteur ; L. RUTA, Auteur ; F. MARINO, Auteur ; G. BIAMONTI, Auteur ; G. PIOGGIA, Auteur . - p.2538-2542.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2538-2542
Mots-clés : Autism Spectrum Disorder/genetics/therapy Autistic Disorder Child Creativity Endophenotypes Humans Male Neuroimaging Research Report Robotics/methods Autism spectrum disorder Neuroendophenotype Social robot Index. décimale : PER Périodiques Résumé : A plethora of neuroimaging studies have focused on the discovery of potential neuroendophenotypes useful to understand the etiopathogenesis of autism and predict treatment response. Social robotics has recently been proposed as an effective tool to strengthen the current treatments in children with autism. However, the high clinical heterogeneity characterizing this disorder might interfere with behavioral effects. Neuroimaging is set to overcome these limitations by capturing the level of heterogeneity. Here, we provide a preliminary evaluation of the neural basis of social robotics and how extracting neural hallmarks useful to design more effective behavioral applications. Despite the endophenotype-oriented neuroimaging research approach is in its relative infancy, this preliminary evidence encourages innovation to address its current limitations. En ligne : http://dx.doi.org/10.1007/s10803-020-04708-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452