4 recherche sur le mot-clé 'Autistic women'

Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women / Tanya L. PROCYSHYN in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 20 p. Titre : Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women Type de document : texte imprimé Auteurs : Tanya L. PROCYSHYN, Auteur ; Michael V. LOMBARDO, Auteur ; Meng-Chuan LAI, Auteur ; Bonnie AUYEUNG, Auteur ; Sarah K. CROCKFORD, Auteur ; J. DEAKIN, Auteur ; S. SOUBRAMANIAN, Auteur ; A. SULE, Auteur ; Simon BARON-COHEN, Auteur ; Richard A.I. BETHLEHEM, Auteur Article en page(s) : 20 p. Langues : Anglais (eng) Mots-clés : Autism  Autistic women  Oestradiol  Oxytocin  Salivary hormone levels  Sex steroids  Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones. However, to date, the effects of oxytocin administration on endogenous hormones have only been examined in neurotypical individuals. The need to consider multi-hormone interactions is particularly warranted in oxytocin trials for autism due to evidence of irregularities in both oxytocin and sex steroid systems. METHODS: In this double-blind cross-over study, saliva samples were collected from 16 autistic and 29 neurotypical women before and after intranasal administration of 24 IU oxytocin or placebo. Oestradiol, testosterone, and oxytocin levels were quantified in saliva samples. Participants also completed the Autism-Spectrum Quotient (AQ) and Empathy Quotient (EQ) questionnaires. RESULTS: Distinct patterns of change in testosterone and oestradiol levels pre- to-post-administration were observed in autistic relative to neurotypical women (ANCOVA, p < 0.05 main effect of Group), controlling for sample collection time. The mean percent change oestradiol was + 8.8% for the autism group and - 13.0% for the neurotypical group (t = 1.81, p = 0.08), while the mean percent change testosterone was + 1.1% in the autism group and - 12.6% in the neurotypical group (t = 1.26, p = 0.22). In the oxytocin condition, the mean percent change oestradiol was + 12.6% in the autism group and - 6.9% in the neurotypical group (t = 1.78, p = 0.08), while the mean percent change testosterone was + 14.4% in the autism group and - 15.2% in the neurotypical group (t = 3.00, p = 0.006). Robust regression confirmed that group differences in percent change hormone levels were not driven by a small number of influential individuals. Baseline hormone levels did not differ between groups when considered individually. However, baseline testosterone relative to oestradiol (T:E2 ratio) was higher in autistic women (p = 0.023, Cohen's d = 0.63), and this ratio correlated positively and negatively with AQ and EQ scores, respectively, in the combined sample. LIMITATIONS: Further studies with larger and more diverse autistic sample are warranted to confirm these effects. CONCLUSIONS: This study provides the first evidence that oxytocin influences endogenous testosterone levels in autistic individuals, with autistic women showing increases similar to previous reports of neurotypical men. These findings highlight the need to consider sex steroid hormones as a variable in future oxytocin trials. En ligne : http://dx.doi.org/10.1186/s13229-020-00326-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women [texte imprimé] / Tanya L. PROCYSHYN, Auteur ; Michael V. LOMBARDO, Auteur ; Meng-Chuan LAI, Auteur ; Bonnie AUYEUNG, Auteur ; Sarah K. CROCKFORD, Auteur ; J. DEAKIN, Auteur ; S. SOUBRAMANIAN, Auteur ; A. SULE, Auteur ; Simon BARON-COHEN, Auteur ; Richard A.I. BETHLEHEM, Auteur . - 20 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 20 p. Mots-clés : Autism  Autistic women  Oestradiol  Oxytocin  Salivary hormone levels  Sex steroids  Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones. However, to date, the effects of oxytocin administration on endogenous hormones have only been examined in neurotypical individuals. The need to consider multi-hormone interactions is particularly warranted in oxytocin trials for autism due to evidence of irregularities in both oxytocin and sex steroid systems. METHODS: In this double-blind cross-over study, saliva samples were collected from 16 autistic and 29 neurotypical women before and after intranasal administration of 24 IU oxytocin or placebo. Oestradiol, testosterone, and oxytocin levels were quantified in saliva samples. Participants also completed the Autism-Spectrum Quotient (AQ) and Empathy Quotient (EQ) questionnaires. RESULTS: Distinct patterns of change in testosterone and oestradiol levels pre- to-post-administration were observed in autistic relative to neurotypical women (ANCOVA, p < 0.05 main effect of Group), controlling for sample collection time. The mean percent change oestradiol was + 8.8% for the autism group and - 13.0% for the neurotypical group (t = 1.81, p = 0.08), while the mean percent change testosterone was + 1.1% in the autism group and - 12.6% in the neurotypical group (t = 1.26, p = 0.22). In the oxytocin condition, the mean percent change oestradiol was + 12.6% in the autism group and - 6.9% in the neurotypical group (t = 1.78, p = 0.08), while the mean percent change testosterone was + 14.4% in the autism group and - 15.2% in the neurotypical group (t = 3.00, p = 0.006). Robust regression confirmed that group differences in percent change hormone levels were not driven by a small number of influential individuals. Baseline hormone levels did not differ between groups when considered individually. However, baseline testosterone relative to oestradiol (T:E2 ratio) was higher in autistic women (p = 0.023, Cohen's d = 0.63), and this ratio correlated positively and negatively with AQ and EQ scores, respectively, in the combined sample. LIMITATIONS: Further studies with larger and more diverse autistic sample are warranted to confirm these effects. CONCLUSIONS: This study provides the first evidence that oxytocin influences endogenous testosterone levels in autistic individuals, with autistic women showing increases similar to previous reports of neurotypical men. These findings highlight the need to consider sex steroid hormones as a variable in future oxytocin trials. En ligne : http://dx.doi.org/10.1186/s13229-020-00326-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

The diagnostic journey of autistic women as shared on TikTok / Karen Whisenhunt SAAR ; Siva Priya SANTHANAM ; Shahryar HEYDARI in Research in Autism, 120 (February 2025)  

Public ISBD [article]  inResearch in Autism > 120 (February 2025) . - 202529 Titre : The diagnostic journey of autistic women as shared on TikTok Type de document : texte imprimé Auteurs : Karen Whisenhunt SAAR, Auteur ; Siva Priya SANTHANAM, Auteur ; Shahryar HEYDARI, Auteur Article en page(s) : 202529 Langues : Anglais (eng) Mots-clés : Autistic women  Diagnosis  Social media  TikTok  Autistic identity  Autistic community Index. décimale : PER Périodiques Résumé : Background TikTok serves as a social media platform for fostering social empowerment and facilitating community discussions. Recent research indicates that autistic adults use TikTok to share insights into their diagnoses. Adding to this line of inquiry, the current study examines the diagnostic journey of autistic women as shared on TikTok. Method Personal narratives of autistic women regarding their diagnostic experiences as shared on TikTok were identified and analyzed using reflexive thematic analysis (Braun and Clarke, 2021) to inductively identify shared themes. Results Data related to theme I (i.e., "I have spent my whole life trying to fix myself"), II (i.e., "No one realized I was struggling"), and III (i.e., "This isn t how it should be") was consistent with other research examining the experiences of autistic women in their diagnostic journey. Theme IV (i.e., "You know yourself better than anyone") provided unique findings with regard to the TikTok community. Specifically, content creators used TikTok as a platform for communal discourse and social empowerment. They provided and sought reciprocal support and direction. Conclusions Autistic women are turning to TikTok to share experiences and express perspectives. The data informs professionals on how to support women in their journey toward understanding themselves within an autistic identity. En ligne : https://doi.org/10.1016/j.reia.2025.202529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] The diagnostic journey of autistic women as shared on TikTok [texte imprimé] / Karen Whisenhunt SAAR, Auteur ; Siva Priya SANTHANAM, Auteur ; Shahryar HEYDARI, Auteur . - 202529. Langues : Anglais (eng) in Research in Autism > 120 (February 2025) . - 202529 Mots-clés : Autistic women  Diagnosis  Social media  TikTok  Autistic identity  Autistic community Index. décimale : PER Périodiques Résumé : Background TikTok serves as a social media platform for fostering social empowerment and facilitating community discussions. Recent research indicates that autistic adults use TikTok to share insights into their diagnoses. Adding to this line of inquiry, the current study examines the diagnostic journey of autistic women as shared on TikTok. Method Personal narratives of autistic women regarding their diagnostic experiences as shared on TikTok were identified and analyzed using reflexive thematic analysis (Braun and Clarke, 2021) to inductively identify shared themes. Results Data related to theme I (i.e., "I have spent my whole life trying to fix myself"), II (i.e., "No one realized I was struggling"), and III (i.e., "This isn t how it should be") was consistent with other research examining the experiences of autistic women in their diagnostic journey. Theme IV (i.e., "You know yourself better than anyone") provided unique findings with regard to the TikTok community. Specifically, content creators used TikTok as a platform for communal discourse and social empowerment. They provided and sought reciprocal support and direction. Conclusions Autistic women are turning to TikTok to share experiences and express perspectives. The data informs professionals on how to support women in their journey toward understanding themselves within an autistic identity. En ligne : https://doi.org/10.1016/j.reia.2025.202529 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

'When my autism broke': A qualitative study spotlighting autistic voices on menopause / Rachel L. MOSELEY in Autism, 24-6 (August 2020)  

Public ISBD [article]  inAutism > 24-6 (August 2020) . - p.1423-1437 Titre : 'When my autism broke': A qualitative study spotlighting autistic voices on menopause Type de document : texte imprimé Auteurs : Rachel L. MOSELEY, Auteur ; Tanya DRUCE, Auteur ; Julie M. TURNER-COBB, Auteur Article en page(s) : p.1423-1437 Langues : Anglais (eng) Mots-clés : autistic people  autistic women  climacteric syndrome  knowledge  menopause  perimenopause  reproductive lifespan  sensory sensitivity  support Index. décimale : PER Périodiques Résumé : Autistic girls are known to struggle with the onset of menstruation, reporting that during their period, sensory sensitivities are heightened, it becomes more difficult to think clearly and control their emotions and they struggle more with everyday life and self-care. Yet surprisingly, nothing is known about how autistic women handle the menopausal transition in midlife. In non-autistic women, the menopause brings many physical changes and challenging symptoms from hot flushes to feeling more anxious and depressed. Because autistic women are already vulnerable to suicide, poor physical and mental health, and because they may already struggle with planning, controlling their emotions and coping with change, the menopause may be an especially challenging time. Yet, not one single study exists on the menopause in autism, so we conducted an online discussion (focus group) with seven autistic women. They confirmed that very little is known about menopause in autistic people, very little support is available and that menopause might be especially difficult for autistic people. Autism-related difficulties (including sensory sensitivity, socializing with others and communicating needs) were reported to worsen during the menopause, often so dramatically that some participants suggested they found it impossible to continue to mask their struggles. Participants also reported having extreme meltdowns, experiencing anxiety and depression, and feeling suicidal. This study highlights how important it is that professionals pay attention to menopause in autism, and discusses future research directions. En ligne : http://dx.doi.org/10.1177/1362361319901184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] 'When my autism broke': A qualitative study spotlighting autistic voices on menopause [texte imprimé] / Rachel L. MOSELEY, Auteur ; Tanya DRUCE, Auteur ; Julie M. TURNER-COBB, Auteur . - p.1423-1437. Langues : Anglais (eng) in Autism > 24-6 (August 2020) . - p.1423-1437 Mots-clés : autistic people  autistic women  climacteric syndrome  knowledge  menopause  perimenopause  reproductive lifespan  sensory sensitivity  support Index. décimale : PER Périodiques Résumé : Autistic girls are known to struggle with the onset of menstruation, reporting that during their period, sensory sensitivities are heightened, it becomes more difficult to think clearly and control their emotions and they struggle more with everyday life and self-care. Yet surprisingly, nothing is known about how autistic women handle the menopausal transition in midlife. In non-autistic women, the menopause brings many physical changes and challenging symptoms from hot flushes to feeling more anxious and depressed. Because autistic women are already vulnerable to suicide, poor physical and mental health, and because they may already struggle with planning, controlling their emotions and coping with change, the menopause may be an especially challenging time. Yet, not one single study exists on the menopause in autism, so we conducted an online discussion (focus group) with seven autistic women. They confirmed that very little is known about menopause in autistic people, very little support is available and that menopause might be especially difficult for autistic people. Autism-related difficulties (including sensory sensitivity, socializing with others and communicating needs) were reported to worsen during the menopause, often so dramatically that some participants suggested they found it impossible to continue to mask their struggles. Participants also reported having extreme meltdowns, experiencing anxiety and depression, and feeling suicidal. This study highlights how important it is that professionals pay attention to menopause in autism, and discusses future research directions. En ligne : http://dx.doi.org/10.1177/1362361319901184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428