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Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? / Jaqueline Bohrer SCHUCH in Research in Autism Spectrum Disorders, 26 (June 2016)
[article]
Titre : Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? Type de document : Texte imprimé et/ou numérique Auteurs : Jaqueline Bohrer SCHUCH, Auteur ; Diana MÜLLER, Auteur ; Renata Giuliani ENDRES, Auteur ; Cleonice Alves BOSA, Auteur ; Dânae LONGO, Auteur ; Lavinia SCHULER-FACCINI, Auteur ; Josiane RANZAN, Auteur ; Michele Michelin BECKER, Auteur ; Rudimar dos Santos RIESGO, Auteur ; Tatiana ROMAN, Auteur Article en page(s) : p.48-56 Langues : Anglais (eng) Mots-clés : ASD Serotonin transporter gene Clinical symptoms Sex differences Association Family-based test Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction and repetitive and stereotyped behaviors. Serotoninergic transmission has been suggested as an important neuronal pathway in ASD. In this study, we analyzed four polymorphisms (5HTTLPR, rs2066713, STin2, rs1042173; 5? ? 3? end) at the serotonin transporter gene (SLC6A4) in a sample of 209 ASD children and their biological parents. Both single markers and haplotypes were tested for association with ASD diagnosis and with clinical symptoms (aggression, echolalia, seizures, mood instability, psychomotor agitation, repetitive behaviors and sleep disorders) commonly present in ASD patients. The family-based analyses showed a significant result for one haplotype (H4: S-G-12R-T), which did not hold in global analyses. In male patients, a nominal association between the rs1042173 GG genotype and a diminished psychomotor agitation was observed; a trend for an association between the 5HTTLPR LaLa genotype and mood instability was also verified. Through interesting results that are mainly related to clinical manifestations and gender differences, our study adds to knowledge of ASD. Future investigations may corroborate the relevance of our data to upcoming clinical and pharmacological interventions. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.48-56[article] Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene? [Texte imprimé et/ou numérique] / Jaqueline Bohrer SCHUCH, Auteur ; Diana MÜLLER, Auteur ; Renata Giuliani ENDRES, Auteur ; Cleonice Alves BOSA, Auteur ; Dânae LONGO, Auteur ; Lavinia SCHULER-FACCINI, Auteur ; Josiane RANZAN, Auteur ; Michele Michelin BECKER, Auteur ; Rudimar dos Santos RIESGO, Auteur ; Tatiana ROMAN, Auteur . - p.48-56.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 26 (June 2016) . - p.48-56
Mots-clés : ASD Serotonin transporter gene Clinical symptoms Sex differences Association Family-based test Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction and repetitive and stereotyped behaviors. Serotoninergic transmission has been suggested as an important neuronal pathway in ASD. In this study, we analyzed four polymorphisms (5HTTLPR, rs2066713, STin2, rs1042173; 5? ? 3? end) at the serotonin transporter gene (SLC6A4) in a sample of 209 ASD children and their biological parents. Both single markers and haplotypes were tested for association with ASD diagnosis and with clinical symptoms (aggression, echolalia, seizures, mood instability, psychomotor agitation, repetitive behaviors and sleep disorders) commonly present in ASD patients. The family-based analyses showed a significant result for one haplotype (H4: S-G-12R-T), which did not hold in global analyses. In male patients, a nominal association between the rs1042173 GG genotype and a diminished psychomotor agitation was observed; a trend for an association between the 5HTTLPR LaLa genotype and mood instability was also verified. Through interesting results that are mainly related to clinical manifestations and gender differences, our study adds to knowledge of ASD. Future investigations may corroborate the relevance of our data to upcoming clinical and pharmacological interventions. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 Parental perception of stress and emotional-behavioural difficulties of children with autism spectrum disorder and specific language impairment / Magda DI RENZO in Autism & Developmental Language Impairments, 5 (January-December 2020)
[article]
Titre : Parental perception of stress and emotional-behavioural difficulties of children with autism spectrum disorder and specific language impairment Type de document : Texte imprimé et/ou numérique Auteurs : Magda DI RENZO, Auteur ; Federico BIANCHI DI CASTELBIANCO, Auteur ; Elena VANADIA, Auteur ; Massimiliano PETRILLO, Auteur ; Lidia RACINARO, Auteur ; Monica REA, Auteur Langues : Anglais (eng) Mots-clés : Autism spectrum disorder emotional difficulties parental perception clinical symptoms Index. décimale : PER Périodiques Résumé : Background and aimsThe daily challenges of caring for a child with autism spectrum disorder affect many areas of everyday life and parental well-being, as well as parents’ ability to manage the needs of the family and the child concerned. A better understanding of parents’ perception of their child’s characteristics can allow better support for them and individualize intervention protocols in a more accurate way. The main objective of this study is the evaluation of the perception of stress by parents of children with autism compared to parents of children with specific language impairment.MethodsThe parents of 87 children aged between 2 and 6?years were included in this study, 34 children with a specific language impairment diagnosis and 53 children with an autism spectrum disorder diagnosis (ASD) or at risk of developing it. They were asked to complete a self-report on perceived stress and rating scales on adaptive/problematic behaviours, executive functions and sensory profile of the child.ResultsThe results reveal that parents of ASD children, compared to the control group, showed significantly higher levels of stress, mainly due to the difficulty of managing unexpected events, the feeling of loss of control over one's life and the fear of not being able to cope with the adversities they were experiences. The most critical area, both for ASD and control group, concern the executive function related to emotional reactions.ConclusionsThus, we argue that the difficulties in self-control, sensory modulation and emotional regulation, represent an element of stress for parents of children with developmental disorders.Implications: Regarding the difficulties of children with ASD, supporting the ways in which caregivers adapt to the signals of children is an important strategy, which has now become a key element of treatments for autism mediated by parents. En ligne : http://dx.doi.org/10.1177/2396941520971502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Autism & Developmental Language Impairments > 5 (January-December 2020)[article] Parental perception of stress and emotional-behavioural difficulties of children with autism spectrum disorder and specific language impairment [Texte imprimé et/ou numérique] / Magda DI RENZO, Auteur ; Federico BIANCHI DI CASTELBIANCO, Auteur ; Elena VANADIA, Auteur ; Massimiliano PETRILLO, Auteur ; Lidia RACINARO, Auteur ; Monica REA, Auteur.
Langues : Anglais (eng)
in Autism & Developmental Language Impairments > 5 (January-December 2020)
Mots-clés : Autism spectrum disorder emotional difficulties parental perception clinical symptoms Index. décimale : PER Périodiques Résumé : Background and aimsThe daily challenges of caring for a child with autism spectrum disorder affect many areas of everyday life and parental well-being, as well as parents’ ability to manage the needs of the family and the child concerned. A better understanding of parents’ perception of their child’s characteristics can allow better support for them and individualize intervention protocols in a more accurate way. The main objective of this study is the evaluation of the perception of stress by parents of children with autism compared to parents of children with specific language impairment.MethodsThe parents of 87 children aged between 2 and 6?years were included in this study, 34 children with a specific language impairment diagnosis and 53 children with an autism spectrum disorder diagnosis (ASD) or at risk of developing it. They were asked to complete a self-report on perceived stress and rating scales on adaptive/problematic behaviours, executive functions and sensory profile of the child.ResultsThe results reveal that parents of ASD children, compared to the control group, showed significantly higher levels of stress, mainly due to the difficulty of managing unexpected events, the feeling of loss of control over one's life and the fear of not being able to cope with the adversities they were experiences. The most critical area, both for ASD and control group, concern the executive function related to emotional reactions.ConclusionsThus, we argue that the difficulties in self-control, sensory modulation and emotional regulation, represent an element of stress for parents of children with developmental disorders.Implications: Regarding the difficulties of children with ASD, supporting the ways in which caregivers adapt to the signals of children is an important strategy, which has now become a key element of treatments for autism mediated by parents. En ligne : http://dx.doi.org/10.1177/2396941520971502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438