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Associations between physical growth and general cognitive functioning in international adoptees from Eastern Europe at 30 months post-arrival / M. G. KROUPINA in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : Associations between physical growth and general cognitive functioning in international adoptees from Eastern Europe at 30 months post-arrival Type de document : Texte imprimé et/ou numérique Auteurs : M. G. KROUPINA, Auteur ; J. K. ECKERLE, Auteur ; A. J. FUGLESTAD, Auteur ; L. TOEMEN, Auteur ; S. MOBERG, Auteur ; J. H. HIMES, Auteur ; B. S. MILLER, Auteur ; A. PETRYK, Auteur ; D. E. JOHNSON, Auteur Article en page(s) : p.36 Langues : Anglais (eng) Mots-clés : Cognitive functioning Early adversity Growth hormone system International adoption Physical growth Index. décimale : PER Périodiques Résumé : BACKGROUND: Internationally adopted children have often experienced early adversity and growth suppression as a consequence of institutional care. Furthermore, these children are at risk for impaired cognitive development due to their early adverse experiences. This study examined the association between physical growth, the growth hormone (GH) system, and general cognitive functioning post-adoption. Based on previous research, we expected to find that a child's initial physical growth status and normalization of the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis would be positive predictors of general cognitive functioning. METHODS: Post-institutionalized children (n = 46) adopted from Eastern Europe were seen approximately 1 month after their arrival into the USA to determine baseline measurements. They were seen again 6 and 30 months later for two follow-up sessions. Measures included anthropometry, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), Mullen Scales of Early Learning, and Stanford-Binet Intelligence Scales. Information about parental education was also collected. RESULTS: We found that a child's general cognitive functioning at 30 months post-adoption was predicted by their general developmental scores at 6 months post-adoption, their initial height status, and markers of the growth hormone system. Children with lower initial IGFBP-3 standard deviation (SD) scores had higher verbal IQ scores at 30 months. Furthermore, a child's initial height was found to be a significant positive predictor of non-verbal IQ. CONCLUSIONS: These results suggest an association between a child's suppressed physical growth in response to early adversity and alterations in GH system functioning and subsequent recovery in cognitive functioning. En ligne : http://dx.doi.org/10.1186/s11689-015-9132-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.36[article] Associations between physical growth and general cognitive functioning in international adoptees from Eastern Europe at 30 months post-arrival [Texte imprimé et/ou numérique] / M. G. KROUPINA, Auteur ; J. K. ECKERLE, Auteur ; A. J. FUGLESTAD, Auteur ; L. TOEMEN, Auteur ; S. MOBERG, Auteur ; J. H. HIMES, Auteur ; B. S. MILLER, Auteur ; A. PETRYK, Auteur ; D. E. JOHNSON, Auteur . - p.36.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.36
Mots-clés : Cognitive functioning Early adversity Growth hormone system International adoption Physical growth Index. décimale : PER Périodiques Résumé : BACKGROUND: Internationally adopted children have often experienced early adversity and growth suppression as a consequence of institutional care. Furthermore, these children are at risk for impaired cognitive development due to their early adverse experiences. This study examined the association between physical growth, the growth hormone (GH) system, and general cognitive functioning post-adoption. Based on previous research, we expected to find that a child's initial physical growth status and normalization of the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis would be positive predictors of general cognitive functioning. METHODS: Post-institutionalized children (n = 46) adopted from Eastern Europe were seen approximately 1 month after their arrival into the USA to determine baseline measurements. They were seen again 6 and 30 months later for two follow-up sessions. Measures included anthropometry, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), Mullen Scales of Early Learning, and Stanford-Binet Intelligence Scales. Information about parental education was also collected. RESULTS: We found that a child's general cognitive functioning at 30 months post-adoption was predicted by their general developmental scores at 6 months post-adoption, their initial height status, and markers of the growth hormone system. Children with lower initial IGFBP-3 standard deviation (SD) scores had higher verbal IQ scores at 30 months. Furthermore, a child's initial height was found to be a significant positive predictor of non-verbal IQ. CONCLUSIONS: These results suggest an association between a child's suppressed physical growth in response to early adversity and alterations in GH system functioning and subsequent recovery in cognitive functioning. En ligne : http://dx.doi.org/10.1186/s11689-015-9132-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 Associations of age, anxiety, cognitive functioning, and social impairment with aggression in youth with autism / Ethan RINALDO in Research in Autism Spectrum Disorders, 108 (October 2023)
[article]
Titre : Associations of age, anxiety, cognitive functioning, and social impairment with aggression in youth with autism Type de document : Texte imprimé et/ou numérique Auteurs : Ethan RINALDO, Auteur ; Adrienne PERRY, Auteur Article en page(s) : p.102246 Mots-clés : Autism Aggression Anxiety Social impairment Cognitive functioning Index. décimale : PER Périodiques Résumé : Background Previous research has indicated that aggression in children with autism is associated with cognitive functioning, age, anxiety, and social functioning, although most samples only include parent-report measures and participants without intellectual disability. Furthermore, there is a lack of research investigating how different aspects of social impairment are associated with aggressive behaviour in youth with autism while anxiety is included in the analyses. The aim of this study was to clarify the relationships of these variables with aggression in a large sample, diverse in age and cognitive level, using both parent- and teacher-report measures. Method Participants were 1179 youth (age 4-18) with a diagnosis of autism spectrum disorder, from the SFARI database. Parent- and teacher-report measures were obtained for aggression, anxiety, and social impairment. Univariate statistics were calculated to determine how each variable was associated with aggression and hierarchical regressions were conducted with all variables together. Results Age and intellectual disability presence/severity had small positive relationships with teacher-measured aggression while anxiety and social impairment severity had strong relationships with aggression when rated by both parents and teachers. In a regression analysis, anxiety and social communication problems had the strongest positive relationships with aggression while social motivation problems had a negative relationship with aggression. Conclusion These results indicate the importance of anxiety and social problems, particularly in social communication and motivation, when studying and treating aggression in youth with autism. En ligne : https://doi.org/10.1016/j.rasd.2023.102246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102246[article] Associations of age, anxiety, cognitive functioning, and social impairment with aggression in youth with autism [Texte imprimé et/ou numérique] / Ethan RINALDO, Auteur ; Adrienne PERRY, Auteur . - p.102246.
in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102246
Mots-clés : Autism Aggression Anxiety Social impairment Cognitive functioning Index. décimale : PER Périodiques Résumé : Background Previous research has indicated that aggression in children with autism is associated with cognitive functioning, age, anxiety, and social functioning, although most samples only include parent-report measures and participants without intellectual disability. Furthermore, there is a lack of research investigating how different aspects of social impairment are associated with aggressive behaviour in youth with autism while anxiety is included in the analyses. The aim of this study was to clarify the relationships of these variables with aggression in a large sample, diverse in age and cognitive level, using both parent- and teacher-report measures. Method Participants were 1179 youth (age 4-18) with a diagnosis of autism spectrum disorder, from the SFARI database. Parent- and teacher-report measures were obtained for aggression, anxiety, and social impairment. Univariate statistics were calculated to determine how each variable was associated with aggression and hierarchical regressions were conducted with all variables together. Results Age and intellectual disability presence/severity had small positive relationships with teacher-measured aggression while anxiety and social impairment severity had strong relationships with aggression when rated by both parents and teachers. In a regression analysis, anxiety and social communication problems had the strongest positive relationships with aggression while social motivation problems had a negative relationship with aggression. Conclusion These results indicate the importance of anxiety and social problems, particularly in social communication and motivation, when studying and treating aggression in youth with autism. En ligne : https://doi.org/10.1016/j.rasd.2023.102246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 Comparing cognitive functioning in schizophrenia and autism using WAIS-III / Marion DE BOER in Research in Autism Spectrum Disorders, 8-7 (July 2014)
[article]
Titre : Comparing cognitive functioning in schizophrenia and autism using WAIS-III Type de document : Texte imprimé et/ou numérique Auteurs : Marion DE BOER, Auteur ; Annelies A. SPEK, Auteur ; Jill LOBBESTAEL, Auteur Article en page(s) : p.737-745 Langues : Anglais (eng) Mots-clés : Schizophrenia Autism Cognitive functioning WAIS-III Processing speed Index. décimale : PER Périodiques Résumé : Abstract The main goal of this study was to investigate differences and similarities in general cognitive functioning between adults with schizophrenia and autism, because this has not been systematically investigated. We used a cross-sectional design to compare adults with schizophrenia (n = 27), with autism (n = 114) and a healthy control group (n = 30). Schizophrenia diagnoses were based on the Structured Clinical Interview for the DSM-IV Axis I (SCID-I) and behavioral symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Autism was diagnosed with a DSM-IV questionnaire for autism spectrum disorders and the Autistic Diagnostic Interview, revised version. The Wechsler Adult Intelligence Scale, third version (WAIS-III) was used to assess cognitive functions. All participants were between 18 and 65 years of age and had a minimum full scale intelligence of 80. Results showed that patients with schizophrenia scored significantly lower on processing speed than patients with autism and the healthy control group. Differences on other index scales were not found. In participants with schizophrenia a correlation was found between processing speed impairment and negative symptoms. Diagnosis could be predicted correctly with WAIS-III profile in 70.4% of the cases with schizophrenia compared to 56.7% of the healthy control group and 22.8% of the autism group. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.737-745[article] Comparing cognitive functioning in schizophrenia and autism using WAIS-III [Texte imprimé et/ou numérique] / Marion DE BOER, Auteur ; Annelies A. SPEK, Auteur ; Jill LOBBESTAEL, Auteur . - p.737-745.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.737-745
Mots-clés : Schizophrenia Autism Cognitive functioning WAIS-III Processing speed Index. décimale : PER Périodiques Résumé : Abstract The main goal of this study was to investigate differences and similarities in general cognitive functioning between adults with schizophrenia and autism, because this has not been systematically investigated. We used a cross-sectional design to compare adults with schizophrenia (n = 27), with autism (n = 114) and a healthy control group (n = 30). Schizophrenia diagnoses were based on the Structured Clinical Interview for the DSM-IV Axis I (SCID-I) and behavioral symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Autism was diagnosed with a DSM-IV questionnaire for autism spectrum disorders and the Autistic Diagnostic Interview, revised version. The Wechsler Adult Intelligence Scale, third version (WAIS-III) was used to assess cognitive functions. All participants were between 18 and 65 years of age and had a minimum full scale intelligence of 80. Results showed that patients with schizophrenia scored significantly lower on processing speed than patients with autism and the healthy control group. Differences on other index scales were not found. In participants with schizophrenia a correlation was found between processing speed impairment and negative symptoms. Diagnosis could be predicted correctly with WAIS-III profile in 70.4% of the cases with schizophrenia compared to 56.7% of the healthy control group and 22.8% of the autism group. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers / Caitlin M. HUDAC in Autism Research, 13-8 (August 2020)
[article]
Titre : Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers Type de document : Texte imprimé et/ou numérique Auteurs : Caitlin M. HUDAC, Auteur ; Joanna BOVE, Auteur ; Shelley BARBER, Auteur ; Michael DUYZEND, Auteur ; Ari WALLACE, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur ; Ellen HANSON, Auteur ; Robin P GOIN-KOCHEL, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Wendy K. CHUNG, Auteur ; Evan E. EICHLER, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.1300-1310 Langues : Anglais (eng) Mots-clés : 16p11.2 deletion 16p11.2 duplication adaptive functioning autism spectrum disorder cognitive functioning individual variability/heterogeneity Index. décimale : PER Périodiques Résumé : Individuals with 16p11.2 copy number variant (CNV) show considerable phenotypic heterogeneity. Although autism spectrum disorder (ASD) is reported in approximately 20-23% of individuals with 16p11.2 CNVs, ASD-associated symptoms are observed in those without a clinical ASD diagnosis. Previous work has shown that genetic variation and prenatal and perinatal birth complications influence ASD risk and symptom severity. This study examined the impact of genetic and environmental risk factors on phenotypic heterogeneity among 16p11.2 CNV carriers. Participants included individuals with a 16p11.2 deletion (N = 96) or duplication (N = 77) with exome sequencing from the Simons VIP study. The presence of prenatal factors, perinatal events, additional genetic events, and gender was studied. Regression analyses examined the contribution of each risk factor on ASD symptomatology, cognitive functioning, and adaptive abilities. For deletion carriers, perinatal and additional genetic events were associated with increased ASD symptomatology and decrements in cognitive and adaptive functioning. For duplication carriers, secondary genetic events were associated with greater cognitive impairments. Being female sex was a protective factor for both deletion and duplication carriers. Our findings suggest that ASD-associated risk factors contribute to the variability in symptom presentation in individuals with 16p11.2 CNVs. LAY SUMMARY: There are a wide range of autism spectrum disorder (ASD) symptoms and abilities observed for individuals with genetic changes of the 16p11.2 region. Here, we found perinatal complications contributed to more severe ASD symptoms (deletion carriers) and additional genetic mutations contributed to decreased cognitive abilities (deletion and duplication carriers). A potential protective factor was also observed for females with 16p11.2 variations. Autism Res 2020, 13: 1300-1310. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Autism Research > 13-8 (August 2020) . - p.1300-1310[article] Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers [Texte imprimé et/ou numérique] / Caitlin M. HUDAC, Auteur ; Joanna BOVE, Auteur ; Shelley BARBER, Auteur ; Michael DUYZEND, Auteur ; Ari WALLACE, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur ; Ellen HANSON, Auteur ; Robin P GOIN-KOCHEL, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Wendy K. CHUNG, Auteur ; Evan E. EICHLER, Auteur ; Raphael BERNIER, Auteur . - p.1300-1310.
Langues : Anglais (eng)
in Autism Research > 13-8 (August 2020) . - p.1300-1310
Mots-clés : 16p11.2 deletion 16p11.2 duplication adaptive functioning autism spectrum disorder cognitive functioning individual variability/heterogeneity Index. décimale : PER Périodiques Résumé : Individuals with 16p11.2 copy number variant (CNV) show considerable phenotypic heterogeneity. Although autism spectrum disorder (ASD) is reported in approximately 20-23% of individuals with 16p11.2 CNVs, ASD-associated symptoms are observed in those without a clinical ASD diagnosis. Previous work has shown that genetic variation and prenatal and perinatal birth complications influence ASD risk and symptom severity. This study examined the impact of genetic and environmental risk factors on phenotypic heterogeneity among 16p11.2 CNV carriers. Participants included individuals with a 16p11.2 deletion (N = 96) or duplication (N = 77) with exome sequencing from the Simons VIP study. The presence of prenatal factors, perinatal events, additional genetic events, and gender was studied. Regression analyses examined the contribution of each risk factor on ASD symptomatology, cognitive functioning, and adaptive abilities. For deletion carriers, perinatal and additional genetic events were associated with increased ASD symptomatology and decrements in cognitive and adaptive functioning. For duplication carriers, secondary genetic events were associated with greater cognitive impairments. Being female sex was a protective factor for both deletion and duplication carriers. Our findings suggest that ASD-associated risk factors contribute to the variability in symptom presentation in individuals with 16p11.2 CNVs. LAY SUMMARY: There are a wide range of autism spectrum disorder (ASD) symptoms and abilities observed for individuals with genetic changes of the 16p11.2 region. Here, we found perinatal complications contributed to more severe ASD symptoms (deletion carriers) and additional genetic mutations contributed to decreased cognitive abilities (deletion and duplication carriers). A potential protective factor was also observed for females with 16p11.2 variations. Autism Res 2020, 13: 1300-1310. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 Local processing and social skills in children with Autism Spectrum Disorders: The role of anxiety and cognitive functioning / Trenesha L. HILL in Research in Autism Spectrum Disorders, 8-9 (September 2014)
[article]
Titre : Local processing and social skills in children with Autism Spectrum Disorders: The role of anxiety and cognitive functioning Type de document : Texte imprimé et/ou numérique Auteurs : Trenesha L. HILL, Auteur ; R. Enrique VARELA, Auteur ; Jodi L. KAMPS, Auteur ; Laura A. NIDITCH, Auteur Article en page(s) : p.1243-1251 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Local processing Anxiety Social skills Cognitive functioning Index. décimale : PER Périodiques Résumé : Abstract The present study examined the relations between anxiety, cognitive functioning, local processing, and social skills in a group of 102 children diagnosed with an Autism Spectrum Disorder. The results indicated that children diagnosed with Asperger's Disorder had significantly higher cognitive functioning and enhanced local processing (i.e., Block Design scores) compared to those diagnosed with Autistic Disorder or PDD-NOS. Regression analyses results showed that anxiety and cognitive functioning moderated the association between local processing and social skills. For children with low cognitive functioning and high anxiety, greater local processing was associated with poorer social skills than those with high cognitive functioning, high anxiety, and greater local processing. For children with high cognitive functioning and high anxiety, enhanced local processing was associated with better social skills than those with high cognitive functioning and reduced local processing. Implications of these findings are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1243-1251[article] Local processing and social skills in children with Autism Spectrum Disorders: The role of anxiety and cognitive functioning [Texte imprimé et/ou numérique] / Trenesha L. HILL, Auteur ; R. Enrique VARELA, Auteur ; Jodi L. KAMPS, Auteur ; Laura A. NIDITCH, Auteur . - p.1243-1251.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-9 (September 2014) . - p.1243-1251
Mots-clés : Autism spectrum disorders Local processing Anxiety Social skills Cognitive functioning Index. décimale : PER Périodiques Résumé : Abstract The present study examined the relations between anxiety, cognitive functioning, local processing, and social skills in a group of 102 children diagnosed with an Autism Spectrum Disorder. The results indicated that children diagnosed with Asperger's Disorder had significantly higher cognitive functioning and enhanced local processing (i.e., Block Design scores) compared to those diagnosed with Autistic Disorder or PDD-NOS. Regression analyses results showed that anxiety and cognitive functioning moderated the association between local processing and social skills. For children with low cognitive functioning and high anxiety, greater local processing was associated with poorer social skills than those with high cognitive functioning, high anxiety, and greater local processing. For children with high cognitive functioning and high anxiety, enhanced local processing was associated with better social skills than those with high cognitive functioning and reduced local processing. Implications of these findings are discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.06.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Revisiting Cognitive and Adaptive Functioning in Children and Adolescents with Autism Spectrum Disorder / Nicole L. MATTHEWS in Journal of Autism and Developmental Disorders, 45-1 (January 2015)
PermalinkAdaptive Functioning in Autism Spectrum Disorder During the Transition to Adulthood / Nicole L. MATTHEWS in Journal of Autism and Developmental Disorders, 45-8 (August 2015)
PermalinkCo-occurring Down Syndrome and Autism Spectrum Disorder: Cognitive, Adaptive, and Behavioral Characteristics / K. R. BRADBURY in Journal of Autism and Developmental Disorders, 52-3 (March 2022)
PermalinkCross-Sectional Evidence for a Decrease in Cognitive Function With Age in Children With Autism Spectrum Disorders? / Petra Suzanne BARNEVELD in Autism Research, 7-5 (October 2014)
PermalinkToward the identification of adaptive functioning intervention targets for intellectually-able, transition-aged youth with autism: An examination of caregiver responses on the Vineland-II / Nicole L. MATTHEWS in Autism Research, 10-12 (December 2017)
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