8 recherche sur le mot-clé 'Diffusion Magnetic Resonance Imaging'

A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children / Derek Sayre ANDREWS in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 32 Titre : A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children Type de document : texte imprimé Auteurs : Derek Sayre ANDREWS, Auteur ; Joshua K. LEE, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur Article en page(s) : 32 Langues : Anglais (eng) Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Child, Preschool  Cross-Sectional Studies  Diffusion Magnetic Resonance Imaging  Female  Humans  Image Processing, Computer-Assisted  Male  Sex Characteristics  White Matter/diagnostic imaging/pathology Index. décimale : PER Périodiques Résumé : BACKGROUND: The core symptoms of autism spectrum disorder (ASD) are widely theorized to result from altered brain connectivity. Diffusion-weighted magnetic resonance imaging (DWI) has been a versatile method for investigating underlying microstructural properties of white matter (WM) in ASD. Despite phenotypic and etiological heterogeneity, DWI studies in majority male samples of older children, adolescents, and adults with ASD have largely reported findings of decreased fractional anisotropy (FA) across several commissural, projection, and association fiber tracts. However, studies in preschool-aged children (i.e., < 30-40 months) suggest individuals with ASD have increased measures of WM FA earlier in development. METHODS: We analyzed 127 individuals with ASD (85♂, 42♀) and 54 typically developing (TD) controls (42♂, 26♀), aged 25.1-49.6 months. Voxel-wise effects of ASD diagnosis, sex, age, and their interaction on DWI measures of FA, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were investigated using tract-based spatial statistics (TBSS) while controlling mean absolute and relative motion. RESULTS: Compared to TD controls, males and females with ASD had significantly increased measures of FA in eight clusters (threshold-free cluster enhancement p < 0.05) that incorporated several WM tracts including regions of the genu, body, and splenium of the corpus callosum, inferior frontal-occipital fasciculi, inferior and superior longitudinal fasciculi, middle and superior cerebellar peduncles, and corticospinal tract. A diagnosis by sex interaction was observed in measures of AD across six significant clusters incorporating areas of the body, genu, and splenium of the corpus collosum. In these tracts, females with ASD showed increased AD compared to TD females, while males with ASD showed decreased AD compared to TD males. CONCLUSIONS: The current findings support growing evidence that preschool-aged children with ASD have atypical measures of WM microstructure that appear to differ in directionality from alterations observed in older individuals with the condition. To our knowledge, this study represents the largest sample of preschool-aged females with ASD to be evaluated using DWI. Microstructural differences associated with ASD largely overlapped between sexes. However, differential relationships of AD measures indicate that sex likely modulates ASD neuroanatomical phenotypes. Further longitudinal study is needed to confirm and quantify the developmental relationship of WM structure in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9291-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children [texte imprimé] / Derek Sayre ANDREWS, Auteur ; Joshua K. LEE, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur . - 32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 32 Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Child, Preschool  Cross-Sectional Studies  Diffusion Magnetic Resonance Imaging  Female  Humans  Image Processing, Computer-Assisted  Male  Sex Characteristics  White Matter/diagnostic imaging/pathology Index. décimale : PER Périodiques Résumé : BACKGROUND: The core symptoms of autism spectrum disorder (ASD) are widely theorized to result from altered brain connectivity. Diffusion-weighted magnetic resonance imaging (DWI) has been a versatile method for investigating underlying microstructural properties of white matter (WM) in ASD. Despite phenotypic and etiological heterogeneity, DWI studies in majority male samples of older children, adolescents, and adults with ASD have largely reported findings of decreased fractional anisotropy (FA) across several commissural, projection, and association fiber tracts. However, studies in preschool-aged children (i.e., < 30-40 months) suggest individuals with ASD have increased measures of WM FA earlier in development. METHODS: We analyzed 127 individuals with ASD (85♂, 42♀) and 54 typically developing (TD) controls (42♂, 26♀), aged 25.1-49.6 months. Voxel-wise effects of ASD diagnosis, sex, age, and their interaction on DWI measures of FA, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were investigated using tract-based spatial statistics (TBSS) while controlling mean absolute and relative motion. RESULTS: Compared to TD controls, males and females with ASD had significantly increased measures of FA in eight clusters (threshold-free cluster enhancement p < 0.05) that incorporated several WM tracts including regions of the genu, body, and splenium of the corpus callosum, inferior frontal-occipital fasciculi, inferior and superior longitudinal fasciculi, middle and superior cerebellar peduncles, and corticospinal tract. A diagnosis by sex interaction was observed in measures of AD across six significant clusters incorporating areas of the body, genu, and splenium of the corpus collosum. In these tracts, females with ASD showed increased AD compared to TD females, while males with ASD showed decreased AD compared to TD males. CONCLUSIONS: The current findings support growing evidence that preschool-aged children with ASD have atypical measures of WM microstructure that appear to differ in directionality from alterations observed in older individuals with the condition. To our knowledge, this study represents the largest sample of preschool-aged females with ASD to be evaluated using DWI. Microstructural differences associated with ASD largely overlapped between sexes. However, differential relationships of AD measures indicate that sex likely modulates ASD neuroanatomical phenotypes. Further longitudinal study is needed to confirm and quantify the developmental relationship of WM structure in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9291-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA / June Christoph KANG in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA Type de document : texte imprimé Auteurs : June Christoph KANG, Auteur ; SuHyuk CHI, Auteur ; Young Eun MOK, Auteur ; Jeong-Ahn KIM, Auteur ; So Hyun KIM, Auteur ; Moon Soo LEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Tic Disorders/diagnostic imaging/physiopathology/pathology  Diffusion Tensor Imaging  Adolescent  Corpus Callosum/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Tic disorder is a neuropsychiatric disorder characterized by involuntary movements or vocalizations. Previous studies utilizing diffusion-weighted imaging to explore white-matter alterations in tic disorders have reported inconsistent results regarding the affected tracts. We aimed to address this gap by employing a novel tractography technique for more detailed analysis. METHODS: We analyzed MRI data from 23 children with tic disorders and 23 healthy controls using TRActs Constrained by UnderLying Anatomy (TRACULA), an advanced automated probabilistic tractography method. We examined fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity, and mean diffusivity in 42 specific significant white matter tracts. RESULTS: Our findings revealed notable differences in the children with tic disorders compared to the control group. Specifically, there was a significant reduction in FA in the parietal part and splenium of the corpus callosum and the left corticospinal tract. Increased RD was observed in the temporal and splenium areas of the corpus callosum, the left corticospinal tract, and the left acoustic radiation. A higher mean diffusivity was also noted in the left middle longitudinal fasciculus. A significant correlation emerged between the severity of motor symptoms, measured by the Yale Global Tic Severity Scale, and FA in the parietal part of the corpus callosum, as well as RD in the left acoustic radiation. CONCLUSION: These results indicate a pattern of reduced interhemispheric connectivity in the corpus callosum, aligning with previous studies and novel findings in the diffusion indices changes in the left corticospinal tract, left acoustic radiation, and left middle longitudinal fasciculus. Tic disorders might involve structural abnormalities in key white matter tracts, offering new insights into their pathogenesis. En ligne : https://dx.doi.org/10.1186/s11689-024-09558-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA [texte imprimé] / June Christoph KANG, Auteur ; SuHyuk CHI, Auteur ; Young Eun MOK, Auteur ; Jeong-Ahn KIM, Auteur ; So Hyun KIM, Auteur ; Moon Soo LEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Tic Disorders/diagnostic imaging/physiopathology/pathology  Diffusion Tensor Imaging  Adolescent  Corpus Callosum/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Tic disorder is a neuropsychiatric disorder characterized by involuntary movements or vocalizations. Previous studies utilizing diffusion-weighted imaging to explore white-matter alterations in tic disorders have reported inconsistent results regarding the affected tracts. We aimed to address this gap by employing a novel tractography technique for more detailed analysis. METHODS: We analyzed MRI data from 23 children with tic disorders and 23 healthy controls using TRActs Constrained by UnderLying Anatomy (TRACULA), an advanced automated probabilistic tractography method. We examined fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity, and mean diffusivity in 42 specific significant white matter tracts. RESULTS: Our findings revealed notable differences in the children with tic disorders compared to the control group. Specifically, there was a significant reduction in FA in the parietal part and splenium of the corpus callosum and the left corticospinal tract. Increased RD was observed in the temporal and splenium areas of the corpus callosum, the left corticospinal tract, and the left acoustic radiation. A higher mean diffusivity was also noted in the left middle longitudinal fasciculus. A significant correlation emerged between the severity of motor symptoms, measured by the Yale Global Tic Severity Scale, and FA in the parietal part of the corpus callosum, as well as RD in the left acoustic radiation. CONCLUSION: These results indicate a pattern of reduced interhemispheric connectivity in the corpus callosum, aligning with previous studies and novel findings in the diffusion indices changes in the left corticospinal tract, left acoustic radiation, and left middle longitudinal fasciculus. Tic disorders might involve structural abnormalities in key white matter tracts, offering new insights into their pathogenesis. En ligne : https://dx.doi.org/10.1186/s11689-024-09558-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study / Linyan FU in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.628-640 Titre : Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study Type de document : texte imprimé Auteurs : Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.628-640 Langues : Anglais (eng) Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/genetics  Child  Child, Preschool  Diffusion Magnetic Resonance Imaging  Diffusion Tensor Imaging/methods  Humans  White Matter  autism spectrum disorder  environmental effects  genetic factors  limbic tracts  twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9 years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study [texte imprimé] / Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur . - p.628-640. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.628-640 Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/genetics  Child  Child, Preschool  Diffusion Magnetic Resonance Imaging  Diffusion Tensor Imaging/methods  Humans  White Matter  autism spectrum disorder  environmental effects  genetic factors  limbic tracts  twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9 years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder / Kristine MCLAUGHLIN in Autism Research, 11-3 (March 2018)  

Public ISBD [article]  inAutism Research > 11-3 (March 2018) . - p.450-462 Titre : Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder Type de document : texte imprimé Auteurs : Kristine MCLAUGHLIN, Auteur ; Brittany G. TRAVERS, Auteur ; Olga I. DADALKO, Auteur ; Douglas C. DEAN III, Auteur ; Do TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Abigail FREEMAN, Auteur ; Molly D.B. PRIGGE, Auteur ; Alyson L. FROEHLICH, Auteur ; Tyler C. DUFFIELD, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Jeffrey S. ANDERSON, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.450-462 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  diffusion magnetic resonance imaging  internal capsule  thalamus  white matter Index. décimale : PER Périodiques Résumé : The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal). Our results showed that the group with ASD exhibited different developmental trajectories of microstructure in all regions, demonstrating childhood group differences that appeared to approach and, in some cases, surpass the typically developing group in adolescence and adulthood. The PLIC (but not ALIC nor thalamus) mediated the relation between age and finger-tapping speed in both groups. Yet, the gap in finger-tapping speed appeared to widen at the same time that the between-group gap in the PLIC appeared to narrow. Overall, these results suggest that childhood group differences in microstructure of the thalamus and PLIC become less robust in adolescence and adulthood. Further, finger-tapping speed appears to be mediated by the PLIC in both groups, but group differences in motor speed that widen during adolescence and adulthood suggest that factors beyond the microstructure of the thalamus and internal capsule may contribute to atypical motor profiles in ASD. Autism Res 2018, 11: 450-462. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Microstructure of the thalamus, a key sensory and motor brain area, appears to develop differently in individuals with autism spectrum disorder (ASD). Microstructure is important because it informs us of the density and organization of different brain tissues. During childhood, thalamic microstructure was distinct in the ASD group compared to the typically developing group. However, these group differences appeared to narrow with age, suggesting that the thalamus continues to dynamically change in ASD into adulthood. En ligne : http://dx.doi.org/10.1002/aur.1909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder [texte imprimé] / Kristine MCLAUGHLIN, Auteur ; Brittany G. TRAVERS, Auteur ; Olga I. DADALKO, Auteur ; Douglas C. DEAN III, Auteur ; Do TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Abigail FREEMAN, Auteur ; Molly D.B. PRIGGE, Auteur ; Alyson L. FROEHLICH, Auteur ; Tyler C. DUFFIELD, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Jeffrey S. ANDERSON, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.450-462. Langues : Anglais (eng) in Autism Research > 11-3 (March 2018) . - p.450-462 Mots-clés : autism spectrum disorder  diffusion magnetic resonance imaging  internal capsule  thalamus  white matter Index. décimale : PER Périodiques Résumé : The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal). Our results showed that the group with ASD exhibited different developmental trajectories of microstructure in all regions, demonstrating childhood group differences that appeared to approach and, in some cases, surpass the typically developing group in adolescence and adulthood. The PLIC (but not ALIC nor thalamus) mediated the relation between age and finger-tapping speed in both groups. Yet, the gap in finger-tapping speed appeared to widen at the same time that the between-group gap in the PLIC appeared to narrow. Overall, these results suggest that childhood group differences in microstructure of the thalamus and PLIC become less robust in adolescence and adulthood. Further, finger-tapping speed appears to be mediated by the PLIC in both groups, but group differences in motor speed that widen during adolescence and adulthood suggest that factors beyond the microstructure of the thalamus and internal capsule may contribute to atypical motor profiles in ASD. Autism Res 2018, 11: 450-462. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Microstructure of the thalamus, a key sensory and motor brain area, appears to develop differently in individuals with autism spectrum disorder (ASD). Microstructure is important because it informs us of the density and organization of different brain tissues. During childhood, thalamic microstructure was distinct in the ASD group compared to the typically developing group. However, these group differences appeared to narrow with age, suggesting that the thalamus continues to dynamically change in ASD into adulthood. En ligne : http://dx.doi.org/10.1002/aur.1909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients / Chia-Jui HSU in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients Type de document : texte imprimé Auteurs : Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients [texte imprimé] / Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

White matter microstructure of children with sensory over-responsivity is associated with affective behavior / Jamie WREN-JARVIS in Journal of Neurodevelopmental Disorders, 16 (2024)  

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Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years / Danielle CHRISTENSEN ; Jingying WANG ; Desirae J. SHIRLEY ; Ann-Marie ORLANDO ; Regilda A. ROMERO ; David E. VAILLANCOURT ; Bradley J. WILKES ; Stephen A. COOMBES ; Zheng WANG in Molecular Autism, 16 (2025)  

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The impact of expressive language development and the left inferior longitudinal fasciculus on listening and reading comprehension / Stephanie N. DEL TUFO in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

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