2 recherche sur le mot-clé 'G × E'

Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information / Jennifer L. HUDSON in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Titre : Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.1086-1094 Langues : Anglais (eng) Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information [Texte imprimé et/ou numérique] / Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur . - p.1086-1094. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects / Maartje P.C.M. LUIJK in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307 Titre : Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects Type de document : Texte imprimé et/ou numérique Auteurs : Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Année de publication : 2011 Article en page(s) : p.1295-1307 Langues : Anglais (eng) Mots-clés : Attachment  Strange Situation Procedure  candidate genes  parenting  sensitivity  G × E Index. décimale : PER Périodiques Résumé : Background and methods:  In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure. Results:  We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples. Conclusions:  This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 [article] Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects [Texte imprimé et/ou numérique] / Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - 2011 . - p.1295-1307. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307 Mots-clés : Attachment  Strange Situation Procedure  candidate genes  parenting  sensitivity  G × E Index. décimale : PER Périodiques Résumé : Background and methods:  In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure. Results:  We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples. Conclusions:  This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147