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Initial action output and feedback-guided motor behaviors in autism spectrum disorder / K. E. UNRUH in Molecular Autism, 12 (2021)
[article]
Titre : Initial action output and feedback-guided motor behaviors in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. E. UNRUH, Auteur ; W. S. MCKINNEY, Auteur ; E. K. BOJANEK, Auteur ; K. K. FLEMING, Auteur ; J. A. SWEENEY, Auteur ; M. W. MOSCONI, Auteur Article en page(s) : 52 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD) Eye movement Lateralization Precision grip Sensorimotor Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensorimotor issues are common in autism spectrum disorder (ASD), related to core symptoms, and predictive of worse functional outcomes. Deficits in rapid behaviors supported primarily by feedforward mechanisms, and continuous, feedback-guided motor behaviors each have been reported, but the degrees to which they are distinct or co-segregate within individuals and across development are not well understood. METHODS: We characterized behaviors that varied in their involvement of feedforward control relative to feedback control across skeletomotor (precision grip force) and oculomotor (saccades) control systems in 109 individuals with ASD and 101 age-matched typically developing controls (range: 5-29 years) including 58 individuals with ASD and 57 controls who completed both grip and saccade tests. Grip force was examined across multiple force (15, 45, and 85% MVC) and visual gain levels (low, medium, high). Maximum grip force also was examined. During grip force tests, reaction time, initial force output accuracy, variability, and entropy were examined. For the saccade test, latency, accuracy, and trial-wise variability of latency and accuracy were examined. RESULTS: Relative to controls, individuals with ASD showed similar accuracy of initial grip force but reduced accuracy of saccadic eye movements specific to older ages of our sample. Force variability was greater in ASD relative to controls, but saccade gain variability (across trials) was not different between groups. Force entropy was reduced in ASD, especially at older ages. We also find reduced grip strength in ASD that was more severe in dominant compared to non-dominant hands. LIMITATIONS: Our age-related findings rely on cross-sectional data. Longitudinal studies of sensorimotor behaviors and their associations with ASD symptoms are needed. CONCLUSIONS: We identify reduced accuracy of initial motor output in ASD that was specific to the oculomotor system implicating deficient feedforward control that may be mitigated during slower occurring behaviors executed in the periphery. Individuals with ASD showed increased continuous force variability but similar levels of trial-to-trial saccade accuracy variability suggesting that feedback-guided refinement of motor commands is deficient specifically when adjustments occur rapidly during continuous behavior. We also document reduced lateralization of grip strength in ASD implicating atypical hemispheric specialization. En ligne : http://dx.doi.org/10.1186/s13229-021-00452-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 52 p.[article] Initial action output and feedback-guided motor behaviors in autism spectrum disorder [Texte imprimé et/ou numérique] / K. E. UNRUH, Auteur ; W. S. MCKINNEY, Auteur ; E. K. BOJANEK, Auteur ; K. K. FLEMING, Auteur ; J. A. SWEENEY, Auteur ; M. W. MOSCONI, Auteur . - 52 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 52 p.
Mots-clés : Autism spectrum disorder (ASD) Eye movement Lateralization Precision grip Sensorimotor Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensorimotor issues are common in autism spectrum disorder (ASD), related to core symptoms, and predictive of worse functional outcomes. Deficits in rapid behaviors supported primarily by feedforward mechanisms, and continuous, feedback-guided motor behaviors each have been reported, but the degrees to which they are distinct or co-segregate within individuals and across development are not well understood. METHODS: We characterized behaviors that varied in their involvement of feedforward control relative to feedback control across skeletomotor (precision grip force) and oculomotor (saccades) control systems in 109 individuals with ASD and 101 age-matched typically developing controls (range: 5-29 years) including 58 individuals with ASD and 57 controls who completed both grip and saccade tests. Grip force was examined across multiple force (15, 45, and 85% MVC) and visual gain levels (low, medium, high). Maximum grip force also was examined. During grip force tests, reaction time, initial force output accuracy, variability, and entropy were examined. For the saccade test, latency, accuracy, and trial-wise variability of latency and accuracy were examined. RESULTS: Relative to controls, individuals with ASD showed similar accuracy of initial grip force but reduced accuracy of saccadic eye movements specific to older ages of our sample. Force variability was greater in ASD relative to controls, but saccade gain variability (across trials) was not different between groups. Force entropy was reduced in ASD, especially at older ages. We also find reduced grip strength in ASD that was more severe in dominant compared to non-dominant hands. LIMITATIONS: Our age-related findings rely on cross-sectional data. Longitudinal studies of sensorimotor behaviors and their associations with ASD symptoms are needed. CONCLUSIONS: We identify reduced accuracy of initial motor output in ASD that was specific to the oculomotor system implicating deficient feedforward control that may be mitigated during slower occurring behaviors executed in the periphery. Individuals with ASD showed increased continuous force variability but similar levels of trial-to-trial saccade accuracy variability suggesting that feedback-guided refinement of motor commands is deficient specifically when adjustments occur rapidly during continuous behavior. We also document reduced lateralization of grip strength in ASD implicating atypical hemispheric specialization. En ligne : http://dx.doi.org/10.1186/s13229-021-00452-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder / K. A. NEELY in Journal of Autism and Developmental Disorders, 49-7 (July 2019)
[article]
Titre : Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. A. NEELY, Auteur ; S. MOHANTY, Auteur ; Lauren M. SCHMITT, Auteur ; Z. WANG, Auteur ; J. A. SWEENEY, Auteur ; M. W. MOSCONI, Auteur Article en page(s) : p.2675-2684 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Motor Precision grip Visual feedback Working memory Index. décimale : PER Périodiques Résumé : Sensorimotor abnormalities are common in individuals with autism spectrum disorder (ASD); however, the processes underlying these deficits remain unclear. This study examined force production with and without visual feedback to determine if individuals with ASD can utilize internal representations to guide sustained force. Individuals with ASD showed a faster rate of force decay in the absence of visual feedback. Comparison of force output and tests of social and verbal abilities demonstrated a link between motor memory impairment and social and verbal deficits in individuals with ASD. This finding suggests that deficits in storage or retrieval of motor memories contribute to sensorimotor deficits and implicates frontoparietal networks involved in short-term consolidation of action dynamics used to optimize ongoing motor output. En ligne : http://dx.doi.org/10.1007/s10803-016-2806-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2675-2684[article] Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. A. NEELY, Auteur ; S. MOHANTY, Auteur ; Lauren M. SCHMITT, Auteur ; Z. WANG, Auteur ; J. A. SWEENEY, Auteur ; M. W. MOSCONI, Auteur . - p.2675-2684.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2675-2684
Mots-clés : Autism spectrum disorder Motor Precision grip Visual feedback Working memory Index. décimale : PER Périodiques Résumé : Sensorimotor abnormalities are common in individuals with autism spectrum disorder (ASD); however, the processes underlying these deficits remain unclear. This study examined force production with and without visual feedback to determine if individuals with ASD can utilize internal representations to guide sustained force. Individuals with ASD showed a faster rate of force decay in the absence of visual feedback. Comparison of force output and tests of social and verbal abilities demonstrated a link between motor memory impairment and social and verbal deficits in individuals with ASD. This finding suggests that deficits in storage or retrieval of motor memories contribute to sensorimotor deficits and implicates frontoparietal networks involved in short-term consolidation of action dynamics used to optimize ongoing motor output. En ligne : http://dx.doi.org/10.1007/s10803-016-2806-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401