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Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder / J. GOODRICH AMANDA in Autism Research, 11-1 (January 2018)
[article]
Titre : Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur Article en page(s) : p.69-80 Langues : Anglais (eng) Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333
in Autism Research > 11-1 (January 2018) . - p.69-80[article] Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder [Texte imprimé et/ou numérique] / J. GOODRICH AMANDA, Auteur ; Heather E. VOLK, Auteur ; Daniel J. TANCREDI, Auteur ; Rob MCCONNELL, Auteur ; W. LURMANN FRED, Auteur ; L. HANSEN ROBIN, Auteur ; Rebecca J. SCHMIDT, Auteur . - p.69-80.
Langues : Anglais (eng)
in Autism Research > 11-1 (January 2018) . - p.69-80
Mots-clés : autism ASD folic acid air pollution prenatal exposure environmental exposure Index. décimale : PER Périodiques Résumé : Independent studies report that periconceptional folic acid (FA) may decrease the risk of autism spectrum disorder (ASD) while exposure to air pollution may increase ASD risk. We examined the joint effects of gestational FA and air pollution exposures in association with ASD. We studied 346 ASD cases and 260 typically developing controls from the CHARGE case?control study. Self?reported FA intake for each month of pregnancy was quantified. Estimates of exposure to near roadway air pollution (NRP) and criteria air pollutant measures were assigned based on maternal residential history. Among mothers with high FA intake (>800 ?g) in the first pregnancy month, exposure to increasing levels of all air pollutants, except ozone, during the first trimester was associated with decreased ASD risk, while increased ASD risk was observed for the same pollutant among mothers with low FA intake (?800 ?g). This difference was statistically significant for NO2 (e.g., NO2 and low FA intake: OR=1.53 (0.91, 2.56) vs NO2 and high FA intake: OR=0.74 (0.46, 1.19), P?interaction=0.04). Mothers exposed to higher levels (? median) of any air pollutant during the first trimester of pregnancy and who reported low FA intake were at a higher ASD risk compared to mothers exposed to lower levels of that air pollutant and who reported high first month FA intake. Joint effects showed significant (alpha?0.10) departures from expected interaction for NRP and NO2. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. Further study is needed to replicate these findings in larger sample sizes and to understand mechanisms of this potential relationship.. Autism Res 2018, 11: 69?80. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We examined interactions between periconceptional folic acid (FA) and air pollution exposure on risk of ASD. Mothers exposed to higher levels of air pollution during the first trimester of pregnancy and who reported low supplemental FA intake during the first pregnancy month were at a higher ASD risk compared to mothers exposed to lower levels of air pollution and who reported high first month FA intake. Our results suggest that periconceptional FA intake may reduce ASD risk in those with high prenatal air pollution exposure. En ligne : https://doi.org/10.1002/aur.1885 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence / Amy E. MARGOLIS in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)
[article]
Titre : Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence Type de document : Texte imprimé et/ou numérique Auteurs : Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica P. PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur Article en page(s) : p.851-860 Langues : Anglais (eng) Mots-clés : Polycyclic aromatic hydrocarbons self-regulation prenatal exposure social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291
in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860[article] Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence [Texte imprimé et/ou numérique] / Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica P. PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur . - p.851-860.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860
Mots-clés : Polycyclic aromatic hydrocarbons self-regulation prenatal exposure social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure / Erica L. SMEARMAN in Development and Psychopathology, 32-1 (February 2020)
[article]
Titre : School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure Type de document : Texte imprimé et/ou numérique Auteurs : Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.21-30 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder language neurodevelopment prenatal exposure serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Development and Psychopathology > 32-1 (February 2020) . - p.21-30[article] School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure [Texte imprimé et/ou numérique] / Erica L. SMEARMAN, Auteur ; Cassandra L. HENDRIX, Auteur ; Dominika A. WINIARSKI, Auteur ; Katrina C. JOHNSON, Auteur ; Alicia K. SMITH, Auteur ; Opal Y. OUSLEY, Auteur ; Zachary N. STOWE, Auteur ; D. Jeffrey NEWPORT, Auteur ; Patricia A. BRENNAN, Auteur . - p.21-30.
Langues : Anglais (eng)
in Development and Psychopathology > 32-1 (February 2020) . - p.21-30
Mots-clés : Autism Spectrum Disorder language neurodevelopment prenatal exposure serotonin Index. décimale : PER Périodiques Résumé : Studies examining associations between fetal serotonin reuptake inhibitor (SRI) exposure and child autism spectrum disorder (ASD) diagnoses or delayed language remain mixed and rarely prospectively follow children or employ gold-standard assessments. We prospectively followed a cohort of mother-child dyads from pregnancy through early elementary school (N = 178), and obtained maternal and alternate-caregiver ratings of behaviors related to ASD (N = 137), as well as direct, gold-standard assessments of child ASD symptoms and pragmatic language among dyads who experienced prenatal depression and either took SRIs or were medication free during pregnancy (N = 44). Prenatal SRI exposure was related to maternal ratings of ASD-related behaviors (beta = 0.24 95% confidence interval; CI [0.07, 0.48]), and, among boys, alternative caregiver ratings (males-only beta = 0.28 95% CI [0.02, 0.55], females-only beta = -0.21 95% CI [-0.63, 0.08]). However, results of our direct assessments suggest an association between SRI exposure and reduced pragmatic language scores (beta = -0.27, 95% CI [-0.53, -0.01], but not ASD (Autism Diagnostic Observation Schedule beta = 0.14 95% CI [-0.15, 0.41]; Social Responsiveness Scale beta = 0.08 95% CI [-0.25, 0.40]). These discrepancies point to issues regarding how ASD is assessed, and the possibility that SRIs may be more strongly associated with language or other broader behaviors that coincide with ASD. Larger prospective studies that incorporate thorough, gold-standard assessments of ASD, language, and other ASD-related behaviors are needed. En ligne : http://dx.doi.org/10.1017/s0954579418001372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Systematic review of prenatal exposure to endocrine disrupting chemicals and autism spectrum disorder in offspring / S. MARÍ-BAUSET in Autism, 26-1 (January 2022)
[article]
Titre : Systematic review of prenatal exposure to endocrine disrupting chemicals and autism spectrum disorder in offspring Type de document : Texte imprimé et/ou numérique Auteurs : S. MARÍ-BAUSET, Auteur ; I. PERAITA-COSTA, Auteur ; C. DONAT-VARGAS, Auteur ; A. LLOPIS-GONZÁLEZ, Auteur ; A. MARÍ-SANCHIS, Auteur ; J. LLOPIS-MORALES, Auteur ; María MORALES-SUÁREZ-VARELA, Auteur Article en page(s) : p.6-32 Langues : Anglais (eng) Mots-clés : autism spectrum disorder developmental neurotoxicants endocrine disrupting chemicals prenatal exposure Index. décimale : PER Périodiques Résumé : Autism spectrum disorders comprise a complex group with many subtypes of behaviorally defined neurodevelopmental abnormalities in two core areas: deficits in social communication and fixated, restricted, repetitive, or stereotyped behaviors and interests each with potential unique risk factors and characteristics. The underlying mechanisms and the possible causes of autism spectrum disorder remain elusive and while increased prevalence is undoubtable, it is unclear if it is a reflection of diagnostic improvement or emerging risk factors such as endocrine disrupting chemicals. Epidemiological studies, which are used to study the relation between endocrine disrupting chemicals and autism spectrum disorder, can have inherent methodological challenges that limit the quality and strength of their findings. The objective of this work is to systematically review the treatment of these challenges and assess the quality and strength of the findings in the currently available literature. The overall quality and strength were "moderate" and "limited," respectively. Risk of bias due to the exclusion of potential confounding factors and the lack of accuracy of exposure assessment methods were the most prevalent. The omnipresence of endocrine disrupting chemicals and the biological plausibility of the association between prenatal exposure and later development of autism spectrum disorder highlight the need to carry out well-designed epidemiological studies that overcome the methodological challenges observed in the currently available literature in order to be able to inform public policy to prevent exposure to these potentially harmful chemicals and aid in the establishment of predictor variables to facilitate early diagnosis of autism spectrum disorder and improve long-term outcomes. En ligne : http://dx.doi.org/10.1177/13623613211039950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 26-1 (January 2022) . - p.6-32[article] Systematic review of prenatal exposure to endocrine disrupting chemicals and autism spectrum disorder in offspring [Texte imprimé et/ou numérique] / S. MARÍ-BAUSET, Auteur ; I. PERAITA-COSTA, Auteur ; C. DONAT-VARGAS, Auteur ; A. LLOPIS-GONZÁLEZ, Auteur ; A. MARÍ-SANCHIS, Auteur ; J. LLOPIS-MORALES, Auteur ; María MORALES-SUÁREZ-VARELA, Auteur . - p.6-32.
Langues : Anglais (eng)
in Autism > 26-1 (January 2022) . - p.6-32
Mots-clés : autism spectrum disorder developmental neurotoxicants endocrine disrupting chemicals prenatal exposure Index. décimale : PER Périodiques Résumé : Autism spectrum disorders comprise a complex group with many subtypes of behaviorally defined neurodevelopmental abnormalities in two core areas: deficits in social communication and fixated, restricted, repetitive, or stereotyped behaviors and interests each with potential unique risk factors and characteristics. The underlying mechanisms and the possible causes of autism spectrum disorder remain elusive and while increased prevalence is undoubtable, it is unclear if it is a reflection of diagnostic improvement or emerging risk factors such as endocrine disrupting chemicals. Epidemiological studies, which are used to study the relation between endocrine disrupting chemicals and autism spectrum disorder, can have inherent methodological challenges that limit the quality and strength of their findings. The objective of this work is to systematically review the treatment of these challenges and assess the quality and strength of the findings in the currently available literature. The overall quality and strength were "moderate" and "limited," respectively. Risk of bias due to the exclusion of potential confounding factors and the lack of accuracy of exposure assessment methods were the most prevalent. The omnipresence of endocrine disrupting chemicals and the biological plausibility of the association between prenatal exposure and later development of autism spectrum disorder highlight the need to carry out well-designed epidemiological studies that overcome the methodological challenges observed in the currently available literature in order to be able to inform public policy to prevent exposure to these potentially harmful chemicals and aid in the establishment of predictor variables to facilitate early diagnosis of autism spectrum disorder and improve long-term outcomes. En ligne : http://dx.doi.org/10.1177/13623613211039950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study / Zeyan LIEW in Autism Research, 9-9 (September 2016)
[article]
Titre : Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur Article en page(s) : p.951-958 Langues : Anglais (eng) Mots-clés : acetaminophen autism spectrum disorders infantile autism childhood behavior prenatal exposure pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Autism Research > 9-9 (September 2016) . - p.951-958[article] Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study [Texte imprimé et/ou numérique] / Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur . - p.951-958.
Langues : Anglais (eng)
in Autism Research > 9-9 (September 2016) . - p.951-958
Mots-clés : acetaminophen autism spectrum disorders infantile autism childhood behavior prenatal exposure pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort / Dina TERLOYEVA in Molecular Autism, 11 (2020)
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