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Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder / Carol L. MURRAY ; John KEALY ; Clodagh TOWNS ; Andrew ROCHE ; Arshed NAZMI ; Michelle DORAN ; John P. LOWRY ; Colm CUNNINGHAM in Molecular Autism, 14 (2023)
[article]
Titre : Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Carol L. MURRAY, Auteur ; John KEALY, Auteur ; Clodagh TOWNS, Auteur ; Andrew ROCHE, Auteur ; Arshed NAZMI, Auteur ; Michelle DORAN, Auteur ; John P. LOWRY, Auteur ; Colm CUNNINGHAM, Auteur Article en page(s) : 43 p. Langues : Anglais (eng) Mots-clés : Humans Mice Animals *Autism Spectrum Disorder/therapy Lipopolysaccharides/toxicity Temperature Disease Models, Animal Mice, Inbred Strains Brain *Hyperthermia, Induced/methods Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are predominantly neurodevelopmental and largely genetically determined. However, there are human data supporting the idea that fever can improve symptoms in some individuals, but those data are limited and there are almost no data to support this from animal models. We aimed to test the hypothesis that elevated body temperature would improve function in two animal models of ASD. METHODS: We used a 4 h whole-body hyperthermia (WBH) protocol and, separately, systemic inflammation induced by bacterial endotoxin (LPS) at 250 ug/kg, to dissociate temperature and inflammatory elements of fever in two ASD animal models: C58/J and Shank3B- mice. We used one- or two-way ANOVA and t-tests with normally distributed data and Kruskal-Wallis or Mann-Whitney with nonparametric data. Post hoc comparisons were made with a level of significance set at p<0.05. For correlation analyses, data were adjusted by a linear regression model. RESULTS: Only LPS induced inflammatory signatures in the brain while only WBH produced fever-range hyperthermia. WBH reduced repetitive behaviours and improved social interaction in C58/J mice and significantly reduced compulsive grooming in Shank3B- mice. LPS significantly suppressed most activities over 5-48 h. LIMITATIONS: We show behavioural, cellular and molecular changes, but provide no specific mechanistic explanation for the observed behavioural improvements. CONCLUSIONS: The data are the first, to our knowledge, to demonstrate that elevated body temperature can improve behavioural signs in 2 distinct ASD models. Given the developmental nature of ASD, evidence that symptoms may be improved by environmental perturbations indicates possibilities for improving function in these individuals. Since experimental hyperthermia in patients would carry significant risks, it is now essential to pursue molecular mechanisms through which hyperthermia might bring about the observed benefits. En ligne : https://dx.doi.org/10.1186/s13229-023-00569-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Molecular Autism > 14 (2023) . - 43 p.[article] Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder [Texte imprimé et/ou numérique] / Carol L. MURRAY, Auteur ; John KEALY, Auteur ; Clodagh TOWNS, Auteur ; Andrew ROCHE, Auteur ; Arshed NAZMI, Auteur ; Michelle DORAN, Auteur ; John P. LOWRY, Auteur ; Colm CUNNINGHAM, Auteur . - 43 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 43 p.
Mots-clés : Humans Mice Animals *Autism Spectrum Disorder/therapy Lipopolysaccharides/toxicity Temperature Disease Models, Animal Mice, Inbred Strains Brain *Hyperthermia, Induced/methods Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are predominantly neurodevelopmental and largely genetically determined. However, there are human data supporting the idea that fever can improve symptoms in some individuals, but those data are limited and there are almost no data to support this from animal models. We aimed to test the hypothesis that elevated body temperature would improve function in two animal models of ASD. METHODS: We used a 4 h whole-body hyperthermia (WBH) protocol and, separately, systemic inflammation induced by bacterial endotoxin (LPS) at 250 ug/kg, to dissociate temperature and inflammatory elements of fever in two ASD animal models: C58/J and Shank3B- mice. We used one- or two-way ANOVA and t-tests with normally distributed data and Kruskal-Wallis or Mann-Whitney with nonparametric data. Post hoc comparisons were made with a level of significance set at p<0.05. For correlation analyses, data were adjusted by a linear regression model. RESULTS: Only LPS induced inflammatory signatures in the brain while only WBH produced fever-range hyperthermia. WBH reduced repetitive behaviours and improved social interaction in C58/J mice and significantly reduced compulsive grooming in Shank3B- mice. LPS significantly suppressed most activities over 5-48 h. LIMITATIONS: We show behavioural, cellular and molecular changes, but provide no specific mechanistic explanation for the observed behavioural improvements. CONCLUSIONS: The data are the first, to our knowledge, to demonstrate that elevated body temperature can improve behavioural signs in 2 distinct ASD models. Given the developmental nature of ASD, evidence that symptoms may be improved by environmental perturbations indicates possibilities for improving function in these individuals. Since experimental hyperthermia in patients would carry significant risks, it is now essential to pursue molecular mechanisms through which hyperthermia might bring about the observed benefits. En ligne : https://dx.doi.org/10.1186/s13229-023-00569-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 Investigating interoception and body awareness in adults with and without autism spectrum disorder / Lisa FIENE in Autism Research, 8-6 (December 2015)
[article]
Titre : Investigating interoception and body awareness in adults with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lisa FIENE, Auteur ; Charlotte BROWNLOW, Auteur Article en page(s) : p.709-716 Langues : Anglais (eng) Mots-clés : Autism Asperger's syndrome interoception body awareness ASD thirst hunger temperature Index. décimale : PER Périodiques Résumé : This study aimed to investigate the current gap in the literature with regard to how adults with and without Autism Spectrum Disorder (ASD) interpret elements of the interoceptive sense, which includes thirst, hunger, temperature, satiety, and the prediction of onset of illness. Adults with a diagnosed ASD (n?=?74; 36 males, 38 females) were compared to a control group (n?=?228; 53 males, 174 females, 1 unspecified) in their self-reported perceptions of body awareness utilizing the Body Awareness Questionnaire (BAQ) and thirst awareness using the Thirst Awareness Scale (TAS). Those in the ASD group reported a clinically significant lower body and thirst awareness compared to the control group, and this was a large effect (BAQ; d?=??1.26, P?0.001; TAS; d?=??1.02, P?0.001). These findings are of clinical importance, as difficulty with sensing internal bodily states could theoretically impact on the physical and mental health, social interactions and self-awareness of adults with ASD. Autism Res 2015, 8: 709–716. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1486 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Autism Research > 8-6 (December 2015) . - p.709-716[article] Investigating interoception and body awareness in adults with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Lisa FIENE, Auteur ; Charlotte BROWNLOW, Auteur . - p.709-716.
Langues : Anglais (eng)
in Autism Research > 8-6 (December 2015) . - p.709-716
Mots-clés : Autism Asperger's syndrome interoception body awareness ASD thirst hunger temperature Index. décimale : PER Périodiques Résumé : This study aimed to investigate the current gap in the literature with regard to how adults with and without Autism Spectrum Disorder (ASD) interpret elements of the interoceptive sense, which includes thirst, hunger, temperature, satiety, and the prediction of onset of illness. Adults with a diagnosed ASD (n?=?74; 36 males, 38 females) were compared to a control group (n?=?228; 53 males, 174 females, 1 unspecified) in their self-reported perceptions of body awareness utilizing the Body Awareness Questionnaire (BAQ) and thirst awareness using the Thirst Awareness Scale (TAS). Those in the ASD group reported a clinically significant lower body and thirst awareness compared to the control group, and this was a large effect (BAQ; d?=??1.26, P?0.001; TAS; d?=??1.02, P?0.001). These findings are of clinical importance, as difficulty with sensing internal bodily states could theoretically impact on the physical and mental health, social interactions and self-awareness of adults with ASD. Autism Res 2015, 8: 709–716. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1486 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 The Interoception Sensory Questionnaire (ISQ): A Scale to Measure Interoceptive Challenges in Adults / L. FIENE in Journal of Autism and Developmental Disorders, 48-10 (October 2018)
[article]
Titre : The Interoception Sensory Questionnaire (ISQ): A Scale to Measure Interoceptive Challenges in Adults Type de document : Texte imprimé et/ou numérique Auteurs : L. FIENE, Auteur ; M. J. IRELAND, Auteur ; Charlotte BROWNLOW, Auteur Article en page(s) : p.3354-3366 Langues : Anglais (eng) Mots-clés : Alexisomia Asperger's syndrome Autism Hunger Interoception Pain Sensory perception Temperature Thirst Index. décimale : PER Périodiques Résumé : Increasing attention is being paid to how adults on the autism spectrum perceive and interpret the interoceptive sense. This 20-item Interoception Sensory Questionnaire represents a single factor scale that can be interpreted as representing confusion about interoceptive bodily states unless these states are extreme (Alexisomia), and has been designed to discriminate across populations (total sample 511 participants). Findings showed that 74% of adults with autism reported interoceptive confusion. Another finding of the study was that as autistic traits increased, interoceptive confusion increased, with adults with diagnosed autism scoring highest on the construct. Implications for physiological self-regulation as well as physical health outcomes are discussed, as well as recommendations for future research. En ligne : http://dx.doi.org/10.1007/s10803-018-3600-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3354-3366[article] The Interoception Sensory Questionnaire (ISQ): A Scale to Measure Interoceptive Challenges in Adults [Texte imprimé et/ou numérique] / L. FIENE, Auteur ; M. J. IRELAND, Auteur ; Charlotte BROWNLOW, Auteur . - p.3354-3366.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3354-3366
Mots-clés : Alexisomia Asperger's syndrome Autism Hunger Interoception Pain Sensory perception Temperature Thirst Index. décimale : PER Périodiques Résumé : Increasing attention is being paid to how adults on the autism spectrum perceive and interpret the interoceptive sense. This 20-item Interoception Sensory Questionnaire represents a single factor scale that can be interpreted as representing confusion about interoceptive bodily states unless these states are extreme (Alexisomia), and has been designed to discriminate across populations (total sample 511 participants). Findings showed that 74% of adults with autism reported interoceptive confusion. Another finding of the study was that as autistic traits increased, interoceptive confusion increased, with adults with diagnosed autism scoring highest on the construct. Implications for physiological self-regulation as well as physical health outcomes are discussed, as well as recommendations for future research. En ligne : http://dx.doi.org/10.1007/s10803-018-3600-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369