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Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis / Xuejun KONG in Journal of Autism and Developmental Disorders, 51-1 (January 2021)
[article]
Titre : Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur Article en page(s) : p.144-157 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD) Autonomic dysfunction Biomarker Gut microbiome Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157[article] Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis [Texte imprimé et/ou numérique] / Xuejun KONG, Auteur ; Jun LIU, Auteur ; Kevin LIU, Auteur ; Madelyn KOH, Auteur ; Ruiyi TIAN, Auteur ; Clara HOBBIE, Auteur ; Michelle FONG, Auteur ; Qiuyi CHEN, Auteur ; Minxuan ZHAO, Auteur ; Christoph BUDJAN, Auteur ; Jian KONG, Auteur . - p.144-157.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.144-157
Mots-clés : Autism spectrum disorders (ASD) Autonomic dysfunction Biomarker Gut microbiome Gut-brain-axis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the "gut brain axis", which consists of an intricate interplay between the gut microbiome, mucosal immune system, enteric nervous system, ANS, and central processes receiving input from the vagus nerve. Measurements of the gut microbiome and the autonomic indices can serve as non-invasive markers of the status of the gut-brain axis in ASD. To our knowledge, no previous studies have explored the relationship between ANS and gut microbiome in individuals with ASD. Furthermore, while previous studies investigated the use of autonomic indices and gut microbiome independently as markers of ASD-related comorbidities, such as anxiety, cardiovascular issues, and gastrointestinal dysfunction, the use of combined autonomic indices and gut microbiome factors to classify ASD and control subjects has not been explored. In this study, we characterized autonomic function of a group of individuals with ASD in comparison to their paired, first-degree relative controls. Second, we explored the ASD gut-brain-axis through the relationship between gut microbiome markers and autonomic indices, as well as the correlation between the gut-brain-axis and clinical presentation of ASD. Lastly, this study explores the predictive capability of gut-brain-axis biomarkers (including autonomic and microbiome indices) in subtyping ASD cases, serving as a starting point to investigate the possibility of assisting in ASD screening and diagnosis that still heavily relies on psychological testing, which may be based on highly subjective standards. En ligne : http://dx.doi.org/10.1007/s10803-020-04524-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders / Dinalankara M. R. DINALANKARA in Autism Research, 10-5 (May 2017)
[article]
Titre : Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur Article en page(s) : p.829-838 Langues : Anglais (eng) Mots-clés : pupillary light reflex autism age latency pupil size autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-5 (May 2017) . - p.829-838[article] Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders [Texte imprimé et/ou numérique] / Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur . - p.829-838.
Langues : Anglais (eng)
in Autism Research > 10-5 (May 2017) . - p.829-838
Mots-clés : pupillary light reflex autism age latency pupil size autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307