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Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial / S. M. EACK in Autism Research, 11-3 (March 2018)
[article]
Titre : Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : S. M. EACK, Auteur ; S. S. HOGARTY, Auteur ; D. P. GREENWALD, Auteur ; M. Y. LITSCHGE, Auteur ; S. A. PORTON, Auteur ; C. A. MAZEFSKY, Auteur ; N. J. MINSHEW, Auteur Article en page(s) : p.519-530 Langues : Anglais (eng) Mots-clés : adult autism cognitive enhancement cognitive remediation neurocognition social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352
in Autism Research > 11-3 (March 2018) . - p.519-530[article] Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18-month randomized clinical trial [Texte imprimé et/ou numérique] / S. M. EACK, Auteur ; S. S. HOGARTY, Auteur ; D. P. GREENWALD, Auteur ; M. Y. LITSCHGE, Auteur ; S. A. PORTON, Auteur ; C. A. MAZEFSKY, Auteur ; N. J. MINSHEW, Auteur . - p.519-530.
Langues : Anglais (eng)
in Autism Research > 11-3 (March 2018) . - p.519-530
Mots-clés : adult autism cognitive enhancement cognitive remediation neurocognition social cognition Index. décimale : PER Périodiques Résumé : Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management. Primary outcomes were composite indexes of neurocognitive and social-cognitive change. Competitive employment was a secondary outcome. Intent-to-treat analyses indicated that CET produced significant differential increases in neurocognitive function relative to EST (d = .46, P = .013). Both CET and EST were associated with large social-cognitive improvements, with CET demonstrating an advantage at 9 (d = .58, P = 0.020), but not 18 months (d = .27, P = 0.298). Effects on employment indicated that participants treated with CET were significantly more likely to gain competitive employment than those in EST, OR = 6.21, P = 0.023, which was mediated by cognitive improvement. CET is a feasible and potentially effective treatment for core cognitive deficits in adult autism spectrum disorder. The treatment of cognitive impairments in this population can contribute to meaningful improvements in adult outcomes. Autism Res 2018, 11: 519-530. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cognitive enhancement therapy (CET), an 18-month cognitive remediation intervention designed to improve thinking and social understanding, was found to be more effective than supportive therapy at improving mental quickness, attention, and employment in adults living with autism. Social understanding was equally improved in CET and supportive therapy. Cognitive remediation interventions are feasible and may confer significant functional benefits to adults with autism. En ligne : http://dx.doi.org/10.1002/aur.1913 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study / Shaun M. EACK in Journal of Autism and Developmental Disorders, 43-12 (December 2013)
[article]
Titre : Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study Type de document : Texte imprimé et/ou numérique Auteurs : Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur Article en page(s) : p.2866-2877 Langues : Anglais (eng) Mots-clés : Cognitive Enhancement Therapy Cognitive rehabilitation Cognitive remediation Psychosocial treatment Cognitive therapy Adult treatment Autism Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877[article] Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorder: Results of an 18-month Feasibility Study [Texte imprimé et/ou numérique] / Shaun M. EACK, Auteur ; Deborah P. GREENWALD, Auteur ; Susan S. HOGARTY, Auteur ; Amber L. BAHORIK, Auteur ; Maralee Y. LITSCHGE, Auteur ; Carla A. MAZEFSKY, Auteur ; Nancy J. MINSHEW, Auteur . - p.2866-2877.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2866-2877
Mots-clés : Cognitive Enhancement Therapy Cognitive rehabilitation Cognitive remediation Psychosocial treatment Cognitive therapy Adult treatment Autism Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Adults with autism experience significant impairments in social and non-social information processing for which few treatments have been developed. This study conducted an 18-month uncontrolled trial of Cognitive Enhancement Therapy (CET), a comprehensive cognitive rehabilitation intervention, in 14 verbal adults with autism spectrum disorder to investigate its feasibility, acceptability, and initial efficacy in treating these impairments. Results indicated that CET was satisfying to participants, with high treatment attendance and retention. Effects on cognitive deficits and social behavior were also large (d = 1.40–2.29) and statistically significant (all p .001). These findings suggest that CET is a feasible, acceptable, and potentially effective intervention for remediating the social and non-social cognitive impairments in verbal adults with autism. En ligne : http://dx.doi.org/10.1007/s10803-013-1834-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme / K. TCHANTURIA in Autism, 23-1 (January 2019)
[article]
Titre : Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme Type de document : Texte imprimé et/ou numérique Auteurs : K. TCHANTURIA, Auteur ; J. ADAMSON, Auteur ; J. LEPPANEN, Auteur ; H. WESTWOOD, Auteur Article en page(s) : p.123-130 Langues : Anglais (eng) Mots-clés : anorexia nervosa autism spectrum disorder Autism Spectrum Quotient short version eating disorder eating-disorders cognitive remediation anxiety disorders social-adjustment traits quotient work comorbidity impairment overlap Psychology Index. décimale : PER Périodiques Résumé : Previous research has demonstrated links between anorexia nervosa and autism spectrum disorder however, few studies have examined the possible impact of symptoms of autism spectrum disorder on clinical outcomes in anorexia nervosa. The aim of this study was to examine the association between symptoms of autism spectrum disorder and eating disorders, and other psychopathology during the course of inpatient treatment in individuals with anorexia nervosa. Participants with anorexia nervosa (n = 171) completed questionnaires exploring eating disorder psychopathology, symptoms of depression and anxiety, and everyday functioning at both admission and discharge. Characteristics associated with autism spectrum disorder were assessed using the Autism Spectrum Quotient, short version. Autism spectrum disorder symptoms were significantly positively correlated with eating disorder psychopathology, work and social functioning, and symptoms of depression and anxiety, but not with body mass index. Autism Spectrum Quotient, short version scores remained relatively stable from admission to discharge but there was a small, significant reduction in scores. There was no interaction between time and Autism Spectrum Quotient, short version scores on clinical symptom change. In anorexia nervosa, autism spectrum disorder symptoms appear to be associated with a more severe clinical presentation on admission to inpatient care. Autism spectrum disorder symptoms as assessed by self-report measures may be exacerbated by other mental health psychopathology, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361317722431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379
in Autism > 23-1 (January 2019) . - p.123-130[article] Characteristics of autism spectrum disorder in anorexia nervosa: A naturalistic study in an inpatient treatment programme [Texte imprimé et/ou numérique] / K. TCHANTURIA, Auteur ; J. ADAMSON, Auteur ; J. LEPPANEN, Auteur ; H. WESTWOOD, Auteur . - p.123-130.
Langues : Anglais (eng)
in Autism > 23-1 (January 2019) . - p.123-130
Mots-clés : anorexia nervosa autism spectrum disorder Autism Spectrum Quotient short version eating disorder eating-disorders cognitive remediation anxiety disorders social-adjustment traits quotient work comorbidity impairment overlap Psychology Index. décimale : PER Périodiques Résumé : Previous research has demonstrated links between anorexia nervosa and autism spectrum disorder however, few studies have examined the possible impact of symptoms of autism spectrum disorder on clinical outcomes in anorexia nervosa. The aim of this study was to examine the association between symptoms of autism spectrum disorder and eating disorders, and other psychopathology during the course of inpatient treatment in individuals with anorexia nervosa. Participants with anorexia nervosa (n = 171) completed questionnaires exploring eating disorder psychopathology, symptoms of depression and anxiety, and everyday functioning at both admission and discharge. Characteristics associated with autism spectrum disorder were assessed using the Autism Spectrum Quotient, short version. Autism spectrum disorder symptoms were significantly positively correlated with eating disorder psychopathology, work and social functioning, and symptoms of depression and anxiety, but not with body mass index. Autism Spectrum Quotient, short version scores remained relatively stable from admission to discharge but there was a small, significant reduction in scores. There was no interaction between time and Autism Spectrum Quotient, short version scores on clinical symptom change. In anorexia nervosa, autism spectrum disorder symptoms appear to be associated with a more severe clinical presentation on admission to inpatient care. Autism spectrum disorder symptoms as assessed by self-report measures may be exacerbated by other mental health psychopathology, which warrants further investigation. En ligne : http://dx.doi.org/10.1177/1362361317722431 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=379