4 recherche sur le mot-clé 'diffusion spectrum imaging'

Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder / Hsiang-Yun CHIEN in Autism Research, 8-6 (December 2015)  

Public ISBD [article]  inAutism Research > 8-6 (December 2015) . - p.694-708 Titre : Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur Article en page(s) : p.694-708 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  mirror neuron system  diffusion spectrum imaging  cortical thickness  white matter integrity  tractography  social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Altered Cortical Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication in Autism Spectrum Disorder [texte imprimé] / Hsiang-Yun CHIEN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yung-Chin HSU, Auteur ; Yu-Jen CHEN, Auteur ; Yu-Chun LO, Auteur ; Yao-Chia SHIH, Auteur ; Wen-Yih Isaac TSENG, Auteur . - p.694-708. Langues : Anglais (eng) in Autism Research > 8-6 (December 2015) . - p.694-708 Mots-clés : autism spectrum disorder  mirror neuron system  diffusion spectrum imaging  cortical thickness  white matter integrity  tractography  social communication Index. décimale : PER Périodiques Résumé : Previous studies using neural activity recording and neuroimaging techniques have reported functional deficits in the mirror neuron system (MNS) for individuals with autism spectrum disorder (ASD). However, a few studies focusing on gray and white matter structures of the MNS have yielded inconsistent results. The current study recruited adolescents and young adults with ASD (aged 15–26 years) and age-matched typically developing (TD) controls (aged 14–25 years). The cortical thickness (CT) and microstructural integrity of the tracts connecting the regions forming the classical MNS were investigated. High-resolution T1-weighted imaging and diffusion spectrum imaging were performed to quantify the CT and tract integrity, respectively. The structural covariance of the CT of the MNS regions revealed a weaker coordination of the MNS network in ASD. A strong correlation was found between the integrity of the right frontoparietal tracts and the social communication subscores measured by the Chinese version of the Social Communication Questionnaire. The results showed that there were no significant mean differences in the CTs and tract integrity between the ASD and TD groups, but revealed a moderate or even reverse age effect on the frontal MNS structures in ASD. In conclusion, aberrant structural coordination may be an underlying factor affecting the function of the MNS in ASD patients. The association between the right frontoparietal tracts and social communication performance implies a neural correlate of communication processing in the autistic brain. This study provides evidence of abnormal MNS structures and their influence on social communication in individuals with ASD. Autism Res 2015, 8: 694–708. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1484 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study / Yu-Chun LO in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.561-570 Titre : Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study Type de document : texte imprimé Auteurs : Yu-Chun LO, Auteur ; Tai-Li CHOU, Auteur ; Li-Ying FAN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Yih Isaac TSENG, Auteur Année de publication : 2013 Article en page(s) : p.561-570 Langues : Anglais (eng) Mots-clés : autism  dual stream model  diffusion spectrum imaging  functional MRI  tractography Index. décimale : PER Périodiques Résumé : Deficits in language and communication are among the core symptoms of autism, a common neurodevelopmental disorder with long-term impairment. Despite the striking nature of the autistic language impairment, knowledge about its corresponding alterations in the brain is still evolving. We hypothesized that the dual stream language network is altered in autism, and that this alteration could be revealed by changes in the relationships between microstructural integrity and functional activation. The study recruited 20 right-handed male youths with autism and 20 carefully matched individually, typically developing (TD) youths. Microstructural integrity of the left dorsal and left ventral pathways responsible for language processing and the functional activation of the connected brain regions were investigated by using diffusion spectrum imaging and functional magnetic resonance imaging of a semantic task, respectively. Youths with autism had significantly poorer language function, and lower functional activation in left dorsal and left ventral regions of the language network, compared with TD youths. The TD group showed a significant correlation of the functional activation of the left dorsal region with microstructural integrity of the left ventral pathway, whereas the autism group showed a significant correlation of the functional activation of the left ventral region with microstructural integrity of the left dorsal pathway, and moreover verbal comprehension index was correlated with microstructural integrity of the left ventral pathway. These altered structure–function relationships in autism suggest possible involvement of the dual pathways in supporting deficient semantic processing. En ligne : http://dx.doi.org/10.1002/aur.1315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Altered Structure–Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study [texte imprimé] / Yu-Chun LO, Auteur ; Tai-Li CHOU, Auteur ; Li-Ying FAN, Auteur ; Susan Shur-Fen GAU, Auteur ; Yen-Nan CHIU, Auteur ; Wen-Yih Isaac TSENG, Auteur . - 2013 . - p.561-570. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.561-570 Mots-clés : autism  dual stream model  diffusion spectrum imaging  functional MRI  tractography Index. décimale : PER Périodiques Résumé : Deficits in language and communication are among the core symptoms of autism, a common neurodevelopmental disorder with long-term impairment. Despite the striking nature of the autistic language impairment, knowledge about its corresponding alterations in the brain is still evolving. We hypothesized that the dual stream language network is altered in autism, and that this alteration could be revealed by changes in the relationships between microstructural integrity and functional activation. The study recruited 20 right-handed male youths with autism and 20 carefully matched individually, typically developing (TD) youths. Microstructural integrity of the left dorsal and left ventral pathways responsible for language processing and the functional activation of the connected brain regions were investigated by using diffusion spectrum imaging and functional magnetic resonance imaging of a semantic task, respectively. Youths with autism had significantly poorer language function, and lower functional activation in left dorsal and left ventral regions of the language network, compared with TD youths. The TD group showed a significant correlation of the functional activation of the left dorsal region with microstructural integrity of the left ventral pathway, whereas the autism group showed a significant correlation of the functional activation of the left ventral region with microstructural integrity of the left dorsal pathway, and moreover verbal comprehension index was correlated with microstructural integrity of the left ventral pathway. These altered structure–function relationships in autism suggest possible involvement of the dual pathways in supporting deficient semantic processing. En ligne : http://dx.doi.org/10.1002/aur.1315 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Longitudinal Changes of the White Matter Microstructural Properties of Autism Spectrum Disorder: A Normative Model Analysis / Yi-Ling CHIEN in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70174 Titre : Longitudinal Changes of the White Matter Microstructural Properties of Autism Spectrum Disorder: A Normative Model Analysis Type de document : texte imprimé Auteurs : Yi-Ling CHIEN, Auteur ; Wan-Ling TSENG, Auteur ; Chang-Le CHEN, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur Article en page(s) : e70174 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental dysconnectivity  diffusion spectrum imaging  normative model  white matter microstructure Index. décimale : PER Périodiques Résumé : ABSTRACT Cross-sectional research documents atypical age-related development of white matter in autism spectrum disorder (ASD). However, little is known about the developmental changes in white matter microstructural properties in ASD. This study aims to investigate developmental changes in white matter tract microstructural properties in ASD using a longitudinal follow-up design and normative model analysis, and to examine clinical correlates of these changes. We assessed 75 autistic individuals (aged 15.3?±?4.2?years) with diffusion spectrum imaging at baseline and 4.7?±?1.9?years later. To measure the magnitude of deviation from the norm, we calculated z-scores for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) for each of 76 tracts based on a norm established in 680 typically developing individuals. Callosal fibers connecting the temporal poles, hippocampus, and amygdala in ASD individuals showed higher AD, RD, and MD at both time points. Several tracts showed significantly greater increases in FA z-scores from baseline to follow-up, including the right superior longitudinal fasciculus, precentral thalamic radiation, frontal aslant tract, right corticospinal tracts, left arcuate fasciculus, callosal fibers connecting genu, and bilateral thalamic radiation, implying a pattern of greater deviation from the norm at Time 2 than Time 1. Higher autistic severity or social deficits at baseline were related to greater increasing rates in the diffusion metrics of callosal fibers connecting the precuneus (AD, RD, and MD), corticospinal tract (AD), right geniculate fibers (AD and MD), and right medial lemniscus (AD and MD) from baseline to follow-up. Using the normative model method to analyze longitudinal data on white matter microstructures, our findings support persistent alterations in callosal fibers and developmental alterations of several tracts in ASD, which were associated with baseline autistic severity. En ligne : https://doi.org/10.1002/aur.70174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Longitudinal Changes of the White Matter Microstructural Properties of Autism Spectrum Disorder: A Normative Model Analysis [texte imprimé] / Yi-Ling CHIEN, Auteur ; Wan-Ling TSENG, Auteur ; Chang-Le CHEN, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Susan Shur-Fen GAU, Auteur . - e70174. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70174 Mots-clés : autism spectrum disorder  developmental dysconnectivity  diffusion spectrum imaging  normative model  white matter microstructure Index. décimale : PER Périodiques Résumé : ABSTRACT Cross-sectional research documents atypical age-related development of white matter in autism spectrum disorder (ASD). However, little is known about the developmental changes in white matter microstructural properties in ASD. This study aims to investigate developmental changes in white matter tract microstructural properties in ASD using a longitudinal follow-up design and normative model analysis, and to examine clinical correlates of these changes. We assessed 75 autistic individuals (aged 15.3?±?4.2?years) with diffusion spectrum imaging at baseline and 4.7?±?1.9?years later. To measure the magnitude of deviation from the norm, we calculated z-scores for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) for each of 76 tracts based on a norm established in 680 typically developing individuals. Callosal fibers connecting the temporal poles, hippocampus, and amygdala in ASD individuals showed higher AD, RD, and MD at both time points. Several tracts showed significantly greater increases in FA z-scores from baseline to follow-up, including the right superior longitudinal fasciculus, precentral thalamic radiation, frontal aslant tract, right corticospinal tracts, left arcuate fasciculus, callosal fibers connecting genu, and bilateral thalamic radiation, implying a pattern of greater deviation from the norm at Time 2 than Time 1. Higher autistic severity or social deficits at baseline were related to greater increasing rates in the diffusion metrics of callosal fibers connecting the precuneus (AD, RD, and MD), corticospinal tract (AD), right geniculate fibers (AD and MD), and right medial lemniscus (AD and MD) from baseline to follow-up. Using the normative model method to analyze longitudinal data on white matter microstructures, our findings support persistent alterations in callosal fibers and developmental alterations of several tracts in ASD, which were associated with baseline autistic severity. En ligne : https://doi.org/10.1002/aur.70174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients / Chia-Jui HSU in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients Type de document : texte imprimé Auteurs : Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients [texte imprimé] / Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575