3 recherche sur le mot-clé 'mercury'

Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg / Reyhane FARMANI in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg Type de document : texte imprimé Auteurs : Reyhane FARMANI, Auteur ; Omid MEHRPOUR, Auteur ; Alireza KOOSHKI, Auteur ; Samaneh NAKHAEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Attention Deficit Disorder with Hyperactivity/epidemiology/chemically induced  Lead/blood/adverse effects  Mercury/urine/blood/adverse effects  Child  Environmental Exposure/adverse effects  Adhd  Attention-deficit/hyperactivity disorder  Heavy metals  Hg  Lead  Mercury  Neurodevelopmental disorders  Pb Index. décimale : PER Périodiques Résumé : INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a recognized neurodevelopmental disorder with a complex, multifactorial origin. Lead (Pb) and mercury (Hg) are highly toxic substances that can potentially impair brain development and have been implicated in the development of ADHD. This systematic review aims to analyze the epidemiological literature regarding the association between Pb and Hg exposure and the diagnosis of ADHD. METHODS: From November 1983 to June 2, 2023, a comprehensive search was conducted in multiple databases and search engines, including PubMed, Web of Science, Scopus, and Google Scholar. Observational studies (case-control, cohort, and cross-sectional) measuring Pb and Hg levels in various biological samples (blood, hair, urine, nail, saliva, teeth, and bone) of children with ADHD or their parents and their association with ADHD symptoms were included. RESULTS: Out of 2059 studies, 87 met the inclusion criteria and were included in this systematic review. Approximately two-thirds of the 74 studies investigating Pb levels in different biological samples reported associations with at least one subtype of ADHD. However, most studies examining Hg levels in various biological samples found no significant association with any ADHD subtype, although there were variations in exposure periods and diagnostic criteria. CONCLUSION: The evidence gathered from the included studies supports an association between Pb exposure and the diagnosis of ADHD, while no significant association was found with Hg exposure. Importantly, even low levels of Pb were found to elevate the risk of ADHD. Further research is needed to explore the comprehensive range of risk factors for ADHD in children, considering its significance as a neurodevelopmental disorder. En ligne : https://dx.doi.org/10.1186/s11689-024-09555-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg [texte imprimé] / Reyhane FARMANI, Auteur ; Omid MEHRPOUR, Auteur ; Alireza KOOSHKI, Auteur ; Samaneh NAKHAEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Attention Deficit Disorder with Hyperactivity/epidemiology/chemically induced  Lead/blood/adverse effects  Mercury/urine/blood/adverse effects  Child  Environmental Exposure/adverse effects  Adhd  Attention-deficit/hyperactivity disorder  Heavy metals  Hg  Lead  Mercury  Neurodevelopmental disorders  Pb Index. décimale : PER Périodiques Résumé : INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a recognized neurodevelopmental disorder with a complex, multifactorial origin. Lead (Pb) and mercury (Hg) are highly toxic substances that can potentially impair brain development and have been implicated in the development of ADHD. This systematic review aims to analyze the epidemiological literature regarding the association between Pb and Hg exposure and the diagnosis of ADHD. METHODS: From November 1983 to June 2, 2023, a comprehensive search was conducted in multiple databases and search engines, including PubMed, Web of Science, Scopus, and Google Scholar. Observational studies (case-control, cohort, and cross-sectional) measuring Pb and Hg levels in various biological samples (blood, hair, urine, nail, saliva, teeth, and bone) of children with ADHD or their parents and their association with ADHD symptoms were included. RESULTS: Out of 2059 studies, 87 met the inclusion criteria and were included in this systematic review. Approximately two-thirds of the 74 studies investigating Pb levels in different biological samples reported associations with at least one subtype of ADHD. However, most studies examining Hg levels in various biological samples found no significant association with any ADHD subtype, although there were variations in exposure periods and diagnostic criteria. CONCLUSION: The evidence gathered from the included studies supports an association between Pb exposure and the diagnosis of ADHD, while no significant association was found with Hg exposure. Importantly, even low levels of Pb were found to elevate the risk of ADHD. Further research is needed to explore the comprehensive range of risk factors for ADHD in children, considering its significance as a neurodevelopmental disorder. En ligne : https://dx.doi.org/10.1186/s11689-024-09555-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? / Maryam M. ABDULLAH in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936 Titre : Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? Type de document : texte imprimé Auteurs : Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur Année de publication : 2012 Article en page(s) : p.929-936 Langues : Anglais (eng) Mots-clés : Autism  ADHD  Metal  Lead  Mercury  Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Heavy Metal in Children’s Tooth Enamel: Related to Autism and Disruptive Behaviors? [texte imprimé] / Maryam M. ABDULLAH, Auteur ; Agnes R. LY, Auteur ; Wendy A. GOLDBERG, Auteur ; K. Alison CLARKE-STEWART, Auteur ; John V. DUDGEON, Auteur ; Christopher G. MULL, Auteur ; Tony J. CHAN, Auteur ; Erin E. KENT, Auteur ; Andrew Z. MASON, Auteur ; Jonathon E. ERICSON, Auteur . - 2012 . - p.929-936. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.929-936 Mots-clés : Autism  ADHD  Metal  Lead  Mercury  Manganese Index. décimale : PER Périodiques Résumé : To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically developing (TD) children. Using laser ablation inductively coupled plasma mass spectrometry, we found no significant differences in levels of these neurotoxicants for children with ASDs compared with TD children, but there was marginal significance indicating that children with ASDs have lower manganese levels. No significant differences emerged between children with HDB and TD children. The current findings challenge the notion that perinatal heavy metal exposure is a major contributor to the development of ASDs and HDB. En ligne : http://dx.doi.org/10.1007/s10803-011-1318-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? / Kerrie SHANDLEY in Autism Research, 7-5 (October 2014)  

Public ISBD [article]  inAutism Research > 7-5 (October 2014) . - p.535-542 Titre : Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? Type de document : texte imprimé Auteurs : Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur Article en page(s) : p.535-542 Langues : Anglais (eng) Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n = 70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n = 36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n = 54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? [texte imprimé] / Kerrie SHANDLEY, Auteur ; David W. AUSTIN, Auteur ; Jahar L. BHOWMIK, Auteur . - p.535-542. Langues : Anglais (eng) in Autism Research > 7-5 (October 2014) . - p.535-542 Mots-clés : porphyrins  biomarker  ASD diagnosis  ASD severity  heavy metals  mercury Index. décimale : PER Périodiques Résumé : A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2–6 years: Group 1—children diagnosed with ASD (n = 70); Group 2—healthy, normally developing siblings of children diagnosed with ASD (n = 36); and Group 3—healthy, normally developing children with no known blood relative diagnosed with ASD (n = 54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res 2014, 7: 535–542. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1385 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241