5 recherche sur le mot-clé 'susceptibility'

Susceptibility to peer influence in adolescents: Associations between psychophysiology and behavior / Zachary M. MEEHAN in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.69-81 Titre : Susceptibility to peer influence in adolescents: Associations between psychophysiology and behavior Type de document : texte imprimé Auteurs : Zachary M. MEEHAN, Auteur ; Julie A. HUBBARD, Auteur ; Christina MOORE, Auteur ; Fanny MLAWER, Auteur Article en page(s) : p.69-81 Langues : Anglais (eng) Mots-clés : antisocial  peer influence  prosocial  psychophysiology  susceptibility Index. décimale : PER Périodiques Résumé : The current study investigated in-the-moment links between adolescents' autonomic nervous system activity and susceptibility to three types of peer influence (indirect, direct, continuing) on two types of behavior (antisocial, prosocial). The sample included 144 racially ethnically diverse adolescents (46% male, 53% female, 1% other; Mage = 16.02 years). We assessed susceptibility to peer influence behaviorally using the Public Goods Game (PGG) while measuring adolescents' mean heart rate (MHR) and pre-ejection period (PEP). Three key findings emerged from bivariate dual latent change score modeling: (1) adolescents whose MHR increased more as they transitioned from playing the PGG alone (pre-influence) to playing while simply observed by peers (indirect influence) displayed more prosocial behavior; (2) adolescents whose PEP activity increased more (greater PEP activity = shorter PEP latency) as they transitioned from indirect influence to being encouraged by peers to engage in antisocial behavior (direct influence) engaged in more antisocial behavior; and (3) adolescents whose PEP activity decreased less as they transitioned from direct influence on prosocial behavior to playing the PGG alone again (continuing influence) displayed more continuing prosocial behavior (marginal effect). The discussion focuses on the role of psychophysiology in understanding adolescents' susceptibility to peer influence. En ligne : https://dx.doi.org/10.1017/S0954579422000967 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Susceptibility to peer influence in adolescents: Associations between psychophysiology and behavior [texte imprimé] / Zachary M. MEEHAN, Auteur ; Julie A. HUBBARD, Auteur ; Christina MOORE, Auteur ; Fanny MLAWER, Auteur . - p.69-81. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.69-81 Mots-clés : antisocial  peer influence  prosocial  psychophysiology  susceptibility Index. décimale : PER Périodiques Résumé : The current study investigated in-the-moment links between adolescents' autonomic nervous system activity and susceptibility to three types of peer influence (indirect, direct, continuing) on two types of behavior (antisocial, prosocial). The sample included 144 racially ethnically diverse adolescents (46% male, 53% female, 1% other; Mage = 16.02 years). We assessed susceptibility to peer influence behaviorally using the Public Goods Game (PGG) while measuring adolescents' mean heart rate (MHR) and pre-ejection period (PEP). Three key findings emerged from bivariate dual latent change score modeling: (1) adolescents whose MHR increased more as they transitioned from playing the PGG alone (pre-influence) to playing while simply observed by peers (indirect influence) displayed more prosocial behavior; (2) adolescents whose PEP activity increased more (greater PEP activity = shorter PEP latency) as they transitioned from indirect influence to being encouraged by peers to engage in antisocial behavior (direct influence) engaged in more antisocial behavior; and (3) adolescents whose PEP activity decreased less as they transitioned from direct influence on prosocial behavior to playing the PGG alone again (continuing influence) displayed more continuing prosocial behavior (marginal effect). The discussion focuses on the role of psychophysiology in understanding adolescents' susceptibility to peer influence. En ligne : https://dx.doi.org/10.1017/S0954579422000967 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Titre : Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3800-3809 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [texte imprimé] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Interactions between infant characteristics and parenting factors rarely replicate across cohorts and developmental domains / Robert EVES in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1234-1248 Titre : Interactions between infant characteristics and parenting factors rarely replicate across cohorts and developmental domains Type de document : texte imprimé Auteurs : Robert EVES, Auteur ; Finiki NEARCHOU, Auteur ; Dieter WOLKE, Auteur ; Michael PLUESS, Auteur ; Sakari LEMOLA, Auteur Article en page(s) : p.1234-1248 Langues : Anglais (eng) Mots-clés : Interaction  moderation  birthweight  temperament  vulnerability  susceptibility  sensitivity Index. décimale : PER Périodiques Résumé : Background Whether, and how, infant characteristics and parenting quality interact is one of developmental psychology's key questions. However, whether specific interaction patterns replicate across cohorts or developmental outcomes is largely unknown. This study investigates whether infant characteristics and parenting quality are independent predictors (additive effects) of child outcomes or interact such that certain infants particularly suffer from poor parenting (diathesis stress), particularly benefit from good parenting (vantage sensitivity) or both (differential susceptibility). Methods Individual participant data from over 30,000 children from four prospective cohorts were pooled. Using a competitive-confirmatory approach of model evaluation, 16 possible permutations of infant characteristics (temperament and birthweight), parenting (maternal-reported stimulating and sensitive parenting) and later developmental outcomes (fluid and crystalised intelligence, internalising and externalising behaviour) were tested. The robustness of results was evaluated by subsequently varying analytic methods, using alternative parenting measures including observer reports and excluding covariates. Results AIC values in 10/16 analyses indicated infant characteristics acted independently of maternal-reported parenting for predicting developmental outcomes. Interaction patterns indicating diathesis stress (4/16), vantage sensitivity (2/16) or differential susceptibility (0/16) were rare or absent. However, diathesis-stress patterns were frequently found regarding birthweight and internalising behaviours, which were largely robust to methodological changes. Conclusions Developmental outcomes are more consistently explained by additive effects rather than by interaction effects. En ligne : https://doi.org/10.1111/jcpp.14149 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Interactions between infant characteristics and parenting factors rarely replicate across cohorts and developmental domains [texte imprimé] / Robert EVES, Auteur ; Finiki NEARCHOU, Auteur ; Dieter WOLKE, Auteur ; Michael PLUESS, Auteur ; Sakari LEMOLA, Auteur . - p.1234-1248. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1234-1248 Mots-clés : Interaction  moderation  birthweight  temperament  vulnerability  susceptibility  sensitivity Index. décimale : PER Périodiques Résumé : Background Whether, and how, infant characteristics and parenting quality interact is one of developmental psychology's key questions. However, whether specific interaction patterns replicate across cohorts or developmental outcomes is largely unknown. This study investigates whether infant characteristics and parenting quality are independent predictors (additive effects) of child outcomes or interact such that certain infants particularly suffer from poor parenting (diathesis stress), particularly benefit from good parenting (vantage sensitivity) or both (differential susceptibility). Methods Individual participant data from over 30,000 children from four prospective cohorts were pooled. Using a competitive-confirmatory approach of model evaluation, 16 possible permutations of infant characteristics (temperament and birthweight), parenting (maternal-reported stimulating and sensitive parenting) and later developmental outcomes (fluid and crystalised intelligence, internalising and externalising behaviour) were tested. The robustness of results was evaluated by subsequently varying analytic methods, using alternative parenting measures including observer reports and excluding covariates. Results AIC values in 10/16 analyses indicated infant characteristics acted independently of maternal-reported parenting for predicting developmental outcomes. Interaction patterns indicating diathesis stress (4/16), vantage sensitivity (2/16) or differential susceptibility (0/16) were rare or absent. However, diathesis-stress patterns were frequently found regarding birthweight and internalising behaviours, which were largely robust to methodological changes. Conclusions Developmental outcomes are more consistently explained by additive effects rather than by interaction effects. En ligne : https://doi.org/10.1111/jcpp.14149 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses / Susan F. TAPERT ; Sandra A. BROWN ; Sonya B. NORMAN ; William E. PELHAM III in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1388-1397 Titre : Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses Type de document : texte imprimé Auteurs : Susan F. TAPERT, Auteur ; Sandra A. BROWN, Auteur ; Sonya B. NORMAN, Auteur ; William E. PELHAM III, Auteur Article en page(s) : p.1388-1397 Langues : Anglais (eng) Mots-clés : Trauma  childhood  adolescence  alcohol  cannabis  nicotine  etiology  self-medication  susceptibility  shared liability Index. décimale : PER Périodiques Résumé : Background Why do potentially traumatic events (PTEs) and substance use (SU) so commonly co-occur during adolescence? Causal hypotheses developed from the study of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults have not yet been subject to rigorous theoretical analysis or empirical tests among adolescents with the precursors to these disorders: PTEs and SU. Establishing causality demands accounting for various factors (e.g. genetics, parent education, race/ethnicity) that distinguish youth endorsing PTEs and SU from those who do not, a step often overlooked in previous research. Methods We leveraged nationwide data from a sociodemographically diverse sample of youth (N 11,468) in the Adolescent Brain and Cognitive Development Study. PTEs and substance use prevalence were assessed annually. To account for the many pre-existing differences between youth with and without PTE/SU (i.e. confounding bias) and provide rigorous tests of causal hypotheses, we linked within-person changes in PTEs and SU (alcohol, cannabis, nicotine) across repeated measurements and adjusted for time-varying factors (e.g. age, internalizing symptoms, externalizing symptoms, and friends' use of substances). Results Before adjusting for confounding using within-person modeling, PTEs and SU exhibited significant concurrent associations (?s .46 1.26, ps < .05) and PTEs prospectively predicted greater SU (?s .55 1.43, ps < .05) but not vice versa. After adjustment for confounding, the PTEs exhibited significant concurrent associations for alcohol (?s .14 .23, ps < .05) and nicotine (?s .16, ps < .05) but not cannabis (?s -.01, ps > .05) and PTEs prospectively predicted greater SU (?s .28 .55, ps > .05) but not vice versa. Conclusions When tested rigorously in a nationwide sample of adolescents, we find support for a model in which PTEs are followed by SU but not for a model in which SU is followed by PTEs. Explanations for why PTSD and SUD co-occur in adults may need further theoretical analysis and adaptation before extension to adolescents. En ligne : https://doi.org/10.1111/jcpp.13985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Do traumatic events and substance use co-occur during adolescence? Testing three causal etiologic hypotheses [texte imprimé] / Susan F. TAPERT, Auteur ; Sandra A. BROWN, Auteur ; Sonya B. NORMAN, Auteur ; William E. PELHAM III, Auteur . - p.1388-1397. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1388-1397 Mots-clés : Trauma  childhood  adolescence  alcohol  cannabis  nicotine  etiology  self-medication  susceptibility  shared liability Index. décimale : PER Périodiques Résumé : Background Why do potentially traumatic events (PTEs) and substance use (SU) so commonly co-occur during adolescence? Causal hypotheses developed from the study of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults have not yet been subject to rigorous theoretical analysis or empirical tests among adolescents with the precursors to these disorders: PTEs and SU. Establishing causality demands accounting for various factors (e.g. genetics, parent education, race/ethnicity) that distinguish youth endorsing PTEs and SU from those who do not, a step often overlooked in previous research. Methods We leveraged nationwide data from a sociodemographically diverse sample of youth (N 11,468) in the Adolescent Brain and Cognitive Development Study. PTEs and substance use prevalence were assessed annually. To account for the many pre-existing differences between youth with and without PTE/SU (i.e. confounding bias) and provide rigorous tests of causal hypotheses, we linked within-person changes in PTEs and SU (alcohol, cannabis, nicotine) across repeated measurements and adjusted for time-varying factors (e.g. age, internalizing symptoms, externalizing symptoms, and friends' use of substances). Results Before adjusting for confounding using within-person modeling, PTEs and SU exhibited significant concurrent associations (?s .46 1.26, ps < .05) and PTEs prospectively predicted greater SU (?s .55 1.43, ps < .05) but not vice versa. After adjustment for confounding, the PTEs exhibited significant concurrent associations for alcohol (?s .14 .23, ps < .05) and nicotine (?s .16, ps < .05) but not cannabis (?s -.01, ps > .05) and PTEs prospectively predicted greater SU (?s .28 .55, ps > .05) but not vice versa. Conclusions When tested rigorously in a nationwide sample of adolescents, we find support for a model in which PTEs are followed by SU but not for a model in which SU is followed by PTEs. Explanations for why PTSD and SUD co-occur in adults may need further theoretical analysis and adaptation before extension to adolescents. En ligne : https://doi.org/10.1111/jcpp.13985 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Variants in several genomic regions associated with asperger disorder / Daria SALYAKINA in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.303-310 Titre : Variants in several genomic regions associated with asperger disorder Type de document : texte imprimé Auteurs : Daria SALYAKINA, Auteur ; D.Q. MA, Auteur ; James M. JAWORSKI, Auteur ; Ioanna KONIDARI, Auteur ; Patrice L. WHITEHEAD, Auteur ; Robin K. HENSON, Auteur ; D. MARTINEZ, Auteur ; J.L. ROBINSON, Auteur ; S. SACHAROW, Auteur ; Harry H. WRIGHT, Auteur ; Ruth K. ABRAMSON, Auteur ; John R. GILBERT, Auteur ; Michael L. CUCCARO, Auteur ; Margaret A.O. PERICAK-VANCE, Auteur Année de publication : 2010 Article en page(s) : p.303-310 Langues : Anglais (eng) Mots-clés : asperger  susceptibility  genetics Index. décimale : PER Périodiques Résumé : Asperger disorder (ASP) is one of the autism spectrum disorders (ASD) and is differentiated from autism largely on the absence of clinically significant cognitive and language delays. Analysis of a homogenous subset of families with ASP may help to address the corresponding effect of genetic heterogeneity on identifying ASD genetic risk factors. To examine the hypothesis that common variation is important in ASD, we performed a genome-wide association study (GWAS) in 124 ASP families in a discovery data set and 110 ASP families in a validation data set. We prioritized the top 100 association results from both cohorts by employing a ranking strategy. Novel regions on 5q21.1 (P = 9.7 × 10−7) and 15q22.1–q22.2 (P = 7.3 × 10−6) were our most significant findings in the combined data set. Three chromosomal regions showing association, 3p14.2 (P = 3.6 × 10−6), 3q25–26 (P = 6.0 × 10–5) and 3p23 (P = 3.3 × 10−4) overlapped linkage regions reported in Finnish ASP families, and eight association regions overlapped ASD linkage areas. Our findings suggest that ASP shares both ASD-related genetic risk factors, as well as has genetic risk factors unique to the ASP phenotype. En ligne : http://dx.doi.org/10.1002/aur.158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Variants in several genomic regions associated with asperger disorder [texte imprimé] / Daria SALYAKINA, Auteur ; D.Q. MA, Auteur ; James M. JAWORSKI, Auteur ; Ioanna KONIDARI, Auteur ; Patrice L. WHITEHEAD, Auteur ; Robin K. HENSON, Auteur ; D. MARTINEZ, Auteur ; J.L. ROBINSON, Auteur ; S. SACHAROW, Auteur ; Harry H. WRIGHT, Auteur ; Ruth K. ABRAMSON, Auteur ; John R. GILBERT, Auteur ; Michael L. CUCCARO, Auteur ; Margaret A.O. PERICAK-VANCE, Auteur . - 2010 . - p.303-310. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.303-310 Mots-clés : asperger  susceptibility  genetics Index. décimale : PER Périodiques Résumé : Asperger disorder (ASP) is one of the autism spectrum disorders (ASD) and is differentiated from autism largely on the absence of clinically significant cognitive and language delays. Analysis of a homogenous subset of families with ASP may help to address the corresponding effect of genetic heterogeneity on identifying ASD genetic risk factors. To examine the hypothesis that common variation is important in ASD, we performed a genome-wide association study (GWAS) in 124 ASP families in a discovery data set and 110 ASP families in a validation data set. We prioritized the top 100 association results from both cohorts by employing a ranking strategy. Novel regions on 5q21.1 (P = 9.7 × 10−7) and 15q22.1–q22.2 (P = 7.3 × 10−6) were our most significant findings in the combined data set. Three chromosomal regions showing association, 3p14.2 (P = 3.6 × 10−6), 3q25–26 (P = 6.0 × 10–5) and 3p23 (P = 3.3 × 10−4) overlapped linkage regions reported in Finnish ASP families, and eight association regions overlapped ASD linkage areas. Our findings suggest that ASP shares both ASD-related genetic risk factors, as well as has genetic risk factors unique to the ASP phenotype. En ligne : http://dx.doi.org/10.1002/aur.158 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115