Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) / Nina STENBERG in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.922-932 Titre : Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) Type de document : Texte imprimé et/ou numérique Auteurs : Nina STENBERG, Auteur ; Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anne-Siri ØYEN, Auteur ; Michaeline BRESNAHAN, Auteur ; Britt Kveim SVENDSEN, Auteur ; Stephen VON TETZCHNER, Auteur ; Nina Torheim THRONÆS, Auteur ; Suzanne MACARI, Auteur ; Domenic V. CICCHETTI, Auteur ; Katarzyna CHAWARSKA, Auteur ; Pål SUREN, Auteur ; Roald A. ØIEN, Auteur Article en page(s) : p.922-932 Langues : Anglais (eng) Mots-clés : Ados  Autism spectrum disorders  Cognition  Early identification  Father and child cohort study  Language  MoBa  Norwegian mother  Screening  Vineland Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child Cohort Study and the Autism Birth Cohort study to explore the subsequent developmental and diagnostic characteristics of children raising developmental concern on the six-critical discriminative item criterion of the M-CHAT (DFA6) at 18 months of age (N = 834). The DFA6 identified 28.8% of children diagnosed with ASD (N = 163), but 4.4% with language disorder (N = 188) and 81.3% with intellectual disability (N = 32) without ASD. Scoring in the «at-risk» range was associated with lower IQ, impaired functional language, and greater severity of autism symptoms whether children had ASD or not. En ligne : http://dx.doi.org/10.1007/s10803-020-04539-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa) [Texte imprimé et/ou numérique] / Nina STENBERG, Auteur ; Synnve SCHJØLBERG, Auteur ; Frederick SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Anne-Siri ØYEN, Auteur ; Michaeline BRESNAHAN, Auteur ; Britt Kveim SVENDSEN, Auteur ; Stephen VON TETZCHNER, Auteur ; Nina Torheim THRONÆS, Auteur ; Suzanne MACARI, Auteur ; Domenic V. CICCHETTI, Auteur ; Katarzyna CHAWARSKA, Auteur ; Pål SUREN, Auteur ; Roald A. ØIEN, Auteur . - p.922-932. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.922-932 Mots-clés : Ados  Autism spectrum disorders  Cognition  Early identification  Father and child cohort study  Language  MoBa  Norwegian mother  Screening  Vineland Index. décimale : PER Périodiques Résumé : Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child Cohort Study and the Autism Birth Cohort study to explore the subsequent developmental and diagnostic characteristics of children raising developmental concern on the six-critical discriminative item criterion of the M-CHAT (DFA6) at 18 months of age (N = 834). The DFA6 identified 28.8% of children diagnosed with ASD (N = 163), but 4.4% with language disorder (N = 188) and 81.3% with intellectual disability (N = 32) without ASD. Scoring in the «at-risk» range was associated with lower IQ, impaired functional language, and greater severity of autism symptoms whether children had ASD or not. En ligne : http://dx.doi.org/10.1007/s10803-020-04539-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

The influence of parental concern on the utility of autism diagnostic instruments / Karoline Alexandra HAVDAHL in Autism Research, 10-10 (October 2017)  

Public ISBD [article]  inAutism Research > 10-10 (October 2017) . - p.1672-1686 Titre : The influence of parental concern on the utility of autism diagnostic instruments Type de document : Texte imprimé et/ou numérique Auteurs : Karoline Alexandra HAVDAHL, Auteur ; Somer L. BISHOP, Auteur ; Pål SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Catherine LORD, Auteur ; Andrew PICKLES, Auteur ; Stephen VON TETZCHNER, Auteur ; Synnve SCHJØLBERG, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; W. Ian LIPKIN, Auteur ; Ezra SUSSER, Auteur ; Michaeline BRESNAHAN, Auteur ; Per MAGNUS, Auteur ; Nina STENBERG, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur Article en page(s) : p.1672-1686 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Interview-Revised  Autism Diagnostic Observation Schedule  early diagnosis  screening Index. décimale : PER Périodiques Résumé : The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35–47 months) from the Norwegian Mother and Child Cohort. We also examined whether parental concern about ASD influenced instrument performance, comparing toddlers identified based on parental ASD concern (n?=?48) and parent-reported signs of developmental problems (screening) without a specific concern about ASD (n?=?400). The ADOS cutoffs showed consistently well-balanced sensitivity and specificity. The ADI-R cutoffs demonstrated good specificity, but reduced sensitivity, missing 43% of toddlers whose parents were not specifically concerned about ASD. The ADI-R and ADOS dimensional scores agreed well with clinical diagnoses (area under the curve???0.85), contributing additively to their prediction. On the ADI-R, different cutoffs were needed according to presence or absence of parental ASD concern, in order to achieve comparable balance of sensitivity and specificity. These results highlight the importance of taking parental concern about ASD into account when interpreting scores from parental report-based instruments such as the ADI-R. While the ADOS cutoffs performed consistently well, the additive contributions of ADI-R and ADOS scores to the prediction of ASD diagnosis underscore the value of combining instruments based on parent accounts and clinician observation in evaluation of ASD. Autism Res 2017, 10: 1672–1686. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] The influence of parental concern on the utility of autism diagnostic instruments [Texte imprimé et/ou numérique] / Karoline Alexandra HAVDAHL, Auteur ; Somer L. BISHOP, Auteur ; Pål SUREN, Auteur ; Anne-Siri ØYEN, Auteur ; Catherine LORD, Auteur ; Andrew PICKLES, Auteur ; Stephen VON TETZCHNER, Auteur ; Synnve SCHJØLBERG, Auteur ; Nina GUNNES, Auteur ; Mady HORNIG, Auteur ; W. Ian LIPKIN, Auteur ; Ezra SUSSER, Auteur ; Michaeline BRESNAHAN, Auteur ; Per MAGNUS, Auteur ; Nina STENBERG, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Camilla STOLTENBERG, Auteur . - p.1672-1686. Langues : Anglais (eng) in Autism Research > 10-10 (October 2017) . - p.1672-1686 Mots-clés : Autism Diagnostic Interview-Revised  Autism Diagnostic Observation Schedule  early diagnosis  screening Index. décimale : PER Périodiques Résumé : The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35–47 months) from the Norwegian Mother and Child Cohort. We also examined whether parental concern about ASD influenced instrument performance, comparing toddlers identified based on parental ASD concern (n?=?48) and parent-reported signs of developmental problems (screening) without a specific concern about ASD (n?=?400). The ADOS cutoffs showed consistently well-balanced sensitivity and specificity. The ADI-R cutoffs demonstrated good specificity, but reduced sensitivity, missing 43% of toddlers whose parents were not specifically concerned about ASD. The ADI-R and ADOS dimensional scores agreed well with clinical diagnoses (area under the curve???0.85), contributing additively to their prediction. On the ADI-R, different cutoffs were needed according to presence or absence of parental ASD concern, in order to achieve comparable balance of sensitivity and specificity. These results highlight the importance of taking parental concern about ASD into account when interpreting scores from parental report-based instruments such as the ADI-R. While the ADOS cutoffs performed consistently well, the additive contributions of ADI-R and ADOS scores to the prediction of ASD diagnosis underscore the value of combining instruments based on parent accounts and clinician observation in evaluation of ASD. Autism Res 2017, 10: 1672–1686. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1817 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder / K. Alexandra HAVDAHL in Autism Research, 9-1 (January 2016)  

Public ISBD [article]  inAutism Research > 9-1 (January 2016) . - p.33-42 Titre : Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. Alexandra HAVDAHL, Auteur ; Stephen VON TETZCHNER, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur ; Somer L. BISHOP, Auteur Article en page(s) : p.33-42 Langues : Anglais (eng) Mots-clés : early detection  diagnosis  emotional/behavioral problems  Child Behavior Checklist (CBCL) Index. décimale : PER Périodiques Résumé : The Child Behavior Checklist (CBCL) has been proposed for screening of autism spectrum disorders (ASD) in clinical settings. Given the already widespread use of the CBCL, this could have great implications for clinical practice. This study examined the utility of CBCL profiles in differentiating children with ASD from children with other clinical disorders. Participants were 226 children with ASD and 163 children with attention-deficit/hyperactivity disorder, intellectual disability, language disorders, or emotional disorders, aged 2–13 years. Diagnosis was based on comprehensive clinical evaluation including well-validated diagnostic instruments for ASD and cognitive testing. Discriminative validity of CBCL profiles proposed for ASD screening was examined with area under the curve (AUC) scores, sensitivity, and specificity. The CBCL profiles showed low discriminative accuracy for ASD (AUC 0.59–0.70). Meeting cutoffs proposed for ASD was associated with general emotional/behavioral problems (EBP; mood problems/aggressive behavior), both in children with and without ASD. Cutoff adjustment depending on EBP-level was associated with improved discriminative accuracy for school-age children. However, the rate of false positives remained high in children with clinical levels of EBP. The results indicate that use of the CBCL profiles for ASD-specific screening would likely result in a large number of misclassifications. Although taking EBP-level into account was associated with improved discriminative accuracy for ASD, acceptable specificity could only be achieved for school-age children with below clinical levels of EBP. Further research should explore the potential of using the EBP adjustment strategy to improve the screening efficiency of other more ASD-specific instruments. En ligne : http://dx.doi.org/10.1002/aur.1515 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. Alexandra HAVDAHL, Auteur ; Stephen VON TETZCHNER, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur ; Somer L. BISHOP, Auteur . - p.33-42. Langues : Anglais (eng) in Autism Research > 9-1 (January 2016) . - p.33-42 Mots-clés : early detection  diagnosis  emotional/behavioral problems  Child Behavior Checklist (CBCL) Index. décimale : PER Périodiques Résumé : The Child Behavior Checklist (CBCL) has been proposed for screening of autism spectrum disorders (ASD) in clinical settings. Given the already widespread use of the CBCL, this could have great implications for clinical practice. This study examined the utility of CBCL profiles in differentiating children with ASD from children with other clinical disorders. Participants were 226 children with ASD and 163 children with attention-deficit/hyperactivity disorder, intellectual disability, language disorders, or emotional disorders, aged 2–13 years. Diagnosis was based on comprehensive clinical evaluation including well-validated diagnostic instruments for ASD and cognitive testing. Discriminative validity of CBCL profiles proposed for ASD screening was examined with area under the curve (AUC) scores, sensitivity, and specificity. The CBCL profiles showed low discriminative accuracy for ASD (AUC 0.59–0.70). Meeting cutoffs proposed for ASD was associated with general emotional/behavioral problems (EBP; mood problems/aggressive behavior), both in children with and without ASD. Cutoff adjustment depending on EBP-level was associated with improved discriminative accuracy for school-age children. However, the rate of false positives remained high in children with clinical levels of EBP. The results indicate that use of the CBCL profiles for ASD-specific screening would likely result in a large number of misclassifications. Although taking EBP-level into account was associated with improved discriminative accuracy for ASD, acceptable specificity could only be achieved for school-age children with below clinical levels of EBP. Further research should explore the potential of using the EBP adjustment strategy to improve the screening efficiency of other more ASD-specific instruments. En ligne : http://dx.doi.org/10.1002/aur.1515 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

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