[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1287-1289

Titre :	Editorial: What is depression?
Type de document :	texte imprimé
Auteurs :	Argyris STRINGARIS, Auteur
Article en page(s) :	p.1287-1289
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	‘Depression is a common, debilitating, and potentially lethal disorder.’ This is a standard opening to many a scientific paper on depression. And it is often followed by some very grim statistics. Over 300 million people in the world are estimated to live with depression, and the disorder is ranked by WHO as the single largest contributor to global disability. Most worryingly, adolescents with major depressive disorder are up to 30 times more likely to commit suicide. Yet, what exactly is depression? Do all 300 million depressed people in the world suffer from the same thing, with the same aetiology? Is depression one disorder that comes in different shades of severity or is it best thought of as heterogeneous mix of problems that we have given one common name to? And, more practically, should we be treating all depression in similar ways?
En ligne :	http://dx.doi.org/10.1111/jcpp.12844
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] Editorial: What is depression? [texte imprimé] / Argyris STRINGARIS, Auteur . - p.1287-1289.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1287-1289

Index. décimale :	PER Périodiques
Résumé :	‘Depression is a common, debilitating, and potentially lethal disorder.’ This is a standard opening to many a scientific paper on depression. And it is often followed by some very grim statistics. Over 300 million people in the world are estimated to live with depression, and the disorder is ranked by WHO as the single largest contributor to global disability. Most worryingly, adolescents with major depressive disorder are up to 30 times more likely to commit suicide. Yet, what exactly is depression? Do all 300 million depressed people in the world suffer from the same thing, with the same aetiology? Is depression one disorder that comes in different shades of severity or is it best thought of as heterogeneous mix of problems that we have given one common name to? And, more practically, should we be treating all depression in similar ways?
En ligne :	http://dx.doi.org/10.1111/jcpp.12844
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1290-1300

Titre :	Research Review: The role of obstetric and neonatal complications in childhood attention deficit and hyperactivity disorder – a systematic review
Type de document :	texte imprimé
Auteurs :	Marta SERATI, Auteur ; Jennifer L. BARKIN, Auteur ; Giulia ORSENIGO, Auteur ; Alfredo Carlo ALTAMURA, Auteur ; Massimiliano BUOLI, Auteur
Article en page(s) :	p.1290-1300
Langues :	Anglais (eng)
Mots-clés :	Attention deficit and hyperactivity disorder  perinatal  complications  child development  review
Index. décimale :	PER Périodiques
Résumé :	Background Attention deficit and hyperactivity disorder (ADHD) is a developmental disorder characterized by an inability to sustain attention, activity levels and impulse control, and, according to the latest studies, the prevalence is about 8% and in some countries less than 1%. Currently, it is well-known that complications during the perinatal period have significant implications on child's physical and mental health. Purpose of the present paper is to review the literature about the association between perinatal complications and future risk of an ADHD diagnosis. Methods A research in the main database sources has been conducted to obtain a systematic review on the perinatal risk factors of ADHD. Results Among perinatal complications, available data indicate low birth weight (LBW) (Cohen's d effect size range: 0.31–1.64-small effect size) and preterm birth (PB) (range d: 0.41–0.68) as the most important factors associated with a future diagnosis of ADHD. Conclusions
En ligne :	http://dx.doi.org/10.1111/jcpp.12779
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] Research Review: The role of obstetric and neonatal complications in childhood attention deficit and hyperactivity disorder – a systematic review [texte imprimé] / Marta SERATI, Auteur ; Jennifer L. BARKIN, Auteur ; Giulia ORSENIGO, Auteur ; Alfredo Carlo ALTAMURA, Auteur ; Massimiliano BUOLI, Auteur . - p.1290-1300.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1290-1300

Mots-clés :	Attention deficit and hyperactivity disorder  perinatal  complications  child development  review
Index. décimale :	PER Périodiques
Résumé :	Background Attention deficit and hyperactivity disorder (ADHD) is a developmental disorder characterized by an inability to sustain attention, activity levels and impulse control, and, according to the latest studies, the prevalence is about 8% and in some countries less than 1%. Currently, it is well-known that complications during the perinatal period have significant implications on child's physical and mental health. Purpose of the present paper is to review the literature about the association between perinatal complications and future risk of an ADHD diagnosis. Methods A research in the main database sources has been conducted to obtain a systematic review on the perinatal risk factors of ADHD. Results Among perinatal complications, available data indicate low birth weight (LBW) (Cohen's d effect size range: 0.31–1.64-small effect size) and preterm birth (PB) (range d: 0.41–0.68) as the most important factors associated with a future diagnosis of ADHD. Conclusions
En ligne :	http://dx.doi.org/10.1111/jcpp.12779
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1301-1309

Titre :	Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms
Type de document :	texte imprimé
Auteurs :	Evelien VAN ASSCHE, Auteur ; Tim MOONS, Auteur ; Ozan CINAR, Auteur ; Wolfgang VIECHTBAUER, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Karla VAN LEEUWEN, Auteur ; Karine VERSCHUEREN, Auteur ; Hilde COLPIN, Auteur ; Diether LAMBRECHTS, Auteur ; Wim VAN DEN NOORTGATE, Auteur ; Luc GOOSSENS, Auteur ; Stephan CLAES, Auteur ; Ruud VAN WINKEL, Auteur
Article en page(s) :	p.1301-1309
Langues :	Anglais (eng)
Mots-clés :	Gene–environment interaction  polygenic  parenting  gene-based testing  adolescents  depression
Index. décimale :	PER Périodiques
Résumé :	Background Most gene-environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that accounts for the polygenic nature of most psychiatric phenotypes and reduces the risk of false-positive findings. We apply this method focusing on the role of perceived parental support, psychological control, and harsh punishment in depressive symptoms in adolescence. Methods Analyses were conducted on 982 adolescents of Caucasian origin (Mage (SD) = 13.78 (.94) years) genotyped for 4,947 SNPs in 263 genes, selected based on a literature survey. The Leuven Adolescent Perceived Parenting Scale (LAPPS) and the Parental Behavior Scale (PBS) were used to assess perceived parental psychological control, harsh punishment, and support. The Center for Epidemiologic Studies Depression Scale (CES-D) was the outcome. We used gene-based testing taking into account linkage disequilibrium to identify genes containing SNPs exhibiting an interaction with environmental factors yielding a p-value per single gene. Significant results at the corrected p-value of p < 1.90 × 10?4 were examined in an independent replication sample of Dutch adolescents (N = 1354). Results Two genes showed evidence for interaction with perceived support: GABRR1 (p = 4.62 × 10?5) and GABRR2 (p = 9.05 × 10?6). No genes interacted significantly with psychological control or harsh punishment. Gene-based analysis was unable to confirm the interaction of GABRR1 or GABRR2 with support in the replication sample. However, for GABRR2, but not GABRR1, the correlation of the estimates between the two datasets was significant (r (46) = .32; p = .027) and a gene-based analysis of the combined datasets supported GABRR2 × support interaction (p = 1.63 × 10?4). Conclusions We present a gene-based method for gene–environment interactions in a polygenic context and show that genes interact differently with particular aspects of parenting. This accentuates the importance of polygenic approaches and the need to accurately assess environmental exposure in G × E.
En ligne :	http://dx.doi.org/10.1111/jcpp.12766
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms [texte imprimé] / Evelien VAN ASSCHE, Auteur ; Tim MOONS, Auteur ; Ozan CINAR, Auteur ; Wolfgang VIECHTBAUER, Auteur ; Albertine J. OLDEHINKEL, Auteur ; Karla VAN LEEUWEN, Auteur ; Karine VERSCHUEREN, Auteur ; Hilde COLPIN, Auteur ; Diether LAMBRECHTS, Auteur ; Wim VAN DEN NOORTGATE, Auteur ; Luc GOOSSENS, Auteur ; Stephan CLAES, Auteur ; Ruud VAN WINKEL, Auteur . - p.1301-1309.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1301-1309

Mots-clés :	Gene–environment interaction  polygenic  parenting  gene-based testing  adolescents  depression
Index. décimale :	PER Périodiques
Résumé :	Background Most gene-environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that accounts for the polygenic nature of most psychiatric phenotypes and reduces the risk of false-positive findings. We apply this method focusing on the role of perceived parental support, psychological control, and harsh punishment in depressive symptoms in adolescence. Methods Analyses were conducted on 982 adolescents of Caucasian origin (Mage (SD) = 13.78 (.94) years) genotyped for 4,947 SNPs in 263 genes, selected based on a literature survey. The Leuven Adolescent Perceived Parenting Scale (LAPPS) and the Parental Behavior Scale (PBS) were used to assess perceived parental psychological control, harsh punishment, and support. The Center for Epidemiologic Studies Depression Scale (CES-D) was the outcome. We used gene-based testing taking into account linkage disequilibrium to identify genes containing SNPs exhibiting an interaction with environmental factors yielding a p-value per single gene. Significant results at the corrected p-value of p < 1.90 × 10?4 were examined in an independent replication sample of Dutch adolescents (N = 1354). Results Two genes showed evidence for interaction with perceived support: GABRR1 (p = 4.62 × 10?5) and GABRR2 (p = 9.05 × 10?6). No genes interacted significantly with psychological control or harsh punishment. Gene-based analysis was unable to confirm the interaction of GABRR1 or GABRR2 with support in the replication sample. However, for GABRR2, but not GABRR1, the correlation of the estimates between the two datasets was significant (r (46) = .32; p = .027) and a gene-based analysis of the combined datasets supported GABRR2 × support interaction (p = 1.63 × 10?4). Conclusions We present a gene-based method for gene–environment interactions in a polygenic context and show that genes interact differently with particular aspects of parenting. This accentuates the importance of polygenic approaches and the need to accurately assess environmental exposure in G × E.
En ligne :	http://dx.doi.org/10.1111/jcpp.12766
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3267

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1310-1318

Titre :	Violence exposure is associated with adolescents' same- and next-day mental health symptoms
Type de document :	texte imprimé
Auteurs :	Candice L. ODGERS, Auteur ; Michael A. RUSSELL, Auteur
Article en page(s) :	p.1310-1318
Langues :	Anglais (eng)
Mots-clés :	Violence exposure  daily stressors  aggression  depression  health-risk behaviors  mobile technologies  ecological momentary assessment  early adolescence
Index. décimale :	PER Périodiques
Résumé :	Background Young people exposed to violence are at increased risk for mental health and behavioral problems. However, very little is known about the immediate, or same-day, associations between violence exposure and adolescents' mental health symptoms or whether daily symptom or behavioral reactivity marks future problems. Methods Young adolescents were assessed three times a day for 30 consecutive days using mobile-phone-based Ecological Momentary Assessment (EMA) (N = 151 adolescents). Over 12,500 assessments and 4,329 person days were obtained via the EMA. Adolescents were recruited from low-income neighborhoods based on parent-reported risk for externalizing symptoms. Mental health symptoms were assessed via parent and child report at baseline, multiple times per day via EMA assessments of the adolescents, and again 18 months later when 93% of the adolescents were reinterviewed. Results Results from multilevel models illustrated that young adolescents were more likely to experience symptoms of anger (OR = 1.74, CI: 1.31–2.30), depression (OR = 1.66, CI: 1.26–2.19), and conduct problems (OR = 2.63, CI: 1.71–4.04) on days that they were exposed versus not exposed to violence. Increases in depressive symptoms were also observed on days following violence exposure (OR = 1.46, CI: 1.09–1.97). Adolescents with the highest levels of violence exposure across the 30-day EMA were less behaviorally reactive to violence exposures in daily life, and heightened behavioral reactivity predicted increased risk for substance use across early adolescence. Conclusions Findings support the need to focus on both the immediate and long-term associations between violence exposure and adolescents' mental health and behavior. Results also suggest that heightened behavioral reactivity during early adolescence may signal emerging substance use problems.
En ligne :	http://dx.doi.org/10.1111/jcpp.12763
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] Violence exposure is associated with adolescents' same- and next-day mental health symptoms [texte imprimé] / Candice L. ODGERS, Auteur ; Michael A. RUSSELL, Auteur . - p.1310-1318.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1310-1318

Mots-clés :	Violence exposure  daily stressors  aggression  depression  health-risk behaviors  mobile technologies  ecological momentary assessment  early adolescence
Index. décimale :	PER Périodiques
Résumé :	Background Young people exposed to violence are at increased risk for mental health and behavioral problems. However, very little is known about the immediate, or same-day, associations between violence exposure and adolescents' mental health symptoms or whether daily symptom or behavioral reactivity marks future problems. Methods Young adolescents were assessed three times a day for 30 consecutive days using mobile-phone-based Ecological Momentary Assessment (EMA) (N = 151 adolescents). Over 12,500 assessments and 4,329 person days were obtained via the EMA. Adolescents were recruited from low-income neighborhoods based on parent-reported risk for externalizing symptoms. Mental health symptoms were assessed via parent and child report at baseline, multiple times per day via EMA assessments of the adolescents, and again 18 months later when 93% of the adolescents were reinterviewed. Results Results from multilevel models illustrated that young adolescents were more likely to experience symptoms of anger (OR = 1.74, CI: 1.31–2.30), depression (OR = 1.66, CI: 1.26–2.19), and conduct problems (OR = 2.63, CI: 1.71–4.04) on days that they were exposed versus not exposed to violence. Increases in depressive symptoms were also observed on days following violence exposure (OR = 1.46, CI: 1.09–1.97). Adolescents with the highest levels of violence exposure across the 30-day EMA were less behaviorally reactive to violence exposures in daily life, and heightened behavioral reactivity predicted increased risk for substance use across early adolescence. Conclusions Findings support the need to focus on both the immediate and long-term associations between violence exposure and adolescents' mental health and behavior. Results also suggest that heightened behavioral reactivity during early adolescence may signal emerging substance use problems.
En ligne :	http://dx.doi.org/10.1111/jcpp.12763
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1319-1329

Titre :	Implicit identification with death predicts change in suicide ideation during psychiatric treatment in adolescents
Type de document :	texte imprimé
Auteurs :	Catherine R. GLENN, Auteur ; Evan M. KLEIMAN, Auteur ; Daniel D. L. COPPERSMITH, Auteur ; Angela C. SANTEE, Auteur ; Erika C. ESPOSITO, Auteur ; Christine B. CHA, Auteur ; Matthew K. NOCK, Auteur ; Randy P. AUERBACH, Auteur
Article en page(s) :	p.1319-1329
Langues :	Anglais (eng)
Mots-clés :	Suicide  suicidal behavior  adolescence  information processing  prediction
Index. décimale :	PER Périodiques
Résumé :	Background Suicidal thoughts and behaviors are major public health concerns in youth. Unfortunately, knowledge of reliable predictors of suicide risk in adolescents is limited. Promising research using a death stimuli version of the Implicit Association Test (Death IAT) indicates that stronger identification with death differs between adults with and without a history of suicidal thoughts and behaviors and uniquely predicts suicide ideation and behavior. However, research in adolescents is lacking and existing findings have been mixed. This study extends previous research by testing whether implicit identification with death predicts changes in suicide ideation during psychiatric treatment in adolescents. Methods Participants included 276 adolescents, ages 13–19, admitted to a short-term residential treatment program. At hospital admission and discharge, adolescents completed the Death IAT and measures of recent suicidal thoughts. Results At admission, implicit identification with death was associated with recent suicide ideation, but did not differ between those who engaged in prior suicidal behavior and those who did not. Prospectively, adolescents' implicit identification with death at admission significantly predicted their suicide ideation severity at discharge, above and beyond explicit suicide ideation. However, this effect only was significant for adolescents with longer treatment stays (i.e., more than 13 days). Conclusions Implicit identification with death predicts suicidal thinking among adolescents in psychiatric treatment. Findings clarify over what period of time implicit cognition about death may predict suicide risk in adolescents.
En ligne :	http://dx.doi.org/10.1111/jcpp.12769
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] Implicit identification with death predicts change in suicide ideation during psychiatric treatment in adolescents [texte imprimé] / Catherine R. GLENN, Auteur ; Evan M. KLEIMAN, Auteur ; Daniel D. L. COPPERSMITH, Auteur ; Angela C. SANTEE, Auteur ; Erika C. ESPOSITO, Auteur ; Christine B. CHA, Auteur ; Matthew K. NOCK, Auteur ; Randy P. AUERBACH, Auteur . - p.1319-1329.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1319-1329

Mots-clés :	Suicide  suicidal behavior  adolescence  information processing  prediction
Index. décimale :	PER Périodiques
Résumé :	Background Suicidal thoughts and behaviors are major public health concerns in youth. Unfortunately, knowledge of reliable predictors of suicide risk in adolescents is limited. Promising research using a death stimuli version of the Implicit Association Test (Death IAT) indicates that stronger identification with death differs between adults with and without a history of suicidal thoughts and behaviors and uniquely predicts suicide ideation and behavior. However, research in adolescents is lacking and existing findings have been mixed. This study extends previous research by testing whether implicit identification with death predicts changes in suicide ideation during psychiatric treatment in adolescents. Methods Participants included 276 adolescents, ages 13–19, admitted to a short-term residential treatment program. At hospital admission and discharge, adolescents completed the Death IAT and measures of recent suicidal thoughts. Results At admission, implicit identification with death was associated with recent suicide ideation, but did not differ between those who engaged in prior suicidal behavior and those who did not. Prospectively, adolescents' implicit identification with death at admission significantly predicted their suicide ideation severity at discharge, above and beyond explicit suicide ideation. However, this effect only was significant for adolescents with longer treatment stays (i.e., more than 13 days). Conclusions Implicit identification with death predicts suicidal thinking among adolescents in psychiatric treatment. Findings clarify over what period of time implicit cognition about death may predict suicide risk in adolescents.
En ligne :	http://dx.doi.org/10.1111/jcpp.12769
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1330-1340

Titre :	Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years
Type de document :	texte imprimé
Auteurs :	Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; Greg PASCO, Auteur ; Rachael BEDFORD, Auteur ; Ming Wai WAN, Auteur ; Mayada ELSABBAGH, Auteur ; Vicky SLONIMS, Auteur ; Teea GLIGA, Auteur ; Emily JONES, Auteur ; Celeste CHEUNG, Auteur ; Tony CHARMAN, Auteur ; Mark JOHNSON, Auteur ; Team THE BRITISH AUTISM STUDY OF INFANT SIBLINGS, Auteur
Article en page(s) :	p.1330-1340
Langues :	Anglais (eng)
Mots-clés :	Pre-emptive intervention  prevention trials  autism  autism spectrum disorder  high-risk siblings  parent-mediated intervention
Index. décimale :	PER Périodiques
Résumé :	Background There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. Primary outcome: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind-rated parent–child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.
En ligne :	http://dx.doi.org/10.1111/jcpp.12728
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years [texte imprimé] / Jonathan GREEN, Auteur ; Andrew PICKLES, Auteur ; Greg PASCO, Auteur ; Rachael BEDFORD, Auteur ; Ming Wai WAN, Auteur ; Mayada ELSABBAGH, Auteur ; Vicky SLONIMS, Auteur ; Teea GLIGA, Auteur ; Emily JONES, Auteur ; Celeste CHEUNG, Auteur ; Tony CHARMAN, Auteur ; Mark JOHNSON, Auteur ; Team THE BRITISH AUTISM STUDY OF INFANT SIBLINGS, Auteur . - p.1330-1340.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1330-1340

Mots-clés :	Pre-emptive intervention  prevention trials  autism  autism spectrum disorder  high-risk siblings  parent-mediated intervention
Index. décimale :	PER Périodiques
Résumé :	Background There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. Primary outcome: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind-rated parent–child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.
En ligne :	http://dx.doi.org/10.1111/jcpp.12728
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3268

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350

Titre :	Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio
Type de document :	texte imprimé
Auteurs :	Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A. TURNER, Auteur ; Vince CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur
Article en page(s) :	p.1341-1350
Langues :	Anglais (eng)
Mots-clés :	DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children
Index. décimale :	PER Périodiques
Résumé :	Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology.
En ligne :	http://dx.doi.org/10.1111/jcpp.12740
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3269

[article] Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio [texte imprimé] / Esther WALTON, Auteur ; Charlotte A. M. CECIL, Auteur ; Matthew SUDERMAN, Auteur ; Jingyu LIU, Auteur ; Jessica A. TURNER, Auteur ; Vince CALHOUN, Auteur ; Stefan EHRLICH, Auteur ; Caroline L. RELTON, Auteur ; Edward D. BARKER, Auteur . - p.1341-1350.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1341-1350

Mots-clés :	DNA methylation  methylome-wide  amygdala  hippocampus  longitudinal  Avon Longitudinal Study of Parents and Children
Index. décimale :	PER Périodiques
Résumé :	Background The ratio between amygdala:hippocampal (AH) volume has been associated with multiple psychiatric problems, including anxiety and aggression. Yet, little is known about its biological underpinnings. Here, we used a methylome-wide approach to test (a) whether DNA methylation in early life (birth, age 7) prospectively associates with total AH volume ratio in early adulthood, and (b) whether significant DNA methylation markers are influenced by prenatal risk factors. Methods Analyses were based on a subsample (n = 109 males) from the Avon Longitudinal Study of Parents and Children, which included measures of prenatal risk, DNA methylation (Infinium Illumina 450k), T1-weighted brain scans and psychopathology in early adulthood (age 18–21). Amygdala and hippocampus measures were derived using Freesurfer 5.3.0. Methylation markers related to AH volume ratio across time were identified using longitudinal multilevel modeling. Results Amygdala:hippocampal volume ratio correlated positively with age 18 psychosis-like symptoms (p = .007). Methylation of a probe in the gene SP6 associated longitudinally with (a) higher AH volume ratio (FDR q-value = .01) and (b) higher stressful life events during pregnancy (p = .046). SP6 is expressed in the hippocampus and amygdala and has been implicated in cognitive decline in Alzheimer's disease. The association between SP6 DNA methylation, AH volume ratio and psychopathology was replicated in an independent dataset of 101 patients with schizophrenia and 111 healthy controls. Conclusions Our findings suggest that epigenetic alterations in genes implicated in neurodevelopment may contribute to a brain-based biomarker of psychopathology.
En ligne :	http://dx.doi.org/10.1111/jcpp.12740
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[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1351-1359

Titre :	Brainstem as a developmental gateway to social attention
Type de document :	texte imprimé
Auteurs :	Ronny GEVA, Auteur ; Ayelet DITAL, Auteur ; Dan RAMON, Auteur ; Jessica YARMOLOVSKY, Auteur ; Maor GIDRON, Auteur ; Jacob KUINT, Auteur
Article en page(s) :	p.1351-1359
Langues :	Anglais (eng)
Mots-clés :	Brainstem  development  social attention  attention
Index. décimale :	PER Périodiques
Résumé :	Background Evolution preserves social attention due to its key role in supporting survival. Humans are attracted to social cues from infancy, but the neurobiological mechanisms for the development of social attention are unknown. An evolutionary-based, vertical-hierarchical theoretical model of self-regulation suggests that neonatal brainstem inputs are key for the development of well-regulated social attention. Methods Neonates born preterm (N = 44, GA 34 w.) were recruited and diagnosed at birth as a function of their auditory brainstem evoked responses (ABR). Participants enrolled in a prospective 8-year-long, double-blind, follow-up study comparing participants with brainstem dysfunctions and well-matched controls. Groups had comparable fetal, neonatal, and familial characteristics. Methods incorporated EEG power analysis and gaze tracking during the Attention Network Test (ANT, four cue types, and two targets) and a Triadic Gaze Engagement task (TGE, three social cue levels). Results Results showed that neonatal brainstem compromise is related to long-term changes in Alpha- and Theta-band power asymmetries (p < .034, p < .016, respectively), suggesting suppressed bottom-up input needed to alert social attention. Gaze tracking indicated dysregulated arousal-modulated attention (p < .004) and difficulty in gaze engagement to socially neutral compared to nonsocial cues (p < .012). Conclusions Integrating models of Autism and cross-species data with current long-term follow-up of infants with discrete neonatal brainstem dysfunction suggests neonatal brainstem input as a gateway for bottom-up regulation of social attention.
En ligne :	http://dx.doi.org/10.1111/jcpp.12746
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[article] Brainstem as a developmental gateway to social attention [texte imprimé] / Ronny GEVA, Auteur ; Ayelet DITAL, Auteur ; Dan RAMON, Auteur ; Jessica YARMOLOVSKY, Auteur ; Maor GIDRON, Auteur ; Jacob KUINT, Auteur . - p.1351-1359.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1351-1359

Mots-clés :	Brainstem  development  social attention  attention
Index. décimale :	PER Périodiques
Résumé :	Background Evolution preserves social attention due to its key role in supporting survival. Humans are attracted to social cues from infancy, but the neurobiological mechanisms for the development of social attention are unknown. An evolutionary-based, vertical-hierarchical theoretical model of self-regulation suggests that neonatal brainstem inputs are key for the development of well-regulated social attention. Methods Neonates born preterm (N = 44, GA 34 w.) were recruited and diagnosed at birth as a function of their auditory brainstem evoked responses (ABR). Participants enrolled in a prospective 8-year-long, double-blind, follow-up study comparing participants with brainstem dysfunctions and well-matched controls. Groups had comparable fetal, neonatal, and familial characteristics. Methods incorporated EEG power analysis and gaze tracking during the Attention Network Test (ANT, four cue types, and two targets) and a Triadic Gaze Engagement task (TGE, three social cue levels). Results Results showed that neonatal brainstem compromise is related to long-term changes in Alpha- and Theta-band power asymmetries (p < .034, p < .016, respectively), suggesting suppressed bottom-up input needed to alert social attention. Gaze tracking indicated dysregulated arousal-modulated attention (p < .004) and difficulty in gaze engagement to socially neutral compared to nonsocial cues (p < .012). Conclusions Integrating models of Autism and cross-species data with current long-term follow-up of infants with discrete neonatal brainstem dysfunction suggests neonatal brainstem input as a gateway for bottom-up regulation of social attention.
En ligne :	http://dx.doi.org/10.1111/jcpp.12746
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3269

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1360-1369

Titre :	Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators
Type de document :	texte imprimé
Auteurs :	Josiane BOURQUE, Auteur ; Mohammad H. AFZALI, Auteur ; Maeve O'LEARY-BARRETT, Auteur ; Patricia CONROD, Auteur
Article en page(s) :	p.1360-1369
Langues :	Anglais (eng)
Mots-clés :	Psychotic-like experiences  trajectory  cannabis use  mediation  depression symptoms  anxiety symptoms  cognitive function
Index. décimale :	PER Périodiques
Résumé :	Background The authors sought to model the different trajectories of psychotic-like experiences (PLE) during adolescence and to examine whether the longitudinal relationship between cannabis use and PLE is mediated by changes in cognitive development and/or change in anxiety or depression symptoms. Methods A total of 2,566 youths were assessed every year for 4-years (from 13- to 16-years of age) on clinical, substance use and cognitive development outcomes. Latent class growth models identified three trajectories of PLE: low decreasing (83.9%), high decreasing (7.9%), and moderate increasing class (8.2%). We conducted logistic regressions to investigate whether baseline levels and growth in cannabis use were associated with PLE trajectory membership. Then, we examined the effects of potential mediators (growth in cognition and anxiety/depression) on the relationship between growth in cannabis use and PLE trajectory. Results A steeper growth in cannabis use from 13- to 16-years was associated with a higher likelihood of being assigned to the moderate increasing trajectory of PLE [odds ratio, 2.59; 95% confidence interval (CI), 1.11–6.03], when controlling for cumulative cigarette use. Growth in depression symptoms, not anxiety or change in cognitive functioning, mediated the relationship between growth in cannabis use and the PLE moderate increasing group (indirect effect: 0.07; 95% CI, 0.03–0.11). Conclusions Depression symptoms partially mediated the longitudinal link between cannabis use and PLE in adolescents, suggesting that there may be a preventative effect to be gained from targeting depression symptoms, in addition to attempting to prevent cannabis use in youth presenting increasing psychotic experiences.
En ligne :	http://dx.doi.org/10.1111/jcpp.12765
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[article] Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators [texte imprimé] / Josiane BOURQUE, Auteur ; Mohammad H. AFZALI, Auteur ; Maeve O'LEARY-BARRETT, Auteur ; Patricia CONROD, Auteur . - p.1360-1369.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1360-1369

Mots-clés :	Psychotic-like experiences  trajectory  cannabis use  mediation  depression symptoms  anxiety symptoms  cognitive function
Index. décimale :	PER Périodiques
Résumé :	Background The authors sought to model the different trajectories of psychotic-like experiences (PLE) during adolescence and to examine whether the longitudinal relationship between cannabis use and PLE is mediated by changes in cognitive development and/or change in anxiety or depression symptoms. Methods A total of 2,566 youths were assessed every year for 4-years (from 13- to 16-years of age) on clinical, substance use and cognitive development outcomes. Latent class growth models identified three trajectories of PLE: low decreasing (83.9%), high decreasing (7.9%), and moderate increasing class (8.2%). We conducted logistic regressions to investigate whether baseline levels and growth in cannabis use were associated with PLE trajectory membership. Then, we examined the effects of potential mediators (growth in cognition and anxiety/depression) on the relationship between growth in cannabis use and PLE trajectory. Results A steeper growth in cannabis use from 13- to 16-years was associated with a higher likelihood of being assigned to the moderate increasing trajectory of PLE [odds ratio, 2.59; 95% confidence interval (CI), 1.11–6.03], when controlling for cumulative cigarette use. Growth in depression symptoms, not anxiety or change in cognitive functioning, mediated the relationship between growth in cannabis use and the PLE moderate increasing group (indirect effect: 0.07; 95% CI, 0.03–0.11). Conclusions Depression symptoms partially mediated the longitudinal link between cannabis use and PLE in adolescents, suggesting that there may be a preventative effect to be gained from targeting depression symptoms, in addition to attempting to prevent cannabis use in youth presenting increasing psychotic experiences.
En ligne :	http://dx.doi.org/10.1111/jcpp.12765
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3269

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1370-1380

Titre :	Interactions between empathy and resting heart rate in early adolescence predict violent behavior in late adolescence and early adulthood
Type de document :	texte imprimé
Auteurs :	Chardée A. GALÁN, Auteur ; Daniel Ewon CHOE, Auteur ; Erika E. FORBES, Auteur ; Daniel S. SHAW, Auteur
Article en page(s) :	p.1370-1380
Langues :	Anglais (eng)
Mots-clés :	Antisocial behavior  psychophysiology  resting heart rate  violence
Index. décimale :	PER Périodiques
Résumé :	Background Although resting heart rate (RHR) and empathy are independently and negatively associated with violent behavior, relatively little is known about the interplay between these psychophysiological and temperament-related risk factors. Methods Using a sample of 160 low-income, racially diverse men followed prospectively from infancy through early adulthood, this study examined whether RHR and empathy during early adolescence independently and interactively predict violent behavior and related correlates in late adolescence and early adulthood. Results Controlling for child ethnicity, family income, and child antisocial behavior at age 12, empathy inversely predicted moral disengagement and juvenile petitions for violent crimes, while RHR was unrelated to all measures of violent behavior. Interactive effects were also evident such that among men with lower but not higher levels of RHR, lower empathy predicted increased violent behavior, as indexed by juvenile arrests for violent offenses, peer-reported violent behavior at age 17, self-reported moral disengagement at age 17, and self-reported violent behavior at age 20. Conclusions Implications for prevention and intervention are considered. Specifically, targeting empathic skills among individuals at risk for violent behavior because of specific psychophysiological profiles may lead to more impactful interventions.
En ligne :	http://dx.doi.org/10.1111/jcpp.12771
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[article] Interactions between empathy and resting heart rate in early adolescence predict violent behavior in late adolescence and early adulthood [texte imprimé] / Chardée A. GALÁN, Auteur ; Daniel Ewon CHOE, Auteur ; Erika E. FORBES, Auteur ; Daniel S. SHAW, Auteur . - p.1370-1380.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1370-1380

Mots-clés :	Antisocial behavior  psychophysiology  resting heart rate  violence
Index. décimale :	PER Périodiques
Résumé :	Background Although resting heart rate (RHR) and empathy are independently and negatively associated with violent behavior, relatively little is known about the interplay between these psychophysiological and temperament-related risk factors. Methods Using a sample of 160 low-income, racially diverse men followed prospectively from infancy through early adulthood, this study examined whether RHR and empathy during early adolescence independently and interactively predict violent behavior and related correlates in late adolescence and early adulthood. Results Controlling for child ethnicity, family income, and child antisocial behavior at age 12, empathy inversely predicted moral disengagement and juvenile petitions for violent crimes, while RHR was unrelated to all measures of violent behavior. Interactive effects were also evident such that among men with lower but not higher levels of RHR, lower empathy predicted increased violent behavior, as indexed by juvenile arrests for violent offenses, peer-reported violent behavior at age 17, self-reported moral disengagement at age 17, and self-reported violent behavior at age 20. Conclusions Implications for prevention and intervention are considered. Specifically, targeting empathic skills among individuals at risk for violent behavior because of specific psychophysiological profiles may lead to more impactful interventions.
En ligne :	http://dx.doi.org/10.1111/jcpp.12771
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3270

[article] 
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1381-1382

Titre :	Editorial Perspective: Whatever happened to temperament?
Type de document :	texte imprimé
Auteurs :	William B. CAREY, Auteur
Article en page(s) :	p.1381-1382
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	A recent editorial in this journal supported our need to be ‘mindful of the field's strict adherence to the disease model of psychopathology, and wondered (not for the first time) whether our total allegiance to this model has obscured important information.’ Dr. Burt pointed to studies in which normal behavioral style traits such as activity and resilience may have been significant factors in the outcome. These traits bear a close relationship to two of the nine normal temperament traits described by Chess and Thomas in their New York Longitudinal Study starting in 1956. Despite past acceptance, their important contribution to outcomes has been largely ignored for some time. However, lately there has been an unexpected revival of them. All nine of the NYLS traits have individually been shown to matter sometimes in mental health outcomes. It is not just activity and resilience or adaptability but all the rest: irregularity, inhibition, intensity, irritability, persistence, distractibility, and sensitivity. Should we not consider all normal temperamental predispositions as possible risk or protective factors in appraisals of behavioral outcomes and not just pathological nature and/or nurture contributions?
En ligne :	http://dx.doi.org/10.1111/jcpp.12816
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[article] Editorial Perspective: Whatever happened to temperament? [texte imprimé] / William B. CAREY, Auteur . - p.1381-1382.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1381-1382

Index. décimale :	PER Périodiques
Résumé :	A recent editorial in this journal supported our need to be ‘mindful of the field's strict adherence to the disease model of psychopathology, and wondered (not for the first time) whether our total allegiance to this model has obscured important information.’ Dr. Burt pointed to studies in which normal behavioral style traits such as activity and resilience may have been significant factors in the outcome. These traits bear a close relationship to two of the nine normal temperament traits described by Chess and Thomas in their New York Longitudinal Study starting in 1956. Despite past acceptance, their important contribution to outcomes has been largely ignored for some time. However, lately there has been an unexpected revival of them. All nine of the NYLS traits have individually been shown to matter sometimes in mental health outcomes. It is not just activity and resilience or adaptability but all the rest: irregularity, inhibition, intensity, irritability, persistence, distractibility, and sensitivity. Should we not consider all normal temperamental predispositions as possible risk or protective factors in appraisals of behavioral outcomes and not just pathological nature and/or nurture contributions?
En ligne :	http://dx.doi.org/10.1111/jcpp.12816
Permalink :	http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3270