Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity / A. RODRIGUEZ in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1073-1083 Titre : Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity Type de document : Texte imprimé et/ou numérique Auteurs : A. RODRIGUEZ, Auteur ; Jouko MIETTUNEN, Auteur ; H. EBELING, Auteur ; A. TAANILA, Auteur ; K.M. LINNET, Auteur ; Tine Brink HENRIKSEN, Auteur ; M. KAAKINEN, Auteur ; A.J. KOTIMAA, Auteur ; Carsten OBEL, Auteur ; Jørn OLSEN, Auteur ; Irma MOILANEN, Auteur ; Marjo-Riitta JARVELIN, Auteur Année de publication : 2009 Article en page(s) : p.1073-1083 Langues : Anglais (eng) Mots-clés : ADHD alcohol inattention/hyperactivity-symptoms prenatal social-factors behavior-problems cross-cultural longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Studies concerning whether exposure to low levels of maternal alcohol consumption during fetal development is related to child inattention and hyperactivity symptoms have shown conflicting results. We examine the contribution of covariates related to social adversity to resolve some inconsistencies in the extant research by conducting parallel analyses of three cohorts with varying alcohol consumption and attitudes towards alcohol use. Methods: We compare three population-based pregnancy–offspring cohorts within the Nordic Network on ADHD from Denmark and Finland. Prenatal data were gathered via self-report during pregnancy and birth outcomes were abstracted from medical charts. A total of 21,678 reports concerning inattention and hyperactivity symptoms in children were available from the Strengths and Difficulties Questionnaire or the Rutter Scale completed by parents and/or teachers. Results: Drinking patterns differed cross-nationally. Women who had at least some social adversity (young, low education, or being single) were more likely to drink than those better off in the Finnish cohort, but the opposite was true for the Danish cohorts. Prenatal alcohol exposure was not related to risk for a high inattention-hyperactivity symptom score in children across cohorts after adjustment for covariates. In contrast, maternal smoking and social adversity during pregnancy were independently and consistently associated with an increase in risk of child symptoms. Conclusions: Low doses of alcohol consumption during pregnancy were not related to child inattention/hyperactivity symptoms once social adversity and smoking were taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02071.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828 [article] Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity [Texte imprimé et/ou numérique] / A. RODRIGUEZ, Auteur ; Jouko MIETTUNEN, Auteur ; H. EBELING, Auteur ; A. TAANILA, Auteur ; K.M. LINNET, Auteur ; Tine Brink HENRIKSEN, Auteur ; M. KAAKINEN, Auteur ; A.J. KOTIMAA, Auteur ; Carsten OBEL, Auteur ; Jørn OLSEN, Auteur ; Irma MOILANEN, Auteur ; Marjo-Riitta JARVELIN, Auteur . - 2009 . - p.1073-1083. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1073-1083 Mots-clés : ADHD alcohol inattention/hyperactivity-symptoms prenatal social-factors behavior-problems cross-cultural longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Studies concerning whether exposure to low levels of maternal alcohol consumption during fetal development is related to child inattention and hyperactivity symptoms have shown conflicting results. We examine the contribution of covariates related to social adversity to resolve some inconsistencies in the extant research by conducting parallel analyses of three cohorts with varying alcohol consumption and attitudes towards alcohol use. Methods: We compare three population-based pregnancy–offspring cohorts within the Nordic Network on ADHD from Denmark and Finland. Prenatal data were gathered via self-report during pregnancy and birth outcomes were abstracted from medical charts. A total of 21,678 reports concerning inattention and hyperactivity symptoms in children were available from the Strengths and Difficulties Questionnaire or the Rutter Scale completed by parents and/or teachers. Results: Drinking patterns differed cross-nationally. Women who had at least some social adversity (young, low education, or being single) were more likely to drink than those better off in the Finnish cohort, but the opposite was true for the Danish cohorts. Prenatal alcohol exposure was not related to risk for a high inattention-hyperactivity symptom score in children across cohorts after adjustment for covariates. In contrast, maternal smoking and social adversity during pregnancy were independently and consistently associated with an increase in risk of child symptoms. Conclusions: Low doses of alcohol consumption during pregnancy were not related to child inattention/hyperactivity symptoms once social adversity and smoking were taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02071.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828

Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study / Zeyan LIEW in Autism Research, 9-9 (September 2016)  

Public ISBD [article]  inAutism Research > 9-9 (September 2016) . - p.951-958 Titre : Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur Article en page(s) : p.951-958 Langues : Anglais (eng) Mots-clés : acetaminophen  autism spectrum disorders  infantile autism  childhood behavior  prenatal exposure  pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study [Texte imprimé et/ou numérique] / Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur . - p.951-958. Langues : Anglais (eng) in Autism Research > 9-9 (September 2016) . - p.951-958 Mots-clés : acetaminophen  autism spectrum disorders  infantile autism  childhood behavior  prenatal exposure  pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders / Jasveer VIRK in Autism, 20-6 (August 2016)  

Public ISBD [article]  inAutism > 20-6 (August 2016) . - p.710-718 Titre : Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jasveer VIRK, Auteur ; Zeyan LIEW, Auteur ; Jørn OLSEN, Auteur ; Ellen A NOHR, Auteur ; Janet M CATOV, Auteur ; Beate RITZ, Auteur Article en page(s) : p.710-718 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  environmental factors Index. décimale : PER Périodiques Résumé : Objective: To evaluate whether early folic acid supplementation during pregnancy prevents diagnosis of autism spectrum disorders in offspring.Methods: Information on autism spectrum disorder diagnosis was obtained from the National Hospital Register and the Central Psychiatric Register. We estimated risk ratios for autism spectrum disorders for children whose mothers took folate or multivitamin supplements from 4?weeks prior from the last menstrual period through to 8?weeks after the last menstrual period (?4 to 8?weeks) by three 4-week periods.Results: We did not find an association between early folate or multivitamin intake for autism spectrum disorder (folic acid—adjusted risk ratio: 1.06, 95% confidence interval: 0.82–1.36; multivitamin—adjusted risk ratio: 1.00, 95% confidence interval: 0.82–1.22), autistic disorder (folic acid—adjusted risk ratio: 1.18, 95% confidence interval: 0.76–1.84; multivitamin—adjusted risk ratio: 1.22, 95% confidence interval: 0.87–1.69), Asperger’s syndrome (folic acid—adjusted risk ratio: 0.85, 95% confidence interval: 0.46–1.53; multivitamin—adjusted risk ratio: 0.95, 95% confidence interval: 0.62–1.46), or pervasive developmental disorder–not otherwise specified (folic acid—adjusted risk ratio: 1.07, 95% confidence interval: 0.75–1.54; multivitamin: adjusted risk ratio: 0.87, 95% confidence interval: 0.65–1.17) compared with women reporting no supplement use in the same period.Conclusion: We did not find any evidence to corroborate previous reports of a reduced risk for autism spectrum disorders in offspring of women using folic acid supplements in early pregnancy. En ligne : http://dx.doi.org/10.1177/1362361315604076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders [Texte imprimé et/ou numérique] / Jasveer VIRK, Auteur ; Zeyan LIEW, Auteur ; Jørn OLSEN, Auteur ; Ellen A NOHR, Auteur ; Janet M CATOV, Auteur ; Beate RITZ, Auteur . - p.710-718. Langues : Anglais (eng) in Autism > 20-6 (August 2016) . - p.710-718 Mots-clés : autism spectrum disorders  environmental factors Index. décimale : PER Périodiques Résumé : Objective: To evaluate whether early folic acid supplementation during pregnancy prevents diagnosis of autism spectrum disorders in offspring.Methods: Information on autism spectrum disorder diagnosis was obtained from the National Hospital Register and the Central Psychiatric Register. We estimated risk ratios for autism spectrum disorders for children whose mothers took folate or multivitamin supplements from 4?weeks prior from the last menstrual period through to 8?weeks after the last menstrual period (?4 to 8?weeks) by three 4-week periods.Results: We did not find an association between early folate or multivitamin intake for autism spectrum disorder (folic acid—adjusted risk ratio: 1.06, 95% confidence interval: 0.82–1.36; multivitamin—adjusted risk ratio: 1.00, 95% confidence interval: 0.82–1.22), autistic disorder (folic acid—adjusted risk ratio: 1.18, 95% confidence interval: 0.76–1.84; multivitamin—adjusted risk ratio: 1.22, 95% confidence interval: 0.87–1.69), Asperger’s syndrome (folic acid—adjusted risk ratio: 0.85, 95% confidence interval: 0.46–1.53; multivitamin—adjusted risk ratio: 0.95, 95% confidence interval: 0.62–1.46), or pervasive developmental disorder–not otherwise specified (folic acid—adjusted risk ratio: 1.07, 95% confidence interval: 0.75–1.54; multivitamin: adjusted risk ratio: 0.87, 95% confidence interval: 0.65–1.17) compared with women reporting no supplement use in the same period.Conclusion: We did not find any evidence to corroborate previous reports of a reduced risk for autism spectrum disorders in offspring of women using folic acid supplements in early pregnancy. En ligne : http://dx.doi.org/10.1177/1362361315604076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark / Jiong LI in Journal of Autism and Developmental Disorders, 39-7 (July 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1047-1052 Titre : Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark Type de document : Texte imprimé et/ou numérique Auteurs : Jiong LI, Auteur ; Jørn OLSEN, Auteur ; Carsten OBEL, Auteur ; Jakob CHRISTENSEN, Auteur ; Dorthe HANSEN PRECHT, Auteur ; Mogens VESTERGAARD, Auteur Année de publication : 2009 Article en page(s) : p.1047-1052 Langues : Anglais (eng) Mots-clés : Prenatal-stress Bereavement Febrile-seizures Fetal-programming Longitudinal-study Index. décimale : PER Périodiques Résumé : We aimed to examine whether exposure to prenatal stress following maternal bereavement is associated with an increased risk of febrile seizures. In a longitudinal population-based cohort study, we followed 1,431,175 children born in Denmark. A total of 34,777 children were born to women who lost a close relative during pregnancy or within 1 year before the pregnancy and they were included in the exposed group. The exposed children had a risk of febrile seizures similar to that of the unexposed children (hazard ratio (HR) 1.00, 95% CI 0.94–1.06). The HRs did not differ according to the nature or timing of bereavement. Our data do not suggest any causal link between exposure to prenatal stress and febrile seizures in childhood. En ligne : http://dx.doi.org/10.1007/s10803-009-0717-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770 [article] Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark [Texte imprimé et/ou numérique] / Jiong LI, Auteur ; Jørn OLSEN, Auteur ; Carsten OBEL, Auteur ; Jakob CHRISTENSEN, Auteur ; Dorthe HANSEN PRECHT, Auteur ; Mogens VESTERGAARD, Auteur . - 2009 . - p.1047-1052. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1047-1052 Mots-clés : Prenatal-stress Bereavement Febrile-seizures Fetal-programming Longitudinal-study Index. décimale : PER Périodiques Résumé : We aimed to examine whether exposure to prenatal stress following maternal bereavement is associated with an increased risk of febrile seizures. In a longitudinal population-based cohort study, we followed 1,431,175 children born in Denmark. A total of 34,777 children were born to women who lost a close relative during pregnancy or within 1 year before the pregnancy and they were included in the exposed group. The exposed children had a risk of febrile seizures similar to that of the unexposed children (hazard ratio (HR) 1.00, 95% CI 0.94–1.06). The HRs did not differ according to the nature or timing of bereavement. Our data do not suggest any causal link between exposure to prenatal stress and febrile seizures in childhood. En ligne : http://dx.doi.org/10.1007/s10803-009-0717-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770

The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design / Carsten OBEL in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.532-537 Titre : The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design Type de document : Texte imprimé et/ou numérique Auteurs : Carsten OBEL, Auteur ; Jin Liang ZHU, Auteur ; Jørn OLSEN, Auteur ; Sanni BREINING, Auteur ; Jiong LI, Auteur ; Therese K. GRØNBORG, Auteur ; Mika GISSLER, Auteur ; Michael RUTTER, Auteur Article en page(s) : p.532-537 Langues : Anglais (eng) Mots-clés : Smoking  pregnancy  attention deficit hyperactivity disorder  hyperkinetic disorder  sibling design Index. décimale : PER Périodiques Résumé : Background Conventional cohort studies have consistently shown that exposure to maternal smoking in pregnancy is associated with about twice the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. However, recent studies using alternative designs to disentangle the effect of social and genetic confounders have suggested that confounding may account for the association. In this study we aimed to estimate the association by a sibling design. Methods We used a design with half and full siblings in a Danish national register-based cohort on all singletons born between January 1991 and December 2006 and followed until January 2011. Data were available for 90% (N = 968,665) of the singleton live births in the period. We used the combination of the International Classification of Diseases (10th version) diagnosis of hyperkinetic disorder (HKD) and ADHD medication to identify children. We used sibling-matched (conditional) Cox regression to control social and genetic confounding. Results Using conventional cohort analyses, we found the expected association between pregnancy smoking and offspring ADHD (adjusted HR 2.01, 95% CI 1.94–2.07). In the sibling analysis, however, we did not detect such a strong association (adjusted HR 1.07, 95% CI 0.94–1.22). There was no difference between results for half- and full sibling analyses. The link between pregnancy smoking and low birth weight remained robust in the sibling design (adjusted OR 1.68, 95% CI 1.33–2.12). Conclusions We found no support for prenatal smoking as a strong causal factor in ADHD. Our findings suggest that the strong association found in most previous epidemiological studies is likely to be due to a strong link between maternal smoking and maternal ADHD genetics or shared family environment. Pregnant women should still be encouraged to stop smoking because of other risks, but we have no reason to believe that this would reduce the risk of ADHD in the offspring. En ligne : http://dx.doi.org/10.1111/jcpp.12478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design [Texte imprimé et/ou numérique] / Carsten OBEL, Auteur ; Jin Liang ZHU, Auteur ; Jørn OLSEN, Auteur ; Sanni BREINING, Auteur ; Jiong LI, Auteur ; Therese K. GRØNBORG, Auteur ; Mika GISSLER, Auteur ; Michael RUTTER, Auteur . - p.532-537. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.532-537 Mots-clés : Smoking  pregnancy  attention deficit hyperactivity disorder  hyperkinetic disorder  sibling design Index. décimale : PER Périodiques Résumé : Background Conventional cohort studies have consistently shown that exposure to maternal smoking in pregnancy is associated with about twice the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. However, recent studies using alternative designs to disentangle the effect of social and genetic confounders have suggested that confounding may account for the association. In this study we aimed to estimate the association by a sibling design. Methods We used a design with half and full siblings in a Danish national register-based cohort on all singletons born between January 1991 and December 2006 and followed until January 2011. Data were available for 90% (N = 968,665) of the singleton live births in the period. We used the combination of the International Classification of Diseases (10th version) diagnosis of hyperkinetic disorder (HKD) and ADHD medication to identify children. We used sibling-matched (conditional) Cox regression to control social and genetic confounding. Results Using conventional cohort analyses, we found the expected association between pregnancy smoking and offspring ADHD (adjusted HR 2.01, 95% CI 1.94–2.07). In the sibling analysis, however, we did not detect such a strong association (adjusted HR 1.07, 95% CI 0.94–1.22). There was no difference between results for half- and full sibling analyses. The link between pregnancy smoking and low birth weight remained robust in the sibling design (adjusted OR 1.68, 95% CI 1.33–2.12). Conclusions We found no support for prenatal smoking as a strong causal factor in ADHD. Our findings suggest that the strong association found in most previous epidemiological studies is likely to be due to a strong link between maternal smoking and maternal ADHD genetics or shared family environment. Pregnant women should still be encouraged to stop smoking because of other risks, but we have no reason to believe that this would reduce the risk of ADHD in the offspring. En ligne : http://dx.doi.org/10.1111/jcpp.12478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

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