Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity / A. RODRIGUEZ in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1073-1083 Titre : Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity Type de document : Texte imprimé et/ou numérique Auteurs : A. RODRIGUEZ, Auteur ; Jouko MIETTUNEN, Auteur ; H. EBELING, Auteur ; A. TAANILA, Auteur ; K.M. LINNET, Auteur ; Tine Brink HENRIKSEN, Auteur ; M. KAAKINEN, Auteur ; A.J. KOTIMAA, Auteur ; Carsten OBEL, Auteur ; Jørn OLSEN, Auteur ; Irma MOILANEN, Auteur ; Marjo-Riitta JARVELIN, Auteur Année de publication : 2009 Article en page(s) : p.1073-1083 Langues : Anglais (eng) Mots-clés : ADHD alcohol inattention/hyperactivity-symptoms prenatal social-factors behavior-problems cross-cultural longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Studies concerning whether exposure to low levels of maternal alcohol consumption during fetal development is related to child inattention and hyperactivity symptoms have shown conflicting results. We examine the contribution of covariates related to social adversity to resolve some inconsistencies in the extant research by conducting parallel analyses of three cohorts with varying alcohol consumption and attitudes towards alcohol use. Methods: We compare three population-based pregnancy–offspring cohorts within the Nordic Network on ADHD from Denmark and Finland. Prenatal data were gathered via self-report during pregnancy and birth outcomes were abstracted from medical charts. A total of 21,678 reports concerning inattention and hyperactivity symptoms in children were available from the Strengths and Difficulties Questionnaire or the Rutter Scale completed by parents and/or teachers. Results: Drinking patterns differed cross-nationally. Women who had at least some social adversity (young, low education, or being single) were more likely to drink than those better off in the Finnish cohort, but the opposite was true for the Danish cohorts. Prenatal alcohol exposure was not related to risk for a high inattention-hyperactivity symptom score in children across cohorts after adjustment for covariates. In contrast, maternal smoking and social adversity during pregnancy were independently and consistently associated with an increase in risk of child symptoms. Conclusions: Low doses of alcohol consumption during pregnancy were not related to child inattention/hyperactivity symptoms once social adversity and smoking were taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02071.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828 [article] Is prenatal alcohol exposure related to inattention and hyperactivity symptoms in children? Disentangling the effects of social adversity [Texte imprimé et/ou numérique] / A. RODRIGUEZ, Auteur ; Jouko MIETTUNEN, Auteur ; H. EBELING, Auteur ; A. TAANILA, Auteur ; K.M. LINNET, Auteur ; Tine Brink HENRIKSEN, Auteur ; M. KAAKINEN, Auteur ; A.J. KOTIMAA, Auteur ; Carsten OBEL, Auteur ; Jørn OLSEN, Auteur ; Irma MOILANEN, Auteur ; Marjo-Riitta JARVELIN, Auteur . - 2009 . - p.1073-1083. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1073-1083 Mots-clés : ADHD alcohol inattention/hyperactivity-symptoms prenatal social-factors behavior-problems cross-cultural longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Studies concerning whether exposure to low levels of maternal alcohol consumption during fetal development is related to child inattention and hyperactivity symptoms have shown conflicting results. We examine the contribution of covariates related to social adversity to resolve some inconsistencies in the extant research by conducting parallel analyses of three cohorts with varying alcohol consumption and attitudes towards alcohol use. Methods: We compare three population-based pregnancy–offspring cohorts within the Nordic Network on ADHD from Denmark and Finland. Prenatal data were gathered via self-report during pregnancy and birth outcomes were abstracted from medical charts. A total of 21,678 reports concerning inattention and hyperactivity symptoms in children were available from the Strengths and Difficulties Questionnaire or the Rutter Scale completed by parents and/or teachers. Results: Drinking patterns differed cross-nationally. Women who had at least some social adversity (young, low education, or being single) were more likely to drink than those better off in the Finnish cohort, but the opposite was true for the Danish cohorts. Prenatal alcohol exposure was not related to risk for a high inattention-hyperactivity symptom score in children across cohorts after adjustment for covariates. In contrast, maternal smoking and social adversity during pregnancy were independently and consistently associated with an increase in risk of child symptoms. Conclusions: Low doses of alcohol consumption during pregnancy were not related to child inattention/hyperactivity symptoms once social adversity and smoking were taken into account. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02071.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828

Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark / Jiong LI in Journal of Autism and Developmental Disorders, 39-7 (July 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1047-1052 Titre : Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark Type de document : Texte imprimé et/ou numérique Auteurs : Jiong LI, Auteur ; Jørn OLSEN, Auteur ; Carsten OBEL, Auteur ; Jakob CHRISTENSEN, Auteur ; Dorthe HANSEN PRECHT, Auteur ; Mogens VESTERGAARD, Auteur Année de publication : 2009 Article en page(s) : p.1047-1052 Langues : Anglais (eng) Mots-clés : Prenatal-stress Bereavement Febrile-seizures Fetal-programming Longitudinal-study Index. décimale : PER Périodiques Résumé : We aimed to examine whether exposure to prenatal stress following maternal bereavement is associated with an increased risk of febrile seizures. In a longitudinal population-based cohort study, we followed 1,431,175 children born in Denmark. A total of 34,777 children were born to women who lost a close relative during pregnancy or within 1 year before the pregnancy and they were included in the exposed group. The exposed children had a risk of febrile seizures similar to that of the unexposed children (hazard ratio (HR) 1.00, 95% CI 0.94–1.06). The HRs did not differ according to the nature or timing of bereavement. Our data do not suggest any causal link between exposure to prenatal stress and febrile seizures in childhood. En ligne : http://dx.doi.org/10.1007/s10803-009-0717-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770 [article] Prenatal Stress and Risk of Febrile Seizures in Children: A Nationwide Longitudinal Study in Denmark [Texte imprimé et/ou numérique] / Jiong LI, Auteur ; Jørn OLSEN, Auteur ; Carsten OBEL, Auteur ; Jakob CHRISTENSEN, Auteur ; Dorthe HANSEN PRECHT, Auteur ; Mogens VESTERGAARD, Auteur . - 2009 . - p.1047-1052. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1047-1052 Mots-clés : Prenatal-stress Bereavement Febrile-seizures Fetal-programming Longitudinal-study Index. décimale : PER Périodiques Résumé : We aimed to examine whether exposure to prenatal stress following maternal bereavement is associated with an increased risk of febrile seizures. In a longitudinal population-based cohort study, we followed 1,431,175 children born in Denmark. A total of 34,777 children were born to women who lost a close relative during pregnancy or within 1 year before the pregnancy and they were included in the exposed group. The exposed children had a risk of febrile seizures similar to that of the unexposed children (hazard ratio (HR) 1.00, 95% CI 0.94–1.06). The HRs did not differ according to the nature or timing of bereavement. Our data do not suggest any causal link between exposure to prenatal stress and febrile seizures in childhood. En ligne : http://dx.doi.org/10.1007/s10803-009-0717-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770

The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design / Carsten OBEL in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.532-537 Titre : The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design Type de document : Texte imprimé et/ou numérique Auteurs : Carsten OBEL, Auteur ; Jin Liang ZHU, Auteur ; Jørn OLSEN, Auteur ; Sanni BREINING, Auteur ; Jiong LI, Auteur ; Therese K. GRØNBORG, Auteur ; Mika GISSLER, Auteur ; Michael RUTTER, Auteur Article en page(s) : p.532-537 Langues : Anglais (eng) Mots-clés : Smoking  pregnancy  attention deficit hyperactivity disorder  hyperkinetic disorder  sibling design Index. décimale : PER Périodiques Résumé : Background Conventional cohort studies have consistently shown that exposure to maternal smoking in pregnancy is associated with about twice the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. However, recent studies using alternative designs to disentangle the effect of social and genetic confounders have suggested that confounding may account for the association. In this study we aimed to estimate the association by a sibling design. Methods We used a design with half and full siblings in a Danish national register-based cohort on all singletons born between January 1991 and December 2006 and followed until January 2011. Data were available for 90% (N = 968,665) of the singleton live births in the period. We used the combination of the International Classification of Diseases (10th version) diagnosis of hyperkinetic disorder (HKD) and ADHD medication to identify children. We used sibling-matched (conditional) Cox regression to control social and genetic confounding. Results Using conventional cohort analyses, we found the expected association between pregnancy smoking and offspring ADHD (adjusted HR 2.01, 95% CI 1.94–2.07). In the sibling analysis, however, we did not detect such a strong association (adjusted HR 1.07, 95% CI 0.94–1.22). There was no difference between results for half- and full sibling analyses. The link between pregnancy smoking and low birth weight remained robust in the sibling design (adjusted OR 1.68, 95% CI 1.33–2.12). Conclusions We found no support for prenatal smoking as a strong causal factor in ADHD. Our findings suggest that the strong association found in most previous epidemiological studies is likely to be due to a strong link between maternal smoking and maternal ADHD genetics or shared family environment. Pregnant women should still be encouraged to stop smoking because of other risks, but we have no reason to believe that this would reduce the risk of ADHD in the offspring. En ligne : http://dx.doi.org/10.1111/jcpp.12478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285 [article] The risk of attention deficit hyperactivity disorder in children exposed to maternal smoking during pregnancy – a re-examination using a sibling design [Texte imprimé et/ou numérique] / Carsten OBEL, Auteur ; Jin Liang ZHU, Auteur ; Jørn OLSEN, Auteur ; Sanni BREINING, Auteur ; Jiong LI, Auteur ; Therese K. GRØNBORG, Auteur ; Mika GISSLER, Auteur ; Michael RUTTER, Auteur . - p.532-537. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-4 (April 2016) . - p.532-537 Mots-clés : Smoking  pregnancy  attention deficit hyperactivity disorder  hyperkinetic disorder  sibling design Index. décimale : PER Périodiques Résumé : Background Conventional cohort studies have consistently shown that exposure to maternal smoking in pregnancy is associated with about twice the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. However, recent studies using alternative designs to disentangle the effect of social and genetic confounders have suggested that confounding may account for the association. In this study we aimed to estimate the association by a sibling design. Methods We used a design with half and full siblings in a Danish national register-based cohort on all singletons born between January 1991 and December 2006 and followed until January 2011. Data were available for 90% (N = 968,665) of the singleton live births in the period. We used the combination of the International Classification of Diseases (10th version) diagnosis of hyperkinetic disorder (HKD) and ADHD medication to identify children. We used sibling-matched (conditional) Cox regression to control social and genetic confounding. Results Using conventional cohort analyses, we found the expected association between pregnancy smoking and offspring ADHD (adjusted HR 2.01, 95% CI 1.94–2.07). In the sibling analysis, however, we did not detect such a strong association (adjusted HR 1.07, 95% CI 0.94–1.22). There was no difference between results for half- and full sibling analyses. The link between pregnancy smoking and low birth weight remained robust in the sibling design (adjusted OR 1.68, 95% CI 1.33–2.12). Conclusions We found no support for prenatal smoking as a strong causal factor in ADHD. Our findings suggest that the strong association found in most previous epidemiological studies is likely to be due to a strong link between maternal smoking and maternal ADHD genetics or shared family environment. Pregnant women should still be encouraged to stop smoking because of other risks, but we have no reason to believe that this would reduce the risk of ADHD in the offspring. En ligne : http://dx.doi.org/10.1111/jcpp.12478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=285

Urbanicity and Autism Spectrum Disorders / Marlene B. LAURITSEN in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.394-404 Titre : Urbanicity and Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Marlene B. LAURITSEN, Auteur ; Aske ASTRUP, Auteur ; Carsten Bøcker PEDERSEN, Auteur ; Carsten OBEL, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Erik T. PARNER, Auteur Article en page(s) : p.394-404 Langues : Anglais (eng) Mots-clés : Autism  Risk  Urbanicity  Movement  Diagnosis Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is for the majority of cases unknown and more studies of risk factors are needed. Geographic variation in ASD occurrence has been observed, and urban residence has been suggested to serve as a proxy for etiologic and identification factors in ASD. We examined the association between urbanicity level and ASD at birth and during childhood. The study used a Danish register-based cohort of more than 800,000 children of which nearly 4,000 children were diagnosed with ASD. We found a dose–response association with greater level of urbanicity and risk of ASD. This association was found for residence at birth as well as residence during childhood. Further, we found an increased risk of ASD in children who moved to a higher level of urbanicity after birth. Also, earlier age of ASD diagnosis in urban areas was observed. While we could not directly examine the specific reasons behind these associations, our results demonstrating particularly strong associations between ASD diagnosis and post-birth migration suggest the influence of identification-related factors such as access to services might have a substantive role on the ASD differentials we observed. En ligne : http://dx.doi.org/10.1007/s10803-013-1875-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 [article] Urbanicity and Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Marlene B. LAURITSEN, Auteur ; Aske ASTRUP, Auteur ; Carsten Bøcker PEDERSEN, Auteur ; Carsten OBEL, Auteur ; Diana SCHENDEL, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Erik T. PARNER, Auteur . - p.394-404. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.394-404 Mots-clés : Autism  Risk  Urbanicity  Movement  Diagnosis Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorders (ASD) is for the majority of cases unknown and more studies of risk factors are needed. Geographic variation in ASD occurrence has been observed, and urban residence has been suggested to serve as a proxy for etiologic and identification factors in ASD. We examined the association between urbanicity level and ASD at birth and during childhood. The study used a Danish register-based cohort of more than 800,000 children of which nearly 4,000 children were diagnosed with ASD. We found a dose–response association with greater level of urbanicity and risk of ASD. This association was found for residence at birth as well as residence during childhood. Further, we found an increased risk of ASD in children who moved to a higher level of urbanicity after birth. Also, earlier age of ASD diagnosis in urban areas was observed. While we could not directly examine the specific reasons behind these associations, our results demonstrating particularly strong associations between ASD diagnosis and post-birth migration suggest the influence of identification-related factors such as access to services might have a substantive role on the ASD differentials we observed. En ligne : http://dx.doi.org/10.1007/s10803-013-1875-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223

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