Altered Dynamics of the fMRI Response to Faces in Individuals with Autism / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Titre : Altered Dynamics of the fMRI Response to Faces in Individuals with Autism Type de document : texte imprimé Auteurs : Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur Année de publication : 2016 Article en page(s) : p.232-241 Langues : Anglais (eng) Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Altered Dynamics of the fMRI Response to Faces in Individuals with Autism [texte imprimé] / Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur . - 2016 . - p.232-241. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Brain Chemistry: Magnetic Resonance Spectroscopy / Stephen R. DAGER

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Brain Chemistry: Magnetic Resonance Spectroscopy Type de document : texte imprimé Auteurs : Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Todd RICHARDS, Auteur ; Dennis W.W. SHAW, Auteur Année de publication : 2011 Importance : p.576-592 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Brain Chemistry: Magnetic Resonance Spectroscopy [texte imprimé] / Stephen R. DAGER, Auteur ; Neva M. CORRIGAN, Auteur ; Todd RICHARDS, Auteur ; Dennis W.W. SHAW, Auteur . - 2011 . - p.576-592. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 39-7 (July 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1079-1086 Titre : Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder Type de document : texte imprimé Auteurs : Natalia M. KLEINHANS, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur ; Todd RICHARDS, Auteur ; Kurt E. WEAVER, Auteur ; Olivia LIANG, Auteur Année de publication : 2009 Article en page(s) : p.1079-1086 Langues : Anglais (eng) Mots-clés : Amygdala Autism Asperger’s-disorder MRS Index. décimale : PER Périodiques Résumé : Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0707-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770 [article] Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder [texte imprimé] / Natalia M. KLEINHANS, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur ; Todd RICHARDS, Auteur ; Kurt E. WEAVER, Auteur ; Olivia LIANG, Auteur . - 2009 . - p.1079-1086. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-7 (July 2009) . - p.1079-1086 Mots-clés : Amygdala Autism Asperger’s-disorder MRS Index. décimale : PER Périodiques Résumé : Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0707-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=770

Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders / Susan J. ASTLEY in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.61-80 Titre : Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders Type de document : texte imprimé Auteurs : Susan J. ASTLEY, Auteur ; Elizabeth H. AYLWARD, Auteur ; Heather Carmichael OLSON, Auteur ; Kimberly A. KERNS, Auteur ; Allison BROOKS, Auteur ; Truman E. COGGINS, Auteur ; Julian DAVIES, Auteur ; Susan DORN, Auteur ; Beth GENDLER, Auteur ; Tracy JIRIKOWIC, Auteur ; Paul KRAEGEL, Auteur ; Kenneth MARAVILLA, Auteur ; Todd RICHARDS, Auteur Article en page(s) : p.61-80 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A comprehensive neuropsychological/psychiatric, MR imaging, (MRI), MR spectroscopy (MRS), and functional MRI (fMRI) assessment was administered to children with fetal alcohol spectrum disorders (FASD) to determine if global and/or focal abnormalities could be identified, and distinguish diagnostic subclassifications across the spectrum. The four study groups included: 1. FAS/Partial FAS; 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported here. The neuropsychological/psychiatric, MRI, and MRS outcomes are reported separately. fMRI was used to assess activation in seven brain regions during performance of N-back working memory tasks. Children across the full spectrum of FASD exhibited significant working memory deficits and altered activation patterns in brain regions that are known to be involved in working memory. These results demonstrate the potential research and diagnostic value of this non-invasive MR tool in the field of FASD. En ligne : http://dx.doi.org/10.1007/s11689-009-9004-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders [texte imprimé] / Susan J. ASTLEY, Auteur ; Elizabeth H. AYLWARD, Auteur ; Heather Carmichael OLSON, Auteur ; Kimberly A. KERNS, Auteur ; Allison BROOKS, Auteur ; Truman E. COGGINS, Auteur ; Julian DAVIES, Auteur ; Susan DORN, Auteur ; Beth GENDLER, Auteur ; Tracy JIRIKOWIC, Auteur ; Paul KRAEGEL, Auteur ; Kenneth MARAVILLA, Auteur ; Todd RICHARDS, Auteur . - p.61-80. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.61-80 Index. décimale : PER Périodiques Résumé : A comprehensive neuropsychological/psychiatric, MR imaging, (MRI), MR spectroscopy (MRS), and functional MRI (fMRI) assessment was administered to children with fetal alcohol spectrum disorders (FASD) to determine if global and/or focal abnormalities could be identified, and distinguish diagnostic subclassifications across the spectrum. The four study groups included: 1. FAS/Partial FAS; 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported here. The neuropsychological/psychiatric, MRI, and MRS outcomes are reported separately. fMRI was used to assess activation in seven brain regions during performance of N-back working memory tasks. Children across the full spectrum of FASD exhibited significant working memory deficits and altered activation patterns in brain regions that are known to be involved in working memory. These results demonstrate the potential research and diagnostic value of this non-invasive MR tool in the field of FASD. En ligne : http://dx.doi.org/10.1007/s11689-009-9004-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder / Neva M. CORRIGAN in Journal of Autism and Developmental Disorders, 42-1 (January 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Titre : Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur Année de publication : 2012 Article en page(s) : p.105-115 Langues : Anglais (eng) Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder [texte imprimé] / Neva M. CORRIGAN, Auteur ; Dennis W.W. SHAW, Auteur ; Todd RICHARDS, Auteur ; Annette ESTES, Auteur ; Seth D. FRIEDMAN, Auteur ; Helen PETROPOULOS, Auteur ; Alan ARTRU, Auteur ; Stephen R. DAGER, Auteur . - 2012 . - p.105-115. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-1 (January 2012) . - p.105-115 Mots-clés : Autism  Developmental disorders  MRS  MRI  Mitochondrial disorders  Brain metabolism  Lactate Index. décimale : PER Périodiques Résumé : Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ( 1 HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1 HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship. En ligne : http://dx.doi.org/10.1007/s10803-011-1216-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

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