5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls / Corina BENJET in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179 Titre : 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2010 Article en page(s) : p.173-179 Langues : Anglais (eng) Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls. Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory. Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles. Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 [article] 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Corina BENJET, Auteur ; Renee THOMPSON, Auteur ; Ian H. GOTLIB, Auteur . - 2010 . - p.173-179. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.173-179 Mots-clés : Peer-victimization bullying depression genetic-polymorphisms 5-HTTLPR Index. décimale : PER Périodiques Résumé : Background: Relational peer victimization is associated with internalizing symptoms. Compared to boys, girls are more likely to be both relationally victimized by peers and distressed by the victimization. While previous studies have reported that a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the effect of stressful life events on depressive symptoms, the present study is the first to evaluate the interaction of this polymorphism with relational peer victimization to predict level of depressive symptoms in young girls. Methods: Participants were 78 girls ages 10 to 14 who had no current or past Axis I disorder. Girls were genotyped for 5-HTTLPR; peer victimization was assessed with the Social Experiences Questionnaire, and depressive symptoms with the Children's Depression Inventory. Results: The 5-HTTLPR polymorphism alone did not predict level of depressive symptoms; the interaction of 5-HTTLPR and relational peer victimization, however, was a significant predictor of depressive symptoms. Follow-up analyses indicated that peer victimization significantly predicted level of depressive symptoms only for girls who were homozygous for the short allele, and not for girls homozygous for the long allele or who were heterozygous for the short and long alleles. Conclusions: The findings support the diathesis-stress model of depression: having two 5-HTTLPR short alleles confers vulnerability to depressive symptoms in adolescent girls when they experience relational peer victimization. These findings also suggest that relational peer victimization, at least for girls with genetic vulnerability, is a significant source of stress and should be recognized in the monitoring and prevention of bullying. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02149.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941

Affective and physiological responses to stress in girls at elevated risk for depression / Christian E. WAUGH in Development and Psychopathology, 24-2 (May 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-2 (May 2012) . - p.661-675 Titre : Affective and physiological responses to stress in girls at elevated risk for depression Type de document : Texte imprimé et/ou numérique Auteurs : Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur Année de publication : 2012 Article en page(s) : p.661-675 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Affective and physiological responses to stress in girls at elevated risk for depression [Texte imprimé et/ou numérique] / Christian E. WAUGH, Auteur ; Luma MUHTADIE, Auteur ; Renee THOMPSON, Auteur ; Jutta JOORMANN, Auteur ; Ian H. GOTLIB, Auteur . - 2012 . - p.661-675. Langues : Anglais (eng) in Development and Psychopathology > 24-2 (May 2012) . - p.661-675 Index. décimale : PER Périodiques Résumé : Children of depressed parents are significantly more likely to develop depression and other mental health disorders than are children of never-depressed parents. Investigations of the physiological mechanisms underlying this elevated risk have generally focused on basal functioning. It is important to note, however, that physiological reactivity or responses to stress are also critical determinants of mental and physical health. In the current study, we examined whether children of depressed parents exhibit altered physiological responses to stress. In two studies, never-depressed adolescent daughters of either recurrently depressed mothers (RISK) or never-depressed mothers (CTL) underwent social stressors while their physiological responses were measured (cortisol in Study 1, heart rate in Study 2). In both studies, affective responses to the stressors predicted physiological responses in RISK girls, but not in never-depressed girls. For RISK girls, decreased positive affect in response to stress predicted increased cortisol reactivity; in addition, decreased positive affect and increased negative affect were associated with poorer heart rate recovery and habituation, respectively. Future research is needed to examine explicitly whether this coherence between affect and physiology is a mechanism underlying the increased risk for psychopathology in children of depressed parents. En ligne : http://dx.doi.org/10.1017/S0954579412000235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms / Rajpreet CHAHAL in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 557-571 Titre : An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : 557-571 Langues : Anglais (eng) Mots-clés : adolescence  adversity  dimensions  connectivity  development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms [Texte imprimé et/ou numérique] / Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur . - 557-571. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 557-571 Mots-clés : adolescence  adversity  dimensions  connectivity  development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation / Ian H. GOTLIB in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1037-1046 Titre : Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation Type de document : Texte imprimé et/ou numérique Auteurs : Ian H. GOTLIB, Auteur Article en page(s) : p.1037-1046 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Exposure to adversity early in life (ELA) has been associated with elevated risk for depression during adolescence, particularly for females; the mechanisms underlying this association, however, are poorly understood. One potential mechanism linking ELA and sex differences in depressive symptoms is sleep disturbances, which increase during adolescence and are more common in females. Here, we examined whether sleep disturbances mediate the association between ELA and increases in depressive symptoms during adolescence and whether this mediation differs by sex. Methods 224 (N = 132 females) youth were recruited at age 9-13?years and assessed every 2?years across three timepoints. At the first timepoint, we conducted extensive interviews about stressful events participants experienced; participants provided subjective severity ratings of events and we objectively scored the severity of each event. Self-reported sleep disturbances and depressive symptoms were assessed at all timepoints. We conducted linear mixed models to estimate both initial levels and changes in sleep disturbances and depressive symptoms, and moderated mediation analyses to test whether initial levels and/or changes in sleep disturbances mediated the association of ELA (objective and subjective) with increases in depressive symptoms across adolescence and whether the mediations differed by sex. Results While higher initial levels and increases in sleep problems were uniquely associated with increases in depressive symptoms for males and females, they were related to ELA differently by sex. For females, greater ELA (both objectively and subjectively rated) was associated with higher initial levels of sleep problems, which in turn were associated with increases in depressive symptoms from early to late adolescence. In contrast, for males, ELA exposure was not associated with either initial levels of, or increases in, sleep problems. Conclusions These findings highlight the role of sleep disturbances during the transition to adolescence in mediating sex differences in the effects of ELA on depressive symptoms. En ligne : https://doi.org/10.1111/jcpp.13942 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation [Texte imprimé et/ou numérique] / Ian H. GOTLIB, Auteur . - p.1037-1046. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1037-1046 Index. décimale : PER Périodiques Résumé : Background Exposure to adversity early in life (ELA) has been associated with elevated risk for depression during adolescence, particularly for females; the mechanisms underlying this association, however, are poorly understood. One potential mechanism linking ELA and sex differences in depressive symptoms is sleep disturbances, which increase during adolescence and are more common in females. Here, we examined whether sleep disturbances mediate the association between ELA and increases in depressive symptoms during adolescence and whether this mediation differs by sex. Methods 224 (N = 132 females) youth were recruited at age 9-13?years and assessed every 2?years across three timepoints. At the first timepoint, we conducted extensive interviews about stressful events participants experienced; participants provided subjective severity ratings of events and we objectively scored the severity of each event. Self-reported sleep disturbances and depressive symptoms were assessed at all timepoints. We conducted linear mixed models to estimate both initial levels and changes in sleep disturbances and depressive symptoms, and moderated mediation analyses to test whether initial levels and/or changes in sleep disturbances mediated the association of ELA (objective and subjective) with increases in depressive symptoms across adolescence and whether the mediations differed by sex. Results While higher initial levels and increases in sleep problems were uniquely associated with increases in depressive symptoms for males and females, they were related to ELA differently by sex. For females, greater ELA (both objectively and subjectively rated) was associated with higher initial levels of sleep problems, which in turn were associated with increases in depressive symptoms from early to late adolescence. In contrast, for males, ELA exposure was not associated with either initial levels of, or increases in, sleep problems. Conclusions These findings highlight the role of sleep disturbances during the transition to adolescence in mediating sex differences in the effects of ELA on depressive symptoms. En ligne : https://doi.org/10.1111/jcpp.13942 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning / Kathryn L. HUMPHREYS in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182 Titre : Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1174-1182 Langues : Anglais (eng) Mots-clés : Early life stress  attentional bias  fearful faces  social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning [Texte imprimé et/ou numérique] / Kathryn L. HUMPHREYS, Auteur ; Katharina KIRCANSKI, Auteur ; Natalie L. COLICH, Auteur ; Ian H. GOTLIB, Auteur . - p.1174-1182. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1174-1182 Mots-clés : Early life stress  attentional bias  fearful faces  social problems Index. décimale : PER Périodiques Résumé : Background Early life stress is associated with poorer social functioning. Attentional biases in response to threat-related cues, linked to both early experience and psychopathology, may explain this association. To date, however, no study has examined attentional biases to fearful facial expressions as a function of early life stress or examined these biases as a potential mediator of the relation between early life stress and social problems. Methods In a sample of 154 children (ages 9–13 years) we examined the associations among interpersonal early life stressors (i.e., birth through age 6 years), attentional biases to emotional facial expressions using a dot-probe task, and social functioning on the Child Behavior Checklist. Results High levels of early life stress were associated with both greater levels of social problems and an attentional bias away from fearful facial expressions, even after accounting for stressors occurring in later childhood. No biases were found for happy or sad facial expressions as a function of early life stress. Finally, attentional biases to fearful faces mediated the association between early life stress and social problems. Conclusions Attentional avoidance of fearful facial expressions, evidenced by a bias away from these stimuli, may be a developmental response to early adversity and link the experience of early life stress to poorer social functioning. En ligne : http://dx.doi.org/10.1111/jcpp.12607 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Attentional bias training in girls at risk for depression / Joelle LEMOULT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

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Coping with having a depressed mother: The role of stress and coping in hypothalamic–pituitary–adrenal axis dysfunction in girls at familial risk for major depression / Lara C. FOLAND-ROSS in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

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Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics / Jaclyn S. KIRSHENBAUM in Journal of Child Psychology and Psychiatry, 63-6 (June 2022)  

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Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

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Emotion identification in girls at high risk for depression / Jutta JOORMANN in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

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Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress / Jonas G. MILLER in Development and Psychopathology, 34-5 (December 2022)  

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Information processing in adolescents with bipolar I disorder / Jane WHITNEY in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

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Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study / Jonas G. MILLER ; Nima AGHAEEPOUR ; Lucy S. KING ; David K. STEVENSON ; Gary M. SHAW ; Ronald J. WONG ; Ian H. GOTLIB in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

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Maternal-prenatal stress and depression predict infant temperament during the COVID-19 pandemic / Jessica L. BUTHMANN in Development and Psychopathology, 36-1 (February 2024)  

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A person-centered approach to the assessment of early life stress: Associations with the volume of stress-sensitive brain regions in early adolescence / Lucy S. KING in Development and Psychopathology, 31-2 (May 2019)  

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