An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms / Rajpreet CHAHAL in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 557-571 Titre : An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : 557-571 Langues : Anglais (eng) Mots-clés : adolescence  adversity  dimensions  connectivity  development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744 [article] An exploration of dimensions of early adversity and the development of functional brain network connectivity during adolescence: Implications for trajectories of internalizing symptoms [Texte imprimé et/ou numérique] / Rajpreet CHAHAL, Auteur ; Jonas G. MILLER, Auteur ; Justin P. YUAN, Auteur ; Jessica L. BUTHMANN, Auteur ; Ian H. GOTLIB, Auteur . - 557-571. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 557-571 Mots-clés : adolescence  adversity  dimensions  connectivity  development Index. décimale : PER Périodiques Résumé : Different dimensions of adversity may affect mental health through distinct neurobiological mechanisms, though current supporting evidence consists largely of cross-sectional associations between threat or deprivation and fronto-limbic circuitry. In this exploratory three-wave longitudinal study spanning ages 9?19 years, we examined the associations between experiences of unpredictability, threat, and deprivation with the development of functional connectivity within and between three brain networks implicated in psychopathology: the salience (SAL), default mode (DMN), and fronto-parietal (FPN) networks, and tested whether network trajectories moderated associations between adversity and changes in internalizing symptoms. Connectivity decreased with age on average; these changes differed by dimension of adversity. Whereas family-level deprivation was associated with lower initial levels and more stability across most networks, unpredictability was associated with stability only in SAL connectivity, and threat was associated with stability in FPN and DMN-SAL connectivity. In youth exposed to higher levels of any adversity, lower initial levels and more stability in connectivity were related to smaller increases in internalizing symptoms. Our findings suggest that whereas deprivation is associated with widespread neurodevelopmental differences in cognitive and emotion processing networks, unpredictability is related selectively to salience detection circuitry. Studies with wider developmental windows should examine whether these neurodevelopmental alterations are adaptive or serve to maintain internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579421001814 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744

Empathy and Anxiety in Young Girls with Fragile X Syndrome / Jonas G. MILLER in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2213-2223 Titre : Empathy and Anxiety in Young Girls with Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Jonas G. MILLER, Auteur ; Kristi L. BARTHOLOMAY, Auteur ; Cindy H. LEE, Auteur ; Jennifer L. BRUNO, Auteur ; Amy A. LIGHTBODY, Auteur ; Allan L. REISS, Auteur Article en page(s) : p.2213-2223 Langues : Anglais (eng) Mots-clés : Anxiety  Anxiety Disorders/psychology  Autism Spectrum Disorder/complications  Empathy  Female  Fragile X Syndrome/psychology  Humans  Adolescence  Childhood  Females  Fragile X syndrome Index. décimale : PER Périodiques Résumé : We tested whether empathy is impaired and associated with anxiety in girls with fragile X syndrome (FXS). We measured parent-reported empathy and self-reported anxiety in young girls with FXS and in a developmentally-matched comparison group. Girls with FXS received higher parent-reported scores on cognitive and affective empathy but also self-reported more severe anxiety symptoms, particularly separation anxiety and phobia symptoms, than girls in the comparison group. Girls with FXS who received higher cognitive empathy scores, however, appeared buffered against risk for separation anxiety and phobia symptoms. Girls with FXS experience elevated empathy and anxiety relative to their developmentally-matched peers. Higher cognitive empathy in girls with FXS may indicate resilience against specific forms of anxiety that are commonly observed in FXS. En ligne : http://dx.doi.org/10.1007/s10803-021-05105-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4764 [article] Empathy and Anxiety in Young Girls with Fragile X Syndrome [Texte imprimé et/ou numérique] / Jonas G. MILLER, Auteur ; Kristi L. BARTHOLOMAY, Auteur ; Cindy H. LEE, Auteur ; Jennifer L. BRUNO, Auteur ; Amy A. LIGHTBODY, Auteur ; Allan L. REISS, Auteur . - p.2213-2223. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2213-2223 Mots-clés : Anxiety  Anxiety Disorders/psychology  Autism Spectrum Disorder/complications  Empathy  Female  Fragile X Syndrome/psychology  Humans  Adolescence  Childhood  Females  Fragile X syndrome Index. décimale : PER Périodiques Résumé : We tested whether empathy is impaired and associated with anxiety in girls with fragile X syndrome (FXS). We measured parent-reported empathy and self-reported anxiety in young girls with FXS and in a developmentally-matched comparison group. Girls with FXS received higher parent-reported scores on cognitive and affective empathy but also self-reported more severe anxiety symptoms, particularly separation anxiety and phobia symptoms, than girls in the comparison group. Girls with FXS who received higher cognitive empathy scores, however, appeared buffered against risk for separation anxiety and phobia symptoms. Girls with FXS experience elevated empathy and anxiety relative to their developmentally-matched peers. Higher cognitive empathy in girls with FXS may indicate resilience against specific forms of anxiety that are commonly observed in FXS. En ligne : http://dx.doi.org/10.1007/s10803-021-05105-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4764

Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress / Jonas G. MILLER in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1974-1985 Titre : Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress Type de document : Texte imprimé et/ou numérique Auteurs : Jonas G. MILLER, Auteur ; Rajpreet CHAHAL, Auteur ; Jaclyn S. KIRSHENBAUM, Auteur ; Tiffany C. HO, Auteur ; Anthony J. GIFUNI, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1974-1985 Langues : Anglais (eng) Mots-clés : adolescence  biological sensitivity to context  COVID-19  diathesis stress  differential susceptibility  heart rate variability Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated with COVID-19 stress and COVID-19 family adversity. Approximately 4 years prior to the pandemic, we assessed resting HRV and HRV reactivity to a well-validated stress paradigm in 87 adolescents. During the pandemic, these adolescents (ages 13 “19) reported on their health-related stress and concerns about COVID-19, family adversity related to COVID-19, and their recent emotional problems. The association between COVID-19 stress and emotional problems was significantly stronger for adolescents who previously exhibited higher resting HRV or higher HRV reactivity. For adolescents who exhibited lower resting HRV or HRV augmentation, COVID-19 stress was not associated with emotional problems. Conversely, lower resting HRV indicated vulnerability to the effect of COVID-19 family adversity on emotional problems. Different patterns of parasympathetic functioning may reflect differential susceptibility to the effects of COVID-19 stress versus vulnerability to the effects of COVID-19 family adversity on mental health during the pandemic. En ligne : http://dx.doi.org/10.1017/S095457942100033X Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4921 [article] Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress [Texte imprimé et/ou numérique] / Jonas G. MILLER, Auteur ; Rajpreet CHAHAL, Auteur ; Jaclyn S. KIRSHENBAUM, Auteur ; Tiffany C. HO, Auteur ; Anthony J. GIFUNI, Auteur ; Ian H. GOTLIB, Auteur . - p.1974-1985. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1974-1985 Mots-clés : adolescence  biological sensitivity to context  COVID-19  diathesis stress  differential susceptibility  heart rate variability Index. décimale : PER Périodiques Résumé : The COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated with COVID-19 stress and COVID-19 family adversity. Approximately 4 years prior to the pandemic, we assessed resting HRV and HRV reactivity to a well-validated stress paradigm in 87 adolescents. During the pandemic, these adolescents (ages 13 “19) reported on their health-related stress and concerns about COVID-19, family adversity related to COVID-19, and their recent emotional problems. The association between COVID-19 stress and emotional problems was significantly stronger for adolescents who previously exhibited higher resting HRV or higher HRV reactivity. For adolescents who exhibited lower resting HRV or HRV augmentation, COVID-19 stress was not associated with emotional problems. Conversely, lower resting HRV indicated vulnerability to the effect of COVID-19 family adversity on emotional problems. Different patterns of parasympathetic functioning may reflect differential susceptibility to the effects of COVID-19 stress versus vulnerability to the effects of COVID-19 family adversity on mental health during the pandemic. En ligne : http://dx.doi.org/10.1017/S095457942100033X Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4921

Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents / Tiffany C. HO in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1914-1925 Titre : Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany C. HO, Auteur ; Holly T. PHAM, Auteur ; Jonas G. MILLER, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1914-1925 Langues : Anglais (eng) Mots-clés : Adolescent  Anxiety  Autonomic Nervous System  Female  Heart Rate  Humans  Male  *Respiratory Sinus Arrhythmia  Stress, Psychological  Sympathetic Nervous System  *adolescence  *skin conductance level stress  *social anxiety disorder Index. décimale : PER Périodiques Résumé : Social anxiety disorder (SAD) is commonly diagnosed during adolescence and is associated with psychological stress reactivity and heightened physiological arousal. No study, however, has systematically examined which aspects of autonomic nervous system function mediate likely links between stress sensitivity and social anxiety symptoms in adolescents. Here, we assessed 163 adolescents (90 females; 12.29 ± 1.39 years) with respect to life stress and social anxiety symptoms, and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a psychosocial stress paradigm. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective severity and changes in autonomic regulation using standardized change scores in RSA and SCL. In females only, stress sensitivity and social anxiety symptoms were significantly correlated with each other (p < .001) and with autonomic regulation during both reactivity and recovery (all ps < 0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and social anxiety symptoms (B = 1.06, 95% CI: 0.02-2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and social anxiety symptoms were not significantly associated (all ps > 0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes. En ligne : http://dx.doi.org/10.1017/s0954579420001261 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4377 [article] Sympathetic nervous system dominance during stress recovery mediates associations between stress sensitivity and social anxiety symptoms in female adolescents [Texte imprimé et/ou numérique] / Tiffany C. HO, Auteur ; Holly T. PHAM, Auteur ; Jonas G. MILLER, Auteur ; Katharina KIRCANSKI, Auteur ; Ian H. GOTLIB, Auteur . - p.1914-1925. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1914-1925 Mots-clés : Adolescent  Anxiety  Autonomic Nervous System  Female  Heart Rate  Humans  Male  *Respiratory Sinus Arrhythmia  Stress, Psychological  Sympathetic Nervous System  *adolescence  *skin conductance level stress  *social anxiety disorder Index. décimale : PER Périodiques Résumé : Social anxiety disorder (SAD) is commonly diagnosed during adolescence and is associated with psychological stress reactivity and heightened physiological arousal. No study, however, has systematically examined which aspects of autonomic nervous system function mediate likely links between stress sensitivity and social anxiety symptoms in adolescents. Here, we assessed 163 adolescents (90 females; 12.29 ± 1.39 years) with respect to life stress and social anxiety symptoms, and measured respiratory sinus arrhythmia (RSA) and skin conductance levels (SCL) during a psychosocial stress paradigm. We operationalized stress sensitivity as the residual variance in subjective stress severity after accounting for objective severity and changes in autonomic regulation using standardized change scores in RSA and SCL. In females only, stress sensitivity and social anxiety symptoms were significantly correlated with each other (p < .001) and with autonomic regulation during both reactivity and recovery (all ps < 0.04). Further, sympathetic nervous system dominance during recovery specifically mediated associations between stress sensitivity and social anxiety symptoms (B = 1.06, 95% CI: 0.02-2.64). In contrast, in males, stress sensitivity, autonomic regulation during reactivity or recovery, and social anxiety symptoms were not significantly associated (all ps > 0.1). We interpret these results in the context of psychobiological models of SAD and discuss implications for interventions targeting autonomic processes. En ligne : http://dx.doi.org/10.1017/s0954579420001261 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4377

---

1 (1 - 4 / 4)