Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders / Lauren E. KENWORTHY in Journal of Autism and Developmental Disorders, 40-4 (April 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-4 (April 2010) . - p.416-423 Titre : Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Alex MARTIN, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur Année de publication : 2010 Article en page(s) : p.416-423 Langues : Anglais (eng) Mots-clés : Autism Adaptive-behavior Social-skills IQ Symptomatology Asperger’s-syndrome Index. décimale : PER Périodiques Résumé : Caregiver report on the Adaptive Behavior Assessment System-II (ABAS) for 40 high-functioning individuals with Autism Spectrum Disorders (ASD) and 30 typically developing (TD) individuals matched for age, IQ, and sex ratio revealed global adaptive behavior deficits in ASD, with social skills impairments particularly prominent. Within the ASD group, adaptive communication skills were positively related to IQ while global adaptive functioning was negatively associated with autism symptomatology. Autistic behavior ratings related negatively to ABAS scores in the TD but not the ASD group. This investigation demonstrates: the utility of an adaptive functioning checklist for capturing impairments, even in high-functioning individuals with ASD; and that a relationship between social abilities and autism exists independently of intelligence. En ligne : http://dx.doi.org/10.1007/s10803-009-0911-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=991 [article] Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lauren E. KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Alex MARTIN, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur . - 2010 . - p.416-423. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-4 (April 2010) . - p.416-423 Mots-clés : Autism Adaptive-behavior Social-skills IQ Symptomatology Asperger’s-syndrome Index. décimale : PER Périodiques Résumé : Caregiver report on the Adaptive Behavior Assessment System-II (ABAS) for 40 high-functioning individuals with Autism Spectrum Disorders (ASD) and 30 typically developing (TD) individuals matched for age, IQ, and sex ratio revealed global adaptive behavior deficits in ASD, with social skills impairments particularly prominent. Within the ASD group, adaptive communication skills were positively related to IQ while global adaptive functioning was negatively associated with autism symptomatology. Autistic behavior ratings related negatively to ABAS scores in the TD but not the ASD group. This investigation demonstrates: the utility of an adaptive functioning checklist for capturing impairments, even in high-functioning individuals with ASD; and that a relationship between social abilities and autism exists independently of intelligence. En ligne : http://dx.doi.org/10.1007/s10803-009-0911-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=991

Diminished Sensitivity to Sad Facial Expressions in High Functioning Autism Spectrum Disorders is Associated with Symptomatology and Adaptive Functioning / Gregory L. WALLACE in Journal of Autism and Developmental Disorders, 41-11 (November 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1475-1486 Titre : Diminished Sensitivity to Sad Facial Expressions in High Functioning Autism Spectrum Disorders is Associated with Symptomatology and Adaptive Functioning Type de document : Texte imprimé et/ou numérique Auteurs : Gregory L. WALLACE, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur ; Jennifer A. SILVERS, Auteur ; Lauren E. KENWORTHY, Auteur ; Alex MARTIN, Auteur Année de publication : 2011 Article en page(s) : p.1475-1486 Langues : Anglais (eng) Mots-clés : Autism  Emotion  Face  Symptomatology  Adaptive functioning Index. décimale : PER Périodiques Résumé : Prior studies implicate facial emotion recognition (FER) difficulties among individuals with autism spectrum disorders (ASD); however, many investigations focus on FER accuracy alone and few examine ecological validity through links with everyday functioning. We compared FER accuracy and perceptual sensitivity (from neutral to full expression) between 42 adolescents with high functioning (IQ > 80) ASD and 31 typically developing adolescents (matched on age, IQ, sex ratio) across six basic emotions and examined links between FER and symptomatology/adaptive functioning within the ASD group. Adolescents with ASD required more intense facial expressions for accurate emotion identification. Controlling for this overall group difference revealed particularly diminished sensitivity to sad facial expressions in ASD, which was uniquely correlated with ratings of autism-related behavior and adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-010-1170-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 [article] Diminished Sensitivity to Sad Facial Expressions in High Functioning Autism Spectrum Disorders is Associated with Symptomatology and Adaptive Functioning [Texte imprimé et/ou numérique] / Gregory L. WALLACE, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur ; Jennifer A. SILVERS, Auteur ; Lauren E. KENWORTHY, Auteur ; Alex MARTIN, Auteur . - 2011 . - p.1475-1486. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-11 (November 2011) . - p.1475-1486 Mots-clés : Autism  Emotion  Face  Symptomatology  Adaptive functioning Index. décimale : PER Périodiques Résumé : Prior studies implicate facial emotion recognition (FER) difficulties among individuals with autism spectrum disorders (ASD); however, many investigations focus on FER accuracy alone and few examine ecological validity through links with everyday functioning. We compared FER accuracy and perceptual sensitivity (from neutral to full expression) between 42 adolescents with high functioning (IQ > 80) ASD and 31 typically developing adolescents (matched on age, IQ, sex ratio) across six basic emotions and examined links between FER and symptomatology/adaptive functioning within the ASD group. Adolescents with ASD required more intense facial expressions for accurate emotion identification. Controlling for this overall group difference revealed particularly diminished sensitivity to sad facial expressions in ASD, which was uniquely correlated with ratings of autism-related behavior and adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-010-1170-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147

Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study / Madeline B. HARMS in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1895-1903 Titre : Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Madeline B. HARMS, Auteur ; Rasmus BIRN, Auteur ; Nadine PROVENCAL, Auteur ; Tobias WIECHMANN, Auteur ; Elisabeth B. BINDER, Auteur ; Sebastian W. GIAKAS, Auteur ; Barbara J. ROEBER, Auteur ; Seth D. POLLAK, Auteur Article en page(s) : p.1895-1903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation. En ligne : http://dx.doi.org/10.1017/S095457941700147X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study [Texte imprimé et/ou numérique] / Madeline B. HARMS, Auteur ; Rasmus BIRN, Auteur ; Nadine PROVENCAL, Auteur ; Tobias WIECHMANN, Auteur ; Elisabeth B. BINDER, Auteur ; Sebastian W. GIAKAS, Auteur ; Barbara J. ROEBER, Auteur ; Seth D. POLLAK, Auteur . - p.1895-1903. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1895-1903 Index. décimale : PER Périodiques Résumé : Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation. En ligne : http://dx.doi.org/10.1017/S095457941700147X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Erratum to: Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders / Lauren E. KENWORTHY in Journal of Autism and Developmental Disorders, 40-4 (April 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-4 (April 2010) . - p.424 Titre : Erratum to: Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Alex MARTIN, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur Année de publication : 2010 Article en page(s) : p.424 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0919-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=992 [article] Erratum to: Adaptive Behavior Ratings Correlate With Symptomatology and IQ Among Individuals With High-Functioning Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lauren E. KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Alex MARTIN, Auteur ; Laura CASE, Auteur ; Madeline B. HARMS, Auteur . - 2010 . - p.424. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-4 (April 2010) . - p.424 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-009-0919-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=992

Interests in high-functioning autism are more intense, interfering, and idiosyncratic than those in neurotypical development / Laura G. ANTHONY in Development and Psychopathology, 25-3 (August 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-3 (August 2013) . - p.643-652 Titre : Interests in high-functioning autism are more intense, interfering, and idiosyncratic than those in neurotypical development Type de document : Texte imprimé et/ou numérique Auteurs : Laura G. ANTHONY, Auteur ; Lauren E. KENWORTHY, Auteur ; Benjamin E. YERYS, Auteur ; Kathryn F. JANKOWSKI, Auteur ; Joette D. JAMES, Auteur ; Madeline B. HARMS, Auteur ; Alex MARTIN, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.643-652 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although circumscribed interests are pathognomonic with autism, much about these interests remains unknown. Using the Interests Scale (IS), this study compares interests between 76 neurotypical (NT) individuals and 109 individuals with high-functioning autism spectrum disorder (HF-ASD) matched groupwise on age, IQ, and gender ratio. Participants and their parents/caregivers completed diagnostic measures (the Autism Diagnostic Interview—Revised and the Autism Diagnostic Observation Schedule; HF-ASD only), cognitive tests (Wechsler IQ Scales), and questionnaires (the Repetitive Behavior Scale—Revised, the Behavior Rating Inventory of Executive Function, and the Social Responsiveness Scale), in addition to the IS. Consistent with previous research, HF-ASD and NT individuals did not differ in number of interest areas, but the types of interests and intensity of those interests differed considerably. Using only the IS intensity score, 81% of individuals were correctly classified (NT or HF-ASD) in a logistic regression analysis. Among individuals with HF-ASD, Interests Scale scores were significantly related to Autism Diagnostic Observation Schedule, Behavior Rating Inventory of Executive Function, Repetitive Behavior Scale—Revised, and Social Responsiveness Scale scores, but they were not related to Autism Diagnostic Interview—Revised scores, IQ, gender, age, or psychotropic medication use. The type and intensity, but not the number, of interests distinguish high-functioning individuals with ASD from NT individuals. En ligne : http://dx.doi.org/10.1017/S0954579413000072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Interests in high-functioning autism are more intense, interfering, and idiosyncratic than those in neurotypical development [Texte imprimé et/ou numérique] / Laura G. ANTHONY, Auteur ; Lauren E. KENWORTHY, Auteur ; Benjamin E. YERYS, Auteur ; Kathryn F. JANKOWSKI, Auteur ; Joette D. JAMES, Auteur ; Madeline B. HARMS, Auteur ; Alex MARTIN, Auteur ; Gregory L. WALLACE, Auteur . - p.643-652. Langues : Anglais (eng) in Development and Psychopathology > 25-3 (August 2013) . - p.643-652 Index. décimale : PER Périodiques Résumé : Although circumscribed interests are pathognomonic with autism, much about these interests remains unknown. Using the Interests Scale (IS), this study compares interests between 76 neurotypical (NT) individuals and 109 individuals with high-functioning autism spectrum disorder (HF-ASD) matched groupwise on age, IQ, and gender ratio. Participants and their parents/caregivers completed diagnostic measures (the Autism Diagnostic Interview—Revised and the Autism Diagnostic Observation Schedule; HF-ASD only), cognitive tests (Wechsler IQ Scales), and questionnaires (the Repetitive Behavior Scale—Revised, the Behavior Rating Inventory of Executive Function, and the Social Responsiveness Scale), in addition to the IS. Consistent with previous research, HF-ASD and NT individuals did not differ in number of interest areas, but the types of interests and intensity of those interests differed considerably. Using only the IS intensity score, 81% of individuals were correctly classified (NT or HF-ASD) in a logistic regression analysis. Among individuals with HF-ASD, Interests Scale scores were significantly related to Autism Diagnostic Observation Schedule, Behavior Rating Inventory of Executive Function, Repetitive Behavior Scale—Revised, and Social Responsiveness Scale scores, but they were not related to Autism Diagnostic Interview—Revised scores, IQ, gender, age, or psychotropic medication use. The type and intensity, but not the number, of interests distinguish high-functioning individuals with ASD from NT individuals. En ligne : http://dx.doi.org/10.1017/S0954579413000072 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

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