Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents / Armin RAZNAHAN in Autism Research, 5-2 (April 2012)  

Public ISBD [article]  inAutism Research > 5-2 (April 2012) . - p.93-100 Titre : Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2012 Article en page(s) : p.93-100 Langues : Anglais (eng) Mots-clés : autism  HOXA1  cerebellum  gene  brain  MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents [Texte imprimé et/ou numérique] / Armin RAZNAHAN, Auteur ; Yohan LEE, Auteur ; Catherine VAITUZIS, Auteur ; Lan TRAN, Auteur ; Susan MACKIE, Auteur ; Henning TIEMEIER, Auteur ; Liv S. CLASEN, Auteur ; Francois LALONDE, Auteur ; Deanna GREENSTEIN, Auteur ; Ron PIERSON, Auteur ; Jay N. GIEDD, Auteur . - 2012 . - p.93-100. Langues : Anglais (eng) in Autism Research > 5-2 (April 2012) . - p.93-100 Mots-clés : autism  HOXA1  cerebellum  gene  brain  MRI Index. décimale : PER Périodiques Résumé : Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1—A218G (rs10951154)—has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P = 0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P = 0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P = 0.9), by age 23 it was 12% greater in Gcar than AA (P = 0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. En ligne : http://dx.doi.org/10.1002/aur.238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

Autism Risk Gene MET Variation and Cortical Thickness in Typically Developing Children and Adolescents / Alexis HEDRICK in Autism Research, 5-6 (December 2012)  

Public ISBD [article]  inAutism Research > 5-6 (December 2012) . - p.434-439 Titre : Autism Risk Gene MET Variation and Cortical Thickness in Typically Developing Children and Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Alexis HEDRICK, Auteur ; Yohan LEE, Auteur ; Gregory L. WALLACE, Auteur ; Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Armin RAZNAHAN, Auteur Article en page(s) : p.434-439 Mots-clés : MET receptor tyrosine kinase  cortex  autism  development  MRI Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1256 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Autism Risk Gene MET Variation and Cortical Thickness in Typically Developing Children and Adolescents [Texte imprimé et/ou numérique] / Alexis HEDRICK, Auteur ; Yohan LEE, Auteur ; Gregory L. WALLACE, Auteur ; Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Armin RAZNAHAN, Auteur . - p.434-439. in Autism Research > 5-6 (December 2012) . - p.434-439 Mots-clés : MET receptor tyrosine kinase  cortex  autism  development  MRI Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1256 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Childhood onset schizophrenia: cortical brain abnormalities as young adults / Deanna GREENSTEIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1003–1012 Titre : Childhood onset schizophrenia: cortical brain abnormalities as young adults Type de document : Texte imprimé et/ou numérique Auteurs : Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Jason LERCH, Auteur ; Philip SHAW, Auteur ; Peter GOCHMAN, Auteur ; Judith RAPOPORT, Auteur ; Nitin GOGTAY, Auteur Année de publication : 2007 Article en page(s) : p.1003–1012 Langues : Anglais (eng) Mots-clés : Childhood-onset-schizophrenia MRI cortical-thickness development neurodevelopment schizophrenia Index. décimale : PER Périodiques Résumé : Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient–control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naïve and medicated adult onset patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=790 [article] Childhood onset schizophrenia: cortical brain abnormalities as young adults [Texte imprimé et/ou numérique] / Deanna GREENSTEIN, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur ; Jason LERCH, Auteur ; Philip SHAW, Auteur ; Peter GOCHMAN, Auteur ; Judith RAPOPORT, Auteur ; Nitin GOGTAY, Auteur . - 2007 . - p.1003–1012. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1003–1012 Mots-clés : Childhood-onset-schizophrenia MRI cortical-thickness development neurodevelopment schizophrenia Index. décimale : PER Périodiques Résumé : Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient–control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naïve and medicated adult onset patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=790

Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders / Nancy RAITANO LEE in Journal of Child Psychology and Psychiatry, 53-10 (October 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-10 (October 2012) . - p.1072-81 Titre : Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Nancy RAITANO LEE, Auteur ; Gregory L. WALLACE, Auteur ; Elizabeth I. ADEYEMI, Auteur ; Katherine C. LOPEZ, Auteur ; Jonathan D. BLUMENTHAL, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2012 Article en page(s) : p.1072-81 Langues : Anglais (eng) Mots-clés : Chromosome anomalies  social cognition  language disorder  autistic disorder  sex differences  Cognition sociale Index. décimale : PER Périodiques Résumé : Background:  Supernumerary sex chromosome aneuploidies (X/Y-aneuploidies), the presence of extra X and/or Y chromosomes, are associated with heightened rates of language impairments and social difficulties. However, no single study has examined different language domains and social functioning in the same sample of children with tri-, tetra-, and pentasomy X/Y-aneuploidy. The current research sought to fill this gap in the literature and to examine dosage effects of X and Y chromosomes on language and social functioning. Methods:  Participants included 110 youth with X/Y-aneuploidies (32 female) and 52 with typical development (25 female) matched on age (mean ∼12 years; range 4–22) and maternal education. Participants completed the Wechsler intelligence scales, and parents completed the Children’s Communication Checklist-2 and the Social Responsiveness Scale to assess language skills and autistic traits, respectively. Results:  Both supernumerary X and Y chromosomes were related to depressed structural and pragmatic language skills and increased autistic traits. The addition of a Y chromosome had a disproportionately greater impact on pragmatic language; the addition of one or more X chromosomes had a disproportionately greater impact on structural language. Conclusions:  Given that we link extra X chromosomes with structural language impairments and an extra Y chromosome with pragmatic language impairments, X/Y-aneuploidies may provide clues to genetic mechanisms contributing to idiopathic language impairment and autism spectrum disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02573.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 [article] Dosage effects of X and Y chromosomes on language and social functioning in children with supernumerary sex chromosome aneuploidies: implications for idiopathic language impairment and autism spectrum disorders [Texte imprimé et/ou numérique] / Nancy RAITANO LEE, Auteur ; Gregory L. WALLACE, Auteur ; Elizabeth I. ADEYEMI, Auteur ; Katherine C. LOPEZ, Auteur ; Jonathan D. BLUMENTHAL, Auteur ; Liv S. CLASEN, Auteur ; Jay N. GIEDD, Auteur . - 2012 . - p.1072-81. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-10 (October 2012) . - p.1072-81 Mots-clés : Chromosome anomalies  social cognition  language disorder  autistic disorder  sex differences  Cognition sociale Index. décimale : PER Périodiques Résumé : Background:  Supernumerary sex chromosome aneuploidies (X/Y-aneuploidies), the presence of extra X and/or Y chromosomes, are associated with heightened rates of language impairments and social difficulties. However, no single study has examined different language domains and social functioning in the same sample of children with tri-, tetra-, and pentasomy X/Y-aneuploidy. The current research sought to fill this gap in the literature and to examine dosage effects of X and Y chromosomes on language and social functioning. Methods:  Participants included 110 youth with X/Y-aneuploidies (32 female) and 52 with typical development (25 female) matched on age (mean ∼12 years; range 4–22) and maternal education. Participants completed the Wechsler intelligence scales, and parents completed the Children’s Communication Checklist-2 and the Social Responsiveness Scale to assess language skills and autistic traits, respectively. Results:  Both supernumerary X and Y chromosomes were related to depressed structural and pragmatic language skills and increased autistic traits. The addition of a Y chromosome had a disproportionately greater impact on pragmatic language; the addition of one or more X chromosomes had a disproportionately greater impact on structural language. Conclusions:  Given that we link extra X chromosomes with structural language impairments and an extra Y chromosome with pragmatic language impairments, X/Y-aneuploidies may provide clues to genetic mechanisms contributing to idiopathic language impairment and autism spectrum disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02573.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181

Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness / Nitin GOGTAY in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.852–862 Titre : Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness Type de document : Texte imprimé et/ou numérique Auteurs : Nitin GOGTAY, Auteur ; Liv S. CLASEN, Auteur ; Paul M. THOMPSON, Auteur ; Arthur W. TOGA, Auteur ; Tom F. III NUGENT, Auteur ; David JUNG, Auteur ; Wendy SHARP, Auteur ; Marge LENANE, Auteur ; Kiralee M. HAYASHI, Auteur ; David H. HERMAN, Auteur ; Anna ORDONEZ, Auteur ; Ellen LEIBENLUFT, Auteur ; Judith RAPOPORT, Auteur ; Deanna GREENSTEIN, Auteur ; Jay N. GIEDD, Auteur ; Catherine VAITUZIS, Auteur Année de publication : 2007 Article en page(s) : p.852–862 Langues : Anglais (eng) Mots-clés : Pediatric bipolar MRI mapping gray matter Index. décimale : PER Périodiques Résumé : Background: There are, to date, no pre-post onset longitudinal imaging studies of bipolar disorder at any age. We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset. Method: We contrast this pattern with that observed in a matched group of healthy children as well as in a matched group of 8 children with ‘atypical psychosis’ who had similar initial presentation marked by mood dysregulation and transient psychosis (labeled as ‘multi-dimensionally impaired’ (MDI)) as in the bipolar group, but have not, to date, developed bipolar illness. Results: Dynamic maps, reconstructed by applying novel cortical pattern matching algorithms, for the children who became bipolar I showed subtle, regionally specific, bilaterally asymmetrical cortical changes. Cortical GM increased over the left temporal cortex and decreased bilaterally in the anterior (and sub genual) cingulate cortex. This was seen most strikingly after the illness onset, and showed a pattern distinct from that seen in childhood onset schizophrenia. The bipolar neurodevelopmental trajectory was generally shared by the children who remained with MDI diagnosis without converting to bipolar I, suggesting that this pattern of cortical development may reflect affective dysregulation (lability) in general. Conclusions: These dynamic trajectories of cortical development may explain age-related disparate findings from cross-sectional studies of bipolar illness, and suggest the importance of mood disordered non-bipolar control group in future studies. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01747.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness [Texte imprimé et/ou numérique] / Nitin GOGTAY, Auteur ; Liv S. CLASEN, Auteur ; Paul M. THOMPSON, Auteur ; Arthur W. TOGA, Auteur ; Tom F. III NUGENT, Auteur ; David JUNG, Auteur ; Wendy SHARP, Auteur ; Marge LENANE, Auteur ; Kiralee M. HAYASHI, Auteur ; David H. HERMAN, Auteur ; Anna ORDONEZ, Auteur ; Ellen LEIBENLUFT, Auteur ; Judith RAPOPORT, Auteur ; Deanna GREENSTEIN, Auteur ; Jay N. GIEDD, Auteur ; Catherine VAITUZIS, Auteur . - 2007 . - p.852–862. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.852–862 Mots-clés : Pediatric bipolar MRI mapping gray matter Index. décimale : PER Périodiques Résumé : Background: There are, to date, no pre-post onset longitudinal imaging studies of bipolar disorder at any age. We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset. Method: We contrast this pattern with that observed in a matched group of healthy children as well as in a matched group of 8 children with ‘atypical psychosis’ who had similar initial presentation marked by mood dysregulation and transient psychosis (labeled as ‘multi-dimensionally impaired’ (MDI)) as in the bipolar group, but have not, to date, developed bipolar illness. Results: Dynamic maps, reconstructed by applying novel cortical pattern matching algorithms, for the children who became bipolar I showed subtle, regionally specific, bilaterally asymmetrical cortical changes. Cortical GM increased over the left temporal cortex and decreased bilaterally in the anterior (and sub genual) cingulate cortex. This was seen most strikingly after the illness onset, and showed a pattern distinct from that seen in childhood onset schizophrenia. The bipolar neurodevelopmental trajectory was generally shared by the children who remained with MDI diagnosis without converting to bipolar I, suggesting that this pattern of cortical development may reflect affective dysregulation (lability) in general. Conclusions: These dynamic trajectories of cortical development may explain age-related disparate findings from cross-sectional studies of bipolar illness, and suggest the importance of mood disordered non-bipolar control group in future studies. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01747.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

A pediatric twin study of brain morphometry / Gregory L. WALLACE in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

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