Anorexia nervosa and autism: a prospective twin cohort study / Lisa DINKLER in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326 Titre : Anorexia nervosa and autism: a prospective twin cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur Article en page(s) : p.316-326 Langues : Anglais (eng) Mots-clés : Eating disorder  anorexia nervosa  autism spectrum disorders  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Anorexia nervosa and autism: a prospective twin cohort study [Texte imprimé et/ou numérique] / Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur . - p.316-326. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326 Mots-clés : Eating disorder  anorexia nervosa  autism spectrum disorders  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10 / Lina JONSSON in Molecular Autism, (December 2014)  

Public ISBD [article]  inMolecular Autism > (December 2014) . - p.1-9 Titre : Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10 Type de document : Texte imprimé et/ou numérique Auteurs : Lina JONSSON, Auteur ; Anna ZETTERGREN, Auteur ; Erik PETTERSSON, Auteur ; Daniel HOVEY, Auteur ; Henrik ANCKARSATER, Auteur ; Lars WESTBERG, Auteur ; Paul LICHTENSTEIN, Auteur ; Sebastian LUNDSTROM, Auteur ; Jonas MELKE, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autistic-like traits (ALTs) are continuously distributed in the general population, with the autism spectrum disorder (ASD) at the upper extreme end. A genetic overlap has been shown between ALTs and ASD, indicating that common variation in ASD candidate genes may also influence ALTs. In our study, we have investigated the SNP rs4307059 that has been associated with both ALTs and ASD. In addition, we genotyped polymorphisms in a selection of genes involved in synaptic functioning, that is, SHANK3, RELN, and CNTNAP2, which repeatedly have been associated with ASD. The possible associations of these polymorphisms with ALTs, as well as genetic factors for neurodevelopmental problems (NDPs), were investigated in a large cohort from the general population: The Child and Adolescent Twin Study in Sweden. For analyses of ALTs and NDPs, 12,319 subjects (including 2,268 monozygotic (MZ) and 3,805 dizygotic (DZ) twin pairs) and 8,671 subjects (including 2,243 MZ and 2,044 DZ twin pairs), respectively, were included in the analyses. En ligne : http://dx.doi.org/10.1186/2040-2392-5-55 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10 [Texte imprimé et/ou numérique] / Lina JONSSON, Auteur ; Anna ZETTERGREN, Auteur ; Erik PETTERSSON, Auteur ; Daniel HOVEY, Auteur ; Henrik ANCKARSATER, Auteur ; Lars WESTBERG, Auteur ; Paul LICHTENSTEIN, Auteur ; Sebastian LUNDSTROM, Auteur ; Jonas MELKE, Auteur . - p.1-9. Langues : Anglais (eng) in Molecular Autism > (December 2014) . - p.1-9 Index. décimale : PER Périodiques Résumé : Autistic-like traits (ALTs) are continuously distributed in the general population, with the autism spectrum disorder (ASD) at the upper extreme end. A genetic overlap has been shown between ALTs and ASD, indicating that common variation in ASD candidate genes may also influence ALTs. In our study, we have investigated the SNP rs4307059 that has been associated with both ALTs and ASD. In addition, we genotyped polymorphisms in a selection of genes involved in synaptic functioning, that is, SHANK3, RELN, and CNTNAP2, which repeatedly have been associated with ASD. The possible associations of these polymorphisms with ALTs, as well as genetic factors for neurodevelopmental problems (NDPs), were investigated in a large cohort from the general population: The Child and Adolescent Twin Study in Sweden. For analyses of ALTs and NDPs, 12,319 subjects (including 2,268 monozygotic (MZ) and 3,805 dizygotic (DZ) twin pairs) and 8,671 subjects (including 2,243 MZ and 2,044 DZ twin pairs), respectively, were included in the analyses. En ligne : http://dx.doi.org/10.1186/2040-2392-5-55 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort / Paul LICHTENSTEIN in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Titre : Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort Type de document : Texte imprimé et/ou numérique Auteurs : Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.798-806 Langues : Anglais (eng) Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (?(boys) = .24, standard error, SE = 0.03; ?(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (?(boys) = 0.21, SE = 0.04; ?(girls) = 0.17, SE = 0.05) and general factors (?(boys) = 0.45, SE = 0.03; ?(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort [Texte imprimé et/ou numérique] / Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur . - p.798-806. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (?(boys) = .24, standard error, SE = 0.03; ?(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (?(boys) = 0.21, SE = 0.04; ?(girls) = 0.17, SE = 0.05) and general factors (?(boys) = 0.45, SE = 0.03; ?(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710 Titre : Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study Type de document : Texte imprimé et/ou numérique Auteurs : Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.702-710 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  comorbidity  genetics  twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study [Texte imprimé et/ou numérique] / Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur . - p.702-710. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710 Mots-clés : Autism spectrum disorders  comorbidity  genetics  twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Autism Spectrum Disorders and Coexisting Mental Health Problems / Ola STAHLBERG in Key Issues in Mental Health, 180 (2015)

Public ISBD [article]  inKey Issues in Mental Health > 180 (2015) . - p.5-19 Titre : Autism Spectrum Disorders and Coexisting Mental Health Problems Type de document : Texte imprimé et/ou numérique Auteurs : Ola STAHLBERG, Auteur ; Thomas NILSSON, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.5-19 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : It is a rule rather than an exception that mental disorders occur in complex and manifold forms, and a number of models have been proposed to explain this co-occurrence or co-‘morbidity'. Autism spectrum disorders (ASD, i.e. autistic disorder, Asperger syndrome, and pervasive developmental disorder - not otherwise specified) are no exemption. Here, the literature on ASD co-occurring with developmental disorders (such as ADHD), learning disorders, and problems that typically arise during childhood (e.g. oppositional defiant disorder, conduct disorder), and adulthood (e.g. anxiety, affective/mood disorders, and psychotic disorders), will be reviewed. The patterns of mental disorders co-occurring with ASD could not be summarized into any consistent and easy-to-interpret model of co-morbidity. Thus, research on ASD should consider and not rule out coexisting mental conditions (and include persons with complex problems in studies), clinical assessments, and evaluations. Ignoring the complexity of co-occurring conditions will have detrimental effects in research, counteracting our understanding of the etiology behind ASD and the development of evidence-based, comprehensive treatment strategies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271 [article] Autism Spectrum Disorders and Coexisting Mental Health Problems [Texte imprimé et/ou numérique] / Ola STAHLBERG, Auteur ; Thomas NILSSON, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik ANCKARSATER, Auteur . - p.5-19. Langues : Anglais (eng) in Key Issues in Mental Health > 180 (2015) . - p.5-19 Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : It is a rule rather than an exception that mental disorders occur in complex and manifold forms, and a number of models have been proposed to explain this co-occurrence or co-‘morbidity'. Autism spectrum disorders (ASD, i.e. autistic disorder, Asperger syndrome, and pervasive developmental disorder - not otherwise specified) are no exemption. Here, the literature on ASD co-occurring with developmental disorders (such as ADHD), learning disorders, and problems that typically arise during childhood (e.g. oppositional defiant disorder, conduct disorder), and adulthood (e.g. anxiety, affective/mood disorders, and psychotic disorders), will be reviewed. The patterns of mental disorders co-occurring with ASD could not be summarized into any consistent and easy-to-interpret model of co-morbidity. Thus, research on ASD should consider and not rule out coexisting mental conditions (and include persons with complex problems in studies), clinical assessments, and evaluations. Ignoring the complexity of co-occurring conditions will have detrimental effects in research, counteracting our understanding of the etiology behind ASD and the development of evidence-based, comprehensive treatment strategies. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271

Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study / Sebastian LUNDSTROM in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

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Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder / Mark J. TAYLOR ; Henrik LARSSON ; Catarina ALMQVIST ; Paul LICHTENSTEIN ; Sebastian LUNDSTROM ; Sven BÖLTE in Molecular Autism, 14 (2023)  

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Harmonizing behavioral outcomes across studies, raters, and countries: application to the genetic analysis of aggression in the ACTION Consortium / Justin M. LUNINGHAM in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

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Higher aggression is related to poorer academic performance in compulsory education / Eero VUOKSIMAA in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)  

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Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study / Agnieszka BUTWICKA in Journal of Autism and Developmental Disorders, 47-1 (January 2017)  

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Maltreatment-associated neurodevelopmental disorders: a co-twin control analysis / Lisa DINKLER in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

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Perceived child impairment and the 'autism epidemic' / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)  

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The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins / Albert CASTELLHEIM in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

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Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

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A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time / Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

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