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Auteur Maria RASTAM |
Documents disponibles écrits par cet auteur (12)



Adults with Asperger syndrome with and without a cognitive profile associated with “non-verbal learning disability.” A brief report / Agneta NYDEN in Research in Autism Spectrum Disorders, 4-4 (October-December 2010)
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[article]
Titre : Adults with Asperger syndrome with and without a cognitive profile associated with “non-verbal learning disability.” A brief report Type de document : Texte imprimé et/ou numérique Auteurs : Agneta NYDEN, Auteur ; Maria RASTAM, Auteur ; Annika DAHLGREN SANDBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Lena NIKLASSON, Auteur ; Ola STAHLBERG, Auteur ; Elisabeth WENTZ, Auteur Année de publication : 2010 Article en page(s) : p.612-618 Langues : Anglais (eng) Mots-clés : Adults Asperger-syndrome Neuropsychology Non-verbal-learning-disability Index. décimale : PER Périodiques Résumé : Asperger syndrome (AS) and non-verbal learning disability (NLD) are both characterized by impairments in motor coordination, visuo-perceptual abilities, pragmatics and comprehension of language and social understanding. NLD is also defined as a learning disorder affecting functions in the right cerebral hemisphere. The present study investigates if individuals with AS and a cognitive profile consistent with NLD (i.e. verbal IQ > performance IQ) would also have other problems inherent in NLD, visual memory and attention, reading/writing ability and arithmetic in the presence of preserved verbal memory and attention. Forty-four individuals with AS were assessed with a battery of neuropsychological tests. Reading/writing and arithmetic abilities were investigated. Education and global social adaptive levels were studied. Very few AS participants, even though with NLD cognitive profile showed problems with any of the neurocognitive abilities or academic achievements. However, all had poor global social adaptive functioning and few had paid employment, regardless of their cognitive profile. The present study suggests that AS and NLD are two different conditions even though some individuals in both groups have the verbal IQ > performance IQ profile that has been proposed to be typical of both AS and NLD. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Research in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.612-618[article] Adults with Asperger syndrome with and without a cognitive profile associated with “non-verbal learning disability.” A brief report [Texte imprimé et/ou numérique] / Agneta NYDEN, Auteur ; Maria RASTAM, Auteur ; Annika DAHLGREN SANDBERG, Auteur ; Henrik ANCKARSATER, Auteur ; Lena NIKLASSON, Auteur ; Ola STAHLBERG, Auteur ; Elisabeth WENTZ, Auteur . - 2010 . - p.612-618.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.612-618
Mots-clés : Adults Asperger-syndrome Neuropsychology Non-verbal-learning-disability Index. décimale : PER Périodiques Résumé : Asperger syndrome (AS) and non-verbal learning disability (NLD) are both characterized by impairments in motor coordination, visuo-perceptual abilities, pragmatics and comprehension of language and social understanding. NLD is also defined as a learning disorder affecting functions in the right cerebral hemisphere. The present study investigates if individuals with AS and a cognitive profile consistent with NLD (i.e. verbal IQ > performance IQ) would also have other problems inherent in NLD, visual memory and attention, reading/writing ability and arithmetic in the presence of preserved verbal memory and attention. Forty-four individuals with AS were assessed with a battery of neuropsychological tests. Reading/writing and arithmetic abilities were investigated. Education and global social adaptive levels were studied. Very few AS participants, even though with NLD cognitive profile showed problems with any of the neurocognitive abilities or academic achievements. However, all had poor global social adaptive functioning and few had paid employment, regardless of their cognitive profile. The present study suggests that AS and NLD are two different conditions even though some individuals in both groups have the verbal IQ > performance IQ profile that has been proposed to be typical of both AS and NLD. En ligne : http://dx.doi.org/10.1016/j.rasd.2009.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 Anorexia nervosa and autism: a prospective twin cohort study / Lisa DINKLER in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)
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Titre : Anorexia nervosa and autism: a prospective twin cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur Article en page(s) : p.316-326 Langues : Anglais (eng) Mots-clés : Eating disorder anorexia nervosa autism spectrum disorders longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443
in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326[article] Anorexia nervosa and autism: a prospective twin cohort study [Texte imprimé et/ou numérique] / Lisa DINKLER, Auteur ; Mark J. TAYLOR, Auteur ; Maria RASTAM, Auteur ; Nouchine HADJIKHANI, Auteur ; Cynthia M. BULIK, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Sebastian LUNDSTROM, Auteur . - p.316-326.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.316-326
Mots-clés : Eating disorder anorexia nervosa autism spectrum disorders longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. METHODS: In a population-based sample of 5,987 individuals (52.4% female) from the Child and Adolescent Twin Study in Sweden, parents reported autistic traits at ages 9 and 18. AN and ASD diagnoses were retrieved from the Swedish National Patient Register. In addition, AN diagnoses were ascertained by parent-reported treatment for AN. We compared whether individuals with and without AN differed in autistic traits before the first diagnosis of AN (age 9) and after the first diagnosis of AN (age 18). RESULTS: We did not find evidence for elevated autistic traits in 9-year-old children later diagnosed with AN. At age 18, however, there was a marked elevation in restricted/repetitive behavior and interests, but only in the subgroup of individuals with acute AN. A less pronounced elevation was observed for social communication problems. CONCLUSIONS: Coping strategies in individuals with ASD and the somewhat different female ASD phenotype may explain why we did not find elevated autistic traits in children who later developed AN. Alternatively, it is possible that elevated autistic traits were not present prior to the onset of AN, thus questioning the previously reported elevated prevalence of ASD in AN. Future studies should use tailored measurements in order to investigate whether autistic traits in individuals with AN are best conceptualized as an epiphenomenon of the acute AN phase or whether these symptoms indeed represent ASD as a clinically verifiable neurodevelopmental disorder. En ligne : http://dx.doi.org/10.1111/jcpp.13265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)
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Titre : Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study Type de document : Texte imprimé et/ou numérique Auteurs : Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur Article en page(s) : p.702-710 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders comorbidity genetics twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710[article] Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study [Texte imprimé et/ou numérique] / Sebastian LUNDSTROM, Auteur ; Abraham REICHENBERG, Auteur ; Jonas MELKE, Auteur ; Maria RASTAM, Auteur ; Nora KEREKES, Auteur ; Paul LICHTENSTEIN, Auteur ; Christopher GILLBERG, Auteur ; Henrik ANCKARSATER, Auteur . - p.702-710.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.702-710
Mots-clés : Autism spectrum disorders comorbidity genetics twins Index. décimale : PER Périodiques Résumé : Background Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. En ligne : http://dx.doi.org/10.1111/jcpp.12329 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)
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Titre : Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs Type de document : Texte imprimé et/ou numérique Auteurs : Henrik LARSSON, Auteur ; Henrik ANCKARSATER, Auteur ; Maria RASTAM, Auteur ; Zheng CHANG, Auteur ; Paul LICHTENSTEIN, Auteur Année de publication : 2012 Article en page(s) : p.73-80 Langues : Anglais (eng) Mots-clés : ADHD DSM etiology twins Index. décimale : PER Périodiques Résumé : Background: Although the clinical utility of categorically defined attention-deficit hyperactivity disorder (ADHD) is well established, there is also strong evidence supporting the notion of ADHD as an extreme of a continuous trait. Nevertheless, the question of whether the etiology is the same for different levels of DSM–IV ADHD symptoms remains to be investigated. The aim of this study was to assess genetic links between the extreme and the subthreshold range of ADHD symptoms. Method: Parents of all Swedish 9- and 12-year-old twins born between 1992 and 2000 were interviewed for DSM–IV ADHD symptoms and associated conditions. Two validated cutoff values were used for screening and assigning research diagnoses. Response rate was 80%. Twin methods were applied to investigate the extent to which ADHD is etiologically distinct from subthreshold variations in ADHD symptoms. Results: Extremes analyses indicated a strong genetic link between the extreme and the subthreshold variation, with almost identical group heritability estimates around .60 for the diagnostic (prevalence 1.78%) and screening (prevalence 9.75%) criteria of ADHD. Conclusion: A strong genetic link between the extreme and the subthreshold variation of DSM–IV based assessments of ADHD symptoms was found. The data suggest that ADHD is best viewed as the quantitative extreme of genetic and environmental factors operating dimensionally throughout the distribution of ADHD symptoms, indicating that the same etiologic factors are involved in the full range of symptoms of inattention, hyperactivity and impulsivity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02467.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.73-80[article] Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs [Texte imprimé et/ou numérique] / Henrik LARSSON, Auteur ; Henrik ANCKARSATER, Auteur ; Maria RASTAM, Auteur ; Zheng CHANG, Auteur ; Paul LICHTENSTEIN, Auteur . - 2012 . - p.73-80.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-1 (January 2012) . - p.73-80
Mots-clés : ADHD DSM etiology twins Index. décimale : PER Périodiques Résumé : Background: Although the clinical utility of categorically defined attention-deficit hyperactivity disorder (ADHD) is well established, there is also strong evidence supporting the notion of ADHD as an extreme of a continuous trait. Nevertheless, the question of whether the etiology is the same for different levels of DSM–IV ADHD symptoms remains to be investigated. The aim of this study was to assess genetic links between the extreme and the subthreshold range of ADHD symptoms. Method: Parents of all Swedish 9- and 12-year-old twins born between 1992 and 2000 were interviewed for DSM–IV ADHD symptoms and associated conditions. Two validated cutoff values were used for screening and assigning research diagnoses. Response rate was 80%. Twin methods were applied to investigate the extent to which ADHD is etiologically distinct from subthreshold variations in ADHD symptoms. Results: Extremes analyses indicated a strong genetic link between the extreme and the subthreshold variation, with almost identical group heritability estimates around .60 for the diagnostic (prevalence 1.78%) and screening (prevalence 9.75%) criteria of ADHD. Conclusion: A strong genetic link between the extreme and the subthreshold variation of DSM–IV based assessments of ADHD symptoms was found. The data suggest that ADHD is best viewed as the quantitative extreme of genetic and environmental factors operating dimensionally throughout the distribution of ADHD symptoms, indicating that the same etiologic factors are involved in the full range of symptoms of inattention, hyperactivity and impulsivity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02467.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 A cognitive endophenotype of autism in families with multiple incidence / Agneta NYDEN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)
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Titre : A cognitive endophenotype of autism in families with multiple incidence Type de document : Texte imprimé et/ou numérique Auteurs : Agneta NYDEN, Auteur ; Maria RASTAM, Auteur ; Véronique GOUSSE, Auteur ; Bibbi HAGBERG, Auteur Année de publication : 2011 Article en page(s) : p.191-200 Langues : Anglais (eng) Mots-clés : Multiple-incidence-families Autism-spectrum-disorders Cognitive-endophenotype Sibpair Autism Index. décimale : PER Périodiques Résumé : Twin and family studies have established that there is a strong genetic basis for autism spectrum disorders. To facilitate the identification of susceptibility genes and to study pathways from gene-brain to cognition a more refined endophenotype-based approach may be useful. The purpose of the present study was to examine the neurocognitive endophenotype of autism, in families with multiple incidence autism. Eighty-six members of 18 families containing at least two individuals with autism were neuropsychological assessed. Children with autism, showed weak central coherence, but this “trait” could not be found in their parents nor in non-affected siblings. All family members, including the sibpairs with autism, showed deficits within executive functions, involving planning ability, but normal set-shifting. The sibpairs with autism – but not their other family members – showed significant correlations within two visuo-spatial tasks. Deficits in executive functions (specifically planning ability) appear to characterize the broader endophenotype of autism. Our findings do not confirm the hypotheses of weak central coherence or deficits in theory of mind as part of the broader endophenotype of autism. Deficits in visual scanning may be a feature of the manifest phenotype of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.03.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111
in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.191-200[article] A cognitive endophenotype of autism in families with multiple incidence [Texte imprimé et/ou numérique] / Agneta NYDEN, Auteur ; Maria RASTAM, Auteur ; Véronique GOUSSE, Auteur ; Bibbi HAGBERG, Auteur . - 2011 . - p.191-200.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.191-200
Mots-clés : Multiple-incidence-families Autism-spectrum-disorders Cognitive-endophenotype Sibpair Autism Index. décimale : PER Périodiques Résumé : Twin and family studies have established that there is a strong genetic basis for autism spectrum disorders. To facilitate the identification of susceptibility genes and to study pathways from gene-brain to cognition a more refined endophenotype-based approach may be useful. The purpose of the present study was to examine the neurocognitive endophenotype of autism, in families with multiple incidence autism. Eighty-six members of 18 families containing at least two individuals with autism were neuropsychological assessed. Children with autism, showed weak central coherence, but this “trait” could not be found in their parents nor in non-affected siblings. All family members, including the sibpairs with autism, showed deficits within executive functions, involving planning ability, but normal set-shifting. The sibpairs with autism – but not their other family members – showed significant correlations within two visuo-spatial tasks. Deficits in executive functions (specifically planning ability) appear to characterize the broader endophenotype of autism. Our findings do not confirm the hypotheses of weak central coherence or deficits in theory of mind as part of the broader endophenotype of autism. Deficits in visual scanning may be a feature of the manifest phenotype of autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.03.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study / Søren NIELSEN in Molecular Autism, (March 2015)
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PermalinkGender differences in autism spectrum disorders: Divergence among specific core symptoms / Anita BEGGIATO in Autism Research, 10-4 (April 2017)
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PermalinkIdentification de mutations associées à l'autisme et au syndrome d'Asperger dans deux gènes du chromosome X codant les neuroligines NLGN3 et NLGN4 / Stéphane JAMAIN in Bulletin Scientifique de l'arapi (Le), 11 (automne 2003)
PermalinkProsodic traits in speech produced by children with autism spectrum disorders – Perceptual and acoustic measurements / SvenOlof DAHLGREN in Autism & Developmental Language Impairments, 3 (January-December 2018)
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PermalinkTemperament and Character in Adults with Asperger Syndrome / Maria RASTAM in Autism, 6-3 (September 2002)
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PermalinkThe Asperger Syndrome (and High-Functioning Autism) Diagnostic Interview (ASDI): A Preliminary Study of a New Structured Clinical Interview / Christopher GILLBERG in Autism, 5-1 (March 2001)
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PermalinkTrajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies / Sebastian LUNDSTROM in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)
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